-
1
-
-
21844454763
-
Stress-induced variation in evolution: From behavioural plasticity to genetic assimilation
-
Badyaev, A.V. Stress-induced variation in evolution: From behavioural plasticity to genetic assimilation. Proc. Biol. Sci. 2005, 272, 877–886
-
(2005)
Proc. Biol. Sci
, vol.272
, pp. 877-886
-
-
Badyaev, A.V.1
-
2
-
-
84881493915
-
The spatial structure of cell signaling systems
-
Nussinov, R. The spatial structure of cell signaling systems. Phys. Biol. 2013, 10, 045004
-
(2013)
Phys. Biol
, vol.10
-
-
Nussinov, R.1
-
3
-
-
84896350648
-
A second molecular biology revolution? The energy landscapes of biomolecular function
-
Nussinov, R.; Wolynes, P.G. A second molecular biology revolution? The energy landscapes of biomolecular function. Phys. Chem. Chem. Phys. 2014, 16, 6321–6322
-
(2014)
Phys. Chem. Chem. Phys
, vol.16
, pp. 6321-6322
-
-
Nussinov, R.1
Wolynes, P.G.2
-
4
-
-
77953153048
-
Regulation of basal cellular physiology by the homeostatic unfolded protein response
-
Rutkowski, D.T.; Hegde, R.S. Regulation of basal cellular physiology by the homeostatic unfolded protein response. J. Cell Biol. 2010, 189, 783–794
-
(2010)
J. Cell Biol
, vol.189
, pp. 783-794
-
-
Rutkowski, D.T.1
Hegde, R.S.2
-
5
-
-
0033200063
-
Protein misfolding, evolution and disease
-
Dobson, C.M. Protein misfolding, evolution and disease. Trends Biochem. Sci. 1999, 24, 329–332
-
(1999)
Trends Biochem. Sci
, vol.24
, pp. 329-332
-
-
Dobson, C.M.1
-
6
-
-
2942627626
-
Hydrophobicity: An ancient damage-associated molecular pattern that initiates innate immune responses
-
Seong, S.Y.; Matzinger, P. Hydrophobicity: An ancient damage-associated molecular pattern that initiates innate immune responses. Nat. Rev. Immunol. 2004, 4, 469–478
-
(2004)
Nat. Rev. Immunol
, vol.4
, pp. 469-478
-
-
Seong, S.Y.1
Matzinger, P.2
-
7
-
-
75349097530
-
Cecchi, C.; et al. A causative link between the structure of aberrant protein oligomers and their toxicity
-
Campioni, S.; Mannini, B.; Zampagni, M.; Pensalfini, A.; Parrini, C.; Evangelisti, E.; Relini, A.; Stefani, M.; Dobson, C.M.; Cecchi, C.; et al. A causative link between the structure of aberrant protein oligomers and their toxicity. Nat. Chem. Biol. 2010, 6, 140–147
-
(2010)
Nat. Chem. Biol
, vol.6
, pp. 140-147
-
-
Campioni, S.1
Mannini, B.2
Zampagni, M.3
Pensalfini, A.4
Parrini, C.5
Evangelisti, E.6
Relini, A.7
Stefani, M.8
Dobson, C.M.9
-
8
-
-
34848929022
-
Favrin, G Structural reorganisation and potential toxicity of oligomeric species formed during the assembly of amyloid fibrils
-
Cheon, M.; Chang, I.; Mohanty, S.; Luheshi, L.M.; Dobson, C.M.; Vendruscolo, M.; Favrin, G Structural reorganisation and potential toxicity of oligomeric species formed during the assembly of amyloid fibrils. PLoS Comput. Biol. 2007, 3, 1727–1738
-
(2007)
Plos Comput. Biol
, vol.3
, pp. 1727-1738
-
-
Cheon, M.1
Chang, I.2
Mohanty, S.3
Luheshi, L.M.4
Dobson, C.M.5
Vendruscolo, M.6
-
9
-
-
78650963274
-
Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions
-
Olzscha, H.; Schermann, S.M.; Woerner, A.C.; Pinkert, S.; Hecht, M.H.; Tartaglia, G.G.; Vendruscolo, M.; Hayer-Hartl, M.; Hartl, F.U.; Vabulas, R.M. Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions. Cell 2011, 144, 67–78
-
(2011)
Cell
, vol.144
, pp. 67-78
-
-
Olzscha, H.1
Schermann, S.M.2
Woerner, A.C.3
Pinkert, S.4
Hecht, M.H.5
Tartaglia, G.G.6
Vendruscolo, M.7
Hayer-Hartl, M.8
Hartl, F.U.9
Vabulas, R.M.10
-
10
-
-
84873809834
-
. Single molecule characterization of the interactions between amyloid-β peptides and the membranes of hippocampal cells
-
Narayan, P.; Ganzinger, K.A.; McColl, J.; Weimann, L.; Meehan, S.; Qamar, S.; Carver, J.A.; Wilson, M.R.; St George-Hyslop, P.; Dobson, C.M. et al. Single molecule characterization of the interactions between amyloid-β peptides and the membranes of hippocampal cells. J. Am Chem. Soc. 2013, 135, 1491–1498
-
(2013)
J. Am Chem. Soc
, vol.135
, pp. 1491-1498
-
-
Narayan, P.1
Ganzinger, K.A.2
McColl, J.3
Weimann, L.4
Meehan, S.5
Qamar, S.6
Carver, J.A.7
Wilson, M.R.8
St George-Hyslop, P.9
Dobson, C.M.10
-
11
-
-
79960066445
-
Proteostasis regulation at the endoplasmic reticulum: A new perturbation site for targeted cancer therapy
-
Liu, Y.; Ye, Y. Proteostasis regulation at the endoplasmic reticulum: A new perturbation site for targeted cancer therapy. Cell Res. 2011, 21, 867–883.
-
(2011)
Cell Res
, vol.21
, pp. 867-883
-
-
Liu, Y.1
Ye, Y.2
-
12
-
-
0037342270
-
Quantitating protein synthesis, degradation, and endogenous antigen processing
-
Princiotta, M.F.; Finzi, D.; Qian, S.B.; Gibbs, J.; Schuchmann, S.; Buttgereit, F.; Bennink, J.R.; Yewdell, J.W. Quantitating protein synthesis, degradation, and endogenous antigen processing Immunity 2003, 18, 343–354
-
(2003)
Immunity
, vol.18
, pp. 343-354
-
-
Princiotta, M.F.1
Finzi, D.2
Qian, S.B.3
Gibbs, J.4
Schuchmann, S.5
Buttgereit, F.6
Bennink, J.R.7
Yewdell, J.W.8
-
13
-
-
84863248733
-
Yang, P.; et al. Regular patterns for proteome-wide distribution of protein abundance across species
-
Zhong, F.; Yang, D.; Hao, Y.; Lin, C.; Jiang, Y.; Ying, W.; Wu, S.; Zhu, Y.; Liu, S.; Yang, P.; et al. Regular patterns for proteome-wide distribution of protein abundance across species PLoS ONE 2012, 7, e32423
-
(2012)
Plos ONE
, vol.7
-
-
Zhong, F.1
Yang, D.2
Hao, Y.3
Lin, C.4
Jiang, Y.5
Ying, W.6
Wu, S.7
Zhu, Y.8
Liu, S.9
-
14
-
-
82255173966
-
The unfolded protein response: From stress pathway to homeostatic regulation
-
Walter, P.; Ron, D. The unfolded protein response: From stress pathway to homeostatic regulation. Science 2011, 334, 1081–1086
-
(2011)
Science
, vol.334
, pp. 1081-1086
-
-
Walter, P.1
Ron, D.2
-
15
-
-
84908018421
-
Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 2. Protein misfolding and ER stress
-
Chambers, J.E.; Marciniak, S.J. Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 2. Protein misfolding and ER stress. Am. J. Physiol. Cell Physiol. 2014, 307, C657–C670
-
(2014)
"');">.
, vol.307
-
-
Chambers, J.E.1
Marciniak, S.J.2
-
16
-
-
84922479583
-
Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 3. Orchestrating the unfolded protein response in oncogenesis: An update
-
Manié, S.N.; Lebeau, J.; Chevet, E. Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 3. Orchestrating the unfolded protein response in oncogenesis: An update. Am. J. Physiol. Cell Physiol. 2014, 307, C901–C907
-
(2014)
"');">.
, vol.307
-
-
Manié, S.N.1
Lebeau, J.2
Chevet, E.3
-
17
-
-
84887620237
-
ER stress-induced cell death mechanisms
-
Sano, R.; Reed, J.C. ER stress-induced cell death mechanisms. Biochim. Biophys. Acta 2013, 1833, 3460–3470
-
(2013)
Biochim. Biophys. Acta
, vol.1833
, pp. 3460-3470
-
-
Sano, R.1
Reed, J.C.2
-
18
-
-
34147102801
-
Chaperones and proteases: Cellular fold-controlling factors of proteins in neurodegenerative diseases and aging
-
Hinault, M.P.; Ben-Zvi, A.; Goloubinoff, P. Chaperones and proteases: Cellular fold-controlling factors of proteins in neurodegenerative diseases and aging. J. Mol. Neurosci. 2006, 30, 249–265
-
(2006)
J. Mol. Neurosci
, vol.30
, pp. 249-265
-
-
Hinault, M.P.1
Ben-Zvi, A.2
Goloubinoff, P.3
-
20
-
-
2542530161
-
Protein chemistry: In the footsteps of alchemists
-
Dobson, M.C. Protein chemistry: In the footsteps of alchemists. Science 2004, 304, 1259–1262
-
(2004)
Science
, vol.304
, pp. 1259-1262
-
-
Dobson, M.C.1
-
21
-
-
0015859467
-
Principles that govern folding of protein chains
-
Anfinsen, C.B. Principles that govern folding of protein chains. Science 1973, 181, 223–230
-
(1973)
Science
, vol.181
, pp. 223-230
-
-
Anfinsen, C.B.1
-
22
-
-
14644435825
-
Intrinsically unstructured proteins and their functions
-
Dyson, H.J.; Wright, P.E. Intrinsically unstructured proteins and their functions. Nat. Rev. Mol Cell Biol. 2005, 6, 197–208
-
(2005)
Nat. Rev. Mol Cell Biol
, vol.6
, pp. 197-208
-
-
Dyson, H.J.1
Wright, P.E.2
-
24
-
-
84924854892
-
From local to global changes in proteins: A network view
-
Vuillon, L.; Lesieur, C. From local to global changes in proteins: A network view. Curr. Opin Struct. Biol. 2015, 31, 1–8
-
(2015)
Curr. Opin Struct. Biol
, vol.31
, pp. 1-8
-
-
Vuillon, L.1
Lesieur, C.2
-
25
-
-
84876266689
-
Allostery in disease and in drug discovery
-
Nussinov, R.; Tsai, C.J. Allostery in disease and in drug discovery. Cell 2013, 153, 293–305
-
(2013)
Cell
, vol.153
, pp. 293-305
-
-
Nussinov, R.1
Tsai, C.J.2
-
26
-
-
11144320699
-
Navigating chemical space for biology and medicine
-
Lipinski, C.; Hopkins, A. Navigating chemical space for biology and medicine. Nature 2004, 432, 855–861
-
(2004)
Nature
, vol.432
, pp. 855-861
-
-
Lipinski, C.1
Hopkins, A.2
-
27
-
-
84874473589
-
Ahmad, A Allostery in the Hsp70 chaperone proteins
-
Zuiderweg, E.R.; Bertelsen, E.B.; Rousaki, A.; Mayer, M.P.; Gestwicki, J.E.; Ahmad, A Allostery in the Hsp70 chaperone proteins. Top. Curr. Chem. 2013, 328, 99–153
-
(2013)
Top. Curr. Chem
, vol.328
, pp. 99-153
-
-
Zuiderweg, E.R.1
Bertelsen, E.B.2
Rousaki, A.3
Mayer, M.P.4
Gestwicki, J.E.5
-
28
-
-
84900410568
-
Multisteric regulation by structural disorder in modular signaling proteins: An extension of the concept of allostery
-
Tompa, P. Multisteric regulation by structural disorder in modular signaling proteins: An extension of the concept of allostery. Chem. Rev. 2014, 114, 6715–6732
-
(2014)
Chem. Rev
, vol.114
, pp. 6715-6732
-
-
Tompa, P.1
-
29
-
-
84925752002
-
Real-time dynamics of emerging actin networks in cell-mimicking compartments
-
Deshpande, S.; Pfohl, T. Real-time dynamics of emerging actin networks in cell-mimicking compartments. PLoS ONE 2015, 10, e011652
-
(2015)
Plos ONE
, vol.10
-
-
Deshpande, S.1
Pfohl, T.2
-
30
-
-
77951620965
-
Spatial organization and signal transduction at intercellular junctions
-
Manz, B.N.; Groves, J.T. Spatial organization and signal transduction at intercellular junctions Nat. Rev. Mol. Cell Biol. 2010, 11, 342–352
-
(2010)
Nat. Rev. Mol. Cell Biol
, vol.11
, pp. 342-352
-
-
Manz, B.N.1
Groves, J.T.2
-
31
-
-
33745712594
-
Why do hubs tend to be essential in protein networks?
-
He, X.; Zhang, J. Why do hubs tend to be essential in protein networks? PLoS Genet. 2006, 2, e88.
