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Volumn 14, Issue 2, 2015, Pages 233-272

Flavonoid compounds as reversal agents of the P-glycoprotein-mediated multidrug resistance: biology, chemistry and pharmacology

Author keywords

Drug efflux; Flavonoids; Multidrug resistance; P glycoprotein inhibition

Indexed keywords


EID: 84939874562     PISSN: 15687767     EISSN: 1572980X     Source Type: Journal    
DOI: 10.1007/s11101-014-9358-0     Document Type: Review
Times cited : (48)

References (207)
  • 1
    • 57049186999 scopus 로고    scopus 로고
    • Pachypodol, a flavonol from the leaves of Calycopteris floribunda, inhibits the growth of CaCo-2 colon cancer cell line in vitro
    • COI: 1:CAS:528:DC%2BD1MXhsFSmu7o%3D, PID: 18570232
    • Ali H-A, Chowdhury AKA, Rahman AKM et al (2008) Pachypodol, a flavonol from the leaves of Calycopteris floribunda, inhibits the growth of CaCo-2 colon cancer cell line in vitro. Phytother Res 22:1684–1687
    • (2008) Phytother Res , vol.22 , pp. 1684-1687
    • Ali, H.-A.1    Chowdhury, A.K.A.2    Rahman, A.K.M.3
  • 2
    • 84872161973 scopus 로고    scopus 로고
    • Kaempferitrin induces apoptosis via intrinsic pathway in HeLa cells and exerts antitumor effects
    • COI: 1:CAS:528:DC%2BC38XhvFWhtL%2FM, PID: 23211658
    • Alonso-Castro AJ, Ortiz-Sánchez E, García-Regalado A et al (2013) Kaempferitrin induces apoptosis via intrinsic pathway in HeLa cells and exerts antitumor effects. J Ethnopharmacol 145:476–489
    • (2013) J Ethnopharmacol , vol.145 , pp. 476-489
    • Alonso-Castro, A.J.1    Ortiz-Sánchez, E.2    García-Regalado, A.3
  • 3
    • 74049143120 scopus 로고    scopus 로고
    • Modulation of the activity of ABC transporters (P-Glycoprotein, MRP2, BCRP) by flavonoids and drug response
    • COI: 1:CAS:528:DC%2BD1MXhsF2jsL3N, PID: 19544374
    • Alvarez AI, Real R, Pérez M et al (2010) Modulation of the activity of ABC transporters (P-Glycoprotein, MRP2, BCRP) by flavonoids and drug response. J Pharm Sci 99:598–617
    • (2010) J Pharm Sci , vol.99 , pp. 598-617
    • Alvarez, A.I.1    Real, R.2    Pérez, M.3
  • 4
    • 84882696152 scopus 로고    scopus 로고
    • P-glycoprotein inhibition for optimal drug delivery
    • PID: 24023511
    • Amin ML (2013) P-glycoprotein inhibition for optimal drug delivery. Drug Target Insights 7:27–34
    • (2013) Drug Target Insights , vol.7 , pp. 27-34
    • Amin, M.L.1
  • 5
    • 77955671379 scopus 로고    scopus 로고
    • Effects of the isoflavonoid biochanin A on the transport of mitoxantrone in vitro and in vivo
    • COI: 1:CAS:528:DC%2BC3cXotFeitb8%3D, PID: 20535833
    • An G, Morris ME (2010) Effects of the isoflavonoid biochanin A on the transport of mitoxantrone in vitro and in vivo. Biopharm Drug Dispos 31:340–350
    • (2010) Biopharm Drug Dispos , vol.31 , pp. 340-350
    • An, G.1    Morris, M.E.2
  • 6
    • 62749188875 scopus 로고    scopus 로고
    • Role of ATP-binding cassette (ABC) transporters in interactions between natural products and drugs
    • COI: 1:CAS:528:DC%2BD1MXhsVCgtLY%3D, PID: 19075617
    • Aszalos A (2008) Role of ATP-binding cassette (ABC) transporters in interactions between natural products and drugs. Curr Drug Metab 9:1010–1018
    • (2008) Curr Drug Metab , vol.9 , pp. 1010-1018
    • Aszalos, A.1
  • 7
    • 33645972931 scopus 로고    scopus 로고
    • In silico modelling of the interaction of flavonoids with human P-glycoprotein nucleotide-binding domain
    • COI: 1:CAS:528:DC%2BD28XjslChtLc%3D, PID: 16494971
    • Badhan R, Penny J (2006) In silico modelling of the interaction of flavonoids with human P-glycoprotein nucleotide-binding domain. Eur J Med Chem 41:285–295
    • (2006) Eur J Med Chem , vol.41 , pp. 285-295
    • Badhan, R.1    Penny, J.2
  • 8
    • 14844295815 scopus 로고    scopus 로고
    • Does inhibition of P-glycoprotein lead to drug–drug interactions?
    • COI: 1:CAS:528:DC%2BD2MXitFeqtbo%3D, PID: 15763631
    • Balayssac D, Authier N, Cayre A, Coudore F (2005) Does inhibition of P-glycoprotein lead to drug–drug interactions? Toxicol Lett 156:319–329
    • (2005) Toxicol Lett , vol.156 , pp. 319-329
    • Balayssac, D.1    Authier, N.2    Cayre, A.3    Coudore, F.4
  • 9
    • 48749111850 scopus 로고    scopus 로고
    • Pre-clinical evidence for altered absorption and biliary excretion of irinotecan (CPT-11) in combination with quercetin: possible contribution of P-glycoprotein
    • COI: 1:CAS:528:DC%2BD1cXps1Ghurc%3D, PID: 18619980
    • Bansal T, Awasthi A, Jaggi M et al (2008) Pre-clinical evidence for altered absorption and biliary excretion of irinotecan (CPT-11) in combination with quercetin: possible contribution of P-glycoprotein. Life Sci 83:250–259
    • (2008) Life Sci , vol.83 , pp. 250-259
    • Bansal, T.1    Awasthi, A.2    Jaggi, M.3
  • 10
    • 69949106198 scopus 로고    scopus 로고
    • Emerging significance of flavonoids as P-glycoprotein inhibitors in cancer chemotherapy
    • COI: 1:CAS:528:DC%2BD1MXht1Ghs7vF, PID: 19470292
    • Bansal T, Jaggi M, Khar RK, Talegaonkar S (2009) Emerging significance of flavonoids as P-glycoprotein inhibitors in cancer chemotherapy. J Pharm Pharm Sci 12:46–78
    • (2009) J Pharm Pharm Sci , vol.12 , pp. 46-78
    • Bansal, T.1    Jaggi, M.2    Khar, R.K.3    Talegaonkar, S.4
  • 11
    • 26244450623 scopus 로고    scopus 로고
    • Isoprenoid flavonoids are new leads in the modulation of chemoresistance
    • Barron D, Di Pietro A, Dumontet C, Mcintosh DB (2003) Isoprenoid flavonoids are new leads in the modulation of chemoresistance. Phytochem Rev 1:325–332
    • (2003) Phytochem Rev , vol.1 , pp. 325-332
    • Barron, D.1    Di Pietro, A.2    Dumontet, C.3    Mcintosh, D.B.4
  • 12
    • 0030001378 scopus 로고    scopus 로고
    • P-glycoproteins and multidrug resistance
    • COI: 1:CAS:528:DyaK28Xis1ertb4%3D, PID: 8725386
    • Bellamy WT (1996) P-glycoproteins and multidrug resistance. Annu Rev Pharmacol Toxicol 36:161–183
    • (1996) Annu Rev Pharmacol Toxicol , vol.36 , pp. 161-183
    • Bellamy, W.T.1
  • 13
    • 0032497591 scopus 로고    scopus 로고
    • Halogenated chalcones with high-affinity binding to P-glycoprotein: potential modulators of multidrug resistance
    • COI: 1:CAS:528:DyaK1cXmtVelur8%3D, PID: 9767651
    • Bois F, Beney C, Boumendjel A et al (1998) Halogenated chalcones with high-affinity binding to P-glycoprotein: potential modulators of multidrug resistance. J Med Chem 41:4161–4164
    • (1998) J Med Chem , vol.41 , pp. 4161-4164
    • Bois, F.1    Beney, C.2    Boumendjel, A.3
  • 14
    • 0033384470 scopus 로고    scopus 로고
    • Synthesis and biological activity of 4-alkoxy chalcones: potential hydrophobic modulators of P-glycoprotein-mediated multidrug resistance
    • COI: 1:CAS:528:DC%2BD3cXntFChsg%3D%3D, PID: 10658573
    • Bois F, Boumendjel A, Mariotte AM et al (1999) Synthesis and biological activity of 4-alkoxy chalcones: potential hydrophobic modulators of P-glycoprotein-mediated multidrug resistance. Bioorg Med Chem 7:2691–2695
    • (1999) Bioorg Med Chem , vol.7 , pp. 2691-2695
    • Bois, F.1    Boumendjel, A.2    Mariotte, A.M.3
  • 15
    • 77649200790 scopus 로고    scopus 로고
    • Quercetin as a potential modulator of P-glycoprotein expression and function in cells of human pancreatic carcinoma line resistant to daunorubicin
    • COI: 1:CAS:528:DC%2BC3cXitVemu7c%3D, PID: 20335952
    • Borska S, Sopel M, Chmielewska M et al (2010) Quercetin as a potential modulator of P-glycoprotein expression and function in cells of human pancreatic carcinoma line resistant to daunorubicin. Molecules 15:857–870
    • (2010) Molecules , vol.15 , pp. 857-870
    • Borska, S.1    Sopel, M.2    Chmielewska, M.3
  • 16
    • 0036720280 scopus 로고    scopus 로고
    • Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance
    • COI: 1:CAS:528:DC%2BD38XntFSls78%3D, PID: 12210557
    • Boumendjel A, Di Pietro A, Dumontet C, Barron D (2002) Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance. Med Res Rev 22:512–529
    • (2002) Med Res Rev , vol.22 , pp. 512-529
    • Boumendjel, A.1    Di Pietro, A.2    Dumontet, C.3    Barron, D.4
  • 17
    • 33750353446 scopus 로고    scopus 로고
    • Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients
    • COI: 1:CAS:528:DC%2BD28XhtFers77L, PID: 16978825
    • Brand W, Schutte ME, Williamson G et al (2006) Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients. Biomed Pharmacother 60:508–519
    • (2006) Biomed Pharmacother , vol.60 , pp. 508-519
    • Brand, W.1    Schutte, M.E.2    Williamson, G.3
  • 18
    • 33748792802 scopus 로고    scopus 로고
    • The multidrug transporter hypothesis of drug resistance in epilepsy: proof-of-principle in a rat model of temporal lobe epilepsy
    • COI: 1:CAS:528:DC%2BD28XpvFGjuro%3D, PID: 16928449
    • Brandt C, Bethmann K, Gastens AM, Löscher W (2006) The multidrug transporter hypothesis of drug resistance in epilepsy: proof-of-principle in a rat model of temporal lobe epilepsy. Neurobiol Dis 24:202–211
    • (2006) Neurobiol Dis , vol.24 , pp. 202-211
    • Brandt, C.1    Bethmann, K.2    Gastens, A.M.3    Löscher, W.4
  • 19
    • 84877911075 scopus 로고    scopus 로고
    • New insight into p-glycoprotein as a drug target
    • COI: 1:CAS:528:DC%2BC3sXjvFOntbY%3D, PID: 22931413
    • Breier A, Gibalova L, Seres M et al (2013) New insight into p-glycoprotein as a drug target. Anticancer Agents Med Chem 13:159–170
    • (2013) Anticancer Agents Med Chem , vol.13 , pp. 159-170
    • Breier, A.1    Gibalova, L.2    Seres, M.3
  • 20
    • 73949104134 scopus 로고    scopus 로고
    • Flavonoids: new roles for old molecules
    • COI: 1:CAS:528:DC%2BC3cXitVOhsLc%3D, PID: 20074144
    • Buer CS, Imin N, Djordjevic MA (2010) Flavonoids: new roles for old molecules. J Integr Plant Biol 52:98–111
    • (2010) J Integr Plant Biol , vol.52 , pp. 98-111
    • Buer, C.S.1    Imin, N.2    Djordjevic, M.A.3
  • 21
    • 75949099287 scopus 로고    scopus 로고
    • Cancer-relevant biochemical targets of cytotoxic Lonchocarpus flavonoids: a molecular docking analysis
    • COI: 1:CAS:528:DC%2BC3cXlslGisbo%3D, PID: 19603203
    • Cassidy CE, Setzer WN (2010) Cancer-relevant biochemical targets of cytotoxic Lonchocarpus flavonoids: a molecular docking analysis. J Mol Model 16:311–326
    • (2010) J Mol Model , vol.16 , pp. 311-326
    • Cassidy, C.E.1    Setzer, W.N.2
  • 22
    • 0031060647 scopus 로고    scopus 로고
    • Inhibition of drug transport by genistein in multidrug-resistant cells expressing P-glycoprotein
    • Castro AF, Altenberg GA (1997) Inhibition of drug transport by genistein in multidrug-resistant cells expressing P-glycoprotein. Biochem Pharmacol 53:89–93
    • (1997) Biochem Pharmacol , vol.53 , pp. 89-93
    • Castro, A.F.1    Altenberg, G.A.2
  • 23
    • 35348973560 scopus 로고    scopus 로고
    • Grapefruit juice-drug interactions: grapefruit juice and its components inhibit P-glycoprotein (ABCB1) mediated transport of talinolol in Caco-2 cells
    • PID: 17542018
    • Castro WVDE, Mertens-Talcott S, Derendorf H (2007) Grapefruit juice-drug interactions: grapefruit juice and its components inhibit P-glycoprotein (ABCB1) mediated transport of talinolol in Caco-2 cells. J Pharm Sci 96:2808–2817
    • (2007) J Pharm Sci , vol.96 , pp. 2808-2817
    • Castro, W.V.D.E.1    Mertens-Talcott, S.2    Derendorf, H.3
  • 24
    • 0346728729 scopus 로고    scopus 로고
    • The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability
    • COI: 1:CAS:528:DC%2BD2cXovFSr, PID: 14706810
    • Chan LMS, Lowes S, Hirst BH (2004) The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability. Eur J Pharm Sci 21:25–51
    • (2004) Eur J Pharm Sci , vol.21 , pp. 25-51
    • Chan, L.M.S.1    Lowes, S.2    Hirst, B.H.3
  • 25
    • 65549092069 scopus 로고    scopus 로고
    • Flavonoid dimers as bivalent modulators for p-glycoprotein-based multidrug resistance: structure-activity relationships
