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Volumn 8, Issue 3, 2006, Pages 311-321

Membrane transporter proteins: A challenge for CNS drug development

Author keywords

ATP binding cassette transporter; Blood brain barrier; Drug distribution; Drug transporter; Solute linked carrier

Indexed keywords

ABC TRANSPORTER; AMFEBUTAMONE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIHYPERTENSIVE AGENT; ATORVASTATIN; BREAST CANCER RESISTANCE PROTEIN; CARRIER PROTEIN; CATION TRANSPORT PROTEIN; CENTRAL NERVOUS SYSTEM AGENTS; CITALOPRAM; CLARITHROMYCIN; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLYCOPROTEIN P; LOPERAMIDE; MEMBRANE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; NEUROTRANSMITTER; PAROXETINE; PENICILLIN G; PROBENECID; PROTEIN SOLUTE LINKED CARRIER; QUINIDINE; RISPERIDONE; SERTRALINE; UNCLASSIFIED DRUG; VENLAFAXINE; VERAPAMIL;

EID: 33750589959     PISSN: 12948322     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (105)

References (93)
  • 1
    • 0033756459 scopus 로고    scopus 로고
    • Transporter-mediated permeation of drugs across the blood-brain barrier
    • Tamai I, Tsuji A. Transporter-mediated permeation of drugs across the blood-brain barrier. J Pharm Sci. 2000;89:1371-1388.
    • (2000) J Pharm Sci , vol.89 , pp. 1371-1388
    • Tamai, I.1    Tsuji, A.2
  • 2
    • 0032513049 scopus 로고    scopus 로고
    • Dehydroepiandrosterone sulfate (DHEAS): Identification of a carrier protein in human liver and brain
    • Kullak-Ublick GA, Fisch T, Oswald M, et al. Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain. FEBS Lett. 1998;424:173-176.
    • (1998) FEBS Lett , vol.424 , pp. 173-176
    • Kullak-Ublick, G.A.1    Fisch, T.2    Oswald, M.3
  • 3
    • 0035253135 scopus 로고    scopus 로고
    • Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 1)
    • Kusuhara H, Sugiyama Y. Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 1). Drug Discov Today. 2001;6:150-156.
    • (2001) Drug Discov Today , vol.6 , pp. 150-156
    • Kusuhara, H.1    Sugiyama, Y.2
  • 4
    • 0035254189 scopus 로고    scopus 로고
    • Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 2)
    • Kusuhara H, Sugiyama Y. Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 2). Drug Discov Today. 2001;6:206-212.
    • (2001) Drug Discov Today , vol.6 , pp. 206-212
    • Kusuhara, H.1    Sugiyama, Y.2
  • 6
    • 33750589259 scopus 로고    scopus 로고
    • Intracellular peptide transporters in human - Compartmentalization of the "peptidome"
    • May 18 [Epub ahead of print]
    • Herget M, Tampe R. Intracellular peptide transporters in human - compartmentalization of the "peptidome." Pflugers Arch. 2006;May 18 [Epub ahead of print].
    • (2006) Pflugers Arch
    • Herget, M.1    Tampe, R.2
  • 7
    • 10744220281 scopus 로고    scopus 로고
    • Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy
    • Pauli-Magnus C, Lang T, Meier Y, et al. Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy. Pharmacogenetics. 2004;14:91-102.
    • (2004) Pharmacogenetics , vol.14 , pp. 91-102
    • Pauli-Magnus, C.1    Lang, T.2    Meier, Y.3
  • 9
    • 30944442799 scopus 로고    scopus 로고
    • A novel cell model to study the function of the adrenoleukodystrophy- related protein
    • Gueugnon F, Volodina N, Taouil JE, et al. A novel cell model to study the function of the adrenoleukodystrophy-related protein. Biochem Biophys Res Commun. 2006;341:150-157.
    • (2006) Biochem Biophys Res Commun , vol.341 , pp. 150-157
    • Gueugnon, F.1    Volodina, N.2    Taouil, J.E.3
  • 10
    • 0034329310 scopus 로고    scopus 로고
    • Human ABC7 transporter: Gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation
    • Bekri S, Kispal G, Lange H, et al. Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation. Blood. 2000;96:3256-3264.
    • (2000) Blood , vol.96 , pp. 3256-3264
    • Bekri, S.1    Kispal, G.2    Lange, H.3
  • 11
    • 33646711005 scopus 로고    scopus 로고
    • De novo deletion removes a conserved motif in the C-terminus of ABCA4 and results in cone-rod dystrophy
    • Stenirri S, Battistella S, Fermo I, et al. De novo deletion removes a conserved motif in the C-terminus of ABCA4 and results in cone-rod dystrophy. Clin Chem Lab Med. 2006;44:533-537.