-
(2006)
Plos Genet
, vol.2
-
-
He, X.1
Zhang, J.2
-
32
-
-
84907646536
-
. Molecular crowding effects on conformation and stability of G-quadruplex DNA structure: Insights from molecular dynamics simulation
-
Verdian Doghaei, A.; Housaindokht, M.R.; Bozorgmehr, M.R. Molecular crowding effects on conformation and stability of G-quadruplex DNA structure: Insights from molecular dynamics simulation. J. Theor. Biol.2015, 364, 103–112
-
(2015)
J. Theor. Biol
, vol.364
, pp. 103-112
-
-
Verdian Doghaei, A.1
Housaindokht, M.R.2
Bozorgmehr, M.R.3
-
33
-
-
0036725277
-
Molecular dynamics simulations of biomolecules
-
Karplus, M.; McCammon, A.J. Molecular dynamics simulations of biomolecules. Nat. Struct. Biol 2002, 9, 646–652
-
(2002)
Nat. Struct. Biol
, vol.9
, pp. 646-652
-
-
Karplus, M.1
McCammon, A.J.2
-
34
-
-
73349119086
-
Disorder-to-order conformational transitions in protein structure and its relationship to disease
-
Mendoza-Espinosa, P.; García-González, V.; Moreno, A.; Castillo, R.; Mas-Oliva, J Disorder-to-order conformational transitions in protein structure and its relationship to disease Mol. Cell. Biochem. 2009, 330, 105–120
-
(2009)
Mol. Cell. Biochem
, vol.330
, pp. 105-120
-
-
Mendoza-Espinosa, P.1
García-González, V.2
Moreno, A.3
Castillo, R.4
Mas-Oliva, J.5
-
35
-
-
84870065644
-
. Conditional disorder in chaperone action
-
Bardwell, J.C.; Jakob, U. Conditional disorder in chaperone action. Trends Biochem. Sci. 2012, 37, 517–525
-
(2012)
Trends Biochem. Sci
, vol.37
, pp. 517-525
-
-
Bardwell, J.C.1
Jakob, U.2
-
36
-
-
84931007179
-
Intrinsic disorder of human Yin Yang 1 protein
-
Górecki, A.; Bonarek, P.; Górka, A.K.; Figiel, M.; Wilamowski, M.; Dziedzicka-Wasylewska, M Intrinsic disorder of human Yin Yang 1 protein. Proteins 2015, doi:10.1002/prot.24822
-
(2015)
Proteins
-
-
Górecki, A.1
Bonarek, P.2
Górka, A.K.3
Figiel, M.4
Wilamowski, M.5
Dziedzicka-Wasylewska, M.6
-
37
-
-
79953299218
-
Amyloidogenic properties of a D/N mutated 12 amino acid fragment of the C-terminal domain of the Cholesteryl-Ester Transfer Protein (CETP)
-
García-González, V.; Mas-Oliva, J. Amyloidogenic properties of a D/N mutated 12 amino acid fragment of the C-terminal domain of the Cholesteryl-Ester Transfer Protein (CETP). Int. J Mol. Sci. 2011, 12, 2019–2035
-
(2011)
Int. J Mol. Sci
, vol.12
, pp. 2019-2035
-
-
García-González, V.1
Mas-Oliva, J.2
-
38
-
-
84930225080
-
SnapShot: Intrinsic structural disorder
-
Guharoy, M.; Pauwels, K.; Tompa, P. SnapShot: Intrinsic structural disorder. Cell 2015, 161, 1230–1230
-
(2015)
Cell
, vol.161
-
-
Guharoy, M.1
Pauwels, K.2
Tompa, P.3
-
39
-
-
84883471917
-
From sequence and forces to structure, function, and evolution of intrinsically disordered proteins
-
Forman-Kay, J.D.; Mittag, T. From sequence and forces to structure, function, and evolution of intrinsically disordered proteins. Structure 2013, 21, 1492–1499
-
(2013)
Structure
, vol.21
, pp. 1492-1499
-
-
Forman-Kay, J.D.1
Mittag, T.2
-
41
-
-
57049095821
-
Function and structure of inherently disordered proteins
-
Dunker, A.K.; Silman, I.; Uversky, V.N.; Sussman, J.L. Function and structure of inherently disordered proteins. Curr. Opin. Struct. Biol. 2008, 18, 756–764
-
(2008)
Curr. Opin. Struct. Biol
, vol.18
, pp. 756-764
-
-
Dunker, A.K.1
Silman, I.2
Uversky, V.N.3
Sussman, J.L.4
-
42
-
-
65249102824
-
Close encounters of the third kind: Disordered domains and the interactions of proteins
-
Tompa, P.; Fuxreiter, M.; Oldfield, C.J.; Simon, I.; Dunker, A.K.; Uversky, V.N. Close encounters of the third kind: Disordered domains and the interactions of proteins. BioEssays 2009, 31, 328–335
-
(2009)
Bioessays
, vol.31
, pp. 328-335
-
-
Tompa, P.1
Fuxreiter, M.2
Oldfield, C.J.3
Simon, I.4
Dunker, A.K.5
Uversky, V.N.6
-
43
-
-
33846099868
-
-
Sickmeier, M.; Hamilton, J.A.; LeGall, T.; Vacic, V.; Cortese, M.S.; Tantos, A.; Szabo, B.; Tompa, P.; Chen, J.; Uversky, V.N. et al. DisProt: The database of disordered proteins Nucleic Acids Res. 2007, 35, D786–D793
-
(2007)
Nucleic Acids Res
, vol.35
-
-
Sickmeier, M.1
Hamilton, J.A.2
Legall, T.3
Vacic, V.4
Cortese, M.S.5
Tantos, A.6
Szabo, B.7
Tompa, P.8
Chen, J.9
Uversky, V.N.10
-
44
-
-
82655181911
-
Intrinsic disorder in cell signaling and gene transcription
-
Tantos, A.; Han, K.H.; Tompa, P. Intrinsic disorder in cell signaling and gene transcription Mol. Cell. Endocrinol. 2012, 348, 457–465
-
(2012)
Mol. Cell. Endocrinol
, vol.348
, pp. 457-465
-
-
Tantos, A.1
Han, K.H.2
Tompa, P.3
-
45
-
-
34347235156
-
Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins. Proc. Natl. Acad. Sci
-
Hilser, V.J.; Thompson, E.B. Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins. Proc. Natl. Acad. Sci. USA 2007, 104, 8311–8315
-
(2007)
USA
, vol.104
, pp. 8311-8315
-
-
Hilser, V.J.1
Thompson, E.B.2
-
46
-
-
84879327823
-
Modulation of allostery by protein intrinsic disorder
-
Ferreon, A.C.; Ferreon, J.C.; Wright, P.E.; Deniz, A.A. Modulation of allostery by protein intrinsic disorder. Nature 2013, 498, 390–394
-
(2013)
Nature
, vol.498
, pp. 390-394
-
-
Ferreon, A.C.1
Ferreon, J.C.2
Wright, P.E.3
Deniz, A.A.4
-
47
-
-
23944514504
-
Structural disorder throws new light on moonlighting
-
Tompa, P.; Szász, C.; Buday, L. Structural disorder throws new light on moonlighting Trends Biochem. Sci. 2005, 30, 484–489
-
(2005)
Trends Biochem. Sci
, vol.30
, pp. 484-489
-
-
Tompa, P.1
Szász, C.2
Buday, L.3
-
48
-
-
71749098088
-
-
Gould, C.M.; Diella, F.; Via, A.; Puntervoll, P.; Gemünd, C.; Chabanis-Davidson, S.; Michael, S.; Sayadi, A.; Bryne, J.C.; Chica, C. et al. ELM: The status of the 2010 eukaryotic linear motif resource. Nucleic Acids Res. 2010, 38, D167–D180.
-
(2010)
Nucleic Acids Res
, vol.38
-
-
Gould, C.M.1
Diella, F.2
Via, A.3
Puntervoll, P.4
Gemünd, C.5
Chabanis-Davidson, S.6
Michael, S.7
Sayadi, A.8
Bryne, J.C.9
Chica, C.10
-
49
-
-
49749117432
-
Contextual specificity in peptide-mediated protein interactions
-
Stein, A.; Aloy, P. Contextual specificity in peptide-mediated protein interactions. PLoS ONE 2008, 3, e2524
-
(2008)
Plos ONE
, vol.3
-
-
Stein, A.1
Aloy, P.2
-
50
-
-
1542358787
-
Prediction and functional analysis of native disorder in proteins from the three kingdoms of life
-
Ward, J.J.; Sodhi, J.S.; McGuffin, L.J.; Buxton, B.F.; Jones, D.T. Prediction and functional analysis of native disorder in proteins from the three kingdoms of life. J. Mol. Biol. 2004, 337, 635–645
-
(2004)
J. Mol. Biol
, vol.337
, pp. 635-645
-
-
Ward, J.J.1
Sodhi, J.S.2
McGuffin, L.J.3
Buxton, B.F.4
Jones, D.T.5
-
51
-
-
34548448958
-
Inferring function using patterns of native disorder in proteins
-
Lobley, A.; Swindells, M.B.; Orengo, C.A.; Jones, D.T. Inferring function using patterns of native disorder in proteins. PLoS Comput. Biol. 2007, 3, e162
-
(2007)
Plos Comput. Biol
, vol.3
-
-
Lobley, A.1
Swindells, M.B.2
Orengo, C.A.3
Jones, D.T.4
-
52
-
-
0031616362
-
Protein disorder and the evolution of molecular recognition: Theory, predictions and observations
-
Dunker, A.K.; Garner, E.; Guilliot, S.; Romero, P.; Albrecht, K.; Hart, J.; Obradovic, Z.; Kissinger, C.; Villafranca, J.E. Protein disorder and the evolution of molecular recognition: Theory, predictions and observations. Pac. Symp. Biocomput. 1998, 473–484
-
(1998)
Pac. Symp. Biocomput
, pp. 473-484
-
-
Dunker, A.K.1
Garner, E.2
Guilliot, S.3
Romero, P.4
Albrecht, K.5
Hart, J.6
Obradovic, Z.7
Kissinger, C.8
Villafranca, J.E.9
-
53
-
-
40949117264
-
Flexible nets: Disorder and induced fit in the associations of p53 and 14-3-3 with their partners
-
Oldfield, C.J.; Meng, J.; Yang, J.Y.; Yang, M.Q.; Uversky, V.N.; Dunker, A.K. Flexible nets: Disorder and induced fit in the associations of p53 and 14-3-3 with their partners. BMC Genomics 2008, 9, S1
-
(2008)
BMC Genomics
, vol.9
-
-
Oldfield, C.J.1
Meng, J.2
Yang, J.Y.3
Yang, M.Q.4
Uversky, V.N.5
Dunker, A.K.6
-
54
-
-
84864424878
-
-
Andresen, C.; Helander, S.; Lemak, A.; Farès, C.; Csizmok, V.; Carlsson, J.; Penn, L.Z.; Forman-Kay, J.D.; Arrowsmith, C.H.; Lundström, P. et al. Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding. Nucleic Acids Res. 2012, 40, 6353–6266
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 6266-6353
-
-
Andresen, C.1
Helander, S.2
Lemak, A.3
Farès, C.4
Csizmok, V.5
Carlsson, J.6
Penn, L.Z.7
Forman-Kay, J.D.8
Arrowsmith, C.H.9
Lundström, P.10
-
55
-
-
0036803243
-
Intrinsically unstructured proteins
-
Tompa, P. Intrinsically unstructured proteins. Trends Biochem. Sci. 2002, 27, 527–533
-
(2002)
Trends Biochem. Sci
, vol.27
, pp. 527-533
-
-
Tompa, P.1
-
56
-
-
0038148710
-
Conformational diversity and protein evolution—A 60-year-old hypothesis revisited
-
James, C.; Tawfik, D.S. Conformational diversity and protein evolution—A 60-year-old hypothesis revisited. Trends Biochem. Sci. 2003, 28, 361–368
-
(2003)
Trends Biochem. Sci
, vol.28
, pp. 361-368
-
-
James, C.1
Tawfik, D.S.2
-
57
-
-
33645034035
-
Intrinsic disorder is a key characteristic in partners that bind 14-3-3 proteins
-
Bustos, D.M.; Iglesias, A.A. Intrinsic disorder is a key characteristic in partners that bind 14-3-3 proteins. Proteins 2006, 63, 35–42
-
(2006)
Proteins
, vol.63
, pp. 35-42
-
-
Bustos, D.M.1
Iglesias, A.A.2
-
58
-
-
0029662315
-
Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: Conformational disorder mediates binding diversity
-
Kriwacki, R.W.; Hengst, L.; Tennant, L.; Reed, S.I.; Wright, P.E. Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: Conformational disorder mediates binding diversity. Proc. Natl. Acad. Sci. USA1996, 93, 11504–11509
-
(1996)
"');">.