    • COI: 1:CAS:528:DC%2BD1MXltlCgtr8%3D, PID: 19288491
    • Chan K-F, Zhao Y, Chow TWS et al (2009) Flavonoid dimers as bivalent modulators for p-glycoprotein-based multidrug resistance: structure-activity relationships. ChemMedChem 4:594–614
    • (2009) ChemMedChem , vol.4 , pp. 594-614
    • Chan, K.-F.1    Zhao, Y.2    Chow, T.W.S.3
  • 26
    • 33947397241 scopus 로고    scopus 로고
    • A molecular understanding of ATP-dependent solute transport by multidrug resistance-associated protein MRP1
    • COI: 1:CAS:528:DC%2BD2sXjt1Kqt7k%3D, PID: 17295059
    • Chang X (2007) A molecular understanding of ATP-dependent solute transport by multidrug resistance-associated protein MRP1. Cancer Metastasis Rev 26:15–37
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 15-37
    • Chang, X.1
  • 27
    • 33751525373 scopus 로고    scopus 로고
    • Rapid identification of P-glycoprotein substrates and inhibitors
    • COI: 1:CAS:528:DC%2BD28Xht1yltLjO, PID: 16997908
    • Chang C, Bahadduri PM, Polli JE et al (2006) Rapid identification of P-glycoprotein substrates and inhibitors. Drug Metab Dispos 34:1976–1984
    • (2006) Drug Metab Dispos , vol.34 , pp. 1976-1984
    • Chang, C.1    Bahadduri, P.M.2    Polli, J.E.3
  • 28
    • 77956414625 scopus 로고    scopus 로고
    • Quercetin: a potential drug to reverse multidrug resistance
    • COI: 1:CAS:528:DC%2BC3cXhtFGjt7vL, PID: 20637779
    • Chen C, Zhou J, Ji C (2010) Quercetin: a potential drug to reverse multidrug resistance. Life Sci 87:333–338
    • (2010) Life Sci , vol.87 , pp. 333-338
    • Chen, C.1    Zhou, J.2    Ji, C.3
  • 29
    • 70350348933 scopus 로고    scopus 로고
    • In vitro effects of Mangifera indica and polyphenols derived on ABCB1/P-glycoprotein activity
    • COI: 1:CAS:528:DC%2BD1MXhtlWntrvJ, PID: 19632288
    • Chieli E, Romiti N, Rodeiro I, Garrido G (2009) In vitro effects of Mangifera indica and polyphenols derived on ABCB1/P-glycoprotein activity. Food Chem Toxicol 47:2703–2710
    • (2009) Food Chem Toxicol , vol.47 , pp. 2703-2710
    • Chieli, E.1    Romiti, N.2    Rodeiro, I.3    Garrido, G.4
  • 30
    • 85047681574 scopus 로고    scopus 로고
    • Effect of hesperidin on the oral pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats
    • COI: 1:CAS:528:DC%2BD1MXovV2rsLk%3D, PID: 19505375
    • Cho Y-A, Choi D-H, Choi J-S (2009) Effect of hesperidin on the oral pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats. J Pharm Pharmacol 61:825–829
    • (2009) J Pharm Pharmacol , vol.61 , pp. 825-829
    • Cho, Y.-A.1    Choi, D.-H.2    Choi, J.-S.3
  • 31
    • 80053366326 scopus 로고    scopus 로고
    • Effects of the antioxidant baicalein on the pharmacokinetics of nimodipine in rats: a possible role of P-glycoprotein and CYP3A4 inhibition by baicalein
    • COI: 1:CAS:528:DC%2BC38XitlOgt7w%3D, PID: 22001996
    • Cho Y-A, Choi J-S, Burm J-P (2011) Effects of the antioxidant baicalein on the pharmacokinetics of nimodipine in rats: a possible role of P-glycoprotein and CYP3A4 inhibition by baicalein. Pharmacol Rep 63:1066–1073
    • (2011) Pharmacol Rep , vol.63 , pp. 1066-1073
    • Cho, Y.-A.1    Choi, J.-S.2    Burm, J.-P.3
  • 32
    • 33646428927 scopus 로고    scopus 로고
    • Enhanced nimodipine bioavailability after oral administration of nimodipine with morin, a flavonoid, in rabbits
    • COI: 1:CAS:528:DC%2BD28XltF2gt7Y%3D, PID: 16681041
    • Choi J-S, Burm JP (2006) Enhanced nimodipine bioavailability after oral administration of nimodipine with morin, a flavonoid, in rabbits. Arch Pharm Res 29:333–338
    • (2006) Arch Pharm Res , vol.29 , pp. 333-338
    • Choi, J.-S.1    Burm, J.P.2
  • 33
    • 27444441306 scopus 로고    scopus 로고
    • Pharmacokinetic interaction between diltiazem and morin, a flavonoid, in rats
    • COI: 1:CAS:528:DC%2BD2MXhtFKnsLbJ, PID: 16002304
    • Choi J-S, Han H-K (2005) Pharmacokinetic interaction between diltiazem and morin, a flavonoid, in rats. Pharmacol Res 52:386–391
    • (2005) Pharmacol Res , vol.52 , pp. 386-391
    • Choi, J.-S.1    Han, H.-K.2
  • 34
    • 58449111594 scopus 로고    scopus 로고
    • Enhanced tamoxifen bioavailability after oral administration of tamoxifen in rats pretreated with naringin
    • COI: 1:CAS:528:DC%2BD1cXhsFWrs7vM, PID: 19099234
    • Choi J-S, Kang KW (2008) Enhanced tamoxifen bioavailability after oral administration of tamoxifen in rats pretreated with naringin. Arch Pharm Res 31:1631–1636
    • (2008) Arch Pharm Res , vol.31 , pp. 1631-1636
    • Choi, J.-S.1    Kang, K.W.2
  • 35
    • 19344368397 scopus 로고    scopus 로고
    • Enhanced diltiazem bioavailability after oral administration of diltiazem with quercetin to rabbits
    • COI: 1:CAS:528:DC%2BD2MXkt1ansrs%3D, PID: 15907592
    • Choi J-S, Li X (2005) Enhanced diltiazem bioavailability after oral administration of diltiazem with quercetin to rabbits. Int J Pharm 297:1–8
    • (2005) Int J Pharm , vol.297 , pp. 1-8
    • Choi, J.-S.1    Li, X.2
  • 36
    • 1842789744 scopus 로고    scopus 로고
    • Enhanced bioavailability of paclitaxel after oral coadministration with flavone in rats
    • COI: 1:CAS:528:DC%2BD2cXivFGktbo%3D, PID: 15081147
    • Choi J-S, Choi H-K, Shin S-C (2004a) Enhanced bioavailability of paclitaxel after oral coadministration with flavone in rats. Int J Pharm 275:165–170
    • (2004) Int J Pharm , vol.275 , pp. 165-170
    • Choi, J.-S.1    Choi, H.-K.2    Shin, S.-C.3
  • 37
    • 1442359716 scopus 로고    scopus 로고
    • Enhanced paclitaxel bioavailability after oral administration of paclitaxel or prodrug to rats pretreated with quercetin
    • Choi J-S, Jo B-W, Kim Y-C (2004b) Enhanced paclitaxel bioavailability after oral administration of paclitaxel or prodrug to rats pretreated with quercetin. Eur J Pharm Biopharm 57:313–318
    • (2004) Eur J Pharm Biopharm , vol.57 , pp. 313-318
    • Choi, J.-S.1    Jo, B.-W.2    Kim, Y.-C.3
  • 38
    • 33748684356 scopus 로고    scopus 로고
    • Altered pharmacokinetics of paclitaxel by the concomitant use of morin in rats
    • COI: 1:CAS:528:DC%2BD28XpvVOmtrg%3D, PID: 16806758
    • Choi B-C, Choi J-S, Han H-K (2006) Altered pharmacokinetics of paclitaxel by the concomitant use of morin in rats. Int J Pharm 323:81–85
    • (2006) Int J Pharm , vol.323 , pp. 81-85
    • Choi, B.-C.1    Choi, J.-S.2    Han, H.-K.3
  • 39
    • 77954022331 scopus 로고    scopus 로고
    • Effects of myricetin, an antioxidant, on the pharmacokinetics of losartan and its active metabolite, EXP-3174, in rats: possible role of cytochrome P450 3A4, cytochrome P450 2C9 and P-glycoprotein inhibition by myricetin
    • COI: 1:CAS:528:DC%2BC3cXpt1yitL0%3D, PID: 20636879
    • Choi D-H, Li C, Choi J-S (2010) Effects of myricetin, an antioxidant, on the pharmacokinetics of losartan and its active metabolite, EXP-3174, in rats: possible role of cytochrome P450 3A4, cytochrome P450 2C9 and P-glycoprotein inhibition by myricetin. J Pharm Pharmacol 62:908–914
    • (2010) J Pharm Pharmacol , vol.62 , pp. 908-914
    • Choi, D.-H.1    Li, C.2    Choi, J.-S.3
  • 40
    • 79960407129 scopus 로고    scopus 로고
    • Effects of quercetin on the bioavailability of doxorubicin in rats: role of CYP3A4 and P-gp inhibition by quercetin
    • COI: 1:CAS:528:DC%2BC3MXls1CqsrY%3D, PID: 21544726
    • Choi J-S, Piao Y-J, Kang KW (2011a) Effects of quercetin on the bioavailability of doxorubicin in rats: role of CYP3A4 and P-gp inhibition by quercetin. Arch Pharm Res 34:607–613
    • (2011) Arch Pharm Res , vol.34 , pp. 607-613
    • Choi, J.-S.1    Piao, Y.-J.2    Kang, K.W.3
  • 41
    • 79953299941 scopus 로고    scopus 로고
    • Effects of myricetin on the bioavailability of doxorubicin for oral drug delivery in rats: possible role of CYP3A4 and P-glycoprotein inhibition by myricetin
    • Choi S-J, Shin S-C, Choi J-S (2011b) Effects of myricetin on the bioavailability of doxorubicin for oral drug delivery in rats: possible role of CYP3A4 and P-glycoprotein inhibition by myricetin. Arch Pharm Res 34:309–315
    • (2011) Arch Pharm Res , vol.34 , pp. 309-315
    • Choi, S.-J.1    Shin, S.-C.2    Choi, J.-S.3
  • 42
    • 65349113642 scopus 로고    scopus 로고
    • Bioactive flavonoids of the flowers of Butea monosperma
    • COI: 1:CAS:528:DC%2BD1MXmtl2ms7s%3D
    • Chokchaisiri R, Suaisom C, Sriphota S et al (2009) Bioactive flavonoids of the flowers of Butea monosperma. Chem Pharm Bull (Tokyo) 57:428–432
    • (2009) Chem Pharm Bull (Tokyo) , vol.57 , pp. 428-432
    • Chokchaisiri, R.1    Suaisom, C.2    Sriphota, S.3
  • 43
    • 30544440659 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein by natural products in human breast cancer cells
    • COI: 1:CAS:528:DC%2BD28Xot1ygtA%3D%3D, PID: 16114498
    • Chung SY, Sung MK, Kim NH et al (2005) Inhibition of P-glycoprotein by natural products in human breast cancer cells. Arch Pharm Res 28:823–828
    • (2005) Arch Pharm Res , vol.28 , pp. 823-828
    • Chung, S.Y.1    Sung, M.K.2    Kim, N.H.3
  • 44
    • 34250354277 scopus 로고    scopus 로고
    • Modulation of P-glycoprotein-mediated resistance by kaempferol derivatives isolated from Zingiber zerumbet
    • Chung SY, Jang DS, Han A et al (2007) Modulation of P-glycoprotein-mediated resistance by kaempferol derivatives isolated from Zingiber zerumbet. Phytother Res 21:565–569
    • (2007) Phytother Res , vol.21 , pp. 565-569
    • Chung, S.Y.1    Jang, D.S.2    Han, A.3
  • 45
    • 73949155491 scopus 로고    scopus 로고
    • Overcoming multidrug resistance in cancer: clinical studies of p-glycoprotein inhibitors
    • COI: 1:CAS:528:DC%2BC3cXhvVKhur8%3D, PID: 19949931
    • Coley HM (2010) Overcoming multidrug resistance in cancer: clinical studies of p-glycoprotein inhibitors. Methods Mol Biol 596:341–358
    • (2010) Methods Mol Biol , vol.596 , pp. 341-358
    • Coley, H.M.1
  • 46
    • 0035282638 scopus 로고    scopus 로고
    • C-Isoprenylation of flavonoids enhances binding affinity toward P-glycoprotein and modulation of cancer cell chemoresistance
    • COI: 1:CAS:528:DC%2BD3MXmtF2jsA%3D%3D, PID: 11262086
    • Comte G, Daskiewicz JB, Bayet C et al (2001) C-Isoprenylation of flavonoids enhances binding affinity toward P-glycoprotein and modulation of cancer cell chemoresistance. J Med Chem 44:763–768
    • (2001) J Med Chem , vol.44 , pp. 763-768
    • Comte, G.1    Daskiewicz, J.B.2    Bayet, C.3
  • 47
    • 0032544087 scopus 로고    scopus 로고
    • Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein
    • COI: 1:CAS:528:DyaK1cXlsFSrtr8%3D, PID: 9707561
    • Conseil G, Baubichon-Cortay H, Dayan G et al (1998) Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein. Proc Natl Acad Sci USA 95:9831–9836
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9831-9836
    • Conseil, G.1    Baubichon-Cortay, H.2    Dayan, G.3
  • 48
    • 0029867672 scopus 로고    scopus 로고
    • Flavonoids: chemistry, metabolism, cardioprotective effects, and dietary sources
    • COI: 1:CAS:528:DyaK28XhtlSjt7g%3D
    • Cook N, Samman S (1996) Flavonoids: chemistry, metabolism, cardioprotective effects, and dietary sources. J Nutr Biochem 7:66–76
    • (1996) J Nutr Biochem , vol.7 , pp. 66-76
    • Cook, N.1    Samman, S.2
  • 49
    • 67651177448 scopus 로고    scopus 로고
    • Jatrophane diterpenes from Euphorbia spp. as modulators of multidrug resistance in cancer therapy
    • COI: 1:CAS:528:DC%2BD1MXmtlKntbY%3D
    • Corea G, Di Pietro A, Dumontet C et al (2009) Jatrophane diterpenes from Euphorbia spp. as modulators of multidrug resistance in cancer therapy. Phytochem Rev 8:431–447
    • (2009) Phytochem Rev , vol.8 , pp. 431-447
    • Corea, G.1    Di Pietro, A.2    Dumontet, C.3
  • 50
    • 68149124472 scopus 로고    scopus 로고
    • Dietary phenolics: chemistry, bioavailability and effects on health
    • COI: 1:CAS:528:DC%2BD1MXptFGmsr8%3D, PID: 19636448
