Quantitative relationship between inhibition of respiratory complexes and formation of reactive oxygen species in isolated nerve terminals

Journal of Neurochemistry

Volumn 84, Issue 1, 2003, Pages 112-118

  Sipos, Ildikó ^a   Tretter, Laszlo ^a   Adam Vizi, Vera ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Complex I; Parkinson's disease; Reactive oxygen species; Reactive oxygen species formation; Respiratory complexes

Indexed keywords

ACONITATE HYDRATASE; CITRININ; CYANIDE; CYTOCHROME C OXIDASE; REACTIVE OXYGEN METABOLITE; ROTENONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ISOLATED ORGAN; MAXIMUM ALLOWABLE CONCENTRATION; MEASUREMENT; NERVE ENDING; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RESPIRATORY CHAIN;

ACONITATE HYDRATASE; ANIMALS; ANTIMYCIN A; CEREBRAL CORTEX; CYANIDES; ELECTRON TRANSPORT; GUINEA PIGS; HYDROGEN PEROXIDE; NERVE ENDINGS; OXAZINES; REACTIVE OXYGEN SPECIES; ROTENONE; SYNAPTOSOMES;

ANIMALIA;

EID: 0037269343     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01513.x     Document Type: Article

References (35)

1. Andersson U., Leighton B., Young M. E., Blomstrand E. and Newsholme E. A. (1998) Inactivation of aconitase and oxoglutarate dihydrogenase in skeletal muscle in vitro by superoxide anions and/or nitric oxide. Biochem. Biophys. Res. Commun. 249, 512-516.
2. Beal M. F. (1996) Mitochondria, free radicals, and neurodegeneration. Curr Opin. Neurobiol. 6, 661-666.
3. Beal M. F. (1998) Mitochondrial dysfunction in neurodegenerative diseases. Biochim. Biophys. Acta 1366, 211-223.
4. Betarbet R., Sherer T. B., MacKenzie G., Garcia-Osuna M., Panov A. V. and Greenamyre J. T. (2000) Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat. Neurosci. 12, 1301-1306.
5. Boveris A. and Chance B. (1973) The mitochondrial generation of hydrogen peroxide: general properties and effect of hyperbaric oxygen. Biochem. J. 134, 707-716.
6. Boveris A., Oshino N. and Chance B. (1972) The cellular production of hydrogen peroxide. Biochem. J. 128, 617-630.
7. Boveris A., Cadenas E. and Stoppani A. O. M. (1976) Role of ubiquinone in the mitochondrial generation of hydrogen peroxide. Biochem. J. 156, 435-444.
8. Cadenas E., Boveris A., Ragan C. I. and Stoppani A. O. (1977) Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria. Arch. Biochem. Biophys. 180, 248-257.
9. Chinopoulos C. and Adam-Vizi V. (2001) Mitochondria deficient in complex I activity are depolarized by hydrogen peroxide in nerve terminals: relevance to Parkinson's disease. J. Neurochem. 76, 302-306.
10. Davey G. P. and Clark J. B. (1996) Threshold effects and control of oxidative phosphorylation in nonsynaptic rat brain mitochondria. J. Neurochem. 66, 1617-1624.
11. Davey G. P., Peuchen S. and Clark J. B. (1998) Energy thresholds in brain mitochondria. Potential involvement in neurodegeneration. J. Biol. Chem. 273, 12753-12757.
12. Forman H. J. and Azzi A. (1997) On the virtual existence of superoxide anions in mitochondria: thoughts regarding its role in pathophysiology. FASEB J. 11, 374-375.
13. Gardner P. R., Raineri I., Epstein L. B. and White C. W. (1995) Superoxide radical and iron modulate aconitase activity in mammalian cells. J. Biol. Chem. 270, 13399-13405.