, vol.93
, pp. 11504-11509
-
-
Kriwacki, R.W.1
Hengst, L.2
Tennant, L.3
Reed, S.I.4
Wright, P.E.5
-
59
-
-
0033815822
-
Understanding the sequence determinants of conformational switching using protein design
-
Dalal, S.; Regan, L. Understanding the sequence determinants of conformational switching using protein design. Protein Sci. 2000, 9, 1651–1659
-
(2000)
Protein Sci
, vol.9
, pp. 1651-1659
-
-
Dalal, S.1
Regan, L.2
-
60
-
-
33748272622
-
Rational drug design via intrinsically disordered protein
-
Cheng, Y.; LeGall, T.; Oldfield, C.J.; Mueller, J.P.; Van, Y.Y.; Romero, P.; Cortese, M.S.; Uversky, V.N.; Dunker, A.K. Rational drug design via intrinsically disordered protein Trends Biotechnol. 2006, 2, 435–442
-
(2006)
Trends Biotechnol
, vol.2
, pp. 435-442
-
-
Cheng, Y.1
Legall, T.2
Oldfield, C.J.3
Mueller, J.P.4
Van, Y.Y.5
Romero, P.6
Cortese, M.S.7
Uversky, V.N.8
Dunker, A.K.9
-
61
-
-
0038341134
-
A broken α-helix in folded α-synuclein
-
Chandra, S.; Chen, X.; Rizo, J.; Jahn, R.; Sudhof, T.C. A broken α-helix in folded α-synuclein J. Biol. Chem. 2003, 278, 15313–15318
-
(2003)
J. Biol. Chem
, vol.278
, pp. 15313-15318
-
-
Chandra, S.1
Chen, X.2
Rizo, J.3
Jahn, R.4
Sudhof, T.C.5
-
62
-
-
0031932169
-
Protein aggregation: Folding aggregates, inclusion bodies and amyloid
-
Fink, A.L. Protein aggregation: Folding aggregates, inclusion bodies and amyloid. Fold. Des 1998, 3, R9–R23
-
(1998)
Fold. Des
, vol.3
-
-
Fink, A.L.1
-
63
-
-
84858374665
-
The amyloid state of proteins in human diseases
-
Eisenberg, D.; Jucker, M. The amyloid state of proteins in human diseases. Cell 2012, 148, 1188–1203
-
(2012)
Cell
, vol.148
, pp. 1188-1203
-
-
Eisenberg, D.1
Jucker, M.2
-
64
-
-
33748688511
-
Protein denaturation and aggregation: Cellular responses to denatured and aggregated proteins
-
Meredith, S.C. Protein denaturation and aggregation: Cellular responses to denatured and aggregated proteins. Ann. N. Y. Acad. Sci. 2005, 1066, 181–221
-
(2005)
Ann. N. Y. Acad. Sci
, vol.1066
, pp. 181-221
-
-
Meredith, S.C.1
-
65
-
-
33746377894
-
Protein misfolding, functional amyloid, and human disease
-
Chiti, F.; Dobson, C.M. Protein misfolding, functional amyloid, and human disease Annu. Rev. Biochem. 2006, 75, 333–366
-
(2006)
Annu. Rev. Biochem
, vol.75
, pp. 333-366
-
-
Chiti, F.1
Dobson, C.M.2
-
66
-
-
0347357617
-
Protein folding and misfolding
-
Dobson, C.M. Protein folding and misfolding. Nature 2003, 426, 884–890.
-
(2003)
Nature
, vol.426
, pp. 884-890
-
-
Dobson, C.M.1
-
67
-
-
34249290108
-
-
Sawaya, M.R.; Sambashivan, S.; Nelson, R.; Ivanova, M.I.; Sievers, S.A.; Apostol, M.I.; Thompson, M.J.; Balbirnie, M.; Wiltzius, J.J.; McFarlane, H.T. et al. Atomic structures of amyloid cross-β spines reveal varied steric zippers. Nature 2007, 447, 453–457
-
(2007)
Nature
, vol.447
, pp. 453-457
-
-
Sawaya, M.R.1
Sambashivan, S.2
Nelson, R.3
Ivanova, M.I.4
Sievers, S.A.5
Apostol, M.I.6
Thompson, M.J.7
Balbirnie, M.8
Wiltzius, J.J.9
McFarlane, H.T.10
-
68
-
-
84875871051
-
Atomic structure and hierarchical assembly of a cross-β amyloid fibril
-
Fitzpatrick, A.W.P.; Debelouchina, G.T.; Bayro, M.J.; Clare, D.K.; Caporini, M.A.; Bajaj, V.S.; Jaroniec, C.P.; Wang, L.; Ladizhansky, V.; Müller, S.A. Atomic structure and hierarchical assembly of a cross-β amyloid fibril. Proc. Natl Acad. Sci. USA 2013, 110, 5468–5473
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 5468-5473
-
-
Fitzpatrick, A.1
Debelouchina, G.T.2
Bayro, M.J.3
Clare, D.K.4
Caporini, M.A.5
Bajaj, V.S.6
Jaroniec, C.P.7
Wang, L.8
Ladizhansky, V.9
Müller, S.A.10
-
69
-
-
37549063068
-
Role of intermolecular forces in defining material properties of protein nanofibrils
-
Knowles, T.P.; Fitzpatrick, A.W.; Meehan, S.; Mott, H.R.; Vendruscolo, M.; Dobson, C.M.; Welland, M.E. Role of intermolecular forces in defining material properties of protein nanofibrils. Science 2007, 318, 1900–1903
-
(2007)
Science
, vol.318
, pp. 1900-1903
-
-
Knowles, T.P.1
Fitzpatrick, A.W.2
Meehan, S.3
Mott, H.R.4
Vendruscolo, M.5
Dobson, C.M.6
Welland, M.E.7
-
70
-
-
84937759580
-
Structure of a single-chain fv bound to the 17 N-terminal residues of huntingtin provides insights into pathogenic amyloid formation and suppression
-
De Genst, E.; Chirgadze, D.Y.; Klein, F.A.; Butler, D.C.; Matak-Vinković, D.; Trottier, Y.; Huston, J.S.; Messer, A.; Dobson, C.M. Structure of a single-chain fv bound to the 17 N-terminal residues of huntingtin provides insights into pathogenic amyloid formation and suppression J. Mol. Biol.2015, 427, 2166–2178
-
(2015)
J. Mol. Biol
, vol.427
, pp. 2166-2178
-
-
De Genst, E.1
Chirgadze, D.Y.2
Klein, F.A.3
Butler, D.C.4
Matak-Vinković, D.5
Trottier, Y.6
Huston, J.S.7
Messer, A.8
Dobson, C.M.9
-
71
-
-
84864288105
-
On the possible amyloid origin of protein folds
-
Greenwald, J.; Riek, R. On the possible amyloid origin of protein folds. J. Mol. Biol. 2012, 421, 417–426
-
(2012)
J. Mol. Biol
, vol.421
, pp. 417-426
-
-
Greenwald, J.1
Riek, R.2
-
72
-
-
21744439797
-
A model for the role of short self-assembled peptides in the very early stages of the origin of life
-
Carny, O.; Gazit, E. A model for the role of short self-assembled peptides in the very early stages of the origin of life. FASEB J. 2005, 19, 1051–1055
-
(2005)
FASEB J
, vol.19
, pp. 1051-1055
-
-
Carny, O.1
Gazit, E.2
-
73
-
-
34247899121
-
Functional amyloid—From bacteria to humans
-
Fowler, D.M.; Koulov, A.V.; Balch, W.E.; Kelly, J.W. Functional amyloid—From bacteria to humans. Trends Biochem. Sci. 2007, 32, 217–224
-
(2007)
Trends Biochem. Sci
, vol.32
, pp. 217-224
-
-
Fowler, D.M.1
Koulov, A.V.2
Balch, W.E.3
Kelly, J.W.4
-
74
-
-
0036845354
-
The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation
-
Fandrich, M.; Dobson, C.M. The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation. EMBO J. 2002, 21, 5682–5690
-
(2002)
EMBO J
, vol.21
, pp. 5682-5690
-
-
Fandrich, M.1
Dobson, C.M.2
-
75
-
-
0036468673
-
Hultgren, S.J. Role of Escherichia coli curli operons in directing amyloid fiber formation
-
Chapman, M.R.; Robinson, L.S.; Pinkner, J.S.; Roth, R.; Heuser, J.; Hammar, M.; Normark, S.; Hultgren, S.J. Role of Escherichia coli curli operons in directing amyloid fiber formation Science 2002, 295, 851–855
-
(2002)
Science
, vol.295
, pp. 851-855
-
-
Chapman, M.R.1
Robinson, L.S.2
Pinkner, J.S.3
Roth, R.4
Heuser, J.5
Hammar, M.6
Normark, S.7
-
76
-
-
0038004458
-
A novel class of secreted hydrophobic proteins is involved in aerial hyphae formation in Streptomyces coelicolor by forming amyloid-like fibrils
-
Claessen, D.; Rink, R.; de Jong, W.; Siebring, J.; de Vreugd, P.; Boersma, F.G.; Dijkhuizen, L.; Wosten, H.A. A novel class of secreted hydrophobic proteins is involved in aerial hyphae formation in Streptomyces coelicolor by forming amyloid-like fibrils. Genes Dev. 2003, 17, 1714–1726
-
(2003)
Genes Dev
, vol.17
, pp. 1714-1726
-
-
Claessen, D.1
Rink, R.2
De Jong, W.3
Siebring, J.4
De Vreugd, P.5
Boersma, F.G.6
Dijkhuizen, L.7
Wosten, H.A.8
-
77
-
-
0035089501
-
The hydrophobin EAS is largely unstructured in solution and functions by forming amyloid-like structures
-
Mackay, J.P.; Matthews, J.M.; Winefield, R.D.; Mackay, L.G.; Haverkamp, R.G.; Templeton, M.D The hydrophobin EAS is largely unstructured in solution and functions by forming amyloid-like structures. Structure 2001, 9, 83–91
-
(2001)
Structure
, vol.9
, pp. 83-91
-
-
Mackay, J.P.1
Matthews, J.M.2
Winefield, R.D.3
Mackay, L.G.4
Haverkamp, R.G.5
Templeton, M.D.6
-
78
-
-
0030885650
-
The protein product of the het-s heterokaryon incompatibility gene of the fungus Podospora anserina behaves as a prion analog
-
Coustou, V.; Deleu, C.; Saupe, S.; Begueret, J. The protein product of the het-s heterokaryon incompatibility gene of the fungus Podospora anserina behaves as a prion analog. Proc. Natl Acad. Sci. USA 1997, 94, 9773–9778
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 9773-9778
-
-
Coustou, V.1
Deleu, C.2
Saupe, S.3
Begueret, J.4
-
79
-
-
0030917006
-
Prion-inducing domain 2–114 of yeast Sup35 protein transforms in vitro into amyloid-like filaments
-
King, C.Y.; Tittmann, P.; Gross, H.; Gebert, R.; Aebi, M.; Wüthrich, K. Prion-inducing domain 2–114 of yeast Sup35 protein transforms in vitro into amyloid-like filaments. Proc. Natl. Acad Sci. USA 1997, 94, 6618–6622
-
(1997)
Proc. Natl. Acad Sci. USA
, vol.94
, pp. 6618-6622
-
-
King, C.Y.1
Tittmann, P.2
Gross, H.3
Gebert, R.4
Aebi, M.5
Wüthrich, K.6
-
80
-
-
0034683126
-
Amyloids protect the silkmoth oocyte and embryo
-
Iconomidou, V.A.; Vriend, G.; Hamodrakas, S.J. Amyloids protect the silkmoth oocyte and embryo. FEBS Lett. 2000, 479, 141–145.
-
(2000)
FEBS Lett
, vol.479
, pp. 141-145
-
-
Iconomidou, V.A.1
Vriend, G.2
Hamodrakas, S.J.3
-
81
-
-
33750994604
-
Amyloid fibril formation propensity is inherent into the hexapeptide tandemly repeating sequence of the central domain of silkmoth chorion proteins of the A-family
-
Iconomidou, V.A.; Chryssikos, G.D.; Gionis, V.; Galanis, A.S.; Cordopatis, P.; Hoenger, A.; Hamodrakas, S.J. Amyloid fibril formation propensity is inherent into the hexapeptide tandemly repeating sequence of the central domain of silkmoth chorion proteins of the A-family J. Struct. Biol.2006, 156, 480–488
-
(2006)
J. Struct. Biol
, vol.156
, pp. 480-488
-
-
Iconomidou, V.A.1
Chryssikos, G.D.2
Gionis, V.3
Galanis, A.S.4
Cordopatis, P.5
Hoenger, A.6
Hamodrakas, S.J.7
-
82
-
-
0037986392
-
Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis
-
Berson, J.F.; Theos, A.C.; Harper, D.C.; Tenza, D.; Raposo, G.; Marks, M.S. Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis. J. Cell Biol.2003, 161, 521–533
-
(2003)
J. Cell Biol
, vol.161
, pp. 521-533
-
-
Berson, J.F.1
Theos, A.C.2
Harper, D.C.3
Tenza, D.4
Raposo, G.5
Marks, M.S.6
-
83
-
-
0027986793
-
The Pmel 17/silver locus protein. Characterization and investigation of its melanogenic function
-
Kobayashi, T.; Urabe, K.; Orlow, S.J.; Higashi, K.; Imokawa, G.; Kwon, B.S.; Potterf, B.; Hearing, V.J. The Pmel 17/silver locus protein. Characterization and investigation of its melanogenic function. J. Biol. Chem.1994, 269, 29198–29205
-
(1994)
J. Biol. Chem
, vol.269
, pp. 29198-29205
-
-
Kobayashi, T.1
Urabe, K.2
Orlow, S.J.3
Higashi, K.4
Imokawa, G.5
Kwon, B.S.6
Potterf, B.7
Hearing, V.J.8
-
84
-
-
0344944630
-
Protein aggregation and aggregate toxicity: New insights into protein folding, misfolding diseases and biological evolution
-
Stefani, M.; Dobson, C.M. Protein aggregation and aggregate toxicity: New insights into protein folding, misfolding diseases and biological evolution. J. Mol. Med. 2003, 81, 678–699
-
(2003)
J. Mol. Med
, vol.81
, pp. 678-699
-
-
Stefani, M.1
Dobson, C.M.2
-
85
-
-
84876807340
-
Amyloid fibril formation of peptides derived from the C-terminus of CETP modulated by lipids
-
García-González, V.; Mas-Oliva, J. Amyloid fibril formation of peptides derived from the C-terminus of CETP modulated by lipids. Biochem. Biophys. Res. Commun. 2013, 434, 54–59
-
(2013)
Biochem. Biophys. Res. Commun
, vol.434
, pp. 54-59
-
-
García-González, V.1
Mas-Oliva, J.2
-
86
-
-
5044235541
-
Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins
-
Fernandez-Escamilla, A.M.; Rousseau, F.; Schymkowitz, J.; Serrano, L. Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins Nat. Biotechnol. 2004, 22, 1302–1306
-
(2004)
Nat. Biotechnol
, vol.22
, pp. 1302-1306
-
-
Fernandez-Escamilla, A.M.1
Rousseau, F.2
Schymkowitz, J.3
Serrano, L.4
-
87
-
-
20444403757
-
Prediction of “aggregation-prone” and “aggregation-susceptible” regions in proteins associated with neurodegenerative diseases
-
Pawar, A.P.; Dubay, K.F.; Zurdo, J.; Chiti, F.; Vendruscolo, M.; Dobson, C.M. Prediction of “aggregation-prone” and “aggregation-susceptible” regions in proteins associated with neurodegenerative diseases. J. Mol. Biol.2005, 350, 379–392
-
(2005)
J. Mol. Biol
, vol.350
, pp. 379-392
-
-
Pawar, A.P.1
Dubay, K.F.2
Zurdo, J.3
Chiti, F.4
Vendruscolo, M.5
Dobson, C.M.6
-
88
-
-
33846990935
-
Friendly and dangerous signals: Is the tissue in control?
