An antisense oligonucleotide targeted at MAO-B attenuates rat striatal serotonergic neurotoxicity induced by MDMA

Pharmacology Biochemistry and Behavior

Volumn 72, Issue 3, 2002, Pages 617-622

  Falk, Erin M ^a   Cook, Valerie J ^a   Nichols, David E ^b   Sprague, Jon E ^a  

^a OHIO NORTHERN UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

Antisense; Dopamine; MAO B; MDMA; Microdialysis; Serotonergic neurotoxicity

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; 5 HYDROXYINDOLEACETIC ACID; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; ANTISENSE OLIGONUCLEOTIDE; DOPAMINE; SEROTONIN; AMINE OXIDASE (FLAVIN CONTAINING);

ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE METABOLISM; DOPAMINE RELEASE; DRUG EFFECT; ENZYME ACTIVITY; HYPERTHERMIA; MALE; MICRODIALYSIS; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT; SEROTONIN BRAIN LEVEL; SEROTONINERGIC SYSTEM; ANIMAL; ENZYMOLOGY; METABOLISM; PHYSIOLOGY; SECRETION; SPRAGUE DAWLEY RAT;

GYMNOMYZA SAMOENSIS;

ANIMALS; BODY TEMPERATURE; CORPUS STRIATUM; DOPAMINE; MALE; MONOAMINE OXIDASE; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; OLIGONUCLEOTIDES, ANTISENSE; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN;

EID: 0036011297     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(02)00728-1     Document Type: Article

References (33)

1. The role of dopaminergic systems in the perinatal sensitivity to 3,4-methylenedioxymethamphetamine-induced neurotoxicity in rats
2. Effects of a cold environment or age on methamphetamine-induced dopamine release in the caudate putamen of female rats
3. Free radicals and the pathobiology of brain dopamine systems
4. Effects of LC mobile phase composition on retention times for biogenic amines, and their precursors and metabolites
5. Role of hyperthermia in the protective action of clomethiazole against MDMA ('ecstasy')-induced neurodegeneration, comparison with the novel NMDA channel blocker AR-R15896AR
6. In vivo evidence against clomethiazole being neuroprotective against MDMA ('ecstasy')-induced degeneration of rat brain 5-HT nerve terminals by a free radical scavenging mechanism
7. Studies on the role of dopamine in the degeneration of 5-HT nerve endings in the brain of Dark Agouti rats following 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy') administration
8. 3H]-dopamine uptake by human lymphocytes: Correlates with serotonin transporter activity
9. Biochemical effects of the monoamine neurotoxins DSP-4 and MDMA in specific brain regions of MAO-B deficient mice
10. Carrier-mediated release of serotonin by 3,4-methylenedioxy-methamphetamine: Implications for serotonin-dopamine interactions
11. Unilateral injection of dopamine transporter antisense oligonucleotide into the substantia nigra protects against MDMA-induced serotonergic deficits in the ipsilateral striatum
12. R-(-)-deprenyl (Selegiline, Movergan®) facilitates the activity of the nigrostriatal dopaminergic neuron
13. The striatal dopamine dependency of life span in male rats: Longevity study with (-)deprenyl
14. Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons
15. Co-administration of MDMA with drugs that protect against MDMA neurotoxicity produces different effects on the body temperature in the rat
16. Positron emission tomographic evidence of toxic effect of MDMA ("Ecstasy") on brain serotonin neurons in human beings
17. Ketanserin pretreatment attenuates MDMA-induced DA release in the striatum as measured by in-vivo microdialysis
18. Microdialysis studies of 3,4-methylenedioxymethamphetamine and structurally related analogues
19. Monoamine oxidase inhibitory effects of some 4-aminophenethylamine derivatives
20. Reserpine attenuates D-amphetamine and MDMA-induced transmitter release in vivo: A consideration of dose, core temperature and dopamine synthesis
21. Neurotoxicity of the psychedelic amphetamine, methylenedioxymeth-amphetamine
22. Antagonism of the neurotoxicity due to a single administration of 3,4-methylenedixymethamphetamine
23. Selegiline enhances NGF synthesis and protects central nervous system neurons from excitotoxic and ischemic damage
24. Effect of 3,4-methylenedioxymethamphetamine (MDMA) on hippocampal dopamine and serotonin
25. Mazindol attenuates the 3,4-methylenedioxymethamphetamine-induced formation of hydroxyl radicals and long-term depletion of serotonin in the striatum
26. The monoamine oxidase-B inhibitor L-deprenyl protects against 3,4-methylenedioxymethamphetamine-induced lipid peroxidation and long-term serotonergic deficits
27. An integrated hypothesis for the serotonergic axonal loss induced by 3,4-methylenedioxymethamphetamine
28. Antisense reduction of MAO-B activity and mRNA expression in rat brain fails to protect against MDMA-induced serotonergic neurotoxicity: Relevance to neuroprotection mechanisms
29. The pharmacodynamic characterization of an antisense oligonucleotide against monoamine oxidase-B (MAO-B) in rat brain striatal tissue
30. Role of endogenous dopamine in the central serotonergic deficits induced by 3,4-methylenedioxymethamphetamine
31. In vitro trapping of free radicals by the monoamine oxidase B inhibitors deprenyl and MDL 72,974A
32. Effect of dopamine depletion on MDMA-induced serotonin neurotoxicity