    • (2006) Clin Chem Lab Med , vol.44 , pp. 533-537
    • Stenirri, S.1    Battistella, S.2    Fermo, I.3
  • 12
    • 33646092544 scopus 로고    scopus 로고
    • Progressive cone and cone-rod dystrophies: Phenotypes and underlying molecular genetic basis
    • Michaelides M, Hardcastle AJ, Hunt DM, Moore AT. Progressive cone and cone-rod dystrophies: phenotypes and underlying molecular genetic basis. Surv Ophthalmol. 2006;51:232-528.
    • (2006) Surv Ophthalmol , vol.51 , pp. 232-528
    • Michaelides, M.1    Hardcastle, A.J.2    Hunt, D.M.3    Moore, A.T.4
  • 13
    • 27644489474 scopus 로고    scopus 로고
    • P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model
    • Cirrito JR, Deane R, Fagan AM, et al. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J Clin Invest. 2005;115:3285-3290.
    • (2005) J Clin Invest , vol.115 , pp. 3285-3290
    • Cirrito, J.R.1    Deane, R.2    Fagan, A.M.3
  • 14
    • 2942750350 scopus 로고    scopus 로고
    • ATP-binding cassette (ABC) transporters in human metabolism and diseases
    • Sefkova J, Poledne R, Hubacek JA. ATP-binding cassette (ABC) transporters in human metabolism and diseases. Physiol Res. 2004;53:235-243.
    • (2004) Physiol Res , vol.53 , pp. 235-243
    • Sefkova, J.1    Poledne, R.2    Hubacek, J.A.3
  • 15
    • 24144459853 scopus 로고    scopus 로고
    • Polarized distribution of nucleoside transporters in rat brain endothelial and choroid plexus epithelial cells
    • Redzic ZB, Biringer J, Barnes K, et al. Polarized distribution of nucleoside transporters in rat brain endothelial and choroid plexus epithelial cells. J Neurochem. 2005;94:1420-1426.
    • (2005) J Neurochem , vol.94 , pp. 1420-1426
    • Redzic, Z.B.1    Biringer, J.2    Barnes, K.3
  • 16
    • 16244396148 scopus 로고    scopus 로고
    • Functional characterization and comparison of the outer blood-retina barrier and the blood-brain barrier
    • Steuer H, Jaworski A, Elger B, et al. Functional characterization and comparison of the outer blood-retina barrier and the blood-brain barrier. Invest Ophthalmol Vis Sci. 2005;46:1047-1053.
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 1047-1053
    • Steuer, H.1    Jaworski, A.2    Elger, B.3
  • 17
    • 0036760638 scopus 로고    scopus 로고
    • The complementary membranes forming the blood-brain barrier
    • Hawkins RA, Peterson DR, Vina JR. The complementary membranes forming the blood-brain barrier. IUBMB Life. 2002;54:101-107.
    • (2002) IUBMB Life , vol.54 , pp. 101-107
    • Hawkins, R.A.1    Peterson, D.R.2    Vina, J.R.3
  • 18
    • 0034104737 scopus 로고    scopus 로고
    • Circumventricular organs: Definition and role in the regulation of endocrine and autonomic function
    • Ganong WF. Circumventricular organs: definition and role in the regulation of endocrine and autonomic function. Clin Exp Pharmacol Physiol. 2000;27:422-427.
    • (2000) Clin Exp Pharmacol Physiol , vol.27 , pp. 422-427
    • Ganong, W.F.1
  • 19
    • 4644371691 scopus 로고    scopus 로고
    • Detoxification systems, passive and specific transport for drugs at the blood-CSF barrier in normal and pathological situations
    • Strazielle N, Khuth ST, Ghersi-Egea JF. Detoxification systems, passive and specific transport for drugs at the blood-CSF barrier in normal and pathological situations. Adv Drug Deliv Rev. 2004;56:1717-1740.
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 1717-1740
    • Strazielle, N.1    Khuth, S.T.2    Ghersi-Egea, J.F.3
  • 21
    • 25144450046 scopus 로고    scopus 로고
    • Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport
    • Ito K, Suzuki H, Horie T, Sugiyama Y. Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport. Pharm Res. 2005;22:1559-1577.
    • (2005) Pharm Res , vol.22 , pp. 1559-1577
    • Ito, K.1    Suzuki, H.2    Horie, T.3    Sugiyama, Y.4
  • 22
    • 0035984805 scopus 로고    scopus 로고
    • Choroid plexus transporters for drugs and other xenobiotics
    • Ghersi-Egea JF, Strazielle N. Choroid plexus transporters for drugs and other xenobiotics. J Drug Target. 2002;10:353-357.