14. Kish S. J., Bergeron C., Rajput A., Dozic S., Mastrogiacomo F., Chang L. J., Wilson J. M., DiStefano L. M. and Nobrega J. N. (1992) Brain cytochrome oxidase in Alzheimer's disease. J. Neurochem. 59, 776-779.
15. Klausner R. D., Rouault T. A. and Harford J. B. (1993) Regulating the fate of mRNA: the control of cellular iron metabolism. Cell 72, 19-28.
16. Jakel R. J. and Maragos W. F. (2000) Neuronal cell death in Huntington's disease: a potential role for dopamine. Trends Neurosci. 23, 239-245.
17. Hausladen A. and Fridovich I. (1996) Measuring nitric oxide and superoxide: rate constants for aconitase activity. Meth Enzymol. 269, 37-41.
18. Li Q.-Y., Pedersen C., Day B. J. and Patel M. (2001) Dependence of excitotoxic neurodegeneration on mitochondrial aconitase inactivation. J. Neurochem. 78, 746-755.
19. Liang L. P., Ho Y. S. and Patel M. (2000) Mitochondrial superoxide production in kainite-induced hippocampal damage. Neurosci. 101, 563-570.
20. Liu Y., Fiskum G. and Schubert D. (2002) Generation of reactive oxygen species by the mitochondrial electron transport chain. J. Neurochem. 80, 780-787.
21. 2 production in pigeon heart mitochondria. FEBS Lett. 18, 261-264.
22. 2 formation: relationship with energy conservation. FEBS Lett. 18, 84-88.
23. 2 release from activated human leukocytes using a dihydroxyphenoxazine derivative. J. Immunol. Methods 202, 133-141.
24. Mutisya E. M., Bowling A. C. and Beal M. F. (1994) Cortical cytochrome oxidase activity is reduced in Alzheimer's disease. J. Neurochem. 63, 2179-2184.
25. Parker W. D., Parks J. and Filley C. M. and Kleinschmidt-DeMasters B. K. (1994) Electron transport chain defects in Alzheimer's disease brain. Neurology 44, 1090-1096.
26. Patel M., Day B. J., Crapo J. D., Fridovich I. and McNamara J. O. (1996) Requirement for superoxide in excitotoxic cell death. Neuron 16, 345-355.
27. Ragan C. I., Wilson M. T., Darley-Usmar V. M. and Lowe P. N. (1987) Subfractionation of mitochondria, and isolation of the proteins of oxidative phosphorylation, in Mitochondria, a Practical Approach. (Darley-Usmar V. M., Rickwood D. and Wilson M. T., eds), pp. 79-112. IRL Press. London.
28. Rieske J. S. (1967) Preparation and properties of reduced coenzyme Q-cytochrome c reductase. Meth Enzymol. 10, 239-245.
29. Schapira A. H. V., Cooper J. M., Dexter D., Clark J. B., Jenner P. and Marsden C. D. (1990) Mitochondrial complex I deficiency in Parkinson's disease. J. Neurochem. 54, 823-827.
30. Tretter L. and Adam-Vizi V. (2000) Inhibition of Krebs cycle enzymes by hydrogen peroxide: a key role of α-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress. J. Neurosci. 20, 8972-8979.
31. Turrens J. F. and Boveris A. (1980) Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria. Biochem. J. 191, 421-427.
32. Vasquez-Vivar J., Kalyanaraman B. and Kennedy M. C. (2000) Mitochondrial aconitase is a source of hydroxyl radical. J. Biol. Chem. 275, 14064-14069.
33. m-dependent and -independent production of reactive oxygen species by rat brain mitochondria. J. Neurochem. 79, 266-277.
34. Wharton D. C. and Tzagoloff A. (1967) Cytochrome oxidase from beef heart mitochondria. Meth. Enzymol. 10, 245-250.
35. Zhang Y., Marcillat O., Giulivi C., Ernster L. and Davies K. J. (1990) The oxidative inactivation of mitochondrial electron transport chain components and ATPase. J. Biol. Chem. 265, 16330-16336.