-
Matzinger, P. Friendly and dangerous signals: Is the tissue in control? Nat. Immunol.2007, 8, 11–13
-
(2007)
Nat. Immunol
, vol.8
, pp. 11-13
-
-
Matzinger, P.1
-
89
-
-
39349083915
-
. Adapting proteostasis for disease intervention
-
Balch, W.E.; Morimoto, R.I.; Dillin, A.; Kelly, J.W. Adapting proteostasis for disease intervention Science 2008, 319, 916–919
-
(2008)
Science
, vol.319
, pp. 916-919
-
-
Balch, W.E.1
Morimoto, R.I.2
Dillin, A.3
Kelly, J.W.4
-
90
-
-
84878948560
-
Molecular chaperone functions in protein folding and proteostasis
-
Kim, Y.E.; Hipp, M.S.; Bracher, A.; Hayer-Hartl, M.; Hartl, F.U. Molecular chaperone functions in protein folding and proteostasis. Annu. Rev. Biochem. 2013, 82, 323–355
-
(2013)
Annu. Rev. Biochem
, vol.82
, pp. 323-355
-
-
Kim, Y.E.1
Hipp, M.S.2
Bracher, A.3
Hayer-Hartl, M.4
Hartl, F.U.5
-
91
-
-
84863958621
-
Protein solubility and protein homeostasis: A generic view of protein misfolding disorders
-
Vendruscolo, M.; Knowles, T.P.J.; Dobson, C.M. Protein solubility and protein homeostasis: A generic view of protein misfolding disorders. Cold Spring Harb. Perspect. Biol. 2011, 3, a010454
-
Cold Spring Harb. Perspect. Biol
, vol.3
-
-
Vendruscolo, M.1
Knowles, T.2
Dobson, C.M.3
-
92
-
-
84901355639
-
The amyloid state and its association with protein misfolding diseases
-
Knowles, T.P.; Vendruscolo, M.; Dobson, C.M. The amyloid state and its association with protein misfolding diseases. Nat. Rev. Mol. Cell Biol. 2014, 15, 384–396
-
(2014)
Nat. Rev. Mol. Cell Biol
, vol.15
, pp. 384-396
-
-
Knowles, T.P.1
Vendruscolo, M.2
Dobson, C.M.3
-
93
-
-
84861139210
-
DnaK functions as a central hub in the E. Coli chaperone network
-
Calloni, G.; Chen, T.; Schermann, S.M.; Chang, H.-C.; Genevaux, P.; Agostini, F.; Tartaglia, G.G.; Hayer-Hartl, M.; Hartl, F.U. DnaK functions as a central hub in the E. coli chaperone network Cell Rep. 2012, 1, 251–264
-
(2012)
Cell Rep
, vol.1
, pp. 251-264
-
-
Calloni, G.1
Chen, T.2
Schermann, S.M.3
Chang, H.-C.4
Genevaux, P.5
Agostini, F.6
Tartaglia, G.G.7
Hayer-Hartl, M.8
Hartl, F.U.9
-
94
-
-
84872577837
-
The cotranslational function of ribosome-associated Hsp70 in eukaryotic protein homeostasis
-
Willmund, F.; del Alamo, M.; Pechmann, S.; Chen, T.; Albanese, V.; Dammer, E.B.; Peng, J.; Frydman, J. The cotranslational function of ribosome-associated Hsp70 in eukaryotic protein homeostasis. Cell 2013, 152, 196–209
-
(2013)
Cell
, vol.152
, pp. 196-209
-
-
Willmund, F.1
Del Alamo, M.2
Pechmann, S.3
Chen, T.4
Albanese, V.5
Dammer, E.B.6
Peng, J.7
Frydman, J.8
-
95
-
-
79551687316
-
Protein folding in the cell: Challenges and progress
-
Gershenson, A.; Gierasch, L.M. Protein folding in the cell: Challenges and progress. Curr. Opin Struct. Biol. 2011, 21, 32–41
-
(2011)
Curr. Opin Struct. Biol
, vol.21
, pp. 32-41
-
-
Gershenson, A.1
Gierasch, L.M.2
-
96
-
-
79960652801
-
Molecular chaperones in protein folding and proteostasis
-
Hartl, F.U.; Bracher, A.; Hayer-Hartl, M. Molecular chaperones in protein folding and proteostasis. Nature 2011, 475, 324–332
-
(2011)
Nature
, vol.475
, pp. 324-332
-
-
Hartl, F.U.1
Bracher, A.2
Hayer-Hartl, M.3
-
97
-
-
4344568810
-
Protein crystallization and phase diagrams
-
Asherie, N. Protein crystallization and phase diagrams. Methods 2004, 34, 266–272.
-
(2004)
Methods
, vol.34
, pp. 266-272
-
-
Asherie, N.1
-
98
-
-
84883049362
-
Proteomic data from human cell cultures refine mechanisms of chaperone-mediated protein homeostasis
-
Finka, A.; Goloubinoff, P. Proteomic data from human cell cultures refine mechanisms of chaperone-mediated protein homeostasis. Cell Stress Chaperones 2013, 18, 591–605
-
(2013)
Cell Stress Chaperones
, vol.18
, pp. 591-605
-
-
Finka, A.1
Goloubinoff, P.2
-
99
-
-
84863230577
-
Order out of disorder: Working cycle of an intrinsically unfolded chaperone
-
Reichmann, D.; Xu, Y.; Cremers, C.M.; Ilbert, M.; Mittelman, R.; Fitzgerald, M.C.; Jakob, U Order out of disorder: Working cycle of an intrinsically unfolded chaperone. Cell 2012, 148, 947–957
-
(2012)
Cell
, vol.148
, pp. 947-957
-
-
Reichmann, D.1
Xu, Y.2
Cremers, C.M.3
Ilbert, M.4
Mittelman, R.5
Fitzgerald, M.C.6
Jakob, U.7
-
100
-
-
78650731442
-
-
Rosenbaum, J.C.; Fredrickson, E.K.; Oeser, M.L.; Garrett-Engele, C.M.; Locke, M.N.; Richardson, L.A.; Nelson, Z.W.; Hetrick, E.D.; Milac, T.I.; Gottschling, D.E. et al. Disorder targets misorder in nuclear quality control degradation: A disordered ubiquitin ligase directly recognizes its misfolded substrates. Mol. Cell 2011, 41, 93–106
-
(2011)
Mol. Cell
, vol.41
, pp. 93-106
-
-
Rosenbaum, J.C.1
Fredrickson, E.K.2
Oeser, M.L.3
Garrett-Engele, C.M.4
Locke, M.N.5
Richardson, L.A.6
Nelson, Z.W.7
Hetrick, E.D.8
Milac, T.I.9
Gottschling, D.E.10
-
101
-
-
77955506092
-
Gymnastics of molecular chaperones
-
Mayer, M.P. Gymnastics of molecular chaperones. Mol. Cell 2010, 39, 321–331
-
(2010)
Mol. Cell
, vol.39
, pp. 321-331
-
-
Mayer, M.P.1
-
102
-
-
33745829795
-
Molecular chaperones: Assisting assembly in addition to folding
-
Ellis, R.J. Molecular chaperones: Assisting assembly in addition to folding. Trends Biochem. Sci 2006, 31, 395–401
-
(2006)
Trends Biochem. Sci
, vol.31
, pp. 395-401
-
-
Ellis, R.J.1
-
103
-
-
39149143645
-
Chaperone machines in action
-
Saibil, H.R. Chaperone machines in action. Curr. Opin. Struct. Biol. 2008, 18, 35–42
-
(2008)
Curr. Opin. Struct. Biol
, vol.18
, pp. 35-42
-
-
Saibil, H.R.1
-
104
-
-
49649117517
-
The Hsp90 chaperone machinery
-
Wandinger, S.K.; Richter, K.; Buchner, J. The Hsp90 chaperone machinery. J. Biol. Chem. 2008, 283, 18473–18477
-
(2008)
J. Biol. Chem
, vol.283
, pp. 18473-18477
-
-
Wandinger, S.K.1
Richter, K.2
Buchner, J.3
-
105
-
-
66649132872
-
Chaperonin overexpression promotes genetic variation and enzyme evolution
-
Tokuriki, N.; Tawfik, D.S. Chaperonin overexpression promotes genetic variation and enzyme evolution. Nature 2009, 459, 668–671
-
(2009)
Nature
, vol.459
, pp. 668-671
-
-
Tokuriki, N.1
Tawfik, D.S.2
-
106
-
-
0032569851
-
Hsp90 as a capacitor for morphological evolution
-
Rutherford, S.L.; Lindquist, S. Hsp90 as a capacitor for morphological evolution. Nature 1998, 396, 336–342
-
(1998)
Nature
, vol.396
, pp. 336-342
-
-
Rutherford, S.L.1
Lindquist, S.2
-
107
-
-
0036049850
-
The unfolding story of the Escherichia coli Hsp70 DnaK: Is DnaK a holdase or an unfoldase?
-
Slepenkov, S.V.; Witt, S.N. The unfolding story of the Escherichia coli Hsp70 DnaK: Is DnaK a holdase or an unfoldase? Mol. Microbiol.2002, 45, 1197–1206
-
(2002)
Mol. Microbiol
, vol.45
, pp. 1197-1206
-
-
Slepenkov, S.V.1
Witt, S.N.2
-
108
-
-
33749244758
-
The molecular chaperone Hsp104—A molecular machine for protein disaggregation
-
Bosl, B.; Grimminger, V.; Walter, S. The molecular chaperone Hsp104—A molecular machine for protein disaggregation. J. Struct. Biol. 2006, 156, 139–148
-
(2006)
J. Struct. Biol
, vol.156
, pp. 139-148
-
-
Bosl, B.1
Grimminger, V.2
Walter, S.3
-
109
-
-
0026596223
-
Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding
-
Langer, T.; Lu, C.; Echols, H.; Flanagan, J.; Hayer, M.K.; Hartl, F.U. Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding. Nature 1992, 356, 683–689
-
(1992)
Nature
, vol.356
, pp. 683-689
-
-
Langer, T.1
Lu, C.2
Echols, H.3
Flanagan, J.4
Hayer, M.K.5
Hartl, F.U.6
-
110
-
-
70350020881
-
Chaperonin-mediated protein folding: Using a central cavity to kinetically assist polypeptide chain folding
-
Horwich, A.L.; Fenton, W.A. Chaperonin-mediated protein folding: Using a central cavity to kinetically assist polypeptide chain folding. Q. Rev. Biophys.2009, 42, 83–116
-
(2009)
Q. Rev. Biophys
, vol.42
, pp. 83-116
-
-
Horwich, A.L.1
Fenton, W.A.2
-
111
-
-
84898939969
-
Protein chaperones: A composition of matter review (2008–2013)
-
Taldone, T.; Patel, H.J.; Bolaender, A.; Patel, M.R.; Chiosis, G. Protein chaperones: A composition of matter review (2008–2013). Expert Opin. Ther. Pat. 2014, 24, 501–518
-
(2014)
Expert Opin. Ther. Pat
, vol.24
, pp. 501-518
-
-
Taldone, T.1
Patel, H.J.2
Bolaender, A.3
Patel, M.R.4
Chiosis, G.5
-
112
-
-
80052177927
-
Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor
-
Yan, M.; Li, J.; Sha, B. Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor. Biochem. J. 2011, 438, 447–455
-
(2011)
Biochem. J
, vol.438
, pp. 447-455
-
-
Yan, M.1
Li, J.2
Sha, B.3
-
113
-
-
84866488172
-
The heat shock response: Systems biology of proteotoxic stress in aging and disease
-
Morimoto, R.I. The heat shock response: Systems biology of proteotoxic stress in aging and disease. Cold Spring Harb. Symp. Quant. Biol. 2011, 76, 91–99
-
(2011)
Cold Spring Harb. Symp. Quant. Biol
, vol.76
, pp. 91-99
-
-
Morimoto, R.I.1
-
114
-
-
79952577733
-
Protein folding in the cytoplasm and the heat shock response
-
Vabulas, R.M.; Raychaudhuri, S.; Hayer-Hartl, M.; Hartl, F.U. Protein folding in the cytoplasm and the heat shock response. Cold Spring Harb. Perspect. Biol. 2010, 2, a004390
-
(2010)
Cold Spring Harb. Perspect. Biol
, vol.2
-
-
Vabulas, R.M.1
Raychaudhuri, S.2
Hayer-Hartl, M.3
Hartl, F.U.4
-
115
-
-
60749101582
-
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1
-
Westerheide, S.D.; Anckar, J.; Stevens, S.M., Jr.; Sistonen, L.; Morimoto, R.I. Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science 2009, 323, 1063–1066
-
(2009)
Science
, vol.323
, pp. 1063-1066
-
-
Westerheide, S.D.1
Anckar, J.2
Stevens, S.M.3
Sistonen, L.4
Morimoto, R.I.5
-
116
-
-
84866644698
-
Diverse functional manifestations of intrinsic structural disorder in molecular chaperones
-
Kovacs, D.; Tompa, P. Diverse functional manifestations of intrinsic structural disorder in molecular chaperones. Biochem. Soc. Trans. 2012, 40, 963–968
-
(2012)
Biochem. Soc. Trans
, vol.40
, pp. 963-968
-
-
Kovacs, D.1
Tompa, P.2
-
117
-
-
84969577902
-
Unfolded protein responses with or without unfolded proteins?
