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Volumn 34, Issue 1, 2013, Pages 254-263

The neurotoxicity of hallucinogenic amphetamines in primary cultures of hippocampal neurons

Author keywords

5 HT2A receptors; AIF; Amphetamines; Apoptosis; Caspases; DOI; Hallucinogens; Hippocampus; MDMA

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE 8; CYTOCHROME C; LACTATE DEHYDROGENASE; SEROTONIN 2A RECEPTOR; TETRAZOLIUM;

EID: 84872677219     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2012.09.005     Document Type: Article
Times cited : (40)

References (48)
  • 1
    • 78649497837 scopus 로고    scopus 로고
    • Evidence of neurotoxicity of ecstasy: sustained effects on electroencephalographic activity in polydrug users
    • Adamaszek M., Khaw A.V., Buck U., Andresen B., Thomasius R. Evidence of neurotoxicity of ecstasy: sustained effects on electroencephalographic activity in polydrug users. PLoS One 2010, 5:e14097.
    • (2010) PLoS One , vol.5
    • Adamaszek, M.1    Khaw, A.V.2    Buck, U.3    Andresen, B.4    Thomasius, R.5
  • 2
    • 33744732146 scopus 로고    scopus 로고
    • Damage of serotonergic axons and immunolocalization of Hsp27, Hsp72, and Hsp90 molecular chaperones after a single dose of MDMA administration in Dark Agouti rat: temporal, spatial, and cellular patterns
    • ádori C., Andó R.D., Kovács G.G., Bagdy G. Damage of serotonergic axons and immunolocalization of Hsp27, Hsp72, and Hsp90 molecular chaperones after a single dose of MDMA administration in Dark Agouti rat: temporal, spatial, and cellular patterns. J Comp Neurol. 2006, 497:251-269.
    • (2006) J Comp Neurol. , vol.497 , pp. 251-269
    • ádori, C.1    Andó, R.D.2    Kovács, G.G.3    Bagdy, G.4
  • 3
    • 0027157108 scopus 로고
    • Oral administration of 3,4-methylenedioxymethamphetamine (MDMA) produces selective serotonergic depletion in the nonhuman primate
    • Ali S.F., Newport G.D., Scallet A.C., Binienda Z., Ferguson S.A., Bailey J.R., et al. Oral administration of 3,4-methylenedioxymethamphetamine (MDMA) produces selective serotonergic depletion in the nonhuman primate. Neurotoxicol Teratol 1993, 15:91-96.
    • (1993) Neurotoxicol Teratol , vol.15 , pp. 91-96
    • Ali, S.F.1    Newport, G.D.2    Scallet, A.C.3    Binienda, Z.4    Ferguson, S.A.5    Bailey, J.R.6
  • 4
    • 73649099089 scopus 로고    scopus 로고
    • MDMA (" ecstasy") impairs learning in the Morris water maze and reduces hippocampal LTP in young rats
    • Arias-Cavieres A., Rozas C., Reyes-Parada M., Barrera N., Pancetti F., Loyola S., et al. MDMA (" ecstasy") impairs learning in the Morris water maze and reduces hippocampal LTP in young rats. Neurosci Lett 2010, 469:375-379.
    • (2010) Neurosci Lett , vol.469 , pp. 375-379
    • Arias-Cavieres, A.1    Rozas, C.2    Reyes-Parada, M.3    Barrera, N.4    Pancetti, F.5    Loyola, S.6
  • 5
    • 0023914535 scopus 로고
    • Pharmacologic profile of MDMA (3,4-methylenedioxymethamphetamine) at various brain recognition sites
    • Battaglia G., Brooks B., Kulsakdinun C., Souza E.D. Pharmacologic profile of MDMA (3,4-methylenedioxymethamphetamine) at various brain recognition sites. Eur J Pharmacol 1988, 149:159-163.
    • (1988) Eur J Pharmacol , vol.149 , pp. 159-163
    • Battaglia, G.1    Brooks, B.2    Kulsakdinun, C.3    Souza, E.D.4
  • 6
    • 0028868824 scopus 로고
    • Serum-free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus
    • Brewer G.J. Serum-free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus. J Neurosci Res 1995, 42:674-768.
    • (1995) J Neurosci Res , vol.42 , pp. 674-768
    • Brewer, G.J.1
  • 10
    • 33646162180 scopus 로고    scopus 로고
    • Ecstasy-induced cell death in cortical neuronal cultures is serotonin 2A-receptor-dependent and potentiated under hyperthermia
    • Capela J.P., Ruscher K., Lautenschlager M., Freyer D., Dirnagl U., Gaio A.R., et al. Ecstasy-induced cell death in cortical neuronal cultures is serotonin 2A-receptor-dependent and potentiated under hyperthermia. Neuroscience 2006, 139:1069-1081.
