-
1
-
-
0033756459
-
Transporter-mediated permeation of drugs across the blood-brain barrier
-
Tamai I, Tsuji A. Transporter-mediated permeation of drugs across the blood-brain barrier. J Pharm Sci. 2000;89:1371-1388.
-
(2000)
J Pharm Sci
, vol.89
, pp. 1371-1388
-
-
Tamai, I.1
Tsuji, A.2
-
2
-
-
0032513049
-
Dehydroepiandrosterone sulfate (DHEAS): Identification of a carrier protein in human liver and brain
-
Kullak-Ublick GA, Fisch T, Oswald M, et al. Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain. FEBS Lett. 1998;424:173-176.
-
(1998)
FEBS Lett
, vol.424
, pp. 173-176
-
-
Kullak-Ublick, G.A.1
Fisch, T.2
Oswald, M.3
-
3
-
-
0035253135
-
Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 1)
-
Kusuhara H, Sugiyama Y. Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 1). Drug Discov Today. 2001;6:150-156.
-
(2001)
Drug Discov Today
, vol.6
, pp. 150-156
-
-
Kusuhara, H.1
Sugiyama, Y.2
-
4
-
-
0035254189
-
Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 2)
-
Kusuhara H, Sugiyama Y. Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 2). Drug Discov Today. 2001;6:206-212.
-
(2001)
Drug Discov Today
, vol.6
, pp. 206-212
-
-
Kusuhara, H.1
Sugiyama, Y.2
-
5
-
-
27844565841
-
Control of the CFTR channel's gates
-
Vergani P, Basso C, Mense M, Nairn AC, Gadsby DC. Control of the CFTR channel's gates. Biochem Soc Trans. 2005;33(Pt 5):1003-1007.
-
(2005)
Biochem Soc Trans
, vol.33
, Issue.PART 5
, pp. 1003-1007
-
-
Vergani, P.1
Basso, C.2
Mense, M.3
Nairn, A.C.4
Gadsby, D.C.5
-
6
-
-
33750589259
-
Intracellular peptide transporters in human - Compartmentalization of the "peptidome"
-
May 18 [Epub ahead of print]
-
Herget M, Tampe R. Intracellular peptide transporters in human - compartmentalization of the "peptidome." Pflugers Arch. 2006;May 18 [Epub ahead of print].
-
(2006)
Pflugers Arch
-
-
Herget, M.1
Tampe, R.2
-
7
-
-
10744220281
-
Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy
-
Pauli-Magnus C, Lang T, Meier Y, et al. Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy. Pharmacogenetics. 2004;14:91-102.
-
(2004)
Pharmacogenetics
, vol.14
, pp. 91-102
-
-
Pauli-Magnus, C.1
Lang, T.2
Meier, Y.3
-
8
-
-
33745952809
-
Mutation spectra of ABCC8 gene in Spanish patients with hyperinsulinism of infancy (HI)
-
Fernandez-Marmiesse A, Salas A, Vega A, Fernandez-Lorenzo JR, Barreiro J, Carracedo A. Mutation spectra of ABCC8 gene in Spanish patients with hyperinsulinism of infancy (HI). Hum Mutat. 2006;27:214.
-
(2006)
Hum Mutat
, vol.27
, pp. 214
-
-
Fernandez-Marmiesse, A.1
Salas, A.2
Vega, A.3
Fernandez-Lorenzo, J.R.4
Barreiro, J.5
Carracedo, A.6
-
9
-
-
30944442799
-
A novel cell model to study the function of the adrenoleukodystrophy- related protein
-
Gueugnon F, Volodina N, Taouil JE, et al. A novel cell model to study the function of the adrenoleukodystrophy-related protein. Biochem Biophys Res Commun. 2006;341:150-157.
-
(2006)
Biochem Biophys Res Commun
, vol.341
, pp. 150-157
-
-
Gueugnon, F.1
Volodina, N.2
Taouil, J.E.3
-
10
-
-
0034329310
-
Human ABC7 transporter: Gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation
-
Bekri S, Kispal G, Lange H, et al. Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation. Blood. 2000;96:3256-3264.
-
(2000)
Blood
, vol.96
, pp. 3256-3264
-
-
Bekri, S.1
Kispal, G.2
Lange, H.3
-
11
-
-
33646711005
-
De novo deletion removes a conserved motif in the C-terminus of ABCA4 and results in cone-rod dystrophy
-
Stenirri S, Battistella S, Fermo I, et al. De novo deletion removes a conserved motif in the C-terminus of ABCA4 and results in cone-rod dystrophy. Clin Chem Lab Med. 2006;44:533-537.