    • (2002) J Drug Target , vol.10 , pp. 353-357
    • Ghersi-Egea, J.F.1    Strazielle, N.2
  • 23
    • 0036916855 scopus 로고    scopus 로고
    • Transport of xenobiotics across the blood-brain barrier
    • Hagenbuch B, Gao B, Meier PJ. Transport of xenobiotics across the blood-brain barrier. News Physiol Sci. 2002;17:231-234.
    • (2002) News Physiol Sci , vol.17 , pp. 231-234
    • Hagenbuch, B.1    Gao, B.2    Meier, P.J.3
  • 24
    • 22744440362 scopus 로고    scopus 로고
    • Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases
    • Loscher W, Potschka H. Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases. Prog Neurobiol. 2005;76:22-76.
    • (2005) Prog Neurobiol , vol.76 , pp. 22-76
    • Loscher, W.1    Potschka, H.2
  • 25
    • 33644781452 scopus 로고    scopus 로고
    • Implications of genetic polymorphisms in drug transporters for pharmacotherapy
    • Kerb R. Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett. 2006;234:4-33.
    • (2006) Cancer Lett , vol.234 , pp. 4-33
    • Kerb, R.1
  • 26
    • 0036206904 scopus 로고    scopus 로고
    • The impact of efflux transporters in the brain on the development of drugs for CNS disorders
    • Taylor EM. The impact of efflux transporters in the brain on the development of drugs for CNS disorders. Clin Pharmacokinet. 2002;41:81-92.
    • (2002) Clin Pharmacokinet , vol.41 , pp. 81-92
    • Taylor, E.M.1
  • 27
    • 0029028792 scopus 로고
    • Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
    • Wacher VJ, Wu CY, Benet LZ. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol Carcinog. 1995;13:129-134.
    • (1995) Mol Carcinog , vol.13 , pp. 129-134
    • Wacher, V.J.1    Wu, C.Y.2    Benet, L.Z.3
  • 28
    • 12344261030 scopus 로고    scopus 로고
    • Active efflux across the blood-brain barrier: Role of the solute carrier family
    • Kusuhara H, Sugiyama Y. Active efflux across the blood-brain barrier: role of the solute carrier family. NeuroRx. 2005;2:73-85.
    • (2005) NeuroRx , vol.2 , pp. 73-85
    • Kusuhara, H.1    Sugiyama, Y.2
  • 30
    • 17544368685 scopus 로고    scopus 로고
    • Multidrug resistance proteins: Role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
    • Leslie EM, Deeley RG, Cole SP. Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol Appl Pharmacol. 2005;204:216-237.
    • (2005) Toxicol Appl Pharmacol , vol.204 , pp. 216-237
    • Leslie, E.M.1    Deeley, R.G.2    Cole, S.P.3
  • 31
    • 0027984511 scopus 로고
    • The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates
    • Leier I, Jedlitschky G, Buchholz U, Cole SP, Deeley RG, Keppler D. The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. J Biol Chem. 1994;269:27807-27810.
    • (1994) J Biol Chem , vol.269 , pp. 27807-27810
    • Leier, I.1    Jedlitschky, G.2    Buchholz, U.3    Cole, S.P.4    Deeley, R.G.5    Keppler, D.6
  • 32
    • 0029912351 scopus 로고    scopus 로고
    • ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump
    • Leier I, Jedlitschky G, Buchholz U, et al. ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump. Biochem J. 1996;314(Pt 2):433-437.
    • (1996) Biochem J , vol.314 , Issue.PART 2 , pp. 433-437
    • Leier, I.1    Jedlitschky, G.2    Buchholz, U.3
  • 33
    • 24344439264 scopus 로고    scopus 로고
    • Transporters and drug therapy: Implications for drug disposition and disease
    • Ho RH, Kim RB. Transporters and drug therapy: implications for drug disposition and disease. Clin Pharmacol Ther. 2005;78:260-277.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 260-277
    • Ho, R.H.1    Kim, R.B.2
  • 34
    • 32344432793 scopus 로고    scopus 로고
    • Differential, strain-specific cellular and subcellular distribution of multidrug transporters in murine choroid plexus and blood-brain barrier
    • Soontornmalai A, Vlaming ML, Fritschy JM. Differential, strain-specific cellular and subcellular distribution of multidrug transporters in murine choroid plexus and blood-brain barrier. Neuroscience. 2006;138:159-169.
    • (2006) Neuroscience , vol.138 , pp. 159-169
    • Soontornmalai, A.1    Vlaming, M.L.2    Fritschy, J.M.3
  • 35
    • 26944461925 scopus 로고    scopus 로고
    • Expression of drug resistance proteins Pgp, MRP1, MRP3, MRP5 and GST-pi in human glioma
    • Calatozzolo C, Gelati M, Ciusani E, et al. Expression of drug resistance proteins Pgp, MRP1, MRP3, MRP5 and GST-pi in human glioma. J Neurooncol. 2005;74:113-121.