    • (2006) Neuroscience , vol.139 , pp. 1069-1081
    • Capela, J.P.1    Ruscher, K.2    Lautenschlager, M.3    Freyer, D.4    Dirnagl, U.5    Gaio, A.R.6
  • 11
    • 34248993569 scopus 로고    scopus 로고
    • Chronic 3,4-methylenedioxymethamphetamine treatment suppresses cell proliferation in the adult mouse dentate gyrus
    • Cho K.-O., Kim S.-K., Rhee G.S., Kwack S.J., Cho D.H., Sung K.W., et al. Chronic 3,4-methylenedioxymethamphetamine treatment suppresses cell proliferation in the adult mouse dentate gyrus. Eur J Pharmacol 2007, 566:120-123.
    • (2007) Eur J Pharmacol , vol.566 , pp. 120-123
    • Cho, K.-O.1    Kim, S.-K.2    Rhee, G.S.3    Kwack, S.J.4    Cho, D.H.5    Sung, K.W.6
  • 12
    • 0029916656 scopus 로고    scopus 로고
    • Disposition of methylenodioxymethamphetamine and three metabolites in the brains of different rat strains and their possible roles in acute serotonin depletion
    • Chu T., Kumagai Y., DiStefano E.W., Cho A.K. Disposition of methylenodioxymethamphetamine and three metabolites in the brains of different rat strains and their possible roles in acute serotonin depletion. Biochem Pharmacol 1996, 51:789-796.
    • (1996) Biochem Pharmacol , vol.51 , pp. 789-796
    • Chu, T.1    Kumagai, Y.2    DiStefano, E.W.3    Cho, A.K.4
  • 13
    • 22544443904 scopus 로고    scopus 로고
    • Learning and memory after neonatal exposure to 3,4-methylenedioxymethamphetamine (ecstasy) in rats: interaction with exposure in adulthood
    • Cohen A.M., Skelton R.M., Schaefer T.L., Gudelsky G.A., Vorhees C., Williams M.T. Learning and memory after neonatal exposure to 3,4-methylenedioxymethamphetamine (ecstasy) in rats: interaction with exposure in adulthood. Synapse 2005, 57:148-159.
    • (2005) Synapse , vol.57 , pp. 148-159
    • Cohen, A.M.1    Skelton, R.M.2    Schaefer, T.L.3    Gudelsky, G.A.4    Vorhees, C.5    Williams, M.T.6
  • 14
    • 0023255308 scopus 로고
    • Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain
    • Commins D.L., Vosmer G., Virus R.M., Woolverton W.L., Schuster C.R., Seiden L.S. Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain. J Pharmacol Exp Ther 1987, 241:338-345.
    • (1987) J Pharmacol Exp Ther , vol.241 , pp. 338-345
    • Commins, D.L.1    Vosmer, G.2    Virus, R.M.3    Woolverton, W.L.4    Schuster, C.R.5    Seiden, L.S.6
  • 15
    • 2442621492 scopus 로고    scopus 로고
    • Role of AIF in caspase-dependent and caspase-independent cell death
    • Cregan S.P., Dawson V.L., Slack R.S. Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene 2004, 23:2785-2796.
    • (2004) Oncogene , vol.23 , pp. 2785-2796
    • Cregan, S.P.1    Dawson, V.L.2    Slack, R.S.3
  • 16
    • 33646756208 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine
    • Cunha-Oliveira T., Rego A.C., Cardoso S.M., Borges F., Swerdlow R.H., Macedo T., et al. Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine. Brain Res 2006, 1089:44-54.
    • (2006) Brain Res , vol.1089 , pp. 44-54
    • Cunha-Oliveira, T.1    Rego, A.C.2    Cardoso, S.M.3    Borges, F.4    Swerdlow, R.H.5    Macedo, T.6
  • 18
    • 10244241834 scopus 로고    scopus 로고
    • Deadly conversations: nuclear-mitochondrial cross-talk
    • Dawson V.L., Dawson T.M. Deadly conversations: nuclear-mitochondrial cross-talk. J Bioenerg Biomembr 2004, 36:287-294.