-
(2006)
Clin Chem Lab Med
, vol.44
, pp. 533-537
-
-
Stenirri, S.1
Battistella, S.2
Fermo, I.3
-
12
-
-
33646092544
-
Progressive cone and cone-rod dystrophies: Phenotypes and underlying molecular genetic basis
-
Michaelides M, Hardcastle AJ, Hunt DM, Moore AT. Progressive cone and cone-rod dystrophies: phenotypes and underlying molecular genetic basis. Surv Ophthalmol. 2006;51:232-528.
-
(2006)
Surv Ophthalmol
, vol.51
, pp. 232-528
-
-
Michaelides, M.1
Hardcastle, A.J.2
Hunt, D.M.3
Moore, A.T.4
-
13
-
-
27644489474
-
P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model
-
Cirrito JR, Deane R, Fagan AM, et al. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J Clin Invest. 2005;115:3285-3290.
-
(2005)
J Clin Invest
, vol.115
, pp. 3285-3290
-
-
Cirrito, J.R.1
Deane, R.2
Fagan, A.M.3
-
14
-
-
2942750350
-
ATP-binding cassette (ABC) transporters in human metabolism and diseases
-
Sefkova J, Poledne R, Hubacek JA. ATP-binding cassette (ABC) transporters in human metabolism and diseases. Physiol Res. 2004;53:235-243.
-
(2004)
Physiol Res
, vol.53
, pp. 235-243
-
-
Sefkova, J.1
Poledne, R.2
Hubacek, J.A.3
-
15
-
-
24144459853
-
Polarized distribution of nucleoside transporters in rat brain endothelial and choroid plexus epithelial cells
-
Redzic ZB, Biringer J, Barnes K, et al. Polarized distribution of nucleoside transporters in rat brain endothelial and choroid plexus epithelial cells. J Neurochem. 2005;94:1420-1426.
-
(2005)
J Neurochem
, vol.94
, pp. 1420-1426
-
-
Redzic, Z.B.1
Biringer, J.2
Barnes, K.3
-
16
-
-
16244396148
-
Functional characterization and comparison of the outer blood-retina barrier and the blood-brain barrier
-
Steuer H, Jaworski A, Elger B, et al. Functional characterization and comparison of the outer blood-retina barrier and the blood-brain barrier. Invest Ophthalmol Vis Sci. 2005;46:1047-1053.
-
(2005)
Invest Ophthalmol Vis Sci
, vol.46
, pp. 1047-1053
-
-
Steuer, H.1
Jaworski, A.2
Elger, B.3
-
17
-
-
0036760638
-
The complementary membranes forming the blood-brain barrier
-
Hawkins RA, Peterson DR, Vina JR. The complementary membranes forming the blood-brain barrier. IUBMB Life. 2002;54:101-107.
-
(2002)
IUBMB Life
, vol.54
, pp. 101-107
-
-
Hawkins, R.A.1
Peterson, D.R.2
Vina, J.R.3
-
18
-
-
0034104737
-
Circumventricular organs: Definition and role in the regulation of endocrine and autonomic function
-
Ganong WF. Circumventricular organs: definition and role in the regulation of endocrine and autonomic function. Clin Exp Pharmacol Physiol. 2000;27:422-427.
-
(2000)
Clin Exp Pharmacol Physiol
, vol.27
, pp. 422-427
-
-
Ganong, W.F.1
-
19
-
-
4644371691
-
Detoxification systems, passive and specific transport for drugs at the blood-CSF barrier in normal and pathological situations
-
Strazielle N, Khuth ST, Ghersi-Egea JF. Detoxification systems, passive and specific transport for drugs at the blood-CSF barrier in normal and pathological situations. Adv Drug Deliv Rev. 2004;56:1717-1740.
-
(2004)
Adv Drug Deliv Rev
, vol.56
, pp. 1717-1740
-
-
Strazielle, N.1
Khuth, S.T.2
Ghersi-Egea, J.F.3
-
20
-
-
3442876210
-
The choroid plexus: Function, pathology and therapeutic potential of its transplantation
-
Emerich DF, Vasconcellos AV, Elliott RB, Skinner SJ, Borlongan CV. The choroid plexus: function, pathology and therapeutic potential of its transplantation. Expert Opin Biol Ther. 2004;4:1191-201.
-
(2004)
Expert Opin Biol Ther
, vol.4
, pp. 1191-1201
-
-
Emerich, D.F.1
Vasconcellos, A.V.2
Elliott, R.B.3
Skinner, S.J.4
Borlongan, C.V.5
-
21
-
-
25144450046
-
Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport
-
Ito K, Suzuki H, Horie T, Sugiyama Y. Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport. Pharm Res. 2005;22:1559-1577.
-
(2005)
Pharm Res
, vol.22
, pp. 1559-1577
-
-
Ito, K.1
Suzuki, H.2
Horie, T.3
Sugiyama, Y.4
-
22
-
-
0035984805
-
Choroid plexus transporters for drugs and other xenobiotics
-
Ghersi-Egea JF, Strazielle N. Choroid plexus transporters for drugs and other xenobiotics. J Drug Target. 2002;10:353-357.
