Synthesis and biological activity of 4-alkoxy chalcones: Potential hydrophobic modulators of P-glycoprotein-mediated multidrug resistance

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 12, 1999, Pages 2691-2695

  Bois, Frédéric ^a   Boumendjel, Ahcène ^a   Mariotte, Anne Marie ^a   Conseil, Gwenaëlle ^b   Di Petro, Attilio ^b  

^a UNIV GRENOBLE ALPES   (France)

^b INSTITUT DE BIOLOGIE ET CHIMIE DES PROTÉINES   (France)

Author keywords

Hydrophobic chalcones; Multidrug resistance; P glycoprotein

Indexed keywords

4 ALKOXY 2',4',6' TRIHYDROXYCHALCONE; CHALCONE; CHALCONE DERIVATIVE; GLYCOPROTEIN P; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG ACTIVITY; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HYDROPHOBICITY; MULTIDRUG RESISTANCE; NONHUMAN; PROTEIN DOMAIN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; BINDING SITES; CHALCONE; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, MULTIPLE; MAGNETIC RESONANCE SPECTROSCOPY; P-GLYCOPROTEIN; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033384470     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00218-7     Document Type: Article

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