    • (2004) J Bioenerg Biomembr , vol.36 , pp. 287-294
    • Dawson, V.L.1    Dawson, T.M.2
  • 20
    • 0033564773 scopus 로고    scopus 로고
    • Altered serotonin innervation patterns in the forebrain of monkeys treated with (+/-)3,4-methylenedioxymethamphetamine seven years previously: factors influencing abnormal recovery
    • Hatzidimitriou G., McCann U.D., Ricaurte G.A. Altered serotonin innervation patterns in the forebrain of monkeys treated with (+/-)3,4-methylenedioxymethamphetamine seven years previously: factors influencing abnormal recovery. J Neurosci 1999, 15:5096-5107.
    • (1999) J Neurosci , vol.15 , pp. 5096-5107
    • Hatzidimitriou, G.1    McCann, U.D.2    Ricaurte, G.A.3
  • 21
    • 33749667756 scopus 로고    scopus 로고
    • Binge administration of 3,4-methylenedioxymethamphetamine (" ecstasy") impairs the survival of neural precursors in adult rat dentate gyrus
    • Hernandez-Rabaza V., Dominguez-Escriba L., Barcia J.A., Rosel J.F., Romero F.J., Garcia-Verdugo J.M., et al. Binge administration of 3,4-methylenedioxymethamphetamine (" ecstasy") impairs the survival of neural precursors in adult rat dentate gyrus. Neuropharmacology 2006, 51:967-973.
    • (2006) Neuropharmacology , vol.51 , pp. 967-973
    • Hernandez-Rabaza, V.1    Dominguez-Escriba, L.2    Barcia, J.A.3    Rosel, J.F.4    Romero, F.J.5    Garcia-Verdugo, J.M.6
  • 23
    • 11144354601 scopus 로고    scopus 로고
    • Neurotoxicity of amphetamine derivatives is mediated by caspase pathway activation in rat cerebellar granule cells
    • Jimenez A., Jorda E.G., Verdaguer E., Pubill D., Sureda F.X., Canudas A.M., et al. Neurotoxicity of amphetamine derivatives is mediated by caspase pathway activation in rat cerebellar granule cells. Toxicol Appl Pharmacol 2004, 196:223-234.
    • (2004) Toxicol Appl Pharmacol , vol.196 , pp. 223-234
    • Jimenez, A.1    Jorda, E.G.2    Verdaguer, E.3    Pubill, D.4    Sureda, F.X.5    Canudas, A.M.6
  • 24
    • 2542526070 scopus 로고    scopus 로고
    • Brain concentrations of d-MDMA are increased after stress
    • Johnson E.A., O'Callaghan J.P., Miller D.B. Brain concentrations of d-MDMA are increased after stress. Psychopharmacology 2004, 173:278-286.
    • (2004) Psychopharmacology , vol.173 , pp. 278-286
    • Johnson, E.A.1    O'Callaghan, J.P.2    Miller, D.B.3
  • 25
    • 33749580026 scopus 로고    scopus 로고
    • Methamphetamine induces autophagy and apoptosis in a mesencephalic dopaminergic neuronal culture model: role of cathepsin-d in methamphetamine-induced apoptotic cell death
    • Kanthasamy A., Anantharam V., Ali S.F., Kanthasamy A.G. Methamphetamine induces autophagy and apoptosis in a mesencephalic dopaminergic neuronal culture model: role of cathepsin-d in methamphetamine-induced apoptotic cell death. Ann NY Acad Sci 2006, 1074:234-244.
    • (2006) Ann NY Acad Sci , vol.1074 , pp. 234-244
    • Kanthasamy, A.1    Anantharam, V.2    Ali, S.F.3    Kanthasamy, A.G.4
  • 26
    • 33847134493 scopus 로고    scopus 로고
    • Apoptosis-inducing factor: a matter of neuron life and death
    • Krantic S., Mechawar N., Reix S., Quirion R. Apoptosis-inducing factor: a matter of neuron life and death. Prog Neurobiol 2007, 81:179-196.
    • (2007) Prog Neurobiol , vol.81 , pp. 179-196
    • Krantic, S.1    Mechawar, N.2    Reix, S.3    Quirion, R.4
  • 27
    • 18144363937 scopus 로고    scopus 로고
    • Amphetamine induces apoptosis of medium spiny striatal projection neurons via the mitochondria-dependent pathway
    • Krasnova I.N., Ladenheim B., Cadet J.L. Amphetamine induces apoptosis of medium spiny striatal projection neurons via the mitochondria-dependent pathway. FASEB J 2005, 19:851-853.
    • (2005) FASEB J , vol.19 , pp. 851-853
    • Krasnova, I.N.1    Ladenheim, B.2    Cadet, J.L.3
  • 28
    • 0032587879 scopus 로고    scopus 로고
    • Cognitive performance in 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) users: a controlled study
    • McCann U., Mertl M., Eligulashvili V., Ricaurte G. Cognitive performance in 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) users: a controlled study. Psychopharmacology 1999, 143:417-425.