-
(2002)
J Drug Target
, vol.10
, pp. 353-357
-
-
Ghersi-Egea, J.F.1
Strazielle, N.2
-
23
-
-
0036916855
-
Transport of xenobiotics across the blood-brain barrier
-
Hagenbuch B, Gao B, Meier PJ. Transport of xenobiotics across the blood-brain barrier. News Physiol Sci. 2002;17:231-234.
-
(2002)
News Physiol Sci
, vol.17
, pp. 231-234
-
-
Hagenbuch, B.1
Gao, B.2
Meier, P.J.3
-
24
-
-
22744440362
-
Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases
-
Loscher W, Potschka H. Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases. Prog Neurobiol. 2005;76:22-76.
-
(2005)
Prog Neurobiol
, vol.76
, pp. 22-76
-
-
Loscher, W.1
Potschka, H.2
-
25
-
-
33644781452
-
Implications of genetic polymorphisms in drug transporters for pharmacotherapy
-
Kerb R. Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett. 2006;234:4-33.
-
(2006)
Cancer Lett
, vol.234
, pp. 4-33
-
-
Kerb, R.1
-
26
-
-
0036206904
-
The impact of efflux transporters in the brain on the development of drugs for CNS disorders
-
Taylor EM. The impact of efflux transporters in the brain on the development of drugs for CNS disorders. Clin Pharmacokinet. 2002;41:81-92.
-
(2002)
Clin Pharmacokinet
, vol.41
, pp. 81-92
-
-
Taylor, E.M.1
-
27
-
-
0029028792
-
Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
-
Wacher VJ, Wu CY, Benet LZ. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol Carcinog. 1995;13:129-134.
-
(1995)
Mol Carcinog
, vol.13
, pp. 129-134
-
-
Wacher, V.J.1
Wu, C.Y.2
Benet, L.Z.3
-
28
-
-
12344261030
-
Active efflux across the blood-brain barrier: Role of the solute carrier family
-
Kusuhara H, Sugiyama Y. Active efflux across the blood-brain barrier: role of the solute carrier family. NeuroRx. 2005;2:73-85.
-
(2005)
NeuroRx
, vol.2
, pp. 73-85
-
-
Kusuhara, H.1
Sugiyama, Y.2
-
30
-
-
17544368685
-
Multidrug resistance proteins: Role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
-
Leslie EM, Deeley RG, Cole SP. Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol Appl Pharmacol. 2005;204:216-237.
-
(2005)
Toxicol Appl Pharmacol
, vol.204
, pp. 216-237
-
-
Leslie, E.M.1
Deeley, R.G.2
Cole, S.P.3
-
31
-
-
0027984511
-
The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates
-
Leier I, Jedlitschky G, Buchholz U, Cole SP, Deeley RG, Keppler D. The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. J Biol Chem. 1994;269:27807-27810.
-
(1994)
J Biol Chem
, vol.269
, pp. 27807-27810
-
-
Leier, I.1
Jedlitschky, G.2
Buchholz, U.3
Cole, S.P.4
Deeley, R.G.5
Keppler, D.6
-
32
-
-
0029912351
-
ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump
-
Leier I, Jedlitschky G, Buchholz U, et al. ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump. Biochem J. 1996;314(Pt 2):433-437.
-
(1996)
Biochem J
, vol.314
, Issue.PART 2
, pp. 433-437
-
-
Leier, I.1
Jedlitschky, G.2
Buchholz, U.3
-
33
-
-
24344439264
-
Transporters and drug therapy: Implications for drug disposition and disease
-
Ho RH, Kim RB. Transporters and drug therapy: implications for drug disposition and disease. Clin Pharmacol Ther. 2005;78:260-277.
-
(2005)
Clin Pharmacol Ther
, vol.78
, pp. 260-277
-
-
Ho, R.H.1
Kim, R.B.2
-
34
-
-
32344432793
-
Differential, strain-specific cellular and subcellular distribution of multidrug transporters in murine choroid plexus and blood-brain barrier
-
Soontornmalai A, Vlaming ML, Fritschy JM. Differential, strain-specific cellular and subcellular distribution of multidrug transporters in murine choroid plexus and blood-brain barrier. Neuroscience. 2006;138:159-169.
-
(2006)
Neuroscience
, vol.138
, pp. 159-169
-
-
Soontornmalai, A.1
Vlaming, M.L.2
Fritschy, J.M.3
-
35
-
-
26944461925
-
Expression of drug resistance proteins Pgp, MRP1, MRP3, MRP5 and GST-pi in human glioma
-
Calatozzolo C, Gelati M, Ciusani E, et al. Expression of drug resistance proteins Pgp, MRP1, MRP3, MRP5 and GST-pi in human glioma. J Neurooncol. 2005;74:113-121.