-
Snapp, E.L. Unfolded protein responses with or without unfolded proteins? Cells 2012, 1, 926–950.
-
(2012)
Cells
, vol.1
, pp. 926-950
-
-
Snapp, E.L.1
-
118
-
-
84964698311
-
Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling
-
Carrara, M.; Prischi, F.; Nowak, P.R.; Kopp, M.C.; Ali, M.M. Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling. Elife 2015, 4, doi:10.7554/eLife.03522
-
(2015)
Elife
, vol.4
-
-
Carrara, M.1
Prischi, F.2
Nowak, P.R.3
Kopp, M.C.4
Ali, M.M.5
-
119
-
-
84875833455
-
Chaperone activation by unfolding
-
Foit, L.; George, J.S.; Zhang, B.W.; Brooks, C.L.,; Bardwell, J.C. Chaperone activation by unfolding. Proc. Natl. Acad. Sci. USA 2013, 110, E1254–E1262
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
-
-
Foit, L.1
George, J.S.2
Zhang, B.W.3
Brooks, C.L.4
Bardwell, J.C.5
-
120
-
-
84855966721
-
Role of endoplasmic reticulum stress in metabolic disease and other disorders
-
Ozcan, L.; Tabas, I. Role of endoplasmic reticulum stress in metabolic disease and other disorders. Annu. Rev. Med. 2012, 63, 317–328
-
(2012)
Annu. Rev. Med
, vol.63
, pp. 317-328
-
-
Ozcan, L.1
Tabas, I.2
-
121
-
-
0037336295
-
Quality control in the endoplasmic reticulum
-
Ellgaard, L.; Helenius, A. Quality control in the endoplasmic reticulum. Nat. Rev. Mol. Cell Biol 2003, 4, 181–191
-
(2003)
Nat. Rev. Mol. Cell Biol
, vol.4
, pp. 181-191
-
-
Ellgaard, L.1
Helenius, A.2
-
122
-
-
84870159094
-
Structural basis of the unfolded protein response
-
Korennykh, A.; Walter, P. Structural basis of the unfolded protein response. Annu. Rev. Cell Dev. Biol. 2012, 28, 251–277
-
(2012)
Annu. Rev. Cell Dev. Biol
, vol.28
, pp. 251-277
-
-
Korennykh, A.1
Walter, P.2
-
123
-
-
33749233991
-
The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response
-
Zhou, J.; Liu, C.Y.; Back, S.H.; Clark, R.L.; Peisach, D.; Xu, Z.; Kaufman, R.J. The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proc. Natl. Acad. Sci. USA 2006, 103, 14343–14348
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 14343-14348
-
-
Zhou, J.1
Liu, C.Y.2
Back, S.H.3
Clark, R.L.4
Peisach, D.5
Xu, Z.6
Kaufman, R.J.7
-
124
-
-
82255161944
-
Road to ruin: Targeting proteins for degradation in the endoplasmic reticulum
-
Smith, M.H.; Ploegh, H.L.; Weissman, J.S. Road to ruin: Targeting proteins for degradation in the endoplasmic reticulum. Science 2011, 334, 1086–1090
-
(2011)
Science
, vol.334
, pp. 1086-1090
-
-
Smith, M.H.1
Ploegh, H.L.2
Weissman, J.S.3
-
125
-
-
0036776098
-
Structural organization of the endoplasmic reticulum
-
Voeltz, G.K.; Rolls, M.M.; Rapoport, T.A. Structural organization of the endoplasmic reticulum EMBO Rep. 2002, 3, 944–950
-
(2002)
EMBO Rep
, vol.3
, pp. 944-950
-
-
Voeltz, G.K.1
Rolls, M.M.2
Rapoport, T.A.3
-
126
-
-
70449577164
-
. In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles
-
Schindler, A.J.; Schekman, R. In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles. Proc. Natl. Acad. Sci. USA 2009, 106, 17775–17780
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 17775-17780
-
-
Schindler, A.J.1
Schekman, R.2
-
127
-
-
0032693671
-
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
-
Haze, K.; Yoshida, H.; Yanagi, H.; Yura, T.; Mori, K. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol. Biol. Cell 1999, 10, 3787–3799
-
(1999)
Mol. Biol. Cell
, vol.10
, pp. 3787-3799
-
-
Haze, K.1
Yoshida, H.2
Yanagi, H.3
Yura, T.4
Mori, K.5
-
128
-
-
0034515724
-
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
-
Ye, J.; Rawson, R.B.; Komuro, R.; Chen, X.; Davé, U.P.; Prywes, R.; Brown, M.S.; Goldstein, J.L ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs Mol. Cell 2000, 6, 1355–1364
-
(2000)
Mol. Cell
, vol.6
, pp. 1355-1364
-
-
Ye, J.1
Rawson, R.B.2
Komuro, R.3
Chen, X.4
Davé, U.P.5
Prywes, R.6
Brown, M.S.7
Goldstein, J.L.8
-
129
-
-
10644233167
-
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
-
Marciniak, S.J.; Yun, C.Y.; Oyadomari, S.; Novoa, I.; Zhang, Y.; Jungreis, R.; Nagata, K.; Harding, H.P.; Ron, D. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev. 2004, 18, 3066–3077
-
(2004)
Genes Dev
, vol.18
, pp. 3066-3077
-
-
Marciniak, S.J.1
Yun, C.Y.2
Oyadomari, S.3
Novoa, I.4
Zhang, Y.5
Jungreis, R.6
Nagata, K.7
Harding, H.P.8
Ron, D.9
-
130
-
-
79953288480
-
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis
-
Tsaytler, P.; Harding, H.P.; Ron, D.; Bertolotti, A. Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis. Science 2011, 332, 91–94
-
(2011)
Science
, vol.332
, pp. 91-94
-
-
Tsaytler, P.1
Harding, H.P.2
Ron, D.3
Bertolotti, A.4
-
131
-
-
0037011917
-
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
-
Calfon, M.; Zeng, H.; Urano, F.; Till, J.H.; Hubbard, S.R.; Harding, H.P.; Clark, S.G.; Ron, D IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA Nature 2002, 415, 92–96
-
(2002)
Nature
, vol.415
, pp. 92-96
-
-
Calfon, M.1
Zeng, H.2
Urano, F.3
Till, J.H.4
Hubbard, S.R.5
Harding, H.P.6
Clark, S.G.7
Ron, D.8
-
132
-
-
0035966269
-
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
-
Yoshida, H.; Matsui, T.; Yamamoto, A.; Okada, T.; Mori, K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 2001, 107, 881–891
-
(2001)
Cell
, vol.107
, pp. 881-891
-
-
Yoshida, H.1
Matsui, T.2
Yamamoto, A.3
Okada, T.4
Mori, K.5
-
133
-
-
18244405070
-
-
Shen, X.; Ellis, R.E.; Lee, K.; Liu, C.Y.; Yang, K.; Solomon, A.; Yoshida, H.; Morimoto, R.; Kurnit, D.M.; Mori, K. et al. Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 2001, 107, 893–903.
-
(2001)
Cell
, vol.107
, pp. 893-903
-
-
Shen, X.1
Ellis, R.E.2
Lee, K.3
Liu, C.Y.4
Yang, K.5
Solomon, A.6
Yoshida, H.7
Morimoto, R.8
Kurnit, D.M.9
Mori, K.10
-
134
-
-
0037083755
-
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response
-
Lee, K.; Tirasophon, W.; Shen, X.; Michalak, M.; Prywes, R.; Okada, T.; Yoshida, H.; Mori, K.; Kaufman, R.J. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev. 2002, 16, 452–466
-
(2002)
Genes Dev
, vol.16
, pp. 452-466
-
-
Lee, K.1
Tirasophon, W.2
Shen, X.3
Michalak, M.4
Prywes, R.5
Okada, T.6
Yoshida, H.7
Mori, K.8
Kaufman, R.J.9
-
135
-
-
0037320265
-
A time-dependent phase shift in the mammalian unfolded protein response
-
Yoshida, H.; Matsui, T.; Hosokawa, N.; Kaufman, R.J.; Nagata, K.; Mori, K. A time-dependent phase shift in the mammalian unfolded protein response. Dev. Cell 2003, 4, 265–271
-
(2003)
Dev. Cell
, vol.4
, pp. 265-271
-
-
Yoshida, H.1
Matsui, T.2
Hosokawa, N.3
Kaufman, R.J.4
Nagata, K.5
Mori, K.6
-
136
-
-
0035913294
-
. Plasma cell differentiation requires the transcription factor XBP-1
-
Reimold, A.M.; Iwakoshi, N.N.; Manis, J.; Vallabhajosyula, P.; Szomolanyi-Tsuda, E.; Gravallese, E.M.; Friend, D.; Grusby, M.J.; Alt, F.; Glimcher, L.H. Plasma cell differentiation requires the transcription factor XBP-1. Nature 2001, 412, 300–307
-
(2001)
Natur
, vol.412
, pp. 300-307
-
-
Reimold, A.M.1
Iwakoshi, N.N.2
Manis, J.3
Vallabhajosyula, P.4
Szomolanyi-Tsuda, E.5
Gravallese, E.M.6
Friend, D.7
Grusby, M.J.8
Alt, F.9
Glimcher, L.H.10
-
137
-
-
79959902152
-
Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1
-
Korennykh, A.V.; Egea, P.F.; Korostelev, A.A.; Finer-Moore, J.; Stroud, R.M.; Zhang, C.; Shokat, K.M.; Walter, P. Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. BMC Biol. 2011, 9, 48
-
(2011)
BMC Biol
, vol.9
-
-
Korennykh, A.V.1
Egea, P.F.2
Korostelev, A.A.3
Finer-Moore, J.4
Stroud, R.M.5
Zhang, C.6
Shokat, K.M.7
Walter, P.8
-
138
-
-
84896706762
-
Regulatory crosstalk within the mammalian unfolded protein response
-
Brewer, J.W. Regulatory crosstalk within the mammalian unfolded protein response. Cell Mol Life Sci. 2014, 71, 1067–1079
-
(2014)
Cell Mol Life Sci
, vol.71
, pp. 1067-1079
-
-
Brewer, J.W.1
-
139
-
-
84856111924
-
The unfolded protein response: Controlling cell fate decisions under ER stress and beyond
-
Hetz, C. The unfolded protein response: Controlling cell fate decisions under ER stress and beyond. Nat. Rev. Mol. Cell Biol. 2012, 13, 89–102
-
(2012)
Nat. Rev. Mol. Cell Biol
, vol.13
, pp. 89-102
-
-
Hetz, C.1
-
140
-
-
36049049392
-
IRE1 signaling affects cell fate during the unfolded protein response
-
Lin, J.H.; Li, H.; Yasumura, D.; Cohen, H.R.; Zhang, C.; Panning, B.; Shokat, K.M.; Lavail, M.M.; Walter, P. IRE1 signaling affects cell fate during the unfolded protein response Science 2007, 318, 944–949
-
(2007)
Science
, vol.318
, pp. 944-949
-
-
Lin, J.H.1
Li, H.2
Yasumura, D.3
Cohen, H.R.4
Zhang, C.5
Panning, B.6
Shokat, K.M.7
Lavail, M.M.8
Walter, P.9
-
141
-
-
77958016968
-
Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering
-
Li, H.; Korennykh, A.V.; Behrman, S.L.; Walter, P. Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering. Proc. Natl. Acad. Sci. USA 2010, 107, 16113–16118
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 16113-16118
-
-
Li, H.1
Korennykh, A.V.2
Behrman, S.L.3
Walter, P.4
-
142
-
-
84885095437
-
Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress
-
Escusa-Toret S.; Vonk, W.I.; Frydman, J. Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress. Nat. Cell Biol. 2013, 15, 1231–1243
-
(2013)
Nat. Cell Biol
, vol.15
, pp. 1231-1243
-
-
Escusa-Toret, S.1
Vonk, W.I.2
Frydman, J.3
-
143
-
-
84883210213
-
Principles of cotranslational ubiquitination and quality control at the ribosome
-
Duttler, S.; Pechmann, S.; Frydman, J. Principles of cotranslational ubiquitination and quality control at the ribosome. Mol. Cell 2013, 50, 379–393
-
(2013)
Mol. Cell
, vol.50
, pp. 379-393
-
-
Duttler, S.1
Pechmann, S.2
Frydman, J.3
-
144
-
-
84883229070
-
A cotranslational ubiquitination pathway for quality control of misfolded proteins
-
Wang, F.; Durfee, L.A.; Huibregtse, J.M. A cotranslational ubiquitination pathway for quality control of misfolded proteins. Mol. Cell 2013, 50, 368–378
-
(2013)
Mol. Cell
, vol.50
, pp. 368-378
-
-
Wang, F.1
Durfee, L.A.2
Huibregtse, J.M.3
-
145
-
-
84925553022
-
Local slowdown of translation by nonoptimal codons promotes nascent-chain recognition by SRP in vivo
-
Pechmann, S.; Chartron, J.W.; Frydman, J. Local slowdown of translation by nonoptimal codons promotes nascent-chain recognition by SRP in vivo. Nat. Struct. Mol. Biol. 2014, 21, 1100–1105
-
(2014)
Nat. Struct. Mol. Biol
, vol.21
, pp. 1100-1105
-
-
Pechmann, S.1
Chartron, J.W.2
Frydman, J.3
-
146
-
-
84897129156
-
Differential scales of protein quality control
-
Wolff, S.; Weissman, J.S.; Dillin, A. Differential scales of protein quality control. Cell 2014, 157, 52–64
-
(2014)
Cell
, vol.157
, pp. 52-64
-
-
Wolff, S.1
Weissman, J.S.2
Dillin, A.3
-
147
-
-
67649306771
-
Molecular chaperones antagonize proteotoxicity by differentially modulating protein aggregation pathways
-
Douglas, P.M.; Summers, D.W.; Cyr, D.M. Molecular chaperones antagonize proteotoxicity by differentially modulating protein aggregation pathways. Prion 2009, 3, 51–58
-
(2009)
Prion
, vol.3
, pp. 51-58
-
-
Douglas, P.M.1
Summers, D.W.2
Cyr, D.M.3
-
148
-
-
33748792821
-
Opposing activities protect against age-onset proteotoxicity
-
Cohen, E.; Bieschke, J.; Perciavalle, R.M.; Kelly, J.W.; Dillin, A. Opposing activities protect against age-onset proteotoxicity. Science 2006, 313, 1604–1610
-
(2006)
Science
, vol.313
, pp. 1604-1610
-
-
Cohen, E.1
Bieschke, J.2
Perciavalle, R.M.3
Kelly, J.W.4
Dillin, A.5
-
149
-
-
7244236320
-
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
-
Arrasate, M.; Mitra, S.; Schweitzer, E.S.; Segal, M.R.; Finkbeiner, S. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature 2004, 431, 805–810
-
(2004)
Nature
, vol.431
, pp. 805-810
-
-
Arrasate, M.1
Mitra, S.2
Schweitzer, E.S.3
Segal, M.R.4
Finkbeiner, S.5
-
150
-
-
50649116818
-
Misfolded proteins partition between two distinct quality control compartments
-
Kaganovich, D.; Kopito, R.; Frydman, J. Misfolded proteins partition between two distinct quality control compartments. Nature 2008, 454, 1088–1095.