    • (2005) J Neurooncol , vol.74 , pp. 113-121
    • Calatozzolo, C.1    Gelati, M.2    Ciusani, E.3
  • 36
    • 29244441701 scopus 로고    scopus 로고
    • ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier
    • Bronger H, Konig J, Kopplow K, et al. ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier. Cancer Res. 2005;65:11419-11428.
    • (2005) Cancer Res , vol.65 , pp. 11419-11428
    • Bronger, H.1    Konig, J.2    Kopplow, K.3
  • 37
    • 33644503533 scopus 로고    scopus 로고
    • Distribution and functional activity of P-glycoprotein and multidrug resistance-associated proteins in human brain microvascular endothelial cells in hippocampal sclerosis
    • Kubota H, Ishihara H, Langmann T, et al. Distribution and functional activity of P-glycoprotein and multidrug resistance-associated proteins in human brain microvascular endothelial cells in hippocampal sclerosis. Epilepsy Res. 2006;68:213-228.
    • (2006) Epilepsy Res , vol.68 , pp. 213-228
    • Kubota, H.1    Ishihara, H.2    Langmann, T.3
  • 38
    • 33744936006 scopus 로고    scopus 로고
    • Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[C]verapamil and positron emission tomography
    • Toornvliet R, van Berckel BN, Luurtsema G, et al. Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[C]verapamil and positron emission tomography. Clin Pharmacol Ther. 2006;79:540-548.
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 540-548
    • Toornvliet, R.1    Van Berckel, B.N.2    Luurtsema, G.3
  • 39
    • 20444480695 scopus 로고    scopus 로고
    • Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography
    • Sasongko L, Link JM, Muzi M, et al. Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography. Clin Pharmacol Ther. 2005;77:503-514.
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 503-514
    • Sasongko, L.1    Link, J.M.2    Muzi, M.3
  • 40
    • 1242272736 scopus 로고    scopus 로고
    • Organic anion transporting polypeptides of the OATP/SLC21 family: Phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties
    • Hagenbuch B, Meier PJ. Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch. 2004;447:653-665.
    • (2004) Pflugers Arch , vol.447 , pp. 653-665
    • Hagenbuch, B.1    Meier, P.J.2
  • 41
    • 1242340323 scopus 로고    scopus 로고
    • The ABCs of solute carriers: Physiological, pathological and therapeutic implications of human membrane transport proteins. Introduction
    • Hediger MA, Romero MF, Peng JB, Rolfs A, Takanaga H, Bruford EA. The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins. Introduction. Pflugers Arch. 2004;447:465-468.
    • (2004) Pflugers Arch , vol.447 , pp. 465-468
    • Hediger, M.A.1    Romero, M.F.2    Peng, J.B.3    Rolfs, A.4    Takanaga, H.5    Bruford, E.A.6
  • 42
    • 0037427972 scopus 로고    scopus 로고
    • The superfamily of organic jnion transporting polypeptides
    • Hagenbuch B, Meier PJ. The superfamily of organic jnion transporting polypeptides. Biochim Biophys Acta. 2003;1609:1-18.
    • (2003) Biochim Biophys Acta , vol.1609 , pp. 1-18
    • Hagenbuch, B.1    Meier, P.J.2
  • 43
    • 0036793106 scopus 로고    scopus 로고
    • Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter
    • Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ. Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002;16:2283-2296.
    • (2002) Mol Endocrinol , vol.16 , pp. 2283-2296
    • Pizzagalli, F.1    Hagenbuch, B.2    Stieger, B.3    Klenk, U.4    Folkers, G.5    Meier, P.J.6
  • 44
    • 0347517756 scopus 로고    scopus 로고
    • The loop between helix 4 and helix 5 in the monocarboxylate transporter MCT1 is important for substrate selection and protein stability
    • Galic S, Schneider HP, Broer A, Deitmer JW, Broer S. The loop between helix 4 and helix 5 in the monocarboxylate transporter MCT1 is important for substrate selection and protein stability. Biochem J. 2003;376(Pt 2):413-422.
    • (2003) Biochem J , vol.376 , Issue.PART 2 , pp. 413-422
    • Galic, S.1    Schneider, H.P.2    Broer, A.3    Deitmer, J.W.4    Broer, S.5
  • 45
    • 1242340302 scopus 로고    scopus 로고
    • The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond
    • Halestrap AP, Meredith D. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch. 2004;447:619-628.
    • (2004) Pflugers Arch , vol.447 , pp. 619-628
    • Halestrap, A.P.1    Meredith, D.2
  • 46
    • 0043212093 scopus 로고    scopus 로고
    • Molecular features, regulation, and function of monocarboxylate transporters: Implications for drug delivery
    • Enerson BE, Drewes LR. Molecular features, regulation, and function of monocarboxylate transporters: implications for drug delivery. J Pharm Sci. 2003;92:1531-1544.