-
(2005)
J Neurooncol
, vol.74
, pp. 113-121
-
-
Calatozzolo, C.1
Gelati, M.2
Ciusani, E.3
-
36
-
-
29244441701
-
ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier
-
Bronger H, Konig J, Kopplow K, et al. ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier. Cancer Res. 2005;65:11419-11428.
-
(2005)
Cancer Res
, vol.65
, pp. 11419-11428
-
-
Bronger, H.1
Konig, J.2
Kopplow, K.3
-
37
-
-
33644503533
-
Distribution and functional activity of P-glycoprotein and multidrug resistance-associated proteins in human brain microvascular endothelial cells in hippocampal sclerosis
-
Kubota H, Ishihara H, Langmann T, et al. Distribution and functional activity of P-glycoprotein and multidrug resistance-associated proteins in human brain microvascular endothelial cells in hippocampal sclerosis. Epilepsy Res. 2006;68:213-228.
-
(2006)
Epilepsy Res
, vol.68
, pp. 213-228
-
-
Kubota, H.1
Ishihara, H.2
Langmann, T.3
-
38
-
-
33744936006
-
Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[C]verapamil and positron emission tomography
-
Toornvliet R, van Berckel BN, Luurtsema G, et al. Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[C]verapamil and positron emission tomography. Clin Pharmacol Ther. 2006;79:540-548.
-
(2006)
Clin Pharmacol Ther
, vol.79
, pp. 540-548
-
-
Toornvliet, R.1
Van Berckel, B.N.2
Luurtsema, G.3
-
39
-
-
20444480695
-
Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography
-
Sasongko L, Link JM, Muzi M, et al. Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography. Clin Pharmacol Ther. 2005;77:503-514.
-
(2005)
Clin Pharmacol Ther
, vol.77
, pp. 503-514
-
-
Sasongko, L.1
Link, J.M.2
Muzi, M.3
-
40
-
-
1242272736
-
Organic anion transporting polypeptides of the OATP/SLC21 family: Phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties
-
Hagenbuch B, Meier PJ. Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch. 2004;447:653-665.
-
(2004)
Pflugers Arch
, vol.447
, pp. 653-665
-
-
Hagenbuch, B.1
Meier, P.J.2
-
41
-
-
1242340323
-
The ABCs of solute carriers: Physiological, pathological and therapeutic implications of human membrane transport proteins. Introduction
-
Hediger MA, Romero MF, Peng JB, Rolfs A, Takanaga H, Bruford EA. The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins. Introduction. Pflugers Arch. 2004;447:465-468.
-
(2004)
Pflugers Arch
, vol.447
, pp. 465-468
-
-
Hediger, M.A.1
Romero, M.F.2
Peng, J.B.3
Rolfs, A.4
Takanaga, H.5
Bruford, E.A.6
-
42
-
-
0037427972
-
The superfamily of organic jnion transporting polypeptides
-
Hagenbuch B, Meier PJ. The superfamily of organic jnion transporting polypeptides. Biochim Biophys Acta. 2003;1609:1-18.
-
(2003)
Biochim Biophys Acta
, vol.1609
, pp. 1-18
-
-
Hagenbuch, B.1
Meier, P.J.2
-
43
-
-
0036793106
-
Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter
-
Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ. Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002;16:2283-2296.
-
(2002)
Mol Endocrinol
, vol.16
, pp. 2283-2296
-
-
Pizzagalli, F.1
Hagenbuch, B.2
Stieger, B.3
Klenk, U.4
Folkers, G.5
Meier, P.J.6
-
44
-
-
0347517756
-
The loop between helix 4 and helix 5 in the monocarboxylate transporter MCT1 is important for substrate selection and protein stability
-
Galic S, Schneider HP, Broer A, Deitmer JW, Broer S. The loop between helix 4 and helix 5 in the monocarboxylate transporter MCT1 is important for substrate selection and protein stability. Biochem J. 2003;376(Pt 2):413-422.
-
(2003)
Biochem J
, vol.376
, Issue.PART 2
, pp. 413-422
-
-
Galic, S.1
Schneider, H.P.2
Broer, A.3
Deitmer, J.W.4
Broer, S.5
-
45
-
-
1242340302
-
The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond
-
Halestrap AP, Meredith D. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch. 2004;447:619-628.
-
(2004)
Pflugers Arch
, vol.447
, pp. 619-628
-
-
Halestrap, A.P.1
Meredith, D.2
-
46
-
-
0043212093
-
Molecular features, regulation, and function of monocarboxylate transporters: Implications for drug delivery
-
Enerson BE, Drewes LR. Molecular features, regulation, and function of monocarboxylate transporters: implications for drug delivery. J Pharm Sci. 2003;92:1531-1544.