    • (1999) Psychopharmacology , vol.143 , pp. 417-425
    • McCann, U.1    Mertl, M.2    Eligulashvili, V.3    Ricaurte, G.4
  • 29
    • 0032585201 scopus 로고    scopus 로고
    • Positron emission tomographic evidence of toxic effect of MDMA (" Ecstasy") on brain serotonin neurones in human beings
    • McCann U.D., Szabo Z., Scheffel U., Dannals R.F., Ricaurte G.A. Positron emission tomographic evidence of toxic effect of MDMA (" Ecstasy") on brain serotonin neurones in human beings. Lancet 1998, 352:1433-1437.
    • (1998) Lancet , vol.352 , pp. 1433-1437
    • McCann, U.D.1    Szabo, Z.2    Scheffel, U.3    Dannals, R.F.4    Ricaurte, G.A.5
  • 30
    • 4544267006 scopus 로고    scopus 로고
    • Neurotoxic effects of MDMA (" ecstasy") administration to neonatal rats
    • Meyer J.S., Grande M., Johnson K., Ali S.F. Neurotoxic effects of MDMA (" ecstasy") administration to neonatal rats. Int J Dev Neurosci 2004, 22:261-271.
    • (2004) Int J Dev Neurosci , vol.22 , pp. 261-271
    • Meyer, J.S.1    Grande, M.2    Johnson, K.3    Ali, S.F.4
  • 31
    • 0033063606 scopus 로고    scopus 로고
    • Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, 5-HT2B and 5-HT2C receptors
    • Nelson D.L., Lucaites V.L., Wainscott D.B., Glennon R.A. Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, 5-HT2B and 5-HT2C receptors. N-S Arch Pharmacol 1999, 359:1-6.
    • (1999) N-S Arch Pharmacol , vol.359 , pp. 1-6
    • Nelson, D.L.1    Lucaites, V.L.2    Wainscott, D.B.3    Glennon, R.A.4
  • 32
    • 0842324481 scopus 로고    scopus 로고
    • Hallucinogens
    • Nichols D.E. Hallucinogens. Pharmacol Ther 2004, 101:131-181.
    • (2004) Pharmacol Ther , vol.101 , pp. 131-181
    • Nichols, D.E.1
  • 33
    • 80755153165 scopus 로고    scopus 로고
    • Electrophysiological indices of altered working memory processes in long-term ecstasy users
    • Nulsen C., Fox A., Hammond G. Electrophysiological indices of altered working memory processes in long-term ecstasy users. Hum Psychopharmacol 2011, 26:488-497.
    • (2011) Hum Psychopharmacol , vol.26 , pp. 488-497
    • Nulsen, C.1    Fox, A.2    Hammond, G.3
  • 34
    • 0034781572 scopus 로고    scopus 로고
    • The mechanism of mitochondrial membrane potential retention following release of cytochrome c in apoptotic GT1-7 neural cells
    • Rego A.C., Vesce S., Nicholls D.G. The mechanism of mitochondrial membrane potential retention following release of cytochrome c in apoptotic GT1-7 neural cells. Cell Death Differ 2001, 8:995-1003.
    • (2001) Cell Death Differ , vol.8 , pp. 995-1003
    • Rego, A.C.1    Vesce, S.2    Nicholls, D.G.3
  • 35
    • 0035657153 scopus 로고    scopus 로고
    • Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neurons
    • Reneman L., Booij J., de Bruin K., Reitsma J.B., de Wolff F.A., Gunning W.B., et al. Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neurons. Lancet 2001, 358:1864-1869.
    • (2001) Lancet , vol.358 , pp. 1864-1869
    • Reneman, L.1    Booij, J.2    de Bruin, K.3    Reitsma, J.B.4    de Wolff, F.A.5    Gunning, W.B.6
  • 36
    • 0033623773 scopus 로고    scopus 로고
    • (±)3,4-Methylenedioxymethamphetamine (" Ecstasy")-induced serotonin neurotoxicity: studies in animals
    • Ricaurte G.A., Yuan J., McCann U.D. (±)3,4-Methylenedioxymethamphetamine (" Ecstasy")-induced serotonin neurotoxicity: studies in animals. Neuropsychobiology 2000, 42:5-10.