    • (2003) J Pharm Sci , vol.92 , pp. 1531-1544
    • Enerson, B.E.1    Drewes, L.R.2
  • 47
    • 4644337779 scopus 로고    scopus 로고
    • GHB (gamma-hydroxybutyrate) carrier-mediated transport across the blood-brain barrier
    • Bhattacharya I, Boje KM. GHB (gamma-hydroxybutyrate) carrier-mediated transport across the blood-brain barrier. J Pharmacol Exp Ther. 2004;311:92-98.
    • (2004) J Pharmacol Exp Ther , vol.311 , pp. 92-98
    • Bhattacharya, I.1    Boje, K.M.2
  • 48
    • 0031824347 scopus 로고    scopus 로고
    • Human neurons express the poly-specific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine
    • Busch AE, Karbach U, Miska D, et al. Human neurons express the poly-specific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol Pharmacol. 1998;54:342-352.
    • (1998) Mol Pharmacol , vol.54 , pp. 342-352
    • Busch, A.E.1    Karbach, U.2    Miska, D.3
  • 49
    • 0034968246 scopus 로고    scopus 로고
    • Comparison of "type I" and "type II" organic cation transport by organic cation transporters and organic anion-transporting polypeptides
    • van Montfoort JE, Muller M, Groothuis GM, Meijer DK, Koepsell H, Meier PJ. Comparison of "type I" and "type II" organic cation transport by organic cation transporters and organic anion-transporting polypeptides. J Pharmacol Exp Ther. 2001;298:110-115.
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 110-115
    • Van Montfoort, J.E.1    Muller, M.2    Groothuis, G.M.3    Meijer, D.K.4    Koepsell, H.5    Meier, P.J.6
  • 50
    • 0037421590 scopus 로고    scopus 로고
    • Pharmacogenomics - Drug disposition, drug targets, and side effects
    • Evans WE, McLeod HL. Pharmacogenomics - drug disposition, drug targets, and side effects. N Engl J Med. 2003;348:538-549.
    • (2003) N Engl J Med , vol.348 , pp. 538-549
    • Evans, W.E.1    McLeod, H.L.2
  • 51
    • 33646790191 scopus 로고    scopus 로고
    • Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier
    • Choo EF, Kurnik D, Muszkat M, et al. Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier. J Pharmacol Exp Ther. 2006;317:1012-1018.
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 1012-1018
    • Choo, E.F.1    Kurnik, D.2    Muszkat, M.3
  • 52
    • 15744367808 scopus 로고    scopus 로고
    • Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): Implications for altered drug disposition and central nervous system drug entry
    • Lee W, Glaeser H, Smith LH, et al. Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry. J Biol Chem. 2005;2803610-9617.
    • (2005) J Biol Chem , pp. 2803610-2809617
    • Lee, W.1    Glaeser, H.2    Smith, L.H.3
  • 53
    • 0242640305 scopus 로고    scopus 로고
    • Pharmacogenomics and reducing the frequency of adverse drug events
    • O'Kane DJ, Weinshilboum RM, Moyer TP. Pharmacogenomics and reducing the frequency of adverse drug events. Pharmacogenomics. 2003;4:1-4.
    • (2003) Pharmacogenomics , vol.4 , pp. 1-4
    • O'Kane, D.J.1    Weinshilboum, R.M.2    Moyer, T.P.3
  • 54
    • 0347623323 scopus 로고    scopus 로고
    • Clinical relevance of P-glycoprotein in drug therapy
    • Lin JH, Yamazaki M. Clinical relevance of P-glycoprotein in drug therapy. Drug Metab Rev. 2003;35:417-454.
    • (2003) Drug Metab Rev , vol.35 , pp. 417-454
    • Lin, J.H.1    Yamazaki, M.2
  • 55
    • 0037229942 scopus 로고    scopus 로고
    • Role of P-glycoprotein in pharmacokinetics: Clinical implications
    • Lin JH, Yamazaki M. Role of P-glycoprotein in pharmacokinetics: clinical implications. Clin Pharmacokinet. 2003;42:59-98.
    • (2003) Clin Pharmacokinet , vol.42 , pp. 59-98
    • Lin, J.H.1    Yamazaki, M.2
  • 56
    • 0028229150 scopus 로고
    • Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
    • Schinkel AH, Smit JJ, van Tellingen O, et al. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell. 1994;77:491-502.
