DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: Implications for Parkinson's disease

Aging Cell

Volumn 10, Issue 5, 2011, Pages 807-823

  Wang, Xinglong ^a   Su, Bo ^a   Liu, Wanhong ^b   He, Xiaohua ^b   Gao, Yuan ^a   Castellani, Rudy J ^c   Perry, George ^a,d   Smith, Mark A ^a   Zhu, Xiongwei ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b WUHAN UNIVERSITY   (China)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d University of San Antonio   (United States)

Author keywords

DLP1 Drp1; Mitochondrial dynamics; Mitochondrial fragmentation; MPP+; Neurotoxicity; Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 2 AMINO 5 PHOSPHONOVALERIC ACID; ACETYLCYSTEINE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CALCIUM ION; DYNAMIN; PROTEIN DLP1; REACTIVE OXYGEN METABOLITE; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHAGY; BRAIN MITOCHONDRION; CELL DEATH; CONTROLLED STUDY; DEGRADATION; DOPAMINERGIC NERVE CELL; DRUG TARGETING; HUMAN; HUMAN CELL; MITOCHONDRIAL FRAGMENTATION; MITOCHONDRIAL MEMBRANE POTENTIAL; NERVE CELL DEGENERATION; NEUROPATHOLOGY; NEUROTOXICITY; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

1-METHYL-4-PHENYLPYRIDINIUM; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; AUTOPHAGY; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; DYNAMINS; EXCITATORY AMINO ACID ANTAGONISTS; FLUORESCENT ANTIBODY TECHNIQUE; FLUORESCENT DYES; GENE SILENCING; GENETIC VECTORS; GTP PHOSPHOHYDROLASES; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NEURONS; PARKINSON DISEASE; RATS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; TRANSFECTION; TYROSINE 3-MONOOXYGENASE;

RATTUS;

EID: 80052794422     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2011.00721.x     Document Type: Article

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