-
(2008)
Nature
, vol.454
, pp. 1088-1095
-
-
Kaganovich, D.1
Kopito, R.2
Frydman, J.3
-
151
-
-
84901856381
-
-
Ogrodnik, M.; Salmonowicz, H.; Brown, R.; Turkowska, J.; Średniawa, W.; Pattabiraman, S.; Amen, T.; Abraham, A.C.; Eichler, N.; Lyakhovetsky, R. et al. Dynamic JUNQ inclusion bodies are asymmetrically inherited in mammalian cell lines through the asymmetric partitioning of vimentin. Proc. Natl. Acad. Sci. USA 2014, 11, 8049–8054
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.11
, pp. 8049-8054
-
-
Ogrodnik, M.1
Salmonowicz, H.2
Brown, R.3
Turkowska, J.4
Średniawa, W.5
Pattabiraman, S.6
Amen, T.7
Abraham, A.C.8
Eichler, N.9
Lyakhovetsky, R.10
-
152
-
-
84896779318
-
Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell
-
Polling, S.; Mok, Y.F.; Ramdzan, Y.M.; Turner, B.J.; Yerbury, J.J.; Hill, A.F.; Hatters, D.M Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell. J. Biol. Chem. 2014, 289, 6669–6690
-
(2014)
J. Biol. Chem
, vol.289
, pp. 6669-6690
-
-
Polling, S.1
Mok, Y.F.2
Ramdzan, Y.M.3
Turner, B.J.4
Yerbury, J.J.5
Hill, A.F.6
Hatters, D.M.7
-
153
-
-
84866883258
-
Kaganovich, D Compartmentalization of superoxide dismutase 1 (SOD1G93A) aggregates determines their toxicity
-
Weisberg, S.J.; Lyakhovetsky, R.; Werdiger, A.-C.; Gitler, A.D.; Soen, Y.; Kaganovich, D Compartmentalization of superoxide dismutase 1 (SOD1G93A) aggregates determines their toxicity. Proc. Natl. Acad. Sci. USA 2012, 109, 15811–15816
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 15811-15816
-
-
Weisberg, S.J.1
Lyakhovetsky, R.2
Werdiger, A.-C.3
Gitler, A.D.4
Soen, Y.5
-
154
-
-
84924196173
-
-
Cohen, S.I.; Arosio, P.; Presto, J.; Kurudenkandy, F.R.; Biverstål, H.; Dolfe, L.; Dunning, C.; Yang, X.; Frohm, B.; Vendruscolo, M. et al. A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers. Nat. Struct. Mol. Biol. 2015, 22, 207–213
-
(2015)
Nat. Struct. Mol. Biol
, vol.22
, pp. 207-213
-
-
Cohen, S.I.1
Arosio, P.2
Presto, J.3
Kurudenkandy, F.R.4
Biverstål, H.5
Dolfe, L.6
Dunning, C.7
Yang, X.8
Frohm, B.9
Vendruscolo, M.10
-
155
-
-
84886440159
-
Protein folding: Misfolded proteins join the Q
-
Wrighton, K.H. Protein folding: Misfolded proteins join the Q. Nat. Rev. Mol. Cell Biol. 2013, 14, 608
-
(2013)
Nat. Rev. Mol. Cell Biol
, vol.14
, pp. 608
-
-
Wrighton, K.H.1
-
156
-
-
84930746830
-
The biology of proteostasis in aging and disease
-
Labbadia, J.; Morimoto, R.I. The biology of proteostasis in aging and disease. Annu. Rev. Biochem2015, doi:10.1146/annurev-biochem-060614-033955
-
(2015)
Annu. Rev. Biochem
-
-
Labbadia, J.1
Morimoto, R.I.2
-
157
-
-
77955844171
-
Chaperone networks: Tipping the balance in protein folding diseases
-
Voisine, C.; Pedersen, J.S.; Morimoto, R.I. Chaperone networks: Tipping the balance in protein folding diseases. Neurobiol. Dis. 2010, 40, 12–20
-
(2010)
Neurobiol. Dis
, vol.40
, pp. 12-20
-
-
Voisine, C.1
Pedersen, J.S.2
Morimoto, R.I.3
-
158
-
-
84863723691
-
Selective destruction of abnormal proteins by ubiquitin-mediated protein quality control degradation
-
Fredrickson, E.K.; Gardner, R.G. Selective destruction of abnormal proteins by ubiquitin-mediated protein quality control degradation. Semin. Cell Dev. Biol. 2012, 23, 530–537
-
(2012)
Semin. Cell Dev. Biol
, vol.23
, pp. 530-537
-
-
Fredrickson, E.K.1
Gardner, R.G.2
-
159
-
-
72549095406
-
Regulation mechanisms and signaling pathways of autophagy
-
He, C.; Klionsky, D.J. Regulation mechanisms and signaling pathways of autophagy Annu. Rev. Genet. 2009, 43, 67–93
-
(2009)
Annu. Rev. Genet
, vol.43
, pp. 67-93
-
-
He, C.1
Klionsky, D.J.2
-
160
-
-
84890203542
-
Regulation of proteasome activity in health and disease
-
Schmidt, M.; Finley, D. Regulation of proteasome activity in health and disease Biochim. Biophys. Acta 2014, 1843, 13–25
-
(2014)
Biochim. Biophys. Acta
, vol.1843
, pp. 13-25
-
-
Schmidt, M.1
Finley, D.2
-
161
-
-
58849093135
-
. Molecular mechanisms of proteasome assembly
-
Murata, S.; Yashiroda, H.; Tanaka, K. Molecular mechanisms of proteasome assembly. Nat. Rev Mol. Cell Biol. 2009, 10, 104–115
-
(2009)
Nat. Rev Mol. Cell Biol
, vol.10
, pp. 104-115
-
-
Murata, S.1
Yashiroda, H.2
Tanaka, K.3
-
162
-
-
40949117574
-
A multimeric assembly factor controls the formation of alternative 20S proteasomes
-
Kusmierczyk, A.R.; Kunjappu, M.J.; Funakoshi, M.; Hochstrasser, M. A multimeric assembly factor controls the formation of alternative 20S proteasomes. Nat. Struct. Mol. Biol. 2008, 15, 237–244
-
(2008)
Nat. Struct. Mol. Biol
, vol.15
, pp. 237-244
-
-
Kusmierczyk, A.R.1
Kunjappu, M.J.2
Funakoshi, M.3
Hochstrasser, M.4
-
163
-
-
48949085430
-
-
InInternational Review of Cell and Molecular Biology; Academic Press: San Diego, CA, USA
-
Konstantinova, I.M.; Tsimokha, A.S.; Mittenberg, A.G.; Kwang, W.J. Role of proteasomes in cellular regulation. In International Review of Cell and Molecular Biology; Academic Press: San Diego, CA, USA, 2008; Volume 267, pp. 59–124
-
(2008)
Role of Proteasomes in Cellular Regulation
, vol.267
, pp. 59-124
-
-
Konstantinova, I.M.1
Tsimokha, A.S.2
Mittenberg, A.G.3
Kwang, W.J.4
-
164
-
-
84859702750
-
Molecular model of the human 26S proteasome
-
Da Fonseca, P.C.A.; He, J.; Morris, E.P. Molecular model of the human 26S proteasome Mol. Cell 2012, 46, 54–66
-
(2012)
Mol. Cell
, vol.46
, pp. 54-66
-
-
Da Fonseca, P.1
He, J.2
Morris, E.P.3
-
165
-
-
44849121398
-
The central unit within the 19S regulatory particle of the proteasome
-
Rosenzweig, R.; Osmulski, P.A.; Gaczynska, M.; Glickman, M.H. The central unit within the 19S regulatory particle of the proteasome. Nat. Struct. Mol. Biol. 2008, 15, 573–580
-
(2008)
Nat. Struct. Mol. Biol
, vol.15
, pp. 573-580
-
-
Rosenzweig, R.1
Osmulski, P.A.2
Gaczynska, M.3
Glickman, M.H.4
-
166
-
-
77955107424
-
Co- and post-translational modifications of the 26S proteasome in yeast
-
Kikuchi, J.; Iwafune, Y.; Akiyama, T.; Okayama, A.; Nakamura, H.; Arakawa, N.; Kimura, Y.; Hirano, H. Co- and post-translational modifications of the 26S proteasome in yeast. Proteomics 2010, 10, 2769–2779
-
(2010)
Proteomics
, vol.10
, pp. 2769-2779
-
-
Kikuchi, J.1
Iwafune, Y.2
Akiyama, T.3
Okayama, A.4
Nakamura, H.5
Arakawa, N.6
Kimura, Y.7
Hirano, H.8
-
167
-
-
59249084491
-
The proteasome: Overview of structure and functions
-
Tanaka, K. The proteasome: Overview of structure and functions. Proc. Jpn. Acad. Ser. B 2009, 85, 12–36.