    • (1994) Cell , vol.77 , pp. 491-502
    • Schinkel, A.H.1    Smit, J.J.2    Van Tellingen, O.3
  • 58
    • 28844473946 scopus 로고    scopus 로고
    • Association of the ABCB1 3435C>T polymorphism with antiemetic efficacy of 5-hydroxytryptamine type 3 antagonists
    • Babaoglu MO, Bayar B, Aynacioglu AS, et al. Association of the ABCB1 3435C>T polymorphism with antiemetic efficacy of 5-hydroxytryptamine type 3 antagonists. Clin Pharmacol Ther. 2005;78:619-626.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 619-626
    • Babaoglu, M.O.1    Bayar, B.2    Aynacioglu, A.S.3
  • 59
    • 12344334846 scopus 로고    scopus 로고
    • Clinical aspects of the MDR1 (ABCB1) gene polymorphism
    • Eichelbaum M, Fromm MF, Schwab M. Clinical aspects of the MDR1 (ABCB1) gene polymorphism. Ther Drug Monit. 2004;26:180-185.
    • (2004) Ther Drug Monit , vol.26 , pp. 180-185
    • Eichelbaum, M.1    Fromm, M.F.2    Schwab, M.3
  • 60
    • 0037431040 scopus 로고    scopus 로고
    • Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1
    • Siddiqui A, Kerb R, Weale ME, et al. Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N Engl J Med. 2003;348:1442-1448.
    • (2003) N Engl J Med , vol.348 , pp. 1442-1448
    • Siddiqui, A.1    Kerb, R.2    Weale, M.E.3
  • 61
    • 0037421584 scopus 로고    scopus 로고
    • Inheritance and drug response
    • Weinshilboum R. Inheritance and drug response. N Engl J Med. 2003;348:529-537.
    • (2003) N Engl J Med , vol.348 , pp. 529-537
    • Weinshilboum, R.1
  • 62
    • 33745741280 scopus 로고    scopus 로고
    • Computational approaches for predicting CYP-related metabolism properties in the screening of new drugs
    • Apr 24 [Epub ahead of print]
    • Crivori P, Poggesi I. Computational approaches for predicting CYP-related metabolism properties in the screening of new drugs. Eur J Med Chem. 2006;Apr 24 [Epub ahead of print].
    • (2006) Eur J Med Chem
    • Crivori, P.1    Poggesi, I.2
  • 64
    • 27944460707 scopus 로고    scopus 로고
    • Pharmacogenetics of long-term responses to antiretroviral regimens containing ef avirenz and/or nelfinavir: An adult AIDS Clinical Trials Group Study
    • Haas DW, Smeaton LM, Shafer RW, et al. Pharmacogenetics of long-term responses to antiretroviral regimens containing ef avirenz and/or nelfinavir: an adult AIDS Clinical Trials Group Study. J Infect Dis. 2005;192:1931-1942.
    • (2005) J Infect Dis , vol.192 , pp. 1931-1942
    • Haas, D.W.1    Smeaton, L.M.2    Shafer, R.W.3
  • 65
    • 0037955805 scopus 로고    scopus 로고
    • Digoxin pharmacokinetics and MDR1 genetic polymorphisms
    • Verstuyft C, Schwab M, Schaeffeler E, et al. Digoxin pharmacokinetics and MDR1 genetic polymorphisms. Eur J Clin Pharmacol. 2003;58:809-812.
    • (2003) Eur J Clin Pharmacol , vol.58 , pp. 809-812
    • Verstuyft, C.1    Schwab, M.2    Schaeffeler, E.3
  • 66
    • 0036361009 scopus 로고    scopus 로고
    • A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression
    • Roberts RL, Joyce PR, Mulder RT, Begg EJ, Kennedy MA. A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression. Pharmacogenomics J. 2002;2:191-196.
    • (2002) Pharmacogenomics J , vol.2 , pp. 191-196
    • Roberts, R.L.1    Joyce, P.R.2    Mulder, R.T.3    Begg, E.J.4    Kennedy, M.A.5
  • 67
    • 0036731995 scopus 로고    scopus 로고
    • MDR1 gene polymorphisms affect therapy outcome in acute myeloid leukemia patients
    • Illmer T, Schuler US, Thiede C et al. MDR1 gene polymorphisms affect therapy outcome in acute myeloid leukemia patients. Cancer Res. 2002;62:4955-4962.
    • (2002) Cancer Res , vol.62 , pp. 4955-4962
    • Illmer, T.1    Schuler, U.S.2    Thiede, C.3
  • 68
    • 0037183584 scopus 로고    scopus 로고
    • Neurotoxicity induced by tacrolimus after liver transplantation: Relation to genetic polymorphisms of the ABCB1 (MDR1) gene
    • Yamauchi A, Ieiri I, Kataoka Y, et al. Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene. Transplantation. 2002;74:571-572.
