MDMA impairs mitochondrial neuronal trafficking in a Tau- and Mitofusin2/Drp1-dependent manner

Archives of Toxicology

Volumn 88, Issue 8, 2014, Pages 1561-1572

  Barbosa, Daniel José ^a,b,c,d   Serrat, Román ^b,c,d   Mirra, Serena ^b,c,d   Quevedo, Martí ^b,c,d   Gómez De Barreda, Elena ^d,e   Ávila, Jesús ^d,e   Fernandes, Eduarda ^a   Bastos, Maria De Lourdes ^a   Capela, João Paulo ^a,f   Carvalho, Félix ^a   Soriano, Eduardo ^b,c,d  

^a UNIVERSITY OF PORTO   (Portugal)

^b INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

^d CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^e CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

^f UNIVERSIDADE FERNANDO PESSOA   (Portugal)

Author keywords

3,4 Methylenedioxymethamphetamine (MDMA; "ecstasy"); Drugs of abuse; Mitochondrial dysfunction; Mitochondrial trafficking; Neurotoxicity

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; CALCIUM ION; DYNAMIN RELATED PROTEIN 1; GLYCOGEN SYNTHASE KINASE 3BETA; MITOFUSIN 2; PROTEIN; TAU PROTEIN; UNCLASSIFIED DRUG; CALCIUM; DNM1L PROTEIN, MOUSE; DYNAMIN; GUANOSINE TRIPHOSPHATASE; MAPT PROTEIN, MOUSE; MFN2 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CALCIUM CELL LEVEL; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; HIPPOCAMPAL NEURONAL CULTURE; HIPPOCAMPUS; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL TOXICITY; MOUSE; NERVE FIBER TRANSPORT; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; EMBRYOLOGY; METABOLISM; MITOCHONDRION; NERVE CELL; PHOSPHORYLATION;

ANIMALS; AXONAL TRANSPORT; CALCIUM; CELLS, CULTURED; DYNAMINS; GTP PHOSPHOHYDROLASES; HIPPOCAMPUS; MICE, INBRED C57BL; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; NEURONS; PHOSPHORYLATION; TAU PROTEINS;

EID: 84905002125     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1209-7     Document Type: Article

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