-
(2003)
J Pharm Sci
, vol.92
, pp. 1531-1544
-
-
Enerson, B.E.1
Drewes, L.R.2
-
47
-
-
4644337779
-
GHB (gamma-hydroxybutyrate) carrier-mediated transport across the blood-brain barrier
-
Bhattacharya I, Boje KM. GHB (gamma-hydroxybutyrate) carrier-mediated transport across the blood-brain barrier. J Pharmacol Exp Ther. 2004;311:92-98.
-
(2004)
J Pharmacol Exp Ther
, vol.311
, pp. 92-98
-
-
Bhattacharya, I.1
Boje, K.M.2
-
48
-
-
0031824347
-
Human neurons express the poly-specific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine
-
Busch AE, Karbach U, Miska D, et al. Human neurons express the poly-specific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol Pharmacol. 1998;54:342-352.
-
(1998)
Mol Pharmacol
, vol.54
, pp. 342-352
-
-
Busch, A.E.1
Karbach, U.2
Miska, D.3
-
49
-
-
0034968246
-
Comparison of "type I" and "type II" organic cation transport by organic cation transporters and organic anion-transporting polypeptides
-
van Montfoort JE, Muller M, Groothuis GM, Meijer DK, Koepsell H, Meier PJ. Comparison of "type I" and "type II" organic cation transport by organic cation transporters and organic anion-transporting polypeptides. J Pharmacol Exp Ther. 2001;298:110-115.
-
(2001)
J Pharmacol Exp Ther
, vol.298
, pp. 110-115
-
-
Van Montfoort, J.E.1
Muller, M.2
Groothuis, G.M.3
Meijer, D.K.4
Koepsell, H.5
Meier, P.J.6
-
50
-
-
0037421590
-
Pharmacogenomics - Drug disposition, drug targets, and side effects
-
Evans WE, McLeod HL. Pharmacogenomics - drug disposition, drug targets, and side effects. N Engl J Med. 2003;348:538-549.
-
(2003)
N Engl J Med
, vol.348
, pp. 538-549
-
-
Evans, W.E.1
McLeod, H.L.2
-
51
-
-
33646790191
-
Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier
-
Choo EF, Kurnik D, Muszkat M, et al. Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier. J Pharmacol Exp Ther. 2006;317:1012-1018.
-
(2006)
J Pharmacol Exp Ther
, vol.317
, pp. 1012-1018
-
-
Choo, E.F.1
Kurnik, D.2
Muszkat, M.3
-
52
-
-
15744367808
-
Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): Implications for altered drug disposition and central nervous system drug entry
-
Lee W, Glaeser H, Smith LH, et al. Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry. J Biol Chem. 2005;2803610-9617.
-
(2005)
J Biol Chem
, pp. 2803610-2809617
-
-
Lee, W.1
Glaeser, H.2
Smith, L.H.3
-
53
-
-
0242640305
-
Pharmacogenomics and reducing the frequency of adverse drug events
-
O'Kane DJ, Weinshilboum RM, Moyer TP. Pharmacogenomics and reducing the frequency of adverse drug events. Pharmacogenomics. 2003;4:1-4.
-
(2003)
Pharmacogenomics
, vol.4
, pp. 1-4
-
-
O'Kane, D.J.1
Weinshilboum, R.M.2
Moyer, T.P.3
-
54
-
-
0347623323
-
Clinical relevance of P-glycoprotein in drug therapy
-
Lin JH, Yamazaki M. Clinical relevance of P-glycoprotein in drug therapy. Drug Metab Rev. 2003;35:417-454.
-
(2003)
Drug Metab Rev
, vol.35
, pp. 417-454
-
-
Lin, J.H.1
Yamazaki, M.2
-
55
-
-
0037229942
-
Role of P-glycoprotein in pharmacokinetics: Clinical implications
-
Lin JH, Yamazaki M. Role of P-glycoprotein in pharmacokinetics: clinical implications. Clin Pharmacokinet. 2003;42:59-98.
-
(2003)
Clin Pharmacokinet
, vol.42
, pp. 59-98
-
-
Lin, J.H.1
Yamazaki, M.2
-
56
-
-
0028229150
-
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
-
Schinkel AH, Smit JJ, van Tellingen O, et al. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell. 1994;77:491-502.
-
(1994)
Cell
, vol.77
, pp. 491-502
-
-
Schinkel, A.H.1
Smit, J.J.2
Van Tellingen, O.3
-
58
-
-
28844473946
-
Association of the ABCB1 3435C>T polymorphism with antiemetic efficacy of 5-hydroxytryptamine type 3 antagonists
-
Babaoglu MO, Bayar B, Aynacioglu AS, et al. Association of the ABCB1 3435C>T polymorphism with antiemetic efficacy of 5-hydroxytryptamine type 3 antagonists. Clin Pharmacol Ther. 2005;78:619-626.