    • (2002) Transplantation , vol.74 , pp. 571-572
    • Yamauchi, A.1    Ieiri, I.2    Kataoka, Y.3
  • 69
    • 3042651340 scopus 로고    scopus 로고
    • Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotype
    • Sparreboom A, Gelderblom H, Marsh S, et al. Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotype. Clin Pharmacol Ther. 2004;76:38-44.
    • (2004) Clin Pharmacol Ther , vol.76 , pp. 38-44
    • Sparreboom, A.1    Gelderblom, H.2    Marsh, S.3
  • 70
    • 20244389716 scopus 로고    scopus 로고
    • Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1)
    • Fujita T, Brown C, Carlson EJ, et al. Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). Pharmacogenet Genomics. 2005;15:201-209.
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 201-209
    • Fujita, T.1    Brown, C.2    Carlson, E.J.3
  • 71
    • 0036865724 scopus 로고    scopus 로고
    • Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences
    • Kerb R, Brinkmann U, Chatskaia N, et al. Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences. Pharmacogenetics. 2002;12:591-595.
    • (2002) Pharmacogenetics , vol.12 , pp. 591-595
    • Kerb, R.1    Brinkmann, U.2    Chatskaia, N.3
  • 72
    • 0036020986 scopus 로고    scopus 로고
    • Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function
    • Leabman MK, Huang CC, Kawamoto M, et al. Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. Pharmacogenetics. 2002;12:395-405.
    • (2002) Pharmacogenetics , vol.12 , pp. 395-405
    • Leabman, M.K.1    Huang, C.C.2    Kawamoto, M.3
  • 73
    • 33646754516 scopus 로고    scopus 로고
    • Multidrug resistance-associated proteins: Expression and function in the central nervous system
    • Dallas S, Miller DS, Bendayan R. Multidrug resistance-associated proteins: expression and function in the central nervous system. Pharmacol Rev. 2006;58:140-161.
    • (2006) Pharmacol Rev , vol.58 , pp. 140-161
    • Dallas, S.1    Miller, D.S.2    Bendayan, R.3
  • 74
    • 0037117313 scopus 로고    scopus 로고
    • Genetic defects in hepatobiliary transport
    • Elferink RO, Groen AK. Genetic defects in hepatobiliary transport. Biochim Biophys Acta. 2002;1586:129-145.
    • (2002) Biochim Biophys Acta , vol.1586 , pp. 129-145
    • Elferink, R.O.1    Groen, A.K.2
  • 75
  • 76
    • 0031845356 scopus 로고    scopus 로고
    • Effect of clarithromycin on renal excretion of digoxin: Interaction with P-glycoprotein
    • Wakasugi H, Yano I, Ito T, et al. Effect of clarithromycin on renal excretion of digoxin: interaction with P-glycoprotein. Clin Pharmacol Ther 1998;64:123-128.
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 123-128
    • Wakasugi, H.1    Yano, I.2    Ito, T.3
  • 78
    • 33644655496 scopus 로고    scopus 로고
    • Digitalis intoxication induced by paroxetine co-administration
    • Yasui-Furukori N, Kaneko S. Digitalis intoxication induced by paroxetine co-administration. Lancet. 2006;367:788.
    • (2006) Lancet , vol.367 , pp. 788
    • Yasui-Furukori, N.1    Kaneko, S.2
  • 79
    • 24344442157 scopus 로고
    • Effectiveness of a new compound, benemid, in elevating serum penicillin concentrations
    • Burnell JM, Kirby WM. Effectiveness of a new compound, benemid, in elevating serum penicillin concentrations. J Clin Invest 1951;30:697-700.
    • (1951) J Clin Invest , vol.30 , pp. 697-700
    • Burnell, J.M.1    Kirby, W.M.2
  • 80
    • 0032780906 scopus 로고    scopus 로고
    • The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1
    • Jariyawat S, Sekine T, Takeda M, et al. The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther. 1999;290:672-677.
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 672-677
    • Jariyawat, S.1    Sekine, T.2    Takeda, M.3
  • 81
    • 0034821939 scopus 로고    scopus 로고
    • Role of transport proteins in drug absorption, distribution and excretion
    • Ayrton A, Morgan P. Role of transport proteins in drug absorption, distribution and excretion. Xenobiotica. 2001;31:469-497.
    • (2001) Xenobiotica , vol.31 , pp. 469-497
    • Ayrton, A.1    Morgan, P.2
  • 82
    • 0042349753 scopus 로고    scopus 로고
    • Effects of grapefruit juice on intestinal P-glycoprotein: Evaluation using digoxin in humans
    • Parker RB, Yates CR, Soberman JE, Laizure SC. Effects of grapefruit juice on intestinal P-glycoprotein: evaluation using digoxin in humans. Pharmacotherapy. 2003;23:979-987.