    • Crozier A, Jaganath IB, Clifford MN (2009) Dietary phenolics: chemistry, bioavailability and effects on health. Nat Prod Rep 26:1001–1043
    • (2009) Nat Prod Rep , vol.26 , pp. 1001-1043
    • Crozier, A.1    Jaganath, I.B.2    Clifford, M.N.3
  • 51
    • 0037457796 scopus 로고    scopus 로고
    • Considerations in the design and development of transport inhibitors as adjuncts to drug therapy
    • COI: 1:CAS:528:DC%2BD3sXivVWnuw%3D%3D, PID: 12535578
    • Dantzig AH, de Alwis DP, Burgess M (2003) Considerations in the design and development of transport inhibitors as adjuncts to drug therapy. Adv Drug Deliv Rev 55:133–150
    • (2003) Adv Drug Deliv Rev , vol.55 , pp. 133-150
    • Dantzig, A.H.1    de Alwis, D.P.2    Burgess, M.3
  • 52
    • 47349108866 scopus 로고    scopus 로고
    • Effect of grapefruit juice, naringin, naringenin, and bergamottin on the intestinal carrier-mediated transport of talinolol in rats
    • PID: 18494494
    • De Castro WV, Mertens-Talcott S, Derendorf H, Butterweck V (2008) Effect of grapefruit juice, naringin, naringenin, and bergamottin on the intestinal carrier-mediated transport of talinolol in rats. J Agric Food Chem 56:4840–4845
    • (2008) J Agric Food Chem , vol.56 , pp. 4840-4845
    • De Castro, W.V.1    Mertens-Talcott, S.2    Derendorf, H.3    Butterweck, V.4
  • 53
    • 0035964385 scopus 로고    scopus 로고
    • Sequence requirements of the ATP-binding site within the C-terminal nucleotide-binding domain of mouse P-glycoprotein: structure-activity relationships for flavonoid binding
    • PID: 11513617
    • De Wet H, McIntosh DB, Conseil G et al (2001) Sequence requirements of the ATP-binding site within the C-terminal nucleotide-binding domain of mouse P-glycoprotein: structure-activity relationships for flavonoid binding. Biochemistry 40:10382–10391
    • (2001) Biochemistry , vol.40 , pp. 10382-10391
    • De Wet, H.1    McIntosh, D.B.2    Conseil, G.3
  • 54
    • 33745835398 scopus 로고    scopus 로고
    • Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
    • COI: 1:CAS:528:DC%2BD28XnsFGgtb4%3D, PID: 16816140
    • Deeley RG, Westlake C, Cole SPC (2006) Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Physiol Rev 86:849–899
    • (2006) Physiol Rev , vol.86 , pp. 849-899
    • Deeley, R.G.1    Westlake, C.2    Cole, S.P.C.3
  • 55
    • 0037332007 scopus 로고    scopus 로고
    • The effect of food components on the absorption of P-gp substrates: a review
    • COI: 1:CAS:528:DC%2BD3sXisVOjs7c%3D, PID: 12631407
    • Deferme S, Augustijns P (2003) The effect of food components on the absorption of P-gp substrates: a review. J Pharm Pharmacol 55:153–162
    • (2003) J Pharm Pharmacol , vol.55 , pp. 153-162
    • Deferme, S.1    Augustijns, P.2
  • 56
    • 58149164868 scopus 로고    scopus 로고
    • In vitro-in vivo correlation in P-glycoprotein mediated transport in intestinal absorption
    • PID: 19063964
    • Del Amo EM, Heikkinen AT, Mönkkönen J (2009) In vitro-in vivo correlation in P-glycoprotein mediated transport in intestinal absorption. Eur J Pharm Sci 36:200–211
    • (2009) Eur J Pharm Sci , vol.36 , pp. 200-211
    • Del Amo, E.M.1    Heikkinen, A.T.2    Mönkkönen, J.3
  • 57
    • 18244376403 scopus 로고    scopus 로고
    • Cellular and molecular life sciences modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters
    • PID: 11915946
    • Di Pietro A, Conseil G, Pérez-victoria JM et al (2002) Cellular and molecular life sciences modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters. Cell Mol Life Sci 59:307–322
    • (2002) Cell Mol Life Sci , vol.59 , pp. 307-322
    • Di Pietro, A.1    Conseil, G.2    Pérez-victoria, J.M.3
  • 58
    • 33749065926 scopus 로고    scopus 로고
    • P-glycoprotein induction: an antidotal pathway for paraquat-induced lung toxicity
    • COI: 1:CAS:528:DC%2BD28XhtVagtLvJ, PID: 17015168
    • Dinis-Oliveira RJ, Remião F, Duarte J et al (2006) P-glycoprotein induction: an antidotal pathway for paraquat-induced lung toxicity. Free Radic Biol Med 41:1213–1224
    • (2006) Free Radic Biol Med , vol.41 , pp. 1213-1224
    • Dinis-Oliveira, R.J.1    Remião, F.2    Duarte, J.3
  • 59
    • 19944425121 scopus 로고    scopus 로고
    • The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model
    • COI: 1:CAS:528:DC%2BD2MXltlentw%3D%3D, PID: 15502009
    • Doran A, Obach RS, Smith BJ et al (2005) The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model. Drug Metab Dispos 33:165–174
    • (2005) Drug Metab Dispos , vol.33 , pp. 165-174
    • Doran, A.1    Obach, R.S.2    Smith, B.J.3
  • 60
    • 84870581169 scopus 로고    scopus 로고
    • Epigallocatechin Gallate (EGCG) is the most effective cancer chemopreventive polyphenol in green tea
    • COI: 1:CAS:528:DC%2BC38XhvVagsr%2FK, PID: 23201840
    • Du G-J, Zhang Z, Wen X-D et al (2012) Epigallocatechin Gallate (EGCG) is the most effective cancer chemopreventive polyphenol in green tea. Nutrients 4:1679–1691
    • (2012) Nutrients , vol.4 , pp. 1679-1691
    • Du, G.-J.1    Zhang, Z.2    Wen, X.-D.3
  • 61
    • 18844369300 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic interactions of morin and cyclosporin
    • COI: 1:CAS:528:DC%2BD2MXktVGksrc%3D, PID: 15885265
    • Fang S-H, Hou Y-C, Chao P-DL (2005) Pharmacokinetic and pharmacodynamic interactions of morin and cyclosporin. Toxicol Appl Pharmacol 205:65–70
    • (2005) Toxicol Appl Pharmacol , vol.205 , pp. 65-70
    • Fang, S.-H.1    Hou, Y.-C.2    Chao, P.-D.L.3
  • 62
    • 17444424615 scopus 로고    scopus 로고
    • Synergistic interaction between hesperidin, a natural flavonoid, and diazepam
    • PID: 15840404
    • Fernández SP, Wasowski C, Paladini AC, Marder M (2005) Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. Eur J Pharmacol 512:189–198
    • (2005) Eur J Pharmacol , vol.512 , pp. 189-198
    • Fernández, S.P.1    Wasowski, C.2    Paladini, A.C.3    Marder, M.4
  • 63
    • 84857558058 scopus 로고    scopus 로고
    • In vitro and in vivo relevance of the P-glycoprotein probe substrates in drug discovery and development: focus on rhodamine 123, digoxin and talinolol
    • Fortuna A, Alves G, Falcão A (2011) In vitro and in vivo relevance of the P-glycoprotein probe substrates in drug discovery and development: focus on rhodamine 123, digoxin and talinolol. J Bioequiv Availab 01:1–23
    • (2011) J Bioequiv Availab , vol.1 , pp. 1-23
    • Fortuna, A.1    Alves, G.2    Falcão, A.3
  • 64
    • 3242785620 scopus 로고    scopus 로고
    • Importance of P-glycoprotein at blood-tissue barriers
    • COI: 1:CAS:528:DC%2BD2cXmtVaht7Y%3D, PID: 15276711
    • Fromm MF (2004) Importance of P-glycoprotein at blood-tissue barriers. Trends Pharmacol Sci 25:423–429
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 423-429
    • Fromm, M.F.1
  • 65
    • 33847265733 scopus 로고    scopus 로고
    • Silybin and silymarin-new and emerging applications in medicine
    • PID: 17305535
    • Gazák R, Walterová D, Kren V (2007) Silybin and silymarin-new and emerging applications in medicine. Curr Med Chem 14:315–338
    • (2007) Curr Med Chem , vol.14 , pp. 315-338
    • Gazák, R.1    Walterová, D.2    Kren, V.3
  • 66
    • 77649216536 scopus 로고    scopus 로고
    • Membrane transporters in drug development
    • COI: 1:CAS:528:DC%2BC3cXisFelu74%3D, PID: 20190787
    • Giacomini KM, Huang S-M, Tweedie DJ et al (2010) Membrane transporters in drug development. Nat Rev Drug Discov 9:215–236
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 215-236
    • Giacomini, K.M.1    Huang, S.-M.2    Tweedie, D.J.3
  • 67
    • 33750589959 scopus 로고    scopus 로고
    • Membrane transporter proteins: a challenge for CNS drug development
    • PID: 17117613
    • Girardin F (2006) Membrane transporter proteins: a challenge for CNS drug development. Dialogues Clin Neurosci 8:311–321
    • (2006) Dialogues Clin Neurosci , vol.8 , pp. 311-321
    • Girardin, F.1
  • 68
    • 70349479411 scopus 로고    scopus 로고
    • Evaluation of the flavonoid oroxylin A as an inhibitor of P-glycoprotein-mediated cellular efflux
    • COI: 1:CAS:528:DC%2BD1MXhtFWqt7jE, PID: 19739602
    • Go WJ, Ryu JH, Qiang F, Han H-K (2009) Evaluation of the flavonoid oroxylin A as an inhibitor of P-glycoprotein-mediated cellular efflux. J Nat Prod 72:1616–1619
    • (2009) J Nat Prod , vol.72 , pp. 1616-1619
    • Go, W.J.1    Ryu, J.H.2    Qiang, F.3    Han, H.-K.4
  • 69
    • 84939927223 scopus 로고    scopus 로고
    • Drug interaction studies: study design, data analysis, and implications for dosing and labeling. U.S. Department of Health and Human Services, FDA, CDER
    • Guidance for Industry (2006) Drug interaction studies: study design, data analysis, and implications for dosing and labeling. U.S. Department of Health and Human Services, FDA, CDER, CBER
    • (2006) CBER
  • 70
    • 0038248843 scopus 로고    scopus 로고
    • Modulation of P-glycoprotein-mediated multidrug resistance by flavonoid derivatives and analogues
    • COI: 1:CAS:528:DC%2BD3sXjtFagtrg%3D, PID: 12747785
    • Hadjeri M, Barbier M, Ronot X et al (2003) Modulation of P-glycoprotein-mediated multidrug resistance by flavonoid derivatives and analogues. J Med Chem 46:2125–2131
    • (2003) J Med Chem , vol.46 , pp. 2125-2131
    • Hadjeri, M.1    Barbier, M.2    Ronot, X.3
  • 71
    • 0002240683 scopus 로고
    • Plant polyphenols. 5: occurrence of azalein and related pigments in flowers of Plumbago and Rhododendron species
    • COI: 1:CAS:528:DyaF38Xmt1CgtQ%3D%3D, PID: 13904580
    • Harborne JB (1962) Plant polyphenols. 5: occurrence of azalein and related pigments in flowers of Plumbago and Rhododendron species. Arch Biochem Biophys 96:171–178
    • (1962) Arch Biochem Biophys , vol.96 , pp. 171-178
    • Harborne, J.B.1
  • 72
    • 0011442646 scopus 로고    scopus 로고
    • Two new flavonoid glycosides from the leaves of Phellodendron amurense Ruprecht
    • Hasegawa M, Shirato T (2002) Two new flavonoid glycosides from the leaves of Phellodendron amurense Ruprecht. J Am Chem Soc 75:5507–5511
    • (2002) J Am Chem Soc , vol.75 , pp. 5507-5511
    • Hasegawa, M.1    Shirato, T.2
  • 73
    • 30144442832 scopus 로고    scopus 로고
    • Flavonoid-membrane interactions: possible consequences for biological effects of some polyphenolic compounds
    • COI: 1:CAS:528:DC%2BD28XktlKitA%3D%3D, PID: 16364208
    • Hendrich AB (2006) Flavonoid-membrane interactions: possible consequences for biological effects of some polyphenolic compounds. Acta Pharmacol Sin 27:27–40
    • (2006) Acta Pharmacol Sin , vol.27 , pp. 27-40
    • Hendrich, A.B.1
  • 74
    • 33846215616 scopus 로고    scopus 로고
    • A primer on the mechanics of P-glycoprotein the multidrug transporter
    • COI: 1:CAS:528:DC%2BD2sXntlequg%3D%3D, PID: 17095241
    • Hennessy M, Spiers JP (2007) A primer on the mechanics of P-glycoprotein the multidrug transporter. Pharmacol Res 55:1–15
    • (2007) Pharmacol Res , vol.55 , pp. 1-15
    • Hennessy, M.1    Spiers, J.P.2
  • 75
    • 36749085605 scopus 로고
    • Flavonoids of the Ponderosa lemon
    • COI: 1:CAS:528:DyaF3cXnsFahsw%3D%3D, PID: 14403185
    • Horowitz RM, Gentili B (1960) Flavonoids of the Ponderosa lemon. Nature 185:319
    • (1960) Nature , vol.185 , pp. 319
    • Horowitz, R.M.1    Gentili, B.2
  • 76
    • 0037032676 scopus 로고    scopus 로고
    • Quercetin significantly decreased cyclosporin oral bioavailability in pigs and rats
    • COI: 1:CAS:528:DC%2BD38XosFCktbY%3D, PID: 12427482
    • Hsiu S-L, Hou Y-C, Wang Y-H et al (2002) Quercetin significantly decreased cyclosporin oral bioavailability in pigs and rats. Life Sci 72:227–235
    • (2002) Life Sci , vol.72 , pp. 227-235
    • Hsiu, S.-L.1    Hou, Y.-C.2    Wang, Y.-H.3
  • 77
    • 0037307995 scopus 로고    scopus 로고