-
(2005)
Clin Pharmacol Ther
, vol.78
, pp. 619-626
-
-
Babaoglu, M.O.1
Bayar, B.2
Aynacioglu, A.S.3
-
59
-
-
12344334846
-
Clinical aspects of the MDR1 (ABCB1) gene polymorphism
-
Eichelbaum M, Fromm MF, Schwab M. Clinical aspects of the MDR1 (ABCB1) gene polymorphism. Ther Drug Monit. 2004;26:180-185.
-
(2004)
Ther Drug Monit
, vol.26
, pp. 180-185
-
-
Eichelbaum, M.1
Fromm, M.F.2
Schwab, M.3
-
60
-
-
0037431040
-
Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1
-
Siddiqui A, Kerb R, Weale ME, et al. Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N Engl J Med. 2003;348:1442-1448.
-
(2003)
N Engl J Med
, vol.348
, pp. 1442-1448
-
-
Siddiqui, A.1
Kerb, R.2
Weale, M.E.3
-
61
-
-
0037421584
-
Inheritance and drug response
-
Weinshilboum R. Inheritance and drug response. N Engl J Med. 2003;348:529-537.
-
(2003)
N Engl J Med
, vol.348
, pp. 529-537
-
-
Weinshilboum, R.1
-
62
-
-
33745741280
-
Computational approaches for predicting CYP-related metabolism properties in the screening of new drugs
-
Apr 24 [Epub ahead of print]
-
Crivori P, Poggesi I. Computational approaches for predicting CYP-related metabolism properties in the screening of new drugs. Eur J Med Chem. 2006;Apr 24 [Epub ahead of print].
-
(2006)
Eur J Med Chem
-
-
Crivori, P.1
Poggesi, I.2
-
64
-
-
27944460707
-
Pharmacogenetics of long-term responses to antiretroviral regimens containing ef avirenz and/or nelfinavir: An adult AIDS Clinical Trials Group Study
-
Haas DW, Smeaton LM, Shafer RW, et al. Pharmacogenetics of long-term responses to antiretroviral regimens containing ef avirenz and/or nelfinavir: an adult AIDS Clinical Trials Group Study. J Infect Dis. 2005;192:1931-1942.
-
(2005)
J Infect Dis
, vol.192
, pp. 1931-1942
-
-
Haas, D.W.1
Smeaton, L.M.2
Shafer, R.W.3
-
66
-
-
0036361009
-
A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression
-
Roberts RL, Joyce PR, Mulder RT, Begg EJ, Kennedy MA. A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression. Pharmacogenomics J. 2002;2:191-196.
-
(2002)
Pharmacogenomics J
, vol.2
, pp. 191-196
-
-
Roberts, R.L.1
Joyce, P.R.2
Mulder, R.T.3
Begg, E.J.4
Kennedy, M.A.5
-
67
-
-
0036731995
-
MDR1 gene polymorphisms affect therapy outcome in acute myeloid leukemia patients
-
Illmer T, Schuler US, Thiede C et al. MDR1 gene polymorphisms affect therapy outcome in acute myeloid leukemia patients. Cancer Res. 2002;62:4955-4962.
-
(2002)
Cancer Res
, vol.62
, pp. 4955-4962
-
-
Illmer, T.1
Schuler, U.S.2
Thiede, C.3
-
68
-
-
0037183584
-
Neurotoxicity induced by tacrolimus after liver transplantation: Relation to genetic polymorphisms of the ABCB1 (MDR1) gene
-
Yamauchi A, Ieiri I, Kataoka Y, et al. Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene. Transplantation. 2002;74:571-572.
-
(2002)
Transplantation
, vol.74
, pp. 571-572
-
-
Yamauchi, A.1
Ieiri, I.2
Kataoka, Y.3
-
69
-
-
3042651340
-
Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotype
-
Sparreboom A, Gelderblom H, Marsh S, et al. Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotype. Clin Pharmacol Ther. 2004;76:38-44.
-
(2004)
Clin Pharmacol Ther
, vol.76
, pp. 38-44
-
-
Sparreboom, A.1
Gelderblom, H.2
Marsh, S.3
-
70
-
-
20244389716
-
Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1)
-
Fujita T, Brown C, Carlson EJ, et al. Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). Pharmacogenet Genomics. 2005;15:201-209.
-
(2005)
Pharmacogenet Genomics
, vol.15
, pp. 201-209
-
-
Fujita, T.1
Brown, C.2
Carlson, E.J.3
-
71
-
-
0036865724
-
Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences
-
Kerb R, Brinkmann U, Chatskaia N, et al. Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences. Pharmacogenetics. 2002;12:591-595.
-
(2002)
Pharmacogenetics
, vol.12
, pp. 591-595
-
-
Kerb, R.1
Brinkmann, U.2
Chatskaia, N.3
-
72
-
-
0036020986
-
Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function
-
Leabman MK, Huang CC, Kawamoto M, et al. Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. Pharmacogenetics. 2002;12:395-405.