    • (2003) Pharmacotherapy , vol.23 , pp. 979-987
    • Parker, R.B.1    Yates, C.R.2    Soberman, J.E.3    Laizure, S.C.4
  • 83
    • 0033053573 scopus 로고    scopus 로고
    • Combinations of P-glycoprotein blockers, verapamil, PSC833, and cremophor act differently on the multidrug resistance associated protein (MRP) and on P-giycoprotein (Pgp)
    • Aszalos A, Thompson K, Yin JJ, Ross DD. Combinations of P-glycoprotein blockers, verapamil, PSC833, and cremophor act differently on the multidrug resistance associated protein (MRP) and on P-giycoprotein (Pgp). Anticancer Res. 1999;19:1053-1064.
    • (1999) Anticancer Res , vol.19 , pp. 1053-1064
    • Aszalos, A.1    Thompson, K.2    Yin, J.J.3    Ross, D.D.4
  • 84
    • 0033678688 scopus 로고    scopus 로고
    • Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion
    • Boyd RA, Stern RH, Stewart BH, et al. Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein- mediated secretion. J Clin Pharmacol. 2000;40:91-98.
    • (2000) J Clin Pharmacol , vol.40 , pp. 91-98
    • Boyd, R.A.1    Stern, R.H.2    Stewart, B.H.3
  • 85
    • 0033669380 scopus 로고    scopus 로고
    • Evaluation of a vincristine resistant Caco-2 cell line for use in a calcein AM extrusion screening assay for P-glycoprotein interaction
    • Eneroth A, Astrom E, Hoogstraate J, et al. Evaluation of a vincristine resistant Caco-2 cell line for use in a calcein AM extrusion screening assay for P-glycoprotein interaction. Eur J Pharm Sci. 2001;12:205-214.
    • (2001) Eur J Pharm Sci , vol.12 , pp. 205-214
    • Eneroth, A.1    Astrom, E.2    Hoogstraate, J.3
  • 88
    • 28344444695 scopus 로고    scopus 로고
    • Population pharmacokinetic analysis of drug-drug interactions among risperidone, bupropion, and sertraline in CF1 mice
    • Wang JS, DeVane CL, Gibson BB, Donovan JL, Markowitz JS, Zhu HJ. Population pharmacokinetic analysis of drug-drug interactions among risperidone, bupropion, and sertraline in CF1 mice. Psychopharmacology (Berl). 2006;183:490-499.
    • (2006) Psychopharmacology (Berl) , vol.183 , pp. 490-499
    • Wang, J.S.1    DeVane, C.L.2    Gibson, B.B.3    Donovan, J.L.4    Markowitz, J.S.5    Zhu, H.J.6
  • 89
    • 33644868785 scopus 로고    scopus 로고
    • Development, validation and utility of an in vitro technique for assessment of potential clinical drug-drug interactions involving P-glycoprotein
    • Keogh JP, Kunta JR. Development, validation and utility of an in vitro technique for assessment of potential clinical drug-drug interactions involving P-glycoprotein. Eur J Pharm Sci. 2006;27:543-554.
    • (2006) Eur J Pharm Sci , vol.27 , pp. 543-554
    • Keogh, J.P.1    Kunta, J.R.2
  • 90
    • 0031933911 scopus 로고    scopus 로고
    • Toxic digoxin-drug interactions: The major role of renal P-glycoprotein
    • Koren G, Woodland C, Ito S. Toxic digoxin-drug interactions: the major role of renal P-glycoprotein. Vet Hum Toxicol. 1998;40:45-46.
    • (1998) Vet Hum Toxicol , vol.40 , pp. 45-46
    • Koren, G.1    Woodland, C.2    Ito, S.3
  • 91
    • 0036020986 scopus 로고    scopus 로고
    • Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function
    • Leabman MK, Huang CC, Kawamoto M, et al. Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. Pharmacogenetics. 2002;12:395-405.
    • (2002) Pharmacogenetics , vol.12 , pp. 395-405
    • Leabman, M.K.1    Huang, C.C.2    Kawamoto, M.3
  • 92
    • 0042950000 scopus 로고    scopus 로고
    • Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects
    • Dresser GK, Schwarz UI, Wilkinson GR, Kim RB. Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects. Clin Pharmacol Ther. 2003;73:41-50.
    • (2003) Clin Pharmacol Ther , vol.73 , pp. 41-50
    • Dresser, G.K.1    Schwarz, U.I.2    Wilkinson, G.R.3    Kim, R.B.4
  • 93
    • 0033972441 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition
    • Dresser GK, Spence JD, Bailey DG. Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition. Clin Pharmacokinet. 2000;38:41-57.
    • (2000) Clin Pharmacokinet , vol.38 , pp. 41-57
    • Dresser, G.K.1    Spence, J.D.2    Bailey, D.G.3


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