    • Assessing safety and efficacy of directed P-glycoprotein inhibition to improve the pharmacokinetic properties of saquinavir coadministered with ritonavir
    • COI: 1:CAS:528:DC%2BD3sXpvVCgtQ%3D%3D, PID: 12538811
    • Huisman MT, Smit JW, Wiltshire HR et al (2003) Assessing safety and efficacy of directed P-glycoprotein inhibition to improve the pharmacokinetic properties of saquinavir coadministered with ritonavir. J Pharmacol Exp Ther 304:596–602
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 596-602
    • Huisman, M.T.1    Smit, J.W.2    Wiltshire, H.R.3
  • 78
    • 0034634749 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells
    • Ikegawa T, Ushigome F, Koyabu N, Morimoto S (2000) Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells. Cancer Lett 160:21–28
    • (2000) Cancer Lett , vol.160 , pp. 21-28
    • Ikegawa, T.1    Ushigome, F.2    Koyabu, N.3    Morimoto, S.4
  • 79
    • 79952155950 scopus 로고    scopus 로고
    • Flavonoids and the CNS
    • PID: 21311414
    • Jäger AK, Saaby L (2011) Flavonoids and the CNS. Molecules 16:1471–1485
    • (2011) Molecules , vol.16 , pp. 1471-1485
    • Jäger, A.K.1    Saaby, L.2
  • 80
    • 44849099675 scopus 로고    scopus 로고
    • Enhancement of paclitacel transport and cytotoxicity by 7,3’,4’-trimethoxyflavone, a P-glycoprotein inhibitor
    • Jeong J-M, Choi C-H (2007) Enhancement of paclitacel transport and cytotoxicity by 7,3’,4’-trimethoxyflavone, a P-glycoprotein inhibitor. J Pharm Pharm Sci 10:547–553
    • (2007) J Pharm Pharm Sci , vol.10 , pp. 547-553
    • Jeong, J.-M.1    Choi, C.-H.2
  • 81
    • 0037196568 scopus 로고    scopus 로고
    • Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols
    • COI: 1:CAS:528:DC%2BD38Xhtlersbg%3D, PID: 11853888
    • Jodoin J, Demeule M, Beliveau R (2002) Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols. Biochim Biophys Acta 1542:149–159
    • (2002) Biochim Biophys Acta , vol.1542 , pp. 149-159
    • Jodoin, J.1    Demeule, M.2    Beliveau, R.3
  • 82
    • 33645830172 scopus 로고
    • A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
    • COI: 1:CAS:528:DyaE28XlvV2qs70%3D, PID: 990323
    • Juliano RL, Ling V (1976) A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 455:152–162
    • (1976) Biochim Biophys Acta , vol.455 , pp. 152-162
    • Juliano, R.L.1    Ling, V.2
  • 83
    • 41049114858 scopus 로고    scopus 로고
    • Silymarin, a flavonoid from milk thistle (Silybum marianum L.), inhibits UV-induced oxidative stress through targeting infiltrating CD11b+ cells in mouse skin
    • COI: 1:CAS:528:DC%2BD1cXjt1Crurw%3D, PID: 18221354
    • Katiyar SK, Meleth S, Sharma SD (2008) Silymarin, a flavonoid from milk thistle (Silybum marianum L.), inhibits UV-induced oxidative stress through targeting infiltrating CD11b+ cells in mouse skin. Photochem Photobiol 84:266–271
    • (2008) Photochem Photobiol , vol.84 , pp. 266-271
    • Katiyar, S.K.1    Meleth, S.2    Sharma, S.D.3
  • 85
    • 0037478891 scopus 로고    scopus 로고
    • Increased penetration of paclitaxel into the brain by inhibition of P-Glycoprotein
    • COI: 1:CAS:528:DC%2BD3sXlt1yrsbo%3D, PID: 12855665
    • Kemper EM, van Zandbergen AE, Cleypool C et al (2003) Increased penetration of paclitaxel into the brain by inhibition of P-Glycoprotein. Clin Cancer Res 9:2849–2855
    • (2003) Clin Cancer Res , vol.9 , pp. 2849-2855
    • Kemper, E.M.1    van Zandbergen, A.E.2    Cleypool, C.3
  • 86
    • 0027466340 scopus 로고
    • Daidzin: a potent, selective inhibitor of human mitochondrial aldehyde dehydrogenase
    • COI: 1:CAS:528:DyaK3sXhvVGltL8%3D, PID: 8433985
    • Keung WM, Vallee BL (1993) Daidzin: a potent, selective inhibitor of human mitochondrial aldehyde dehydrogenase. Proc Natl Acad Sci USA 90:1247–1251
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1247-1251
    • Keung, W.M.1    Vallee, B.L.2
  • 87
    • 0033765536 scopus 로고    scopus 로고
    • Antigiardial activity of isoflavones from Dalbergia frutescens bark
    • COI: 1:CAS:528:DC%2BD3cXlsFKltro%3D, PID: 11076565
    • Khan IA, Avery MA, Burandt CL et al (2000) Antigiardial activity of isoflavones from Dalbergia frutescens bark. J Nat Prod 63:1414–1416
    • (2000) J Nat Prod , vol.63 , pp. 1414-1416
    • Khan, I.A.1    Avery, M.A.2    Burandt, C.L.3
  • 88
    • 16244364509 scopus 로고    scopus 로고
    • Screening of flavonoids for their potential inhibitory effect on p-glycoprotein activity in human cervical carcinoma KB cells
    • Khantamat O, Chaiwangyen W, Porn-ngarm L (2004) Screening of flavonoids for their potential inhibitory effect on p-glycoprotein activity in human cervical carcinoma KB cells. Chiang Mai Med Bull 43:45–56
    • (2004) Chiang Mai Med Bull , vol.43 , pp. 45-56
    • Khantamat, O.1    Chaiwangyen, W.2    Porn-ngarm, L.3
  • 89
    • 4143101607 scopus 로고    scopus 로고
    • Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces cell cycle arrest in ras-transformed human mammary epithelial cells
    • COI: 1:CAS:528:DC%2BD2cXmslOnsro%3D, PID: 15313404
    • Kim D-H, Na H-K, Oh TY et al (2004) Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces cell cycle arrest in ras-transformed human mammary epithelial cells. Biochem Pharmacol 68:1081–1087
    • (2004) Biochem Pharmacol , vol.68 , pp. 1081-1087
    • Kim, D.-H.1    Na, H.-K.2    Oh, T.Y.3
  • 90
    • 68849107630 scopus 로고    scopus 로고
    • Short-term effect of quercetin on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein, in healthy volunteers
    • COI: 1:CAS:528:DC%2BD1MXntVSktbk%3D, PID: 19221726
    • Kim K-A, Park P-W, Park J-Y (2009) Short-term effect of quercetin on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein, in healthy volunteers. Eur J Clin Pharmacol 65:609–614
    • (2009) Eur J Clin Pharmacol , vol.65 , pp. 609-614
    • Kim, K.-A.1    Park, P.-W.2    Park, J.-Y.3
  • 91
    • 78049280999 scopus 로고    scopus 로고
    • Chrysoeriol isolated from Eurya cilliata leaves protects MC3T3-E1 cells against hydrogen peroxide-induced inhibition of osteoblastic differentiation
    • COI: 1:CAS:528:DC%2BC3cXhtlaqtrfL, PID: 20981859
    • Kim YH, Lee YS, Choi EM (2010) Chrysoeriol isolated from Eurya cilliata leaves protects MC3T3-E1 cells against hydrogen peroxide-induced inhibition of osteoblastic differentiation. J Appl Toxicol 30:666–673
    • (2010) J Appl Toxicol , vol.30 , pp. 666-673
    • Kim, Y.H.1    Lee, Y.S.2    Choi, E.M.3
  • 92
    • 29844435006 scopus 로고    scopus 로고
    • Inhibitory effects of polyphenols on p-glycoprotein-mediated transport
    • COI: 1:CAS:528:DC%2BD28XjsleisL0%3D, PID: 16394499
    • Kitagawa S (2006) Inhibitory effects of polyphenols on p-glycoprotein-mediated transport. Biol Pharm Bull 29:1–6
    • (2006) Biol Pharm Bull , vol.29 , pp. 1-6
    • Kitagawa, S.1
  • 93
    • 4344602767 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein function by tea catechins in KB-C2 cells
    • Kitagawa S, Nabekura T, Kamiyama S (2004) Inhibition of P-glycoprotein function by tea catechins in KB-C2 cells. J Pharm Pharmacol 56:1001–1005
    • (2004) J Pharm Pharmacol , vol.56 , pp. 1001-1005
    • Kitagawa, S.1    Nabekura, T.2    Kamiyama, S.3
  • 94
    • 28744436977 scopus 로고    scopus 로고
    • Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells
    • COI: 1:CAS:528:DC%2BD28Xms1Gisw%3D%3D, PID: 16327165
    • Kitagawa S, Nabekura T, Takahashi T et al (2005) Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells. Biol Pharm Bull 28:2274–2278
    • (2005) Biol Pharm Bull , vol.28 , pp. 2274-2278
    • Kitagawa, S.1    Nabekura, T.2    Takahashi, T.3
  • 95
    • 0033799839 scopus 로고    scopus 로고
    • Multidrug resistance (MDR) in cancer: mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs
    • COI: 1:CAS:528:DC%2BD3cXntF2gtLw%3D, PID: 11033070
    • Krishna R, Mayer LD (2000) Multidrug resistance (MDR) in cancer: mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs. Eur J Pharm Sci 11:265–283
    • (2000) Eur J Pharm Sci , vol.11 , pp. 265-283
    • Krishna, R.1    Mayer, L.D.2
  • 96
    • 33644503533 scopus 로고    scopus 로고
    • Distribution and functional activity of P-glycoprotein and multidrug resistance-associated proteins in human brain microvascular endothelial cells in hippocampal sclerosis
    • COI: 1:CAS:528:DC%2BD28Xhslylurk%3D, PID: 16361082
    • Kubota H, Ishihara H, Langmann T et al (2006) Distribution and functional activity of P-glycoprotein and multidrug resistance-associated proteins in human brain microvascular endothelial cells in hippocampal sclerosis. Epilepsy Res 68:213–228
    • (2006) Epilepsy Res , vol.68 , pp. 213-228
    • Kubota, H.1    Ishihara, H.2    Langmann, T.3
  • 97
    • 84873108317 scopus 로고    scopus 로고
    • Phytochemical composition and in vitro antioxidant activity of aqueous extract of Aerva lanata (L.) Juss. ex Schult. Stem (Amaranthaceae)
    • COI: 1:CAS:528:DC%2BC3sXit1Klu70%3D, PID: 23375030
    • Kumar G, Karthik L, Rao KVB (2013) Phytochemical composition and in vitro antioxidant activity of aqueous extract of Aerva lanata (L.) Juss. ex Schult. Stem (Amaranthaceae). Asian Pac J Trop Med 6:180–187
    • (2013) Asian Pac J Trop Med , vol.6 , pp. 180-187
    • Kumar, G.1    Karthik, L.2    Rao, K.V.B.3
  • 98
    • 13244298981 scopus 로고    scopus 로고
    • Potential role of drug transporters in the pathogenesis of medically intractable epilepsy
    • COI: 1:CAS:528:DC%2BD2MXitFGnt78%3D, PID: 15679503
    • Kwan P, Brodie MJ (2005) Potential role of drug transporters in the pathogenesis of medically intractable epilepsy. Epilepsia 46:224–235
    • (2005) Epilepsia , vol.46 , pp. 224-235
    • Kwan, P.1    Brodie, M.J.2
  • 99
    • 84862526674 scopus 로고    scopus 로고
    • In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent
    • COI: 1:CAS:528:DC%2BC38Xos1ens70%3D, PID: 22707269
    • Lam IK, Alex D, Wang Y-H et al (2012) In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent. Mol Nutr Food Res 56:945–956
    • (2012) Mol Nutr Food Res , vol.56 , pp. 945-956
    • Lam, I.K.1    Alex, D.2    Wang, Y.-H.3
  • 100
    • 34848910711 scopus 로고    scopus 로고
    • ABC transporters during epilepsy and mechanisms underlying multidrug resistance in refractory epilepsy
    • COI: 1:CAS:528:DC%2BD2sXht12rtbbM, PID: 17910594
    • Lazarowski A, Czornyj L, Lubienieki F et al (2007) ABC transporters during epilepsy and mechanisms underlying multidrug resistance in refractory epilepsy. Epilepsia 48(Suppl 5):140–149
    • (2007) Epilepsia , vol.48 , pp. 140-149
    • Lazarowski, A.1    Czornyj, L.2    Lubienieki, F.3
  • 101
    • 77952996831 scopus 로고    scopus 로고
    • Effects of silibinin, inhibitor of CYP3A4 and P-glycoprotein in vitro, on the pharmacokinetics of paclitaxel after oral and intravenous administration in rats
    • COI: 1:CAS:528:DC%2BC3cXosFart7s%3D, PID: 20523105
    • Lee C-K, Choi J-S (2010) Effects of silibinin, inhibitor of CYP3A4 and P-glycoprotein in vitro, on the pharmacokinetics of paclitaxel after oral and intravenous administration in rats. Pharmacology 85:350–356
    • (2010) Pharmacology , vol.85 , pp. 350-356
    • Lee, C.-K.1    Choi, J.-S.2
  • 102
    • 23744444926 scopus 로고    scopus 로고
    • Evaluation of bitter masking flavanones from Herba Santa (Eriodictyon californicum (H. and A.) Torr., Hydrophyllaceae)
    • COI: 1:CAS:528:DC%2BD2MXltlGhtLc%3D, PID: 16028996
    • Ley JP, Krammer G, Reinders G et al (2005) Evaluation of bitter masking flavanones from Herba Santa (Eriodictyon californicum (H. and A.) Torr., Hydrophyllaceae). J Agric Food Chem 53:6061–6066
    • (2005) J Agric Food Chem , vol.53 , pp. 6061-6066
    • Ley, J.P.1    Krammer, G.2    Reinders, G.3
  • 103
    • 34248512624 scopus 로고    scopus 로고
    • Effect of genistein on the pharmacokinetics of paclitaxel administered orally or intravenously in rats
    • COI: 1:CAS:528:DC%2BD2sXlsFagsr0%3D, PID: 17267149
