Effects of the isoflavonoid biochanin A on the transport of mitoxantrone in Vitro and in Vivo

Biopharmaceutics and Drug Disposition

Volumn 31, Issue 5-6, 2010, Pages 340-350

  An, Guohua ^a   Morris, Marilyn E ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Biochanin A; Breast cancer resistance protein; Mitoxantrone transport; Pharmacokinetics

Indexed keywords

BIOCHANIN A; BREAST CANCER RESISTANCE PROTEIN; GLYCOPROTEIN P; ISOFLAVONOID; MITOXANTRONE; ANTINEOPLASTIC AGENT; DRUG COMBINATION; FLAVONOID; GENISTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; BREAST CANCER; CANCER RESISTANCE; CELL STRAIN; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG EFFECT; DRUG METABOLISM; DRUG TRANSPORT; HEART; HUMAN; IN VITRO STUDY; IN VIVO STUDY; KIDNEY; LIVER; LUNG; MALE; MOUSE; NONHUMAN; SPECIES DIFFERENCE; SPLEEN; TISSUE DISTRIBUTION; ANIMAL; DOSE RESPONSE; DRUG COMBINATION; DRUG EFFECTS; DRUG INTERACTION; DRUG RESISTANCE; TRANSFORMED CELL LINE; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; DRUG INTERACTIONS; DRUG RESISTANCE, NEOPLASM; FLAVONOIDS; GENISTEIN; HUMANS; MALE; MICE; MITOXANTRONE; TISSUE DISTRIBUTION;

EID: 77955671379     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.717     Document Type: Article

References (27)

1. Middleton Jr E, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000; 52: 673-751.
2. Moon YJ, Sagawa K, Frederick K, Zhang S, Morris ME. Pharmacokinetics and bioavailability of the isoflavone biochanin A in rats. AAPS J 2006; 8: E433-E442.
3. Setchell KD, Brown NM, Desai P, et al. Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. J Nutr 2001; 131: 1362S-1375S.
4. Zhang S, Yang X, Morris ME. Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport. Mol Pharmacol 2004; 65: 1208-1216. (Pubitemid 38543491)
5. Zhang S, Yang X, Coburn RA, Morris ME. Structure activity relationships and quantitative structure activity relationships for the flavonoid-mediated inhibition of breast cancer resistance protein. Biochem Pharmacol 2005; 70: 627-639.
6. Yang CH, Schneider E, Kuo ML, Volk EL, Rocchi E, Chen YC. BCRP/MXR/ABCP expression in topotecan-resistant human breast carcinoma cells. Biochem Pharmacol 2000; 60: 831-837.
7. Tanaka Y, Slitt AL, Leazer TM, Maher JM, Klaassen CD. Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice. Biochem Biophys Res Commun 2005; 326: 181-187.
8. Maliepaard M, Scheffer GL, Faneyte IF, et al. Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues. Cancer Res 2001; 61: 3458-3464.
9. Jonker JW, Smit JW, Brinkhuis RF, et al. Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan. J Natl Cancer Inst 2000; 92: 1651-1656.
10. Wang X, Morris ME. Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2. Drug Metab Dispos 2007; 35: 268-274.
11. Merino G, Alvarez AI, Pulido MM, Molina AJ, Schinkel AH, Prieto JG. Breast cancer resistance protein (BCRP/ABCG2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics, and milk secretion. Drug Metab Dispos 2006; 34: 690-695.
12. Hirano M, Maeda K, Matsushima S, Nozaki Y, Kusuhara H, Sugiyama Y. Involvement of BCRP (ABCG2) in the biliary excretion of pitavastatin. Mol Pharmacol 2005; 68: 800-807.
13. Zhang S, Yang X, Morris ME. Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport. Pharm Res 2004; 21: 1263-1273. (Pubitemid 38954213)
14. Merino G, Jonker JW, Wagenaar E, et al. Transport of anthelmintic benzimidazole drugs by breast cancer resistance protein (BCRP/ABCG2). Drug Metab Dispos 2005; 33: 614-618. (Pubitemid 40593873)
15. An G, Morris ME. HPLC analysis of mitoxantrone in mouse plasma and tissues: Application in a pharmacokinetic study. J Pharm Biomed Anal 2010; 51: 750-753.
16. Zhang S, Morris ME. Effect of the flavonoids biochanin A and silymarin on the P-glycoprotein-mediated transport of digoxin and vinblastine in human intestinal Caco-2 cells. Pharm Res 2003; 20: 1184-1191.
17. Zhang S, Morris ME. Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport. J Pharmacol Exp Ther 2003; 304: 1258-1267.
18. Peng SX, Ritchie DM, Cousineau M, Danser E, Dewire R, Floden J. Altered oral bioavailability and pharmacokinetics of P-glycoprotein substrates by coadministration of biochanin A. J Pharm Sci 2006; 95: 1984-1993.
19. Zhang S, Sagawa K, Arnold A, Tseng E, Wang X, Morris M. Interactions between the flavonoid biochanin A and P-glycoprotein substrates in rats: in vitro and in vivo. J Pharm Sci 2010; 99: 430-441.
20. Ehninger G, Schuler U, Proksch B, Zeller KP, Blanz J. Pharmacokinetics and metabolism of mitoxantrone. A review. Clin Pharmacokinet 1990; 18: 365-380.
21. Batra VK, Morrison JA, Woodward DL, Siverd NS, Yacobi A. Pharmacokinetics of mitoxantrone in man and laboratory animals. Drug Metab Rev 1986; 17: 311-329.
22. Jodoin J, Demeule M, Beliveau R. Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols. Biochim Biophys Acta 2002; 1542: 149-159.
23. Yoo HH, Lee M, Chung HJ, Lee SK, Kim DH. Effects of diosmin, a flavonoid glycoside in citrus fruits, on P-glycoprotein-mediated drug efflux in human intestinal Caco-2 cells. J Agric Food Chem 2007; 55: 7620-7625. (Pubitemid 47492324)
24. Chieli E, Romiti N, Cervelli F, Tongiani R. Effects of flavonols on P-glycoprotein activity in cultured rat hepatocytes. Life Sci 1995; 57: 1741-1751.
25. Phang JM, Poore CM, Lopaczynska J, Yeh GC. Flavonol-stimulated efflux of 7, 12-dimethylbenz(a)anthracene in multidrug-resistant breast cancer cells. Cancer Res 1993; 53: 5977-5981.
26. Mitsunaga Y, Takanaga H, Matsuo H, et al. Effect of bioflavonoids on vincristine transport across blood-brain barrier. Eur J Pharmacol 2000; 395: 193-201.
27. Wang X, Wolkoff AW, Morris ME. Flavonoids as a novel class of human organic anion-transporting polypeptide OATP1B1 (OATP-C) modulators. Drug Metab Dispos 2005; 33: 1666-1672.