-
(2002)
Pharmacogenetics
, vol.12
, pp. 395-405
-
-
Leabman, M.K.1
Huang, C.C.2
Kawamoto, M.3
-
73
-
-
33646754516
-
Multidrug resistance-associated proteins: Expression and function in the central nervous system
-
Dallas S, Miller DS, Bendayan R. Multidrug resistance-associated proteins: expression and function in the central nervous system. Pharmacol Rev. 2006;58:140-161.
-
(2006)
Pharmacol Rev
, vol.58
, pp. 140-161
-
-
Dallas, S.1
Miller, D.S.2
Bendayan, R.3
-
74
-
-
0037117313
-
Genetic defects in hepatobiliary transport
-
Elferink RO, Groen AK. Genetic defects in hepatobiliary transport. Biochim Biophys Acta. 2002;1586:129-145.
-
(2002)
Biochim Biophys Acta
, vol.1586
, pp. 129-145
-
-
Elferink, R.O.1
Groen, A.K.2
-
76
-
-
0031845356
-
Effect of clarithromycin on renal excretion of digoxin: Interaction with P-glycoprotein
-
Wakasugi H, Yano I, Ito T, et al. Effect of clarithromycin on renal excretion of digoxin: interaction with P-glycoprotein. Clin Pharmacol Ther 1998;64:123-128.
-
(1998)
Clin Pharmacol Ther
, vol.64
, pp. 123-128
-
-
Wakasugi, H.1
Yano, I.2
Ito, T.3
-
77
-
-
0037379938
-
Inhibition of P-glycoprotein by newer antidepressants
-
Weiss J, Dormann SM, Martin-Facklam M, Kerpen O, Ketabi-Kiyanvash N, Haefeli WE. Inhibition of P-glycoprotein by newer antidepressants. J Pharmacol Exp Ther. 2003;305:197-204.
-
(2003)
J Pharmacol Exp Ther
, vol.305
, pp. 197-204
-
-
Weiss, J.1
Dormann, S.M.2
Martin-Facklam, M.3
Kerpen, O.4
Ketabi-Kiyanvash, N.5
Haefeli, W.E.6
-
78
-
-
33644655496
-
Digitalis intoxication induced by paroxetine co-administration
-
Yasui-Furukori N, Kaneko S. Digitalis intoxication induced by paroxetine co-administration. Lancet. 2006;367:788.
-
(2006)
Lancet
, vol.367
, pp. 788
-
-
Yasui-Furukori, N.1
Kaneko, S.2
-
79
-
-
24344442157
-
Effectiveness of a new compound, benemid, in elevating serum penicillin concentrations
-
Burnell JM, Kirby WM. Effectiveness of a new compound, benemid, in elevating serum penicillin concentrations. J Clin Invest 1951;30:697-700.
-
(1951)
J Clin Invest
, vol.30
, pp. 697-700
-
-
Burnell, J.M.1
Kirby, W.M.2
-
80
-
-
0032780906
-
The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1
-
Jariyawat S, Sekine T, Takeda M, et al. The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther. 1999;290:672-677.
-
(1999)
J Pharmacol Exp Ther
, vol.290
, pp. 672-677
-
-
Jariyawat, S.1
Sekine, T.2
Takeda, M.3
-
81
-
-
0034821939
-
Role of transport proteins in drug absorption, distribution and excretion
-
Ayrton A, Morgan P. Role of transport proteins in drug absorption, distribution and excretion. Xenobiotica. 2001;31:469-497.
-
(2001)
Xenobiotica
, vol.31
, pp. 469-497
-
-
Ayrton, A.1
Morgan, P.2
-
82
-
-
0042349753
-
Effects of grapefruit juice on intestinal P-glycoprotein: Evaluation using digoxin in humans
-
Parker RB, Yates CR, Soberman JE, Laizure SC. Effects of grapefruit juice on intestinal P-glycoprotein: evaluation using digoxin in humans. Pharmacotherapy. 2003;23:979-987.
-
(2003)
Pharmacotherapy
, vol.23
, pp. 979-987
-
-
Parker, R.B.1
Yates, C.R.2
Soberman, J.E.3
Laizure, S.C.4
-
83
-
-
0033053573
-
Combinations of P-glycoprotein blockers, verapamil, PSC833, and cremophor act differently on the multidrug resistance associated protein (MRP) and on P-giycoprotein (Pgp)
-
Aszalos A, Thompson K, Yin JJ, Ross DD. Combinations of P-glycoprotein blockers, verapamil, PSC833, and cremophor act differently on the multidrug resistance associated protein (MRP) and on P-giycoprotein (Pgp). Anticancer Res. 1999;19:1053-1064.
-
(1999)
Anticancer Res
, vol.19
, pp. 1053-1064
-
-
Aszalos, A.1
Thompson, K.2
Yin, J.J.3
Ross, D.D.4
-
84
-
-
0033678688
-
Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion
-
Boyd RA, Stern RH, Stewart BH, et al. Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein- mediated secretion. J Clin Pharmacol. 2000;40:91-98.