-
(2009)
Proc. Jpn. Acad. Ser. B
, vol.85
, pp. 12-36
-
-
Tanaka, K.1
-
168
-
-
69249241853
-
Variably modulated gating of the 26S proteasome by ATP and polyubiquitin
-
Li, X.; Demartino, G.N. Variably modulated gating of the 26S proteasome by ATP and polyubiquitin. Biochem. J. 2009, 421, 397–404
-
(2009)
Biochem. J
, vol.421
, pp. 397-404
-
-
Li, X.1
Demartino, G.N.2
-
169
-
-
84876412543
-
Allosteric effects in the regulation of 26S proteasome activities
-
Sledź, P.; Förster, F.; Baumeister, W.J. Allosteric effects in the regulation of 26S proteasome activities. Mol. Biol. 2013, 425, 1415–1423
-
(2013)
Mol. Biol
, vol.425
, pp. 1415-1423
-
-
Sledź, P.1
Förster, F.2
Baumeister, W.J.3
-
170
-
-
0025770134
-
The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer’s disease
-
Price, J.L.; Davis, P.B.; Morris, J.C.; White, D.L. The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer’s disease. Neurobiol. Aging 1991, 12, 295–312
-
(1991)
Neurobiol. Aging
, vol.12
, pp. 295-312
-
-
Price, J.L.1
Davis, P.B.2
Morris, J.C.3
White, D.L.4
-
171
-
-
0012510759
-
Beyreuther, K Amyloid plaque core protein in Alzheimer disease and Down syndrome
-
Masters, C.L.; Simms, G.; Weinman, N.A.; Multhaup, G.; McDonald, B.L.; Beyreuther, K Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc. Natl. Acad Sci. USA 198, 82, 4245–4259
-
Proc. Natl. Acad Sci. USA
, vol.82
, pp. 4245-4259
-
-
Masters, C.L.1
Simms, G.2
Weinman, N.A.3
Multhaup, G.4
McDonald, B.L.5
-
172
-
-
0031026231
-
Binding of amyloid β protein to the 20 S proteasome
-
Gregori, L.; Hainfeld, J.F.; Simon, M.N.; Goldgaber, D. Binding of amyloid β protein to the 20 S proteasome. J. Biol. Chem.1997, 272, 58–62
-
(1997)
J. Biol. Chem
, vol.272
, pp. 58-62
-
-
Gregori, L.1
Hainfeld, J.F.2
Simon, M.N.3
Goldgaber, D.4
-
173
-
-
0028979993
-
Amyloid β-protein inhibits ubiquitin-dependent protein degradation in vitro
-
Gregori, L.; Fuchs, C.; Figueiredo-Pereira, M.E.; van Nostrand, W.E.; Goldgaber, D. Amyloid β-protein inhibits ubiquitin-dependent protein degradation in vitro. J. Biol. Chem.1995, 270, 19702–19708
-
(1995)
J. Biol. Chem
, vol.270
, pp. 19702-19708
-
-
Gregori, L.1
Fuchs, C.2
Figueiredo-Pereira, M.E.3
Van Nostrand, W.E.4
Goldgaber, D.5
-
174
-
-
0037383052
-
Relationship between β-amyloid degradation and the 26S proteasome in neural cells
-
Lopez Salon, M.; Pasquini, L.; Besio Moreno, M.; Pasquini, J.M.; Soto, E. Relationship between β-amyloid degradation and the 26S proteasome in neural cells. Exp. Neurol. 2003, 180, 131–143
-
(2003)
Exp. Neurol
, vol.180
, pp. 131-143
-
-
Lopez Salon, M.1
Pasquini, L.2
Besio Moreno, M.3
Pasquini, J.M.4
Soto, E.5
-
175
-
-
27644522515
-
Amyloid peptide attenuates the proteasome activity in neuronal cells
-
Oh, S.; Hong, H.S.; Hwang, E.; Sim, H.J.; Lee, W.; Shin, S.J.; Mook-Jung, I. Amyloid peptide attenuates the proteasome activity in neuronal cells. Mech. Ageing Dev. 2005, 126, 1292–1299
-
(2005)
Mech. Ageing Dev
, vol.126
, pp. 1292-1299
-
-
Oh, S.1
Hong, H.S.2
Hwang, E.3
Sim, H.J.4
Lee, W.5
Shin, S.J.6
Mook-Jung, I.7
-
176
-
-
84873660610
-
Autophagy in human health and disease
-
Choi, A.M.; Ryter, S.W.; Levine, B. Autophagy in human health and disease. N. Engl. J. Med 2013, 368, 651–662
-
(2013)
N. Engl. J. Med
, vol.368
, pp. 651-662
-
-
Choi, A.M.1
Ryter, S.W.2
Levine, B.3
-
177
-
-
84922946917
-
. Protein quality control and metabolism: Bidirectional control in the heart
-
Wang, Z.V.; Hill, J.A. Protein quality control and metabolism: Bidirectional control in the heart Cell Metab. 2015, 21, 215–226
-
(2015)
Cell Metab
, vol.21
, pp. 215-226
-
-
Wang, Z.V.1
Hill, J.A.2
-
178
-
-
84878562770
-
Autophagic processes in yeast: Mechanism, machinery and regulation
-
Reggiori, F.; Klionsky, D.J. Autophagic processes in yeast: Mechanism, machinery and regulation. Genetics 2013, 194, 341–361
-
(2013)
Genetics
, vol.194
, pp. 341-361
-
-
Reggiori, F.1
Klionsky, D.J.2
-
180
-
-
84891741302
-
Chaperone-mediated autophagy: Roles in disease and aging
-
Cuervo, A.M.; Wong, E. Chaperone-mediated autophagy: Roles in disease and aging. Cell Res2014, 24, 92–104
-
(2014)
Cell Res
, vol.24
, pp. 92-104
-
-
Cuervo, A.M.1
Wong, E.2
-
181
-
-
77951214016
-
Mammalian autophagy: Core molecular machinery and signaling regulation
-
Yang, Z.; Klionsky, D.J. Mammalian autophagy: Core molecular machinery and signaling regulation. Curr. Opin. Cell Biol. 2010, 22, 124–131
-
(2010)
Curr. Opin. Cell Biol
, vol.22
, pp. 124-131
-
-
Yang, Z.1
Klionsky, D.J.2
-
182
-
-
78649338141
-
Autophagy and the integrated stress response
-
Kroemer, G.; Mariño, G.; Levine, B. Autophagy and the integrated stress response. Mol. Cell 2010, 40, 280–293
-
(2010)
Mol. Cell
, vol.40
, pp. 280-293
-
-
Kroemer, G.1
Mariño, G.2
Levine, B.3
-
183
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine, B.; Kroemer, G. Autophagy in the pathogenesis of disease. Cell 2008, 132, 27–42
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
184
-
-
26444587508
-
-
Yu, W.H.; Cuervo, A.M.; Kumar, A.; Peterhoff, C.M.; Schmidt, S.D.; Lee, J.H.; Mohan, P.S.; Mercken, M.; Farmery, M.R.; Tjernberg, L.O. et al. Macroautophagy a novel β-amyloid peptide-generating pathway activated in Alzheimer’s disease. J. Cell Biol.2005, 171, 87–98
-
(2005)
J. Cell Biol
, vol.171
, pp. 87-98
-
-
Yu, W.H.1
Cuervo, A.M.2
Kumar, A.3
Peterhoff, C.M.4
Schmidt, S.D.5
Lee, J.H.6
Mohan, P.S.7
Mercken, M.8
Farmery, M.R.9
Tjernberg, L.O.10
-
185
-
-
33947719279
-
Potential therapeutic applications of autophagy
-
Rubinsztein, D.C.; Gestwicki, J.E.; Murphy, L.O.; Klionsky, D.J. Potential therapeutic applications of autophagy. Nat. Rev. Drug Discov. 2007, 6, 304–312
-
(2007)
Nat. Rev. Drug Discov
, vol.6
, pp. 304-312
-
-
Rubinsztein, D.C.1
Gestwicki, J.E.2
Murphy, L.O.3
Klionsky, D.J.4
-
186
-
-
34249798692
-
Autophagic and apoptotic response to stress signals in mammalian cells
-
Ferraro, E.; Cecconi, F. Autophagic and apoptotic response to stress signals in mammalian cells Arch. Biochem. Biophys. 2007, 462, 210–219.
-
(2007)
Arch. Biochem. Biophys
, vol.462
, pp. 210-219
-
-
Ferraro, E.1
Cecconi, F.2
-
187
-
-
84871650725
-
Small molecules that target protein misfolding
-
Gavrin, L.K.; Denny, R.A.; Saiah, E. Small molecules that target protein misfolding. J. Med. Chem 2012, 55, 10823–10843
-
(2012)
J. Med. Chem
, vol.55
, pp. 10823-10843
-
-
Gavrin, L.K.1
Denny, R.A.2
Saiah, E.3
-
188
-
-
84887606872
-
Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins
-
Ciryam, P.; Tartaglia, G.G.; Morimoto, R.I.; Dobson, C.M.; Vendruscolo, M. Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins. Cell Rep 2013, 5, 781–790
-
(2013)
Cell Rep
, vol.5
, pp. 781-790
-
-
Ciryam, P.1
Tartaglia, G.G.2
Morimoto, R.I.3
Dobson, C.M.4
Vendruscolo, M.5
-
189
-
-
20444453307
-
Protein length in eukaryotic and prokaryotic proteomes
-
Brocchieri, L.; Karlin, S. Protein length in eukaryotic and prokaryotic proteomes. Nucleic Acids Res 2005, 33, 3390–3400
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 3390-3400
-
-
Brocchieri, L.1
Karlin, S.2
-
190
-
-
18844413446
-
Structural insights into translational fidelity
-
Ogle, J.M.; Ramakrishnan, V. Structural insights into translational fidelity. Annu. Rev. Biochem 2005, 74, 129–177
-
(2005)
Annu. Rev. Biochem
, vol.74
, pp. 129-177
-
-
Ogle, J.M.1
Ramakrishnan, V.2
-
191
-
-
84873419140
-
The ribosome as a hub for protein quality control
-
Pechmann, S.; Willmund, F.; Frydman, J. The ribosome as a hub for protein quality control Mol. Cell 2013, 49, 411–421
-
(2013)
Mol. Cell
, vol.49
, pp. 411-421
-
-
Pechmann, S.1
Willmund, F.2
Frydman, J.3
-
192
-
-
34547638958
-
High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated β-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes
-
Huang, C.J.; Lin, C.Y.; Haataja, L.; Gurlo, T.; Butler, A.E.; Rizza, R.A.; Butler, P.C. High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated β-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes Diabetes 2007, 56, 2016–2027
-
(2007)
Diabetes
, vol.56
, pp. 2016-2027
-
-
Huang, C.J.1
Lin, C.Y.2
Haataja, L.3
Gurlo, T.4
Butler, A.E.5
Rizza, R.A.6
Butler, P.C.7
-
193
-
-
84877578475
-
-
Han, J.; Back, S.H.; Hur, J.; Lin, Y.H.; Gildersleeve, R.; Shan, J.; Yuan, C.L.; Krokowski, D.; Wang, S.; Hatzoglou, M. et al. ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nat. Cell Biol. 2013, 15, 481–490
-
(2013)
Nat. Cell Biol
, vol.15
, pp. 481-490
-
-
Han, J.1
Back, S.H.2
Hur, J.3
Lin, Y.H.4
Gildersleeve, R.5
Shan, J.6
Yuan, C.L.7
Krokowski, D.8
Wang, S.9
Hatzoglou, M.10
-
194
-
-
77958487260
-
Cellular strategies for controlling protein aggregation
-
Tyedmers, J.; Mogk, A.; Bukau, B. Cellular strategies for controlling protein aggregation Nat. Rev. Mol. Cell Biol. 2010, 11, 777–788
-
(2010)
Nat. Rev. Mol. Cell Biol
, vol.11
, pp. 777-788
-
-
Tyedmers, J.1
Mogk, A.2
Bukau, B.3
-
195
-
-
0035947372
-
Impairment of the ubiquitin-proteasome system by protein aggregation
-
Bence, N.F.; Sampat, R.M.; Kopito, R.R. Impairment of the ubiquitin-proteasome system by protein aggregation. Science 2001, 292, 1552–1555
-
(2001)
Science
, vol.292
, pp. 1552-1555
-
-
Bence, N.F.1
Sampat, R.M.2
Kopito, R.R.3
-
196
-
-
3142514201
-
Protein aggregation and neurodegenerative disease
-
Ross, C.A.; Poirier, M.A. Protein aggregation and neurodegenerative disease. Nat. Med. 2004, 10, S10–S17
-
(2004)
Nat. Med
, vol.10
-
-
Ross, C.A.1
Poirier, M.A.2
-
197
-
-
0036083396
-
The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction
-
Glickman, M.H.; Ciechanover, A. The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction. Physiol. Rev.2002, 82, 373–428
-
(2002)
Physiol. Rev
, vol.82
, pp. 373-428
-
-
Glickman, M.H.1
Ciechanover, A.2
-
198
-
-
33750363298
-
The roles of intracellular protein-degradation pathways in neurodegeneration
-
Rubinsztein, D.C. The roles of intracellular protein-degradation pathways in neurodegeneration Nature 2006, 443, 780–786
-
(2006)
Nature
, vol.443
, pp. 780-786
-
-
Rubinsztein, D.C.1
-
199
-
-
39849109338
-
Autophagy fights disease through cellular self-digestion
-
Mizushima, N.; Levine, B.; Cuervo, A.M.; Klionsky, D.J. Autophagy fights disease through cellular self-digestion. Nature 2008, 451, 1069–1075
-
(2008)
Nature
, vol.451
, pp. 1069-1075
-
-
Mizushima, N.1
Levine, B.2
Cuervo, A.M.3
Klionsky, D.J.4
-
200
-
-
34547227879
-
Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass
-
Knowles, T.P.J.; Shu, W.; Devlin, G.L.; Meehan, S.; Auer, S.; Dobson, C.M.; Welland, M.E Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass. Proc. Natl. Acad. Sci. USA2007, 104, 10016–10021
-
(2007)
. Proc. Natl. Acad. Sci. Usa
, vol.104
, pp. 10016-10021
-
-
Knowles, T.1
Shu, W.2
Devlin, G.L.3
Meehan, S.4
Auer, S.5
Dobson, C.M.6
Welland, M.E.7
-
201
-
-
84875425248
-
Influence of specific Hsp70 domains on fibril formation of the yeast prion protein Ure2
-
Xu, L.Q.; Wu, S.; Buell, A.K.; Cohen, S.I.; Chen, L.J.; Hu, W.H.; Cusack, S.A.; Itzhaki, L.S.; Zhang, H.; Knowles, T.P. et al. Influence of specific Hsp70 domains on fibril formation of the yeast prion protein Ure2. Philos. Trans. R. Soc. B 2013, 368, 20110410
-
(2013)
Philos. Trans. R. Soc. B
, vol.368
-
-
Xu, L.Q.1
Wu, S.2
Buell, A.K.3
Cohen, S.I.4
Chen, L.J.5
Hu, W.H.6
Cusack, S.A.7
Itzhaki, L.S.8
Zhang, H.9
Knowles, T.P.10
-
202
-
-
84892646801
-
Unfolded protein response signaling and metabolic diseases
-
Lee, J.; Ozcan, U. Unfolded protein response signaling and metabolic diseases. J. Biol. Chem 2014, 289, 1203–1211
-
(2014)
J. Biol. Chem
, vol.289
, pp. 1203-1211
-
-
Lee, J.1
Ozcan, U.2
-
203
-
-
77951245032
-
Finding order within disorder: Elucidating the structure of proteins associated with neurodegenerative disease
-
Huang, A.; Stultz, C.M. Finding order within disorder: Elucidating the structure of proteins associated with neurodegenerative disease. Future Med. Chem.2009, 1, 467–482
-
(2009)
Future Med. Chem
, vol.1
, pp. 467-482
-
-
Huang, A.1
Stultz, C.M.2
-
204
-
-
53849133093
-
An update on lipotoxic endoplasmic reticulum stress in pancreatic β-cells
-
Cnop, M.; Igoillo-Esteve, M.; Cunha, D.A.; Ladrière, L.; Eizirik, D.L. An update on lipotoxic endoplasmic reticulum stress in pancreatic β-cells. Biochem. Soc. Trans. 2008, 36, 909–915.