    • Li X, Choi J-S (2007) Effect of genistein on the pharmacokinetics of paclitaxel administered orally or intravenously in rats. Int J Pharm 337:188–193
    • (2007) Int J Pharm , vol.337 , pp. 188-193
    • Li, X.1    Choi, J.-S.2
  • 104
    • 56749149775 scopus 로고    scopus 로고
    • Effects of epigallocatechin gallate on the bioavailability and pharmacokinetics of diltiazem in rats
    • COI: 1:CAS:528:DC%2BD1cXhsVSlsr%2FM, PID: 19069242
    • Li C, Choi JS (2008) Effects of epigallocatechin gallate on the bioavailability and pharmacokinetics of diltiazem in rats. Pharmazie 63:815–818
    • (2008) Pharmazie , vol.63 , pp. 815-818
    • Li, C.1    Choi, J.S.2
  • 105
    • 64949088858 scopus 로고    scopus 로고
    • Effects of quercetin on the pharmacokinetics of Etoposide after oral or intravenous administration of etoposide in rats
    • COI: 1:CAS:528:DC%2BD1MXltFCgsLc%3D, PID: 19414395
    • Li X, Choi J-S (2009) Effects of quercetin on the pharmacokinetics of Etoposide after oral or intravenous administration of etoposide in rats. Anticancer Res 29:1411–1415
    • (2009) Anticancer Res , vol.29 , pp. 1411-1415
    • Li, X.1    Choi, J.-S.2
  • 106
    • 34248327577 scopus 로고    scopus 로고
    • Effects of morin on the pharmacokinetics of etoposide in rats
    • PID: 17315145
    • Li X, Yun J-K, Choi J-S (2007) Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos 28:151–156
    • (2007) Biopharm Drug Dispos , vol.28 , pp. 151-156
    • Li, X.1    Yun, J.-K.2    Choi, J.-S.3
  • 107
    • 59449092342 scopus 로고    scopus 로고
    • Enhanced bioavailability of etoposide after oral or intravenous administration of etoposide with kaempferol in rats
    • COI: 1:CAS:528:DC%2BD1MXhtFShurc%3D, PID: 19183886
    • Li C, Li X, Choi J-S (2009) Enhanced bioavailability of etoposide after oral or intravenous administration of etoposide with kaempferol in rats. Arch Pharm Res 32:133–138
    • (2009) Arch Pharm Res , vol.32 , pp. 133-138
    • Li, C.1    Li, X.2    Choi, J.-S.3
  • 108
    • 83655203469 scopus 로고    scopus 로고
    • Effects of baicalein on the pharmacokinetics of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in rats: possible role of cytochrome P450 3A4 and P-glycoprotein inhibition by baicalein
    • COI: 1:CAS:528:DC%2BC3MXhsFOit7fL, PID: 22139696
    • Li C, Kim M, Choi H, Choi J (2011) Effects of baicalein on the pharmacokinetics of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in rats: possible role of cytochrome P450 3A4 and P-glycoprotein inhibition by baicalein. Arch Pharm Res 34:1965–1972
    • (2011) Arch Pharm Res , vol.34 , pp. 1965-1972
    • Li, C.1    Kim, M.2    Choi, H.3    Choi, J.4
  • 109
    • 33846103811 scopus 로고    scopus 로고
    • Effects of naringin on the pharmacokinetics of intravenous paclitaxel in rats
    • COI: 1:CAS:528:DC%2BD2sXisVOrtQ%3D%3D, PID: 17009338
    • Lim S-C, Choi J-S (2006) Effects of naringin on the pharmacokinetics of intravenous paclitaxel in rats. Biopharm Drug Dispos 27:443–447
    • (2006) Biopharm Drug Dispos , vol.27 , pp. 443-447
    • Lim, S.-C.1    Choi, J.-S.2
  • 110
    • 0037457793 scopus 로고    scopus 로고
    • Drug–drug interaction mediated by inhibition and induction of P-glycoprotein
    • COI: 1:CAS:528:DC%2BD3sXivVWntw%3D%3D, PID: 12535574
    • Lin JH (2003) Drug–drug interaction mediated by inhibition and induction of P-glycoprotein. Adv Drug Deliv Rev 55:53–81
    • (2003) Adv Drug Deliv Rev , vol.55 , pp. 53-81
    • Lin, J.H.1
  • 111
    • 0037229942 scopus 로고    scopus 로고
    • Role of P-glycoprotein in pharmacokinetics: clinical implications
    • COI: 1:CAS:528:DC%2BD3sXptVymuw%3D%3D, PID: 12489979
    • Lin JH, Yamazaki M (2003) Role of P-glycoprotein in pharmacokinetics: clinical implications. Clin Pharmacokinet 42:59–98
    • (2003) Clin Pharmacokinet , vol.42 , pp. 59-98
    • Lin, J.H.1    Yamazaki, M.2
  • 112
    • 0030738677 scopus 로고    scopus 로고
    • Multidrug resistance: molecular mechanisms and clinical relevance
    • COI: 1:CAS:528:DyaK2sXlsVyrsL0%3D, PID: 9272126
    • Ling V (1997) Multidrug resistance: molecular mechanisms and clinical relevance. Cancer Chemother Pharmacol 40(Suppl):S3–S8
    • (1997) Cancer Chemother Pharmacol , vol.40 , pp. 3-8
    • Ling, V.1
  • 113
    • 38149073214 scopus 로고    scopus 로고
    • A review on the impact of P-glycoprotein on the penetration of drugs into the brain: focus on psychotropic drugs
    • COI: 1:CAS:528:DC%2BD1cXosFGlsw%3D%3D, PID: 17683917
    • Linnet K, Ejsing TB (2008) A review on the impact of P-glycoprotein on the penetration of drugs into the brain: focus on psychotropic drugs. Eur Neuropsychopharmacol 18:157–169
    • (2008) Eur Neuropsychopharmacol , vol.18 , pp. 157-169
    • Linnet, K.1    Ejsing, T.B.2
  • 114
    • 34250196177 scopus 로고    scopus 로고
    • Flavonoids alter P-gp expression in intestinal epithelial cells in vitro and in vivo
    • COI: 1:CAS:528:DC%2BD2sXjs1WqtLg%3D, PID: 17295420
    • Lohner K, Schnäbele K, Daniel H et al (2007) Flavonoids alter P-gp expression in intestinal epithelial cells in vitro and in vivo. Mol Nutr Food Res 51:293–300
    • (2007) Mol Nutr Food Res , vol.51 , pp. 293-300
    • Lohner, K.1    Schnäbele, K.2    Daniel, H.3
  • 115
    • 0036128985 scopus 로고    scopus 로고
    • Role of multidrug transporters in pharmacoresistance to antiepileptic drugs
    • PID: 11907151
    • Löscher W, Potschka H (2002a) Role of multidrug transporters in pharmacoresistance to antiepileptic drugs. J Pharmacol Exp Ther 301:7–14
    • (2002) J Pharmacol Exp Ther , vol.301 , pp. 7-14
    • Löscher, W.1    Potschka, H.2
  • 116
    • 22744440362 scopus 로고    scopus 로고
    • Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases
    • Löscher W, Potschka H (2002b) Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases. Prog Neurobiol 76:22–76
    • (2002) Prog Neurobiol , vol.76 , pp. 22-76
    • Löscher, W.1    Potschka, H.2
  • 117
    • 12344262373 scopus 로고    scopus 로고
    • Blood-brain barrier active efflux transporters: aTP-binding cassette gene family
    • PID: 15717060
    • Löscher W, Potschka H (2005) Blood-brain barrier active efflux transporters: aTP-binding cassette gene family. NeuroRx 2:86–98
    • (2005) NeuroRx , vol.2 , pp. 86-98
    • Löscher, W.1    Potschka, H.2
  • 118
    • 84884207681 scopus 로고    scopus 로고
    • Anti-allergic effects of enzymatically modified isoquercitrin (α-oligoglucosyl quercetin 3-O-glucoside), quercetin 3-O-glucoside, α-oligoglucosyl rutin, and quercetin, when administered orally to mice
    • COI: 1:CAS:528:DC%2BC3sXhsF2gsrbO, PID: 23494818
    • Makino T, Kanemaru M, Okuyama S et al (2013) Anti-allergic effects of enzymatically modified isoquercitrin (α-oligoglucosyl quercetin 3-O-glucoside), quercetin 3-O-glucoside, α-oligoglucosyl rutin, and quercetin, when administered orally to mice. J Nat Med 67:881–886
    • (2013) J Nat Med , vol.67 , pp. 881-886
    • Makino, T.1    Kanemaru, M.2    Okuyama, S.3
  • 119
    • 79953317272 scopus 로고    scopus 로고
    • ABC multidrug transporters: target for modulation of drug pharmacokinetics and drug–drug interactions
    • COI: 1:CAS:528:DC%2BC3MXls1Ortro%3D, PID: 21039335
    • Marquez B, Van Bambeke F (2011) ABC multidrug transporters: target for modulation of drug pharmacokinetics and drug–drug interactions. Curr Drug Targets 12:600–620
    • (2011) Curr Drug Targets , vol.12 , pp. 600-620
    • Marquez, B.1    Van Bambeke, F.2
  • 120
    • 0034964222 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic implications of P-glycoprotein modulation
    • COI: 1:CAS:528:DC%2BD3MXlsFSqtrY%3D, PID: 11444575
    • Matheny CJ, Lamb MW, Brouwer KR, Pollack GM (2001) Pharmacokinetic and pharmacodynamic implications of P-glycoprotein modulation. Pharmacotherapy 21:778–796
    • (2001) Pharmacotherapy , vol.21 , pp. 778-796
    • Matheny, C.J.1    Lamb, M.W.2    Brouwer, K.R.3    Pollack, G.M.4
  • 121
    • 58149252135 scopus 로고    scopus 로고
    • Effect of natsudaidain isolated from Citrus plants on TNF-alpha and cyclooxygenase-2 expression in RBL-2H3 cells
    • COI: 1:CAS:528:DC%2BD1MXhtlCitro%3D, PID: 19126304
    • Matsui T, Ito C, Itoigawa M et al (2009) Effect of natsudaidain isolated from Citrus plants on TNF-alpha and cyclooxygenase-2 expression in RBL-2H3 cells. J Pharm Pharmacol 61:109–114
    • (2009) J Pharm Pharmacol , vol.61 , pp. 109-114
    • Matsui, T.1    Ito, C.2    Itoigawa, M.3
  • 122
    • 34247257725 scopus 로고    scopus 로고
    • Polymethoxylated flavones and other phenolic derivates from citrus in their inhibitory effects on P-glycoprotein-mediated transport of talinolol in Caco-2 cells
    • COI: 1:CAS:528:DC%2BD2sXis1Ghsb8%3D, PID: 17348674
    • Mertens-Talcott SU, De Castro WV, Manthey JA et al (2007) Polymethoxylated flavones and other phenolic derivates from citrus in their inhibitory effects on P-glycoprotein-mediated transport of talinolol in Caco-2 cells. J Agric Food Chem 55:2563–2568
    • (2007) J Agric Food Chem , vol.55 , pp. 2563-2568
    • Mertens-Talcott, S.U.1    De Castro, W.V.2    Manthey, J.A.3
  • 123
    • 46949098349 scopus 로고    scopus 로고
    • Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve CNS pharmacotherapy
    • Miller DS, Bauer B, Hart AMS (2009) Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve CNS pharmacotherapy. Pharmacol Rev 60:196–209
    • (2009) Pharmacol Rev , vol.60 , pp. 196-209
    • Miller, D.S.1    Bauer, B.2    Hart, A.M.S.3
  • 124
    • 0034600237 scopus 로고    scopus 로고
    • Effect of bioflavonoids on vincristine transport across blood–brain barrier
    • COI: 1:CAS:528:DC%2BD3cXjt1eitb0%3D, PID: 10812049
    • Mitsunaga Y, Takanaga H, Matsuo H et al (2000) Effect of bioflavonoids on vincristine transport across blood–brain barrier. Eur J Pharmacol 395:193–201
    • (2000) Eur J Pharmacol , vol.395 , pp. 193-201
    • Mitsunaga, Y.1    Takanaga, H.2    Matsuo, H.3
  • 125
    • 36148968818 scopus 로고    scopus 로고
    • Isolation of antioxidative phenolic glucosides from lemon juice and their suppressive effect on the expression of blood adhesion molecules
    • COI: 1:CAS:528:DC%2BD2sXhtVaju7jM, PID: 17690486
    • Miyake Y, Mochizuki M, Okada M et al (2007) Isolation of antioxidative phenolic glucosides from lemon juice and their suppressive effect on the expression of blood adhesion molecules. Biosci Biotechnol Biochem 71:1911–1919
    • (2007) Biosci Biotechnol Biochem , vol.71 , pp. 1911-1919
    • Miyake, Y.1    Mochizuki, M.2    Okada, M.3
  • 126
    • 0042468096 scopus 로고    scopus 로고
    • Impact of drug transporter studies on drug discovery and development
    • COI: 1:CAS:528:DC%2BD3sXnsVynuro%3D, PID: 12869659
    • Mizuno N, Niwa T, Yotsumoto Y, Sugiyama Y (2003) Impact of drug transporter studies on drug discovery and development. Pharmacol Rev 55:425–461
    • (2003) Pharmacol Rev , vol.55 , pp. 425-461
    • Mizuno, N.1    Niwa, T.2    Yotsumoto, Y.3    Sugiyama, Y.4
  • 127
    • 30644456411 scopus 로고    scopus 로고
    • Dietary flavonoids: effects on xenobiotic and carcinogen metabolism
    • COI: 1:CAS:528:DC%2BD28XksVensQ%3D%3D
    • Moon YJ, Wang X, Morris ME (2006) Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol Vitr 20:187–210
    • (2006) Toxicol Vitr , vol.20 , pp. 187-210
    • Moon, Y.J.1    Wang, X.2    Morris, M.E.3
  • 129
    • 33644914487 scopus 로고    scopus 로고
    • Flavonoid-drug interactions: effects of flavonoids on ABC transporters
    • COI: 1:CAS:528:DC%2BD28XisF2qsb0%3D, PID: 16455109
    • Morris ME, Zhang S (2006) Flavonoid-drug interactions: effects of flavonoids on ABC transporters. Life Sci 78:2116–2130
    • (2006) Life Sci , vol.78 , pp. 2116-2130
    • Morris, M.E.1    Zhang, S.2
  • 130
    • 19444385262 scopus 로고    scopus 로고
    • Modulation of drug transport by selected flavonoids: involvement of P-gp and OCT?