    • (2000) Neuropsychobiology , vol.42 , pp. 5-10
    • Ricaurte, G.A.1    Yuan, J.2    McCann, U.D.3
  • 37
    • 0033902801 scopus 로고    scopus 로고
    • Cognitive performance amongst recreational users of "ecstasy"
    • Rodgers J. Cognitive performance amongst recreational users of "ecstasy". Psychopharmacology 2000, 151:19-24.
    • (2000) Psychopharmacology , vol.151 , pp. 19-24
    • Rodgers, J.1
  • 38
    • 0036896201 scopus 로고    scopus 로고
    • Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model
    • Ruscher K., Freyer D., Karsch M., Isaev N., Megow D., Sawitzki B., et al. Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model. J Neurosci 2002, 22:10291-10301.
    • (2002) J Neurosci , vol.22 , pp. 10291-10301
    • Ruscher, K.1    Freyer, D.2    Karsch, M.3    Isaev, N.4    Megow, D.5    Sawitzki, B.6
  • 39
    • 0023109989 scopus 로고
    • In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain
    • Schmidt C.J., Levin J.A., Lovenberg W. In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain. Biochem Pharmacol 1987, 36:747-755.
    • (1987) Biochem Pharmacol , vol.36 , pp. 747-755
    • Schmidt, C.J.1    Levin, J.A.2    Lovenberg, W.3
  • 40
    • 0037651111 scopus 로고    scopus 로고
    • Demonstration and localization of neuronal degeneration in the rat forebrain following a single exposure to MDMA
    • Schmued L. Demonstration and localization of neuronal degeneration in the rat forebrain following a single exposure to MDMA. Brain Res 2003, 974:127-133.
    • (2003) Brain Res , vol.974 , pp. 127-133
    • Schmued, L.1
  • 41
    • 0038819903 scopus 로고    scopus 로고
    • Hippocampal serotonergic damage induced by MDMA (ecstasy): effects on spatial learning
    • Sprague J.E., Preston A.S., Leifheit M., Woodside B. Hippocampal serotonergic damage induced by MDMA (ecstasy): effects on spatial learning. Physiol Behav 2003, 79:281-287.
    • (2003) Physiol Behav , vol.79 , pp. 281-287
    • Sprague, J.E.1    Preston, A.S.2    Leifheit, M.3    Woodside, B.4
  • 42
    • 0032968347 scopus 로고    scopus 로고
    • Amphetamines induce apoptosis and regulation of bcl-x splice variants in neocortical neurons
    • Stumm G., Schlegel J., Schafer T., Wurz C., Mennel H., Krieg J., et al. Amphetamines induce apoptosis and regulation of bcl-x splice variants in neocortical neurons. FASEB J 1999, 13:1065-1072.
    • (1999) FASEB J , vol.13 , pp. 1065-1072
    • Stumm, G.1    Schlegel, J.2    Schafer, T.3    Wurz, C.4    Mennel, H.5    Krieg, J.6
  • 44
    • 80051686197 scopus 로고    scopus 로고
    • United Nations Office on Drugs and Crime (UNODC), Vienna, Austria, UNODC
    • UNODC World drug report 2011 2011, United Nations Office on Drugs and Crime (UNODC), Vienna, Austria.
    • (2011) World drug report 2011
  • 46
    • 34547743384 scopus 로고    scopus 로고
    • Calpain and caspase proteolytic markers co-localize with rat cortical neurons after exposure to methamphetamine and MDMA
    • Warren M., Larner S., Kobeissy F., Brezing C., Jeung J., Hayes R., et al. Calpain and caspase proteolytic markers co-localize with rat cortical neurons after exposure to methamphetamine and MDMA. Acta Neuropathol 2007, 114:277-286.
    • (2007) Acta Neuropathol , vol.114 , pp. 277-286
    • Warren, M.1    Larner, S.2    Kobeissy, F.3    Brezing, C.4    Jeung, J.5    Hayes, R.6
  • 47
    • 77449153351 scopus 로고    scopus 로고
    • Regulation of death receptor signaling by the ubiquitin system
    • Wertz I.E., Dixit V.M. Regulation of death receptor signaling by the ubiquitin system. Cell Death Differ 2010, 17:14-24.
    • (2010) Cell Death Differ , vol.17 , pp. 14-24
    • Wertz, I.E.1    Dixit, V.M.2
  • 48
    • 0034077103 scopus 로고    scopus 로고
    • Cellular localization of serotonin2A (5HT2A) receptors in the rat brain
    • Xu T., Pandey S.C. Cellular localization of serotonin2A (5HT2A) receptors in the rat brain. Brain Res Bull 2000, 51:499-505.
    • (2000) Brain Res Bull , vol.51 , pp. 499-505
    • Xu, T.1    Pandey, S.C.2


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