Drugs of Abuse Induce Apoptotic Features in PC12 Cells

Annals of the New York Academy of Sciences

Volumn 1010, Issue , 2003, Pages 667-670

  Oliveira, M T ^a   Rego, A C ^a   Macedo, T R A ^a   Oliveira, C R ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Amphetamine; Apoptosis; Cocaine; Dopamine; Heroin; Mitochondria; PC12 cells

Indexed keywords

AMPHETAMINE; APOPTOSIS INDUCING FACTOR; CASPASE 3; COCAINE; CYTOCHROME C; DIAMORPHINE; DOPAMINE; NEUROTOXIN; STAUROSPORINE;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; CELL STRAIN; CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; CONTROLLED STUDY; DOPAMINE RELEASE; DRUG ABUSE; ENZYME ACTIVATION; ENZYME ACTIVITY; LIMBIC CORTEX; MITOCHONDRION; NERVE DEGENERATION; NONHUMAN; RAT;

ANIMALIA;

EID: 1342284249     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1299.121     Document Type: Conference Paper

References (6)

1. DAVIDSON, C., A.J. GOW, T.H. LEE & E.H. ELLINWOOD. 2001. Methamphetamine neurotoxicity: necrotic and apoptotic mechanisms and relevance to human abuse and treatment. Brain Res. Brain Res. Rev. 36: 1-22.
2. ZHANG, L., Y. XIAO & J. HE. 1999. Cocaine and apoptosis in myocardial cells. Anat. Rec. 257: 208-216.
3. FECHO, K. & D.T. LYSLE. 2000. Heroin-induced alterations in leukocyte numbers and apoptosis in the rat spleen. Cell. Immunol. 202: 113-123.
4. OLIVEIRA, M.T., A.C. REGO, M.T. MORGADINHO, et al. 2002. Toxic effects of opioid and stimulant drugs on undifferentiated PC12 cells. Ann. N. Y. Acad. Sci. 965: 487-496.
5. OBERDOERSTER, J., A.R. KAMER & R.A. RABIN. 1998. Differential effect of ethanol on PC12 cell death. J. Pharmacol. Exp. Ther. 287: 359-365.
6. REGO, A.C., S. VESCE & D.G. NICHOLLS. 2001. The mechanism of mitochondrial membrane potential retention following release of cytochrome c in apoptotic GT1-7 neural cells. Cell Death Differ. 8: 995-1003.