Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells

Molecular Biology of the Cell

Volumn 12, Issue 8, 2001, Pages 2245-2256

  Smirnova, E ^a   Griparic, L ^a   Shurland, D L ^a   Van der Bliek, A M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; DYNAMIN; DYNAMIN RELATED PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CELL FRACTIONATION; GENE MUTATION; IMMUNOBLOTTING; MAMMAL CELL; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; YEAST;

EID: 0035166814     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.8.2245     Document Type: Article

References (39)

1. Mitochondrial FtsZ in a chromophyte alga
2. Dynamics of mitochondria in living cells: Shape changes, dislocations, fusion, and fission of mitochondria
3. The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast
4. Dynamin assembles into spirals under physiological salt conditions upon the addition of GDP and gamma-phosphate analogues
5. Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin
6. Experimental production of "septa" and apparent subdivision of muscle mitochondria
7. Mechanism of activation of the Caenorhabditis elegans ras homologue let-60 by a novel, temperature-sensitive, gain-of-function mutation
8. Gag3p, an outer membrane protein required for fission of mitochondrial tubules
9. DNM1, a dynamin-related gene, participates in endosomal trafficking in yeast
10. Mitochondrial dynamics in yeast
11. Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding
12. Immunochemical analysis of rough and smooth microsomes from rat liver. Segregation of docking protein in rough membranes
13. Identification and functional characterization of a novel human protein highly related to the yeast dynamin-like GTPase vps1p
14. Dymple, a novel dynamin-like high molecular weight GTPase lacking a proline-rich carboxyl-terminal domain in mammalian cells
15. C. elegans dynamin-related protein drp-1 controls severing of the mitochondrial outer membrane
16. GTPase activity of dynamin and resulting conformation change are essential for endocytosis
17. Dmn1p GT-Pase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p
18. Domain structure and intramolecular regulation of dynamin GTPase
19. Structure of mouse Mx1 protein. Molecular assembly and GTP-dependent conformational change
20. Chloroplast division in higher plants requires members of two functionally divergent gene families with homology to bacterial ftsZ
21. The dynamin-related GTPase, dnm1p, controls mitochondrial morphology in yeast
22. The dynamin-like protein DLP1 is essential for normal distribution and morphology of the endoplasmic reticulum and mitochondria in mammalian cells
23. Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape
24. Dynamin:GTP controls the formation of constricted coated pits, the rate limiting step in clathrin-mediated endocytosis
25. Impairment of dynamin's GAP domain stimulates receptor-mediated endocytosis
26. Identification and subcellular localization of a novel mammalian dynamin-related protein homologous to yeast Vps1p and Dnm1p
27. Intermolecular and interdomain interactions of a dynamin-related GTP-binding protein, Dnm1p/Vps1p-like protein
28. A model for dynamin self-assembly based on binding between three different protein domains
29. A human dynamin-related protein controls the distribution of mitochondria
30. Mapping dynamin interdomain interactions through two-hybrid and GST-pulldowns
31. Dynamin undergoes a GTP-dependent conformational change causing vesiculation
32. Tubular membrane invaginations coated by dynamin rings are induced by GTP-gamma S in nerve terminals
33. Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria
34. Mdv1p is a WD repeat protein that interacts with the dynamin-related GTPase, Dnm1p, to trigger mitochondrial division
35. Functional diversity in the dynamin family
36. A mitochondrial division apparatus takes shape
37. Dynamin-like protein encoded by the Drosophila shibire gene associated with vesicular traffic
38. Visualization of mitochondrial protein import in cultured mammalian cells with green fluorescent protein and effects of overexpression of the human import receptor Tom20
39. A novel dynamin-like protein associates with cytoplasmic vesicles and tubules of the endoplasmic reticulum in mammalian cells