-
(2008)
Biochem. Soc. Trans
, vol.36
, pp. 909-915
-
-
Cnop, M.1
Igoillo-Esteve, M.2
Cunha, D.A.3
Ladrière, L.4
Eizirik, D.L.5
-
205
-
-
84897094564
-
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases
-
Hetz, C.; Mollereau, B. Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases. Nat. Rev. Neurosci. 2014, 15, 233–249
-
(2014)
Nat. Rev. Neurosci
, vol.15
, pp. 233-249
-
-
Hetz, C.1
Mollereau, B.2
-
206
-
-
0034568802
-
Intramembrane proteolysis by presenilins
-
Steiner, H.; Haass, C. Intramembrane proteolysis by presenilins. Nat. Rev. Mol. Cell Biol. 2000, 1, 217–224
-
(2000)
Nat. Rev. Mol. Cell Biol
, vol.1
, pp. 217-224
-
-
Steiner, H.1
Haass, C.2
-
207
-
-
79551603345
-
Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization
-
Van Laar, V.S.; Arnold, B.; Cassady, S.J.; Chu, C.T.; Burton, E.A.; Berman, S.B.; Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization. Hum. Mol. Genet. 2011, 20, 927–940
-
(2011)
Hum. Mol. Genet
, vol.20
, pp. 927-940
-
-
Van Laar, V.S.1
Arnold, B.2
Cassady, S.J.3
Chu, C.T.4
Burton, E.A.5
Berman, S.B.6
-
208
-
-
84875143788
-
Targeting endoplasmic reticulum stress in metabolic disease
-
Cao, S.S.; Kaufman, R.J. Targeting endoplasmic reticulum stress in metabolic disease. Expert Opin Ther. Targets 2012, 17, 437–448
-
(2012)
Expert Opin Ther. Targets
, vol.17
, pp. 437-448
-
-
Cao, S.S.1
Kaufman, R.J.2
-
209
-
-
77950343252
-
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
-
Hotamisligil, G.S. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease Cell 2010, 140, 900–917
-
(2010)
Cell
, vol.140
, pp. 900-917
-
-
Hotamisligil, G.S.1
-
210
-
-
84873527000
-
Aggregation of islet amyloid polypeptide: From physical chemistry to cell biology
-
Cao, P.; Abedini, A.; Raleigh, D.P. Aggregation of islet amyloid polypeptide: From physical chemistry to cell biology. Curr. Opin. Struct. Biol. 2013, 23, 82–89
-
(2013)
Curr. Opin. Struct. Biol
, vol.23
, pp. 82-89
-
-
Cao, P.1
Abedini, A.2
Raleigh, D.P.3
-
211
-
-
84912064413
-
Human IAPP amyloidogenic properties and pancreatic β-cell death
-
Fernández, M.S. Human IAPP amyloidogenic properties and pancreatic β-cell death. Cell Calcium 2014, 56, 416–427
-
(2014)
Cell Calcium
, vol.56
, pp. 416-427
-
-
Fernández, M.S.1
-
212
-
-
34548462199
-
Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic β-cell apoptosis
-
Casas, S.; Gomis, R.; Gribble, F.M.; Altirriba, J.; Knuutila, S.; Novials, A. Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic β-cell apoptosis Diabetes 2007, 56, 2284–2294
-
(2007)
Diabetes
, vol.56
, pp. 2284-2294
-
-
Casas, S.1
Gomis, R.2
Gribble, F.M.3
Altirriba, J.4
Knuutila, S.5
Novials, A.6
-
213
-
-
78751490442
-
β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency
-
Costes, S.; Huang, C.J.; Gurlo, T.; Daval, M.; Matveyenko, A.V.; Rizza, R.A.; Butler, A.E.; Butler, P.C. β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency. Diabetes 2011, 60, 227–238
-
(2011)
Diabetes
, vol.60
, pp. 227-238
-
-
Costes, S.1
Huang, C.J.2
Gurlo, T.3
Daval, M.4
Matveyenko, A.V.5
Rizza, R.A.6
Butler, A.E.7
Butler, P.C.8
-
214
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
Ozcan, U.; Cao, Q.; Yilmaz, E.; Lee, A.H.; Iwakoshi, N.N.; Ozdelen, E.; Tuncman, G.; Görgün, C.; Glimcher, L.H.; Hotamisligil, G.S. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004, 306, 457–461
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.H.4
Iwakoshi, N.N.5
Ozdelen, E.6
Tuncman, G.7
Görgün, C.8
Glimcher, L.H.9
Hotamisligil, G.S.10
-
215
-
-
1342286820
-
Mono-unsaturated fatty acids protect against β-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure
-
Welters, H.J.; Tadayyon, M.; Scarpello, J.H.; Smith, S.A.; Morgan, N.G. Mono-unsaturated fatty acids protect against β-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure. FEBS Lett. 2004, 560, 103–108
-
(2004)
FEBS Lett
, vol.560
, pp. 103-108
-
-
Welters, H.J.1
Tadayyon, M.2
Scarpello, J.H.3
Smith, S.A.4
Morgan, N.G.5
-
217
-
-
77958003056
-
The role of endoplasmic reticulum stress in the progression of atherosclerosis
-
Tabas, I. The role of endoplasmic reticulum stress in the progression of atherosclerosis. Circ. Res 2010, 107, 839–850
-
(2010)
Circ. Res
, vol.107
, pp. 839-850
-
-
Tabas, I.1
-
218
-
-
0036853914
-
Orchestrating the unfolded protein response in health and disease
-
Kaufman, R.J. Orchestrating the unfolded protein response in health and disease. J. Clin. Investig2002, 110, 1389–1398
-
(2002)
J. Clin. Investig
, vol.110
, pp. 1389-1398
-
-
Kaufman, R.J.1
-
219
-
-
68049110633
-
IRE1α kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates
-
Han, D.; Lerner, A.G.; Vande, W.L.; Upton, J.P.; Xu, W.; Hagen, A.; Backes, B.J.; Oakes, S.A.; Papa, F.R. IRE1α kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell 2009, 138, 562–575
-
(2009)
Cell
, vol.138
, pp. 562-575
-
-
Han, D.1
Lerner, A.G.2
Vande, W.L.3
Upton, J.P.4
Xu, W.5
Hagen, A.6
Backes, B.J.7
Oakes, S.A.8
Papa, F.R.9
-
220
-
-
77954225337
-
Small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity
-
Blais, J.D.; Chin, K.T.; Zito, E.; Zhang, Y.; Heldman, N.; Harding, H.P.; Fass, D.; Thorpe, C.; Ron, D.A. Small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity. J. Biol. Chem. 2010, 285, 20993–21003
-
(2010)
J. Biol. Chem
, vol.285
, pp. 20993-21003
-
-
Blais, J.D.1
Chin, K.T.2
Zito, E.3
Zhang, Y.4
Heldman, N.5
Harding, H.P.6
Fass, D.7
Thorpe, C.8
Ron, D.A.9
-
221
-
-
10344222124
-
The role of the unfolded protein response in tumour development: Friend or foe?
-
Ma, Y.; Hendershot, L.M. The role of the unfolded protein response in tumour development: Friend or foe? Nat. Rev. Cancer 2004, 4, 966–977.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 966-977
-
-
Ma, Y.1
Hendershot, L.M.2
-
222
-
-
36348943088
-
Integrated endoplasmic reticulum stress responses in cancer
-
Moenner, M.; Pluquet, O.; Bouchecareilh, M.; Chevet, E. Integrated endoplasmic reticulum stress responses in cancer. Cancer Res. 2007, 67, 10631–10634
-
(2007)
Cancer Res
, vol.67
, pp. 10631-10634
-
-
Moenner, M.1
Pluquet, O.2
Bouchecareilh, M.3
Chevet, E.4
-
223
-
-
74949118681
-
-
Rouschop, K.M.; van den Beucken, T.; Dubois, L.; Niessen, H.; Bussink, J.; Savelkouls, K.; Keulers, T.; Mujcic, H.; Landuyt, W.; Voncken, J.W. et al. The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. J. Clin. Investig. 2010, 120, 127–141
-
(2010)
J. Clin. Investig
, vol.120
, pp. 127-141
-
-
Rouschop, K.M.1
Van Den Beucken, T.2
Dubois, L.3
Niessen, H.4
Bussink, J.5
Savelkouls, K.6
Keulers, T.7
Mujcic, H.8
Landuyt, W.9
Voncken, J.W.10
-
224
-
-
33845465578
-
-
Blais, J.D.; Addison, C.L.; Edge, R.; Falls, T.; Zhao, H.; Wary, K.; Koumenis, C.; Harding, H.P.; Ron, D.; Holcik, M. et al. Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress. Mol. Cell. Biol.2006, 26, 9517–9532
-
(2006)
Mol. Cell. Biol
, vol.26
, pp. 9517-9532
-
-
Blais, J.D.1
Addison, C.L.2
Edge, R.3
Falls, T.4
Zhao, H.5
Wary, K.6
Koumenis, C.7
Harding, H.P.8
Ron, D.9
Holcik, M.10
-
225
-
-
75149165640
-
Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth
-
Spiotto, M.T.; Banh, A.; Papandreou, I.; Cao, H.; Galvez, M.G.; Gurtner, G.C.; Denko, N.C.; Le, Q.T.; Koong, A.C. Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth. Cancer Res. 2010, 70, 78–88
-
(2010)
Cancer Res
, vol.70
, pp. 78-88
-
-
Spiotto, M.T.1
Banh, A.2
Papandreou, I.3
Cao, H.4
Galvez, M.G.5
Gurtner, G.C.6
Denko, N.C.7
Le, Q.T.8
Koong, A.C.9
-
226
-
-
34248571826
-
GRP78 induction in cancer: Therapeutic and prognostic implications
-
Lee, A.S. GRP78 induction in cancer: Therapeutic and prognostic implications. Cancer Res 2007, 67, 3496–3499
-
(2007)
Cancer Res
, vol.67
, pp. 3496-3499
-
-
Lee, A.S.1
-
227
-
-
35448967382
-
The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas
-
Pyrko, P.; Schonthal, A.H.; Hofman, F.M.; Chen, T.C.; Lee, A.S. The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas Cancer Res. 2007, 67, 9809–9816
-
(2007)
Cancer Res
, vol.67
, pp. 9809-9816
-
-
Pyrko, P.1
Schonthal, A.H.2
Hofman, F.M.3
Chen, T.C.4
Lee, A.S.5
-
228
-
-
79951590699
-
GRP78/BiP modulation of GRP78/BiP in altering sensitivity to chemotherapy
-
Chen, T.C. GRP78/BiP modulation of GRP78/BiP in altering sensitivity to chemotherapy Methods Enzymol. 2011, 491, 25–36
-
(2011)
Methods Enzymol
, vol.491
, pp. 25-36
-
-
Chen, T.C.1
-
229
-
-
79951857650
-
Unfolded protein response in cancer: The physician’s perspective
-
Li, X.; Zhang, K.; Li, Z. Unfolded protein response in cancer: The physician’s perspective J. Hematol. Oncol. 2011, 4, 8
-
(2011)
J. Hematol. Oncol
, vol.4
-
-
Li, X.1
Zhang, K.2
Li, Z.3
-
230
-
-
4444302042
-
Effect on tumor cells of blocking survival response to glucose deprivation
-
Park, H.R.; Tomida, A.; Sato, S.; Tsukumo, Y.; Yun, J.; Yamori, T.; Hayakawa, Y.; Tsuruo, T.; Shin-ya, K. Effect on tumor cells of blocking survival response to glucose deprivation. J. Natl Cancer Inst. 2004, 96, 1300–1310
-
(2004)
J. Natl Cancer Inst
, vol.96
, pp. 1300-1310
-
-
Park, H.R.1
Tomida, A.2
Sato, S.3
Tsukumo, Y.4
Yun, J.5
Yamori, T.6
Hayakawa, Y.7
Tsuruo, T.8
Shin-Ya, K.9
-
231
-
-
66249092010
-
Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation
-
Saito, S.; Furuno, A.; Sakurai, J.; Sakamoto, A.; Park, H.R.; Shin-Ya, K.; Tsuruo, T.; Tomida, A Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation. Cancer Res. 2009, 69, 4225–4234
-
(2009)
Cancer Res
, vol.69
, pp. 4225-4234
-
-
Saito, S.1
Furuno, A.2
Sakurai, J.3
Sakamoto, A.4
Park, H.R.5
Shin-Ya, K.6
Tsuruo, T.7
Tomida, A.8
-
232
-
-
70350728791
-
Chaperone-targeting cytotoxin and endoplasmic reticulum stress-inducing drug synergize to kill cancer cells
-
Backer, J.M.; Krivoshein, A.V.; Hamby, C.V.; Pizzonia, J.; Gