N-Acetylcysteine amide protects against methamphetamine-induced oxidative stress and neurotoxicity in immortalized human brain endothelial cells

Brain Research

Volumn 1275, Issue , 2009, Pages 87-95

  Zhang, Xinsheng ^a   Banerjee, Atrayee ^a   Banks, William A ^b,c   Ercal, Nuran ^a  

^a MISSOURI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SAINT LOUIS UNIVERSITY   (United States)

Author keywords

Antioxidant; Blood brain barrier; Methamphetamine; N acetylcysteine amide; Oxidative stress; Reactive oxygen species; Trans endothelial electric resistance

Indexed keywords

ACETYLCYSTEINE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; METHAMPHETAMINE; REACTIVE OXYGEN METABOLITE;

ARTICLE; BLOOD BRAIN BARRIER; CELL IMMORTALIZATION; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; NEUROTOXICITY; OXIDATIVE STRESS; PRIORITY JOURNAL;

ACETYLCYSTEINE; BRAIN; CELL LINE, TRANSFORMED; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; METHAMPHETAMINE; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

MAMMALIA;

EID: 67349094895     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2009.04.008     Document Type: Article

References (52)

1. Acikgoz O., Gonenc S., Gezer S., Kayatekin B.M., Uysal N., Semin I., and Gure A. Methamphetamine causes depletion of glutathione and an increase in oxidized glutathione in the rat striatum and prefrontal cortex. Neurotox. Res. 3 (2001) 277-280
2. Agarwal R., and Shukla G.S. Potential role of cerebral glutathione in the maintenance of blood-brain barrier integrity in rat. Neurochem. Res. 24 (1999) 1507-1514
3. Amer J., Atlas D., and Fibach E. N-acetylcysteine amide (AD4) attenuates oxidative stress in beta-thalassemia blood cells. Biochim. Biophys. Acta 1780 (2008) 249-255
4. Andersen J. Oxidative stress in neurodegeneration: cause or consequence?. Nat. Rev., Neurosci. 5 (2004) S18-S25
5. Axt K., and Molliver M. Immunocytochemical evidence for methamphetamine-induced serotonergic axon loss in the rat brain. Synapse 9 (1991) 302-313
6. Banks W.A. Physiology and pathophysiology of the blood-brain barrier: implications for microbial pathogenesis, drug delivery and neurodegenerative disorders. J. Neurovirology 5 (1999) 538-555
7. Banks W.A., Ercal N., and Price T.O. The blood-brain barrier in neuroAIDS. Curr. HIV Res. 4 (2006) 259-266
8. Bar-Or A., Nuttall R.K., Duddy M., Alter A., Kim H.J., Ifergan I., Pennington C.J., Bourgoin P., Edwards D.R., and Yong V.W. Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis. Brain 126 (2003) 2738-2749
9. Barr A.M., Panenka W.J., MacEwan G.W., Thorton A.E., Lang D.J., Honer W.G., and Lecomte T. The need for speed: an update on methamphetamine addiction. J. Psychiatry Neurosci. 31 (2006) 301-313
10. Bartov O., Sultana R., Butterfield D.A., and Atlas D. Low molecular weight thiol amides attenuate MAPK activity and protect primary neurons from Ab (1-42) toxicity. Brain Res. 1069 (2006) 198-206
11. Belghmi K., Nicolas J.C., and Crastes de Paulet A. Chemiluminescent assay of lipid hydroperoxides. J. Biolumin. Chemilumin. 2 (1988) 113-119
12. Bowyer J.F., and Ali S. High doses of methamphetamine that cause disruption of the blood-brain barrier in limbic regions produce extensive neuronal degeneration in mouse hippocampus. Synpase 60 (2006) 521-532
13. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
14. Cadet J.L., Sheng P., Ali S., Rothman R., Carlson E., and Epstein C. Attenuation of methamphetamine-induced neurotoxicity in copper/zinc superoxide dismutase transgenic mice. J. Neurochem. 62 (1994) 380-383
15. Cho A. Ice: a new dosage form of an old drug. Science 249 (1990) 631-634
16. Choi H.J., Yoo T.M., Chung S.Y., Yang J.S., Kim J.I., Ha E.S., and Hwang O. Methamphetamine-induced apoptosis in a CNS-derived catecholaminergic cell line. Mol. Cells 13 (2002) 221-227
17. Cubells J.F., Rayport S., Rajendran G., and Sulzer D. Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress. J. Neurosci. 14 (1994) 2260-2271
18. Dallasta L.M., Pisarov L.A., Esplen J.E., Werley J.V., Moses A.V., Nelson J.A., and Achim C.L. Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis. Am. J. Pathol. 155 (1999) 1915-1927
19. Davidson C., Gow A.J., Lee T.H., and Ellinwood E.H. Methamphetamine neurotoxicity: necrotic and apoptotic mechanisms and relevance to human abuse and treatment. Brain Res. Brain Res. Rev. 36 (2001) 1-22
20. Davson H., and Segal M.B. Physiology of the CSF and Blood-Brain Barriers (1996), CRC Press, New York
21. Draper H.H., Squires E.J., Mahmoodi H., Wu J., Agarwal M., and Hadley M. A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials. Free Radic. Biol. Med. 15 (1993) 353-363
22. Ernst T., Chang L., Leonido-Yee M., and Speck O. Evidence for long-term neurotoxicity associated with methamphetamine abuse: a 1H MRS study. Neurology 54 (2000) 1344-1349
23. Fiala M., Liu Q.N., Sayre J., Pop V., Brahmandam V., Graves M.C., and Vinters H.V. Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier. Eur. J. Clin. Invest. 32 (2002) 360-371
24. Fitzmaurice P., Tong J., Yazdanpanah M., Liu P.P., Kalasinsky K.S., and Kish S.J. Levels of 4-hydroxynonenal and malondialdehyde are increased in brain of human chronic users of methamphetamine. J. Pharmacol. Exp. Ther. 319 (2006) 703-709
25. Frey K., Kilbourn M., and Robinson T. Reduced striatal vesicular monoamine transporters after neurotoxic but not after behaviorally-sensitizing doses of methamphetamine. Eur. J. Pharmacol. 334 (1997) 273-279
26. Grinberg L., Fibach E., Amer J., and Atlas D. N-acetylcysteine amide, a novel cell-permeating thiol, restores cellular glutathione and protects human red blood cells from oxidative stress. Free Radic. Biol. Med. 38 (2005) 136-145
27. Haorah J., Knipe B., Leibhart J., Ghorpade A., and Persidsky Y. Alcohol-induced oxidative stress in brain endothelial cells causes blood-brain barrier dysfunction. J. Leukoc. Biol. 78 (2005) 1223-1232
28. Hong H., and Joseph J.A. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic. Biol. Med. 27 (1999) 612-616
29. Iłzecka J. The structure and function of blood-brain barrier in ischaemic brain stroke process. Ann. Univ. Mariae Curie-Sklodowska 51 (1996) 123-127
30. Janero D.R. Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic. Biol. Med. 9 (1990) 515-540
31. LaVoie M.J., and Hastings T.G. Dopamine quinone formation and protein modification associated with the striatal neurotoxicity of methamphetamine: evidence against a role for extracellular dopamine. J. Neurosci. 19 (1999) 1484-1491
32. Mahajan S., Aslinkeel R., Sykes D.E., Reynolds J.L., Bindukumar B., Adal A., Qi M., Toh J., Xu G., Prasad P.N., and Schwartz S.A. Methamphetamine alters blood brain barrier permeability via the modulation of tight junction expression: implication for HIV-1 neuropathogenesis in the context of drug abuse. Brain Res. 1203 (2008) 133-148
33. Morganti-Kossmann M.C., Rancan M., Stahel P.F., and Kossmann T. Inflammatory responses to traumatic brain injury: an overview for the new millennium. Immune and Inflammatory Responses in the Nervous System Oxford, (2002), UK: University Press, UK: University Press Oxford 106-126
34. Moszczynska A., Turenne S., and Kish S. Rat striatal levels of the antioxidant glutathione are decreased following binge administration of methamphetamine. Neurosci. Lett. 255 (1998) 49-52
35. Park M.J., Lee S.K., Lim M.A., Chung H.S., Cho S.I., Jang C.G., and Lee S.M. Effect of alpha-tocopherol and deferoxamine on methamphetamine-induced neurotoxicity. Brain Res. 1109 (2006) 176-182