    • COI: 1:CAS:528:DC%2BD2MXks1Gitrg%3D, PID: 15911222
    • Ofer M, Wolffram S, Koggel A et al (2005) Modulation of drug transport by selected flavonoids: involvement of P-gp and OCT? Eur J Pharm Sci 25:263–271
    • (2005) Eur J Pharm Sci , vol.25 , pp. 263-271
    • Ofer, M.1    Wolffram, S.2    Koggel, A.3
  • 131
    • 33748772294 scopus 로고    scopus 로고
    • Allergy-preventive phenolic glycosides from Populus sieboldii
    • COI: 1:CAS:528:DC%2BD28XnvFOnsbw%3D, PID: 16933880
    • Ogawa Y, Oku H, Iwaoka E et al (2006) Allergy-preventive phenolic glycosides from Populus sieboldii. J Nat Prod 69:1215–1217
    • (2006) J Nat Prod , vol.69 , pp. 1215-1217
    • Ogawa, Y.1    Oku, H.2    Iwaoka, E.3
  • 132
    • 79958812376 scopus 로고    scopus 로고
    • New uses for old drugs: pharmacophore-based screening for the discovery of P-glycoprotein inhibitors
    • COI: 1:CAS:528:DC%2BC3MXosVags7s%3D, PID: 21235729
    • Palmeira A, Rodrigues F, Sousa E et al (2011) New uses for old drugs: pharmacophore-based screening for the discovery of P-glycoprotein inhibitors. Chem Biol Drug Des 78:57–72
    • (2011) Chem Biol Drug Des , vol.78 , pp. 57-72
    • Palmeira, A.1    Rodrigues, F.2    Sousa, E.3
  • 133
    • 84855800458 scopus 로고    scopus 로고
    • Effects of silymarin and formulation on the oral bioavailability of paclitaxel in rats
    • COI: 1:CAS:528:DC%2BC38Xos1GrsQ%3D%3D, PID: 22172604
    • Park JH, Park JH, Hur HJ et al (2012) Effects of silymarin and formulation on the oral bioavailability of paclitaxel in rats. Eur J Pharm Sci 45:296–301
    • (2012) Eur J Pharm Sci , vol.45 , pp. 296-301
    • Park, J.H.1    Park, J.H.2    Hur, H.J.3
  • 134
    • 33846129390 scopus 로고    scopus 로고
    • Effects of Kaempferia Parviflora extracts and their flavone constituents on P-glycoprotein function
    • Patanasethanont D, Nagai J, Yumoto R et al (2007) Effects of Kaempferia Parviflora extracts and their flavone constituents on P-glycoprotein function. J Pharm Sci 96:223–233
    • (2007) J Pharm Sci , vol.96 , pp. 223-233
    • Patanasethanont, D.1    Nagai, J.2    Yumoto, R.3
  • 135
    • 77951034037 scopus 로고    scopus 로고
    • Pre-clinical evidence of enhanced oral bioavailability of the P-glycoprotein substrate talinolol in combination with morin
    • COI: 1:CAS:528:DC%2BC3cXksV2mtr4%3D, PID: 20238375
    • Pathak SM, Udupa N (2010) Pre-clinical evidence of enhanced oral bioavailability of the P-glycoprotein substrate talinolol in combination with morin. Biopharm Drug Dispos 31:202–214
    • (2010) Biopharm Drug Dispos , vol.31 , pp. 202-214
    • Pathak, S.M.1    Udupa, N.2
  • 136
    • 33748931006 scopus 로고    scopus 로고
    • Altered oral bioavailability and pharmacokinetics of P-glycoprotein substrates by coadministration of biochanin A
    • COI: 1:CAS:528:DC%2BD28XpsFehtb4%3D, PID: 16850393
    • Peng SX, Ritchie DM, Cousineau M et al (2006) Altered oral bioavailability and pharmacokinetics of P-glycoprotein substrates by coadministration of biochanin A. J Pharm Sci 95:1984–1993
    • (2006) J Pharm Sci , vol.95 , pp. 1984-1993
    • Peng, S.X.1    Ritchie, D.M.2    Cousineau, M.3
  • 137
    • 33745736603 scopus 로고    scopus 로고
    • Multidrug resistance: retrospect and prospects in anti-cancer drug treatment
    • PID: 16842198
    • Pérez-Tomás R (2006) Multidrug resistance: retrospect and prospects in anti-cancer drug treatment. Curr Med Chem 13:1859–1876
    • (2006) Curr Med Chem , vol.13 , pp. 1859-1876
    • Pérez-Tomás, R.1
  • 138
    • 42549117615 scopus 로고    scopus 로고
    • Effects of morin on the pharmacokinetics of nicardipine after oral and intravenous administration of nicardipine in rats
    • COI: 1:CAS:528:DC%2BD1cXltlemtrg%3D, PID: 18416939
    • Piao Y-J, Choi J-S (2008a) Effects of morin on the pharmacokinetics of nicardipine after oral and intravenous administration of nicardipine in rats. J Pharm Pharmacol 60:625–629
    • (2008) J Pharm Pharmacol , vol.60 , pp. 625-629
    • Piao, Y.-J.1    Choi, J.-S.2
  • 139
    • 43049113508 scopus 로고    scopus 로고
    • Enhanced bioavailability of verapamil after oral administration with hesperidin in rats
    • COI: 1:CAS:528:DC%2BD1cXltlWntbk%3D, PID: 18449511
    • Piao Y-J, Choi J-S (2008b) Enhanced bioavailability of verapamil after oral administration with hesperidin in rats. Arch Pharm Res 31:518–522
    • (2008) Arch Pharm Res , vol.31 , pp. 518-522
    • Piao, Y.-J.1    Choi, J.-S.2
  • 140
    • 44949209644 scopus 로고    scopus 로고
    • Effects of oral kaempferol on the pharmacokinetics of tamoxifen and one of its metabolites, 4-hydroxytamoxifen, after oral administration of tamoxifen to rats
    • COI: 1:CAS:528:DC%2BD1cXntVemsbs%3D, PID: 18338336
    • Piao Y-J, Shin S-C, Choi J-S (2008) Effects of oral kaempferol on the pharmacokinetics of tamoxifen and one of its metabolites, 4-hydroxytamoxifen, after oral administration of tamoxifen to rats. Biopharm Drug Dispos 29:245–249
    • (2008) Biopharm Drug Dispos , vol.29 , pp. 245-249
    • Piao, Y.-J.1    Shin, S.-C.2    Choi, J.-S.3
  • 141
    • 84862906610 scopus 로고    scopus 로고
    • Role of CNS efflux drug transporters in antiepileptic drug delivery: overcoming CNS efflux drug transport
    • COI: 1:CAS:528:DC%2BC38XksFejtL0%3D, PID: 22210135
    • Potschka H (2012) Role of CNS efflux drug transporters in antiepileptic drug delivery: overcoming CNS efflux drug transport. Adv Drug Deliv Rev 64:943–952
    • (2012) Adv Drug Deliv Rev , vol.64 , pp. 943-952
    • Potschka, H.1
  • 143
    • 0035076924 scopus 로고    scopus 로고
    • Bioflavonoids classification, pharmacological, biochemical effects and therapeutic potential
    • Raj (2001) Bioflavonoids classification, pharmacological, biochemical effects and therapeutic potential. Indian J Pharmacol 33:2
    • (2001) Indian J Pharmacol , vol.33 , pp. 2
    • Raj1
  • 144
    • 0034729787 scopus 로고    scopus 로고
    • Naringenin 7-O-methyltransferase involved in the biosynthesis of the flavanone phytoalexin sakuranetin from rice (Oryza sativa L.)
    • COI: 1:CAS:528:DC%2BD3cXjt1aqurw%3D, PID: 10814825
    • Rakwal R, Agrawal G, Yonekura M, Kodama O (2000) Naringenin 7-O-methyltransferase involved in the biosynthesis of the flavanone phytoalexin sakuranetin from rice (Oryza sativa L.). Plant Sci 155:213–221
    • (2000) Plant Sci , vol.155 , pp. 213-221
    • Rakwal, R.1    Agrawal, G.2    Yonekura, M.3    Kodama, O.4
  • 145
    • 22844448146 scopus 로고    scopus 로고
    • The role of P-glycoprotein in the blood–brain barrier
    • COI: 1:CAS:528:DC%2BD2cXhtlGntrY%3D
    • Ramakrishnan P (2003) The role of P-glycoprotein in the blood–brain barrier. Einstein J Biol Med 19:160–165
    • (2003) Einstein J Biol Med , vol.19 , pp. 160-165
    • Ramakrishnan, P.1
  • 146
    • 34547664909 scopus 로고    scopus 로고
    • Effect of silymarin on the oral bioavailability of ranitidine in healthy human volunteers
    • Rao BN, Srinivas M, Kumar YS, Rao YM (2007) Effect of silymarin on the oral bioavailability of ranitidine in healthy human volunteers. Drug Metab Drug Interact 22:175–185
    • (2007) Drug Metab Drug Interact , vol.22 , pp. 175-185
    • Rao, B.N.1    Srinivas, M.2    Kumar, Y.S.3    Rao, Y.M.4
  • 147
    • 79955087504 scopus 로고    scopus 로고
    • Insulin-mimetic action of rhoifolin and cosmosiin isolated from Citrus grandis (L.) Osbeck leaves: enhanced adiponectin secretion and insulin receptor phosphorylation in 3T3-L1 Cells
    • Rao YK, Lee M-J, Chen K et al (2011) Insulin-mimetic action of rhoifolin and cosmosiin isolated from Citrus grandis (L.) Osbeck leaves: enhanced adiponectin secretion and insulin receptor phosphorylation in 3T3-L1 Cells. Evid Based Complement Alternat Med 2011:624375
    • (2011) Evid Based Complement Alternat Med , vol.2011
    • Rao, Y.K.1    Lee, M.-J.2    Chen, K.3
  • 148
    • 33644692007 scopus 로고    scopus 로고
    • P-glycoprotein recognition of substrates and circumvention through rational drug design
    • COI: 1:CAS:528:DC%2BD2MXhtlagu7%2FP, PID: 16686365
    • Raub TJ (2006) P-glycoprotein recognition of substrates and circumvention through rational drug design. Mol Pharm 3:3–25
    • (2006) Mol Pharm , vol.3 , pp. 3-25
    • Raub, T.J.1
  • 149
    • 84886313370 scopus 로고    scopus 로고
    • Novel Insights into the pharmacology of flavonoids
    • COI: 1:CAS:528:DC%2BC3sXhs1yju7fP, PID: 23824931
    • Romano B, Pagano E, Montanaro V et al (2013) Novel Insights into the pharmacology of flavonoids. Phytother Res 27:1588–1596
    • (2013) Phytother Res , vol.27 , pp. 1588-1596
    • Romano, B.1    Pagano, E.2    Montanaro, V.3
  • 150
    • 7544245330 scopus 로고    scopus 로고
    • Effects of grapefruit juice on the multidrug transporter P-glycoprotein in the human proximal tubular cell line HK-2
    • COI: 1:CAS:528:DC%2BD2cXpsFWrtbs%3D, PID: 15531381
    • Romiti N, Tramonti G, Donati A, Chieli E (2004) Effects of grapefruit juice on the multidrug transporter P-glycoprotein in the human proximal tubular cell line HK-2. Life Sci 76:293–302
    • (2004) Life Sci , vol.76 , pp. 293-302
    • Romiti, N.1    Tramonti, G.2    Donati, A.3    Chieli, E.4
  • 151
    • 0036400016 scopus 로고    scopus 로고
    • Dietary flavonoids: bioavailability, metabolic effects, and safety
    • COI: 1:CAS:528:DC%2BD38XmtF2ht7o%3D, PID: 12055336
    • Ross JA, Kasum CM (2002) Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr 22:19–34
    • (2002) Annu Rev Nutr , vol.22 , pp. 19-34
    • Ross, J.A.1    Kasum, C.M.2
  • 152
    • 0030817640 scopus 로고    scopus 로고
    • The effect of isosakuranetin (5,7-dihydroxy 4′-methoxy flavanone) on potassium uptake in wheat root segments
    • COI: 1:CAS:528:DyaK2sXmt1ymtL8%3D
    • Sacco S, Maffei M (1997) The effect of isosakuranetin (5,7-dihydroxy 4′-methoxy flavanone) on potassium uptake in wheat root segments. Phytochemistry 46:245–248
    • (1997) Phytochemistry , vol.46 , pp. 245-248
    • Sacco, S.1    Maffei, M.2
  • 153
    • 0035682157 scopus 로고    scopus 로고
    • The mechanism of action of multidrug-resistance-linked P-glycoprotein
    • Sauna ZE, Smith MM, Marianna M, Kerr KM (2001) The mechanism of action of multidrug-resistance-linked P-glycoprotein. J Bioenerg Biomembr 33:481–491
    • (2001) J Bioenerg Biomembr , vol.33 , pp. 481-491
    • Sauna, Z.E.1    Smith, M.M.2    Marianna, M.3    Kerr, K.M.4
  • 154
    • 0027981909 scopus 로고
    • Quercetin potentiates the effect of Adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible target
    • COI: 1:CAS:528:DyaK2MXis1Onu7o%3D, PID: 7923555
    • Scambia G, Ranelletti FO, Panici PB et al (1994) Quercetin potentiates the effect of Adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible target. Cancer Chemother Pharmacol 34:459–464
    • (1994) Cancer Chemother Pharmacol , vol.34 , pp. 459-464
    • Scambia, G.1    Ranelletti, F.O.2    Panici, P.B.3
  • 155
    • 0033526176 scopus 로고    scopus 로고
    • P-Glycoprotein, a gatekeeper in the blood–brain barrier
    • COI: 1:CAS:528:DyaK1MXhvVCgu7Y%3D, PID: 10837715
    • Schinkel A (1999) P-Glycoprotein, a gatekeeper in the blood–brain barrier. Adv Drug Deliv Rev 36:179–194
    • (1999) Adv Drug Deliv Rev , vol.36 , pp. 179-194
    • Schinkel, A.1
  • 156
    • 0037457802 scopus 로고    scopus 로고
    • Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