-
(2000)
J Clin Pharmacol
, vol.40
, pp. 91-98
-
-
Boyd, R.A.1
Stern, R.H.2
Stewart, B.H.3
-
85
-
-
0033669380
-
Evaluation of a vincristine resistant Caco-2 cell line for use in a calcein AM extrusion screening assay for P-glycoprotein interaction
-
Eneroth A, Astrom E, Hoogstraate J, et al. Evaluation of a vincristine resistant Caco-2 cell line for use in a calcein AM extrusion screening assay for P-glycoprotein interaction. Eur J Pharm Sci. 2001;12:205-214.
-
(2001)
Eur J Pharm Sci
, vol.12
, pp. 205-214
-
-
Eneroth, A.1
Astrom, E.2
Hoogstraate, J.3
-
86
-
-
8844275880
-
In vitro and ex vivo evidence for modulation of P-glycoprotein activity by progestins
-
Frohlich M, Albermann N, Sauer A, Walter-Sack I, Haefeli WE, Weiss J. In vitro and ex vivo evidence for modulation of P-glycoprotein activity by progestins. Biochem Pharmacol. 2004;68:2409-2416.
-
(2004)
Biochem Pharmacol
, vol.68
, pp. 2409-2416
-
-
Frohlich, M.1
Albermann, N.2
Sauer, A.3
Walter-Sack, I.4
Haefeli, W.E.5
Weiss, J.6
-
87
-
-
0033833430
-
Increased drug delivery to the brain by P-glycoprotein inhibition
-
Sadeque AJ, Wandel C, He H, Shah S, Wood AJ. Increased drug delivery to the brain by P-glycoprotein inhibition. Clin Pharmacol Ther. 2000;68:231-237.
-
(2000)
Clin Pharmacol Ther
, vol.68
, pp. 231-237
-
-
Sadeque, A.J.1
Wandel, C.2
He, H.3
Shah, S.4
Wood, A.J.5
-
88
-
-
28344444695
-
Population pharmacokinetic analysis of drug-drug interactions among risperidone, bupropion, and sertraline in CF1 mice
-
Wang JS, DeVane CL, Gibson BB, Donovan JL, Markowitz JS, Zhu HJ. Population pharmacokinetic analysis of drug-drug interactions among risperidone, bupropion, and sertraline in CF1 mice. Psychopharmacology (Berl). 2006;183:490-499.
-
(2006)
Psychopharmacology (Berl)
, vol.183
, pp. 490-499
-
-
Wang, J.S.1
DeVane, C.L.2
Gibson, B.B.3
Donovan, J.L.4
Markowitz, J.S.5
Zhu, H.J.6
-
89
-
-
33644868785
-
Development, validation and utility of an in vitro technique for assessment of potential clinical drug-drug interactions involving P-glycoprotein
-
Keogh JP, Kunta JR. Development, validation and utility of an in vitro technique for assessment of potential clinical drug-drug interactions involving P-glycoprotein. Eur J Pharm Sci. 2006;27:543-554.
-
(2006)
Eur J Pharm Sci
, vol.27
, pp. 543-554
-
-
Keogh, J.P.1
Kunta, J.R.2
-
90
-
-
0031933911
-
Toxic digoxin-drug interactions: The major role of renal P-glycoprotein
-
Koren G, Woodland C, Ito S. Toxic digoxin-drug interactions: the major role of renal P-glycoprotein. Vet Hum Toxicol. 1998;40:45-46.
-
(1998)
Vet Hum Toxicol
, vol.40
, pp. 45-46
-
-
Koren, G.1
Woodland, C.2
Ito, S.3
-
91
-
-
0036020986
-
Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function
-
Leabman MK, Huang CC, Kawamoto M, et al. Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. Pharmacogenetics. 2002;12:395-405.
-
(2002)
Pharmacogenetics
, vol.12
, pp. 395-405
-
-
Leabman, M.K.1
Huang, C.C.2
Kawamoto, M.3
-
92
-
-
0042950000
-
Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects
-
Dresser GK, Schwarz UI, Wilkinson GR, Kim RB. Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects. Clin Pharmacol Ther. 2003;73:41-50.
-
(2003)
Clin Pharmacol Ther
, vol.73
, pp. 41-50
-
-
Dresser, G.K.1
Schwarz, U.I.2
Wilkinson, G.R.3
Kim, R.B.4
-
93
-
-
0033972441
-
Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition
-
Dresser GK, Spence JD, Bailey DG. Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition. Clin Pharmacokinet. 2000;38:41-57.
-
(2000)
Clin Pharmacokinet
, vol.38
, pp. 41-57
-
-
Dresser, G.K.1
Spence, J.D.2
Bailey, D.G.3
|