36. Penugonda S., Mare S., Goldstein G., Banks W.A., and Ercal N. Effects of N-acetylcysteine amide (NACA), a novel thiol antioxidant against glutamate-induced cytotoxicity in neuronal cell line PC-12. Brain Res. 1056 (2005) 132-138
37. Persidsky Y., Stins M., Way D., Witte M.H., Weinand M., Kim K.S., Bock P., Gendelman H.E., and Fiala M. A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis. J. Immunol. 158 (1997) 3499-3510
38. Plateel M., Dehouck M.P., Torpier G., Cecchelli R., and Teissier E. Hypoxia increases the susceptibility to oxidant stress and the permeability of the blood-brain barrier endothelial cell monolayer. J. Neurochem. 65 (1995) 2138-2145
39. Price T.O., Uras F., Banks W.A., and Ercal N. A novel antioxidant, N-acetylcysteine amide prevents gp120 and tat-induced oxidative stress in brain endothelial cells. Exp. Neurol. 201 (2006) 193-202
40. Ridnour L.A., Winters R.A., Ercal N., and Spitz D.R. Measurement of glutathione, glutathione disulfide, and other thiols in mammalian cell and tissue homogenates using high-performance liquid chromatography separation of N-(1-pyrenyl)maleimide derivatives. Methods Enzymol. 299 (1999) 258-267
41. Sattler R., and Tymianski M. Molecular mechanisms of calcium dependent excitotoxicity. J. Mol. Med. 78 (2000) 3-13
42. Scott J.C., Woods S.P., Matt G.E., Meyer R.A., Heaton R.K., Atkinson J.H., and Grant I. Neurocognitive effects of methamphetamine: a critical review and meta-analysis. Neuropsychol. Rev. 17 (2000) 275-297
43. Seiden L., and Ricaurte G. Neurotoxicity of Methamphetamine and Related Drugs Psychopharmacology: a Third Generation of Progress (1987), Raven, New York 359-366
44. Staszewski R.D., and Yamamoto B.K. Methamphetamine-induced spectrin proteolysis in the rat striatum. J. Neurochem. 96 (2006) 1267-1276
45. Tayarani I., Chaudiere J., Lefauconnier J.M., and Bourre J.M. Enzymatic protection against peroxidative damage in isolated brain capillaries. J. Neurochem. 48 (1987) 1399-1402
46. Villemagne V., Yuan J., Wong D.F., Dannals R.F., Hatzidimitriou G., Mathews W.B., Ravert H.T., Musachio J., McCann U.D., and Ricaurte G.A. Brain dopamine neurotoxicity in baboons treated with doses of methamphetamine comparable to those recreationally abused by humans: evidence from [11C] WIN-35,428 positron emission tomography studies and direct in vitro determinations. J. Neurosci. 18 (1998) 419-427
47. Warren M.W., Kobeissy F.H., Liu M.C., Hayes R.L., Gold M.S., and Wang K.K. Concurrent calpain and caspase-3 mediated proteolysis of alpha II-spectrin and tau in rat brain after methamphetamine exposure: a similar profile to traumatic brain injury. Life Sci. 78 (2005) 301-309
48. Wise R., and Hoffman D.C. Localization of drug reward mechanisms by intracranial injections. Synapse 10 (1992) 247-263
49. World Health Organization. Amphetamine-like Stimulants: a Report from the World Health Organization Meeting on Amphetamines, Mdma, and other Psychostimulants (1997), Substance Abuse Department, World Health Organization, Geneva
50. Wu C.W., Ping Y.H., Yen J.C., Chang C.Y., Wang S.F., Yeh C.L., Chi C.W., and Lee H.C. Enhanced oxidative stress and aberrant mitochondrial biogenesis in human neuroblastoma SH-SY5Y cells during methamphetamine induced apoptosis. Toxicol. Appl. Pharmacol. 220 (2007) 243-251
51. Wu W., Abraham L.S., Ogony J., Matthews R., Goldstein G., and Ercal N. Effects of N-acetylcysteine amide, a novel thiol antioxidant on radiation induced cytotoxicity in Chinese hamster ovary cells. Life Sci. 82 (2008) 1122-1130
52. Yamamoto B.K., and Zhu W. The Effects of methamphetamine on the production of free radicals and oxidative stress. J. Pharmacol. Exp. Ther. 287 (1998) 107-114