    • Schinkel AH, Jonker JW (2012) Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv Drug Deliv Rev 55:3–29
    • (2012) Adv Drug Deliv Rev , vol.55 , pp. 3-29
    • Schinkel, A.H.1    Jonker, J.W.2
  • 157
    • 0037072554 scopus 로고    scopus 로고
    • Lack of effects of prolonged treatment with phenobarbital or phenytoin on the expression of P-glycoprotein in various rat brain regions
    • COI: 1:CAS:528:DC%2BD38XmvVCrsbg%3D, PID: 12231384
    • Seegers U, Potschka H, Löscher W (2002) Lack of effects of prolonged treatment with phenobarbital or phenytoin on the expression of P-glycoprotein in various rat brain regions. Eur J Pharmacol 451:149–155
    • (2002) Eur J Pharmacol , vol.451 , pp. 149-155
    • Seegers, U.1    Potschka, H.2    Löscher, W.3
  • 158
    • 84868124527 scopus 로고    scopus 로고
    • Phytotoxic effect, uptake, and transformation of biochanin A in selected weed species
    • COI: 1:CAS:528:DC%2BC38XhsVCgtrvK, PID: 23030687
    • Shajib MTI, Pedersen HA, Mortensen AG et al (2012) Phytotoxic effect, uptake, and transformation of biochanin A in selected weed species. J Agric Food Chem 60:10715–10722
    • (2012) J Agric Food Chem , vol.60 , pp. 10715-10722
    • Shajib, M.T.I.1    Pedersen, H.A.2    Mortensen, A.G.3
  • 159
    • 77956304287 scopus 로고    scopus 로고
    • A quantitative structure-activity relationship for the modulation effects of flavonoids on p-glycoprotein-mediated transport
    • COI: 1:CAS:528:DC%2BC3cXhtlCqtb%2FF
    • Sheu M-T, Liou Y-B, Kao Y-H et al (2010) A quantitative structure-activity relationship for the modulation effects of flavonoids on p-glycoprotein-mediated transport. Chem Pharm Bull (Tokyo) 58:1187–1194
    • (2010) Chem Pharm Bull (Tokyo) , vol.58 , pp. 1187-1194
    • Sheu, M.-T.1    Liou, Y.-B.2    Kao, Y.-H.3
  • 160
    • 33645294093 scopus 로고    scopus 로고
    • Enhanced bioavailability of tamoxifen after oral administration of tamoxifen with quercetin in rats
    • COI: 1:CAS:528:DC%2BD28XjtVGqtb8%3D, PID: 16516418
    • Shin S-C, Choi J-S, Li X (2006) Enhanced bioavailability of tamoxifen after oral administration of tamoxifen with quercetin in rats. Int J Pharm 313:144–149
    • (2006) Int J Pharm , vol.313 , pp. 144-149
    • Shin, S.-C.1    Choi, J.-S.2    Li, X.3
  • 161
    • 45949106460 scopus 로고    scopus 로고
    • Effects of morin on the bioavailability of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in rats
    • COI: 1:CAS:528:DC%2BD1cXotlCksrw%3D
    • Shin S-C, Piao Y-J, Choi J-S (2008) Effects of morin on the bioavailability of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in rats. In Vivo (Brooklyn) 22:391–395
    • (2008) In Vivo (Brooklyn) , vol.22 , pp. 391-395
    • Shin, S.-C.1    Piao, Y.-J.2    Choi, J.-S.3
  • 162
    • 75749098538 scopus 로고    scopus 로고
    • Effects of baicalein, an antioxidant, on the bioavailability of doxorubicin in rats: possible role of P-glycoprotein inhibition by baicalein
    • COI: 1:CAS:528:DC%2BD1MXht12rsb3L, PID: 19827298
    • Shin SC, Li C, Choi JS (2009) Effects of baicalein, an antioxidant, on the bioavailability of doxorubicin in rats: possible role of P-glycoprotein inhibition by baicalein. Pharmazie 64:579–583
    • (2009) Pharmazie , vol.64 , pp. 579-583
    • Shin, S.C.1    Li, C.2    Choi, J.S.3
  • 164
    • 84856252862 scopus 로고    scopus 로고
    • Reduced bioavailability of tamoxifen and its metabolite 4-hydroxytamoxifen after oral administration with biochanin A (an isoflavone) in rats
    • COI: 1:CAS:528:DC%2BC38XhtFWnt74%3D, PID: 22131128
    • Singh SP, Wahajuddin Raju KSR et al (2012) Reduced bioavailability of tamoxifen and its metabolite 4-hydroxytamoxifen after oral administration with biochanin A (an isoflavone) in rats. Phytother Res 26:303–307
    • (2012) Phytother Res , vol.26 , pp. 303-307
    • Singh, S.P.1    Wahajuddin Raju, K.S.R.2
  • 165
    • 38349008651 scopus 로고    scopus 로고
    • The interactions of flavonoids within neuronal signalling pathways
    • COI: 1:CAS:528:DC%2BD1MXhtF2is7zI, PID: 18850181
    • Spencer JPE (2007) The interactions of flavonoids within neuronal signalling pathways. Genes Nutr 2:257–273
    • (2007) Genes Nutr , vol.2 , pp. 257-273
    • Spencer, J.P.E.1
  • 166
    • 0037204543 scopus 로고    scopus 로고
    • Progress in understanding the structure-activity relationships of P-glycoprotein
    • Stouch TR, Gudmundsson O (2002) Progress in understanding the structure-activity relationships of P-glycoprotein. Adv Drug Deliv Rev 54:315–328
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 315-328
    • Stouch, T.R.1    Gudmundsson, O.2
  • 167
    • 78650747680 scopus 로고    scopus 로고
    • Quantitative investigation of the impact of P-glycoprotein inhibition on drug transport across blood–brain barrier in rats
    • COI: 1:CAS:528:DC%2BC3MXls1enuw%3D%3D, PID: 20962062
    • Sugimoto H, Hirabayashi H, Kimura Y et al (2011) Quantitative investigation of the impact of P-glycoprotein inhibition on drug transport across blood–brain barrier in rats. Drug Metab Dispos 39:8–14
    • (2011) Drug Metab Dispos , vol.39 , pp. 8-14
    • Sugimoto, H.1    Hirabayashi, H.2    Kimura, Y.3
  • 168
    • 0037457803 scopus 로고    scopus 로고
    • Drug efflux transporters in the CNS
    • COI: 1:CAS:528:DC%2BD3sXivVWntA%3D%3D, PID: 12535575
    • Sun H, Dai H, Shaik N, Elmquist WF (2003) Drug efflux transporters in the CNS. Adv Drug Deliv Rev 55:83–105
    • (2003) Adv Drug Deliv Rev , vol.55 , pp. 83-105
    • Sun, H.1    Dai, H.2    Shaik, N.3    Elmquist, W.F.4
  • 169
    • 0842284169 scopus 로고    scopus 로고
    • Multidrug resistance P-glycoprotein: crucial significance in drug disposition and interaction
    • Sun J, He Z-G, Cheng G et al (2004) Multidrug resistance P-glycoprotein: crucial significance in drug disposition and interaction. Med Sci Monit 10:5–14
    • (2004) Med Sci Monit , vol.10 , pp. 5-14
    • Sun, J.1    He, Z.-G.2    Cheng, G.3
  • 170
    • 0031790854 scopus 로고    scopus 로고
    • Inhibition of vinblastine efflux mediated by P-glycoprotein by grapefruit juice components in caco-2 cells
    • Takanaga H, Ohnishi A, Matsuo H, Sawada Y (1998) Inhibition of vinblastine efflux mediated by P-glycoprotein by grapefruit juice components in caco-2 cells. Biol Pharm Bull 21:1062–1066
    • (1998) Biol Pharm Bull , vol.21 , pp. 1062-1066
    • Takanaga, H.1    Ohnishi, A.2    Matsuo, H.3    Sawada, Y.4
  • 171
    • 0034029597 scopus 로고    scopus 로고
    • Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cythocrome P450 3A4
    • Takanaga H, Ohnishi A, Yamada S et al (2000) Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cythocrome P450 3A4. J Pharmacol Exp Ther 293:230–236
    • (2000) J Pharmacol Exp Ther , vol.293 , pp. 230-236
    • Takanaga, H.1    Ohnishi, A.2    Yamada, S.3
  • 172
    • 33344464490 scopus 로고    scopus 로고
    • P-glycoprotein : pharmacological relevance relevance
    • COI: 1:CAS:528:DC%2BD28XivVKksLY%3D
    • Tandon VR, Kapoor B, Bano G et al (2006) P-glycoprotein: pharmacological relevance relevance. Indian J Pharmacol 38:13–24
    • (2006) Indian J Pharmacol , vol.38 , pp. 13-24
    • Tandon, V.R.1    Kapoor, B.2    Bano, G.3
  • 174
    • 84883430076 scopus 로고    scopus 로고
    • Flavonoid bioavailability and attempts for bioavailability enhancement
    • PID: 23989753
    • Thilakarathna SH, Rupasinghe HPV (2013) Flavonoid bioavailability and attempts for bioavailability enhancement. Nutrients 5:3367–3387
    • (2013) Nutrients , vol.5 , pp. 3367-3387
    • Thilakarathna, S.H.1    Rupasinghe, H.P.V.2
  • 175
    • 0037358040 scopus 로고    scopus 로고
    • Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting p-glycoprotein
    • Thomas H, Coley HM (2013) Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting p-glycoprotein. Cancer Control 10:159–165
    • (2013) Cancer Control , vol.10 , pp. 159-165
    • Thomas, H.1    Coley, H.M.2
  • 176
    • 84890535643 scopus 로고    scopus 로고
    • Flavonoids from fruit and vegetables: a focus on cardiovascular risk factors
    • COI: 1:STN:280:DC%2BC2c%2FlvFCktg%3D%3D, PID: 24091782
    • Toh JY, Tan VMH, Lim PCY et al (2013) Flavonoids from fruit and vegetables: a focus on cardiovascular risk factors. Curr Atheroscler Rep 15:368
    • (2013) Curr Atheroscler Rep , vol.15 , pp. 368
    • Toh, J.Y.1    Tan, V.M.H.2    Lim, P.C.Y.3
  • 177
    • 39649089139 scopus 로고    scopus 로고
    • 7-O-Methylated anthocyanidin glycosides from Catharanthus roseus
    • COI: 1:CAS:528:DC%2BD1cXitlKju7o%3D, PID: 18164044
    • Toki K, Saito N, Irie Y et al (2008) 7-O-Methylated anthocyanidin glycosides from Catharanthus roseus. Phytochemistry 69:1215–1219
    • (2008) Phytochemistry , vol.69 , pp. 1215-1219
    • Toki, K.1    Saito, N.2    Irie, Y.3
  • 178
    • 79957551963 scopus 로고    scopus 로고
    • Modulation of P-glycoprotein-mediated anticancer drug accumulation, cytotoxicity, and ATPase activity by flavonoid interactions
    • COI: 1:CAS:528:DC%2BC3MXksFKksrY%3D, PID: 21462089
    • Tran VH, Marks D, Duke RK et al (2011) Modulation of P-glycoprotein-mediated anticancer drug accumulation, cytotoxicity, and ATPase activity by flavonoid interactions. Nutr Cancer 63:435–443
    • (2011) Nutr Cancer , vol.63 , pp. 435-443
    • Tran, V.H.1    Marks, D.2    Duke, R.K.3
  • 179
    • 0242383477 scopus 로고    scopus 로고
    • Multiple flavonoid-binding sites within multidrug resistance protein MRP1
    • COI: 1:CAS:528:DC%2BD3sXptVGgtLY%3D, PID: 14618263
    • Trompier D, Baubichon-Cortay H, Chang X-B et al (2003) Multiple flavonoid-binding sites within multidrug resistance protein MRP1. Cell Mol Life Sci 60:2164–2177
    • (2003) Cell Mol Life Sci , vol.60 , pp. 2164-2177
    • Trompier, D.1    Baubichon-Cortay, H.2    Chang, X.-B.3
  • 180
    • 84888347424 scopus 로고    scopus 로고
    • Structure-activity analysis of flavonoids: direct and indirect antioxidant, and antiinflammatory potencies and toxicities
    • COI: 1:CAS:528:DC%2BC3sXhsFyrsLfN, PID: 24087992
    • Tsuji PA, Stephenson KK, Wade KL et al (2013) Structure-activity analysis of flavonoids: direct and indirect antioxidant, and antiinflammatory potencies and toxicities. Nutr Cancer 65:1014–1025
    • (2013) Nutr Cancer , vol.65 , pp. 1014-1025
    • Tsuji, P.A.1    Stephenson, K.K.2    Wade, K.L.3
  • 181
    • 84939890570 scopus 로고    scopus 로고
    • Virtual screening of flavonoids as inhibitory agents of p-glycoprotein
    • Udaya Kumar N, Sailendra M, Peddanna K et al (2011) Virtual screening of flavonoids as inhibitory agents of p-glycoprotein. IJABPT 2:130–140
    • (2011) IJABPT , vol.2 , pp. 130-140
    • Udaya Kumar, N.1    Sailendra, M.2    Peddanna, K.3
  • 182
    • 0033897693 scopus 로고    scopus 로고
    • P-glycoprotein and multidrug resistance protein activities in relation to treatment outcome in acute myeloid leukemia
    • PID: 10955805
    • Van der Kolk DM, de Vries EG, van Putten WJ et al (2000) P-glycoprotein and multidrug resistance protein activities in relation to treatment outcome in acute myeloid leukemia. Clin Cancer Res 6:3205–3214
    • (2000) Clin Cancer Res , vol.6 , pp. 3205-3214
    • Van der Kolk, D.M.1    de Vries, E.G.2    van Putten, W.J.3
  • 183
    • 0042167430 scopus 로고    scopus 로고
    • P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement
    • COI: 1:CAS:528:DC%2BD3sXlvFOktbc%3D, PID: 12902205
    • Varma M (2003) P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement. Pharmacol Res 48:347–359
    • (2003) Pharmacol Res , vol.48 , pp. 347-359
    • Varma, M.1
  • 184
    • 70450223158 scopus 로고    scopus 로고
    • The neuroprotective potential of flavonoids: a multiplicity of effects
    • COI: 1:CAS:528:DC%2BD1MXhtF2isLvM, PID: 18937002
    • Vauzour D, Vafeiadou K, Rodriguez-Mateos A et al (2008) The neuroprotective potential of flavonoids: a multiplicity of effects. Genes Nutr 3:115–126
    • (2008) Genes Nutr , vol.3 , pp. 115-126
    • Vauzour, D.1    Vafeiadou, K.2    Rodriguez-Mateos, A.3
  • 185
    • 0346729785 scopus 로고    scopus 로고
    • Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures
    • COI: 1:CAS:528:DC%2BD2cXosFWn, PID: 14706787
    • Volk H, Burkhardt K, Potschka H et al (2004) Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures. Neuroscience 123:751–759
    • (2004) Neuroscience , vol.123 , pp. 751-759
    • Volk, H.1    Burkhardt, K.2    Potschka, H.3
  • 186
    • 0014452710 scopus 로고
    • Synthesis of poncirin, an isosakuranetin-7-beta-neohesperidoside from Poncirus trifoliata Raf
    • COI: 1:CAS:528:DyaF1MXpslWhsQ%3D%3D, PID: 5802852
    • Wagner H, Aurnhammer G, Hörhammer L et al (1969) Synthesis of poncirin, an isosakuranetin-7-beta-neohesperidoside from Poncirus trifoliata Raf. Chem Ber 102:785–791
    • (1969) Chem Ber , vol.102 , pp. 785-791
    • Wagner, H.1    Aurnhammer, G.2    Hörhammer, L.3
  • 187
    • 0034954793 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein transport function by grapefruit juice psoralen
    • Wang EJ, Casciano CN, Clement RP, Johnson WW (2001) Inhibition of P-glycoprotein transport function by grapefruit juice psoralen. Pharm Res 18:432–438
    • (2001) Pharm Res , vol.18 , pp. 432-438
    • Wang, E.J.1    Casciano, C.N.2    Clement, R.P.3    Johnson, W.W.4
  • 188
    • 0036399061 scopus 로고    scopus 로고
    • Elevation of P-glycoprotein function by a catechin in green tea
    • COI: 1:CAS:528:DC%2BD38XmvFaitb4%3D, PID: 12237135
    • Wang E, Barecki-Roach M, Johnson WW (2002) Elevation of P-glycoprotein function by a catechin in green tea. Biochem Biophys Res Commun 297:412–418
    • (2002) Biochem Biophys Res Commun , vol.297 , pp. 412-418
    • Wang, E.1    Barecki-Roach, M.2    Johnson, W.W.3
  • 189
    • 0347510572 scopus 로고    scopus 로고
    • Lethal quercetin-digoxin interaction in pigs
    • Wang Y-H, Chao P-DL, Hsiu S-L et al (2004) Lethal quercetin-digoxin interaction in pigs. Life Sci 74:1191–1197
    • (2004) Life Sci , vol.74 , pp. 1191-1197
    • Wang, Y.-H.1    Chao, P.-D.L.2    Hsiu, S.-L.3
  • 190
    • 22144463182 scopus 로고    scopus 로고
    • An in silico approach for screening flavonoids as P-glycoprotein inhibitors based on a Bayesian-regularized neural network
    • COI: 1:CAS:528:DC%2BD2MXls1Smsrc%3D, PID: 16059668
    • Wang Y-H, Li Y, Yang S-L, Yang L (2005) An in silico approach for screening flavonoids as P-glycoprotein inhibitors based on a Bayesian-regularized neural network. J Comput Aided Mol Des 19:137–147
    • (2005) J Comput Aided Mol Des , vol.19 , pp. 137-147
    • Wang, Y.-H.1    Li, Y.2    Yang, S.-L.3    Yang, L.4
  • 191
    • 77956078568 scopus 로고    scopus 로고
    • Potential toxicities of flavonoids
    • COI: 1:CAS:528:DC%2BD1cXjsVGh, PID: 18095581
    • Wang H, Zhao X, Wang Y, Yin S (2007) Potential toxicities of flavonoids. Wei Sheng Yan Jiu 36:640–642
    • (2007) Wei Sheng Yan Jiu , vol.36 , pp. 640-642
    • Wang, H.1    Zhao, X.2    Wang, Y.3    Yin, S.4
  • 192
    • 84865988756 scopus 로고    scopus 로고
    • Flavonoids as GABA A receptor ligands: the whole story?
    • COI: 1:CAS:528:DC%2BC38XktlSltrw%3D
    • Wasowski C, Marder M (2012) Flavonoids as GABA A receptor ligands: the whole story? J Exp Pharmacol 4:9–24
    • (2012) J Exp Pharmacol , vol.4 , pp. 9-24
    • Wasowski, C.1    Marder, M.2
  • 193
    • 84860498446 scopus 로고    scopus 로고
    • Interaction of phenothiazines, stilbenes and flavonoids with multidrug resistance-associated transporters, P-glycoprotein and MRP1
    • PID: 22187677
    • Wesołowska O (2011) Interaction of phenothiazines, stilbenes and flavonoids with multidrug resistance-associated transporters, P-glycoprotein and MRP1. Acta Biochim Pol 58:433–448
    • (2011) Acta Biochim Pol , vol.58 , pp. 433-448
    • Wesołowska, O.1
  • 194
    • 63449112695 scopus 로고    scopus 로고
    • Perturbation of the lipid phase of a membrane is not involved in the modulation of MRP1 transport activity by flavonoids
    • PID: 19020811
    • Wesołowska O, Hendrich AB, Łaniapietrzak B et al (2009) Perturbation of the lipid phase of a membrane is not involved in the modulation of MRP1 transport activity by flavonoids. Cell Mol Biol Lett 14:199–221
    • (2009) Cell Mol Biol Lett , vol.14 , pp. 199-221
    • Wesołowska, O.1    Hendrich, A.B.2    Łaniapietrzak, B.3
  • 195
    • 77952312245 scopus 로고    scopus 로고
    • Recent advances in the research of P-glycoprotein inhibitors
    • PID: 20103919
    • Yang K, Wu J, Li X (2008) Recent advances in the research of P-glycoprotein inhibitors. Biosci Trends 2:137–146
    • (2008) Biosci Trends , vol.2 , pp. 137-146
    • Yang, K.1    Wu, J.2    Li, X.3
  • 196
    • 82055176071 scopus 로고    scopus 로고
    • Effects of morin on the pharmacokinetics of docetaxel in rats with 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors
    • Yang SH, Lee JH, Lee DY et al (2011) Effects of morin on the pharmacokinetics of docetaxel in rats with 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors. Arch Pharm Res 34:1729–1734
    • (2011) Arch Pharm Res , vol.34 , pp. 1729-1734
    • Yang, S.H.1    Lee, J.H.2    Lee, D.Y.3
  • 197
    • 84876117475 scopus 로고    scopus 로고
    • Identification of the major metabolites of hyperoside produced by the human intestinal bacteria using ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry
    • COI: 1:CAS:528:DC%2BC3sXktlKmurc%3D, PID: 23458919
    • Yang J, Qian D, Guo J et al (2013) Identification of the major metabolites of hyperoside produced by the human intestinal bacteria using ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry. J Ethnopharmacol 147:174–179
    • (2013) J Ethnopharmacol , vol.147 , pp. 174-179
    • Yang, J.1    Qian, D.2    Guo, J.3
  • 198
    • 33144490279 scopus 로고    scopus 로고
    • Effect of naringin pretreatment on bioavailability of verapamil in rabbits
    • COI: 1:CAS:528:DC%2BD28XitVOmt7k%3D, PID: 16491851
    • Yeum C-H, Choi J-S (2006) Effect of naringin pretreatment on bioavailability of verapamil in rabbits. Arch Pharm Res 29:102–107
    • (2006) Arch Pharm Res , vol.29 , pp. 102-107
    • Yeum, C.-H.1    Choi, J.-S.2
  • 199
    • 34848835701 scopus 로고    scopus 로고
    • Effects of diosmin, a flavonoid glycoside in citrus fruits, on P-glycoprotein-mediated drug efflux in human intestinal Caco-2 cells
    • COI: 1:CAS:528:DC%2BD2sXos1Slu78%3D, PID: 17676865
    • Yoo HH, Lee M, Chung HJ et al (2007) Effects of diosmin, a flavonoid glycoside in citrus fruits, on P-glycoprotein-mediated drug efflux in human intestinal Caco-2 cells. J Agric Food Chem 55:7620–7625
    • (2007) J Agric Food Chem , vol.55 , pp. 7620-7625
    • Yoo, H.H.1    Lee, M.2    Chung, H.J.3
  • 200
    • 0037371275 scopus 로고    scopus 로고
    • Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-Glycoprotein-mediated transport
    • COI: 1:CAS:528:DC%2BD3sXit1eisL0%3D, PID: 12604704
    • Zhang S, Morris ME (2003a) Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-Glycoprotein-mediated transport. J Pharmacol Exp Ther 304:1258–1267
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 1258-1267
    • Zhang, S.1    Morris, M.E.2
  • 201
    • 0043127383 scopus 로고    scopus 로고
    • Effect of the flavonoids biochanin A and silymarin on the P-glycoprotein-mediated transport of digoxin and vinblastine in human intestinal Caco-2 cells
    • COI: 1:CAS:528:DC%2BD3sXmtVGrtLg%3D, PID: 12948016
    • Zhang S, Morris ME (2003b) Effect of the flavonoids biochanin A and silymarin on the P-glycoprotein-mediated transport of digoxin and vinblastine in human intestinal Caco-2 cells. Pharm Res 20:1184–1191
    • (2003) Pharm Res , vol.20 , pp. 1184-1191
    • Zhang, S.1    Morris, M.E.2
  • 202
    • 33644692006 scopus 로고    scopus 로고
    • Scientific perspectives on drug transporters and their role in drug interactions
    • COI: 1:CAS:528:DC%2BD28XlvFSj, PID: 16686370
    • Zhang L, Strong JM, Qiu W et al (2006) Scientific perspectives on drug transporters and their role in drug interactions. Mol Pharm 3:62–69
    • (2006) Mol Pharm , vol.3 , pp. 62-69
    • Zhang, L.1    Strong, J.M.2    Qiu, W.3
  • 203
    • 79952251057 scopus 로고    scopus 로고
    • Determination of paeoniflorin, calycosin-7-O-β-D-glucoside, ononin, calycosin and formononetin in rat plasma after oral administration of Buyang Huanwu decoction for their pharmacokinetic study by liquid chromatography-mass spectrometry
    • COI: 1:CAS:528:DC%2BC3MXislOqt7w%3D, PID: 20734345
    • Zhang J, Yang G, Lin R, Hu Z (2011) Determination of paeoniflorin, calycosin-7-O-β-D-glucoside, ononin, calycosin and formononetin in rat plasma after oral administration of Buyang Huanwu decoction for their pharmacokinetic study by liquid chromatography-mass spectrometry. Biomed Chromatogr 25:450–457
    • (2011) Biomed Chromatogr , vol.25 , pp. 450-457
    • Zhang, J.1    Yang, G.2    Lin, R.3    Hu, Z.4
  • 204
    • 84860706745 scopus 로고    scopus 로고
    • The transport of antiepileptic drugs by P-glycoprotein
    • COI: 1:CAS:528:DC%2BC38XptlWqsLk%3D, PID: 22197850
    • Zhang C, Kwan P, Zuo Z, Baum L (2012) The transport of antiepileptic drugs by P-glycoprotein. Adv Drug Deliv Rev 64:930–942
    • (2012) Adv Drug Deliv Rev , vol.64 , pp. 930-942
    • Zhang, C.1    Kwan, P.2    Zuo, Z.3    Baum, L.4
  • 205
    • 70449688304 scopus 로고    scopus 로고
    • An acetyl flavonol from Nervilia fordii (Hance) Schltr
    • PID: 20183281
    • Zhou G-X, Lu C-L, Wang H-S, Yao X-S (2009) An acetyl flavonol from Nervilia fordii (Hance) Schltr. J Asian Nat Prod Res 11:498–502
    • (2009) J Asian Nat Prod Res , vol.11 , pp. 498-502
    • Zhou, G.-X.1    Lu, C.-L.2    Wang, H.-S.3    Yao, X.-S.4
  • 206
    • 84876331167 scopus 로고    scopus 로고
    • Oroxylin A reverses P-glycoprotein-mediated multidrug resistance of MCF7/ADR cells by G2/M arrest
    • Zhu L, Zhao L, Wang H et al (2013) Oroxylin A reverses P-glycoprotein-mediated multidrug resistance of MCF7/ADR cells by G2/M arrest. Toxicol Lett 219:107–115
    • (2013) Toxicol Lett , vol.219 , pp. 107-115
    • Zhu, L.1    Zhao, L.2    Wang, H.3
  • 207
    • 84862705631 scopus 로고    scopus 로고
    • Comparative evaluation of the teratogenicity of genistein and genistin using rat whole embryo culture and limbud micromass culture methods
    • COI: 1:CAS:528:DC%2BC38XhtVyjs7fK, PID: 22617716
    • Zou P, Xing L, Tang Q et al (2012) Comparative evaluation of the teratogenicity of genistein and genistin using rat whole embryo culture and limbud micromass culture methods. Food Chem Toxicol 50:2831–2836
    • (2012) Food Chem Toxicol , vol.50 , pp. 2831-2836
    • Zou, P.1    Xing, L.2    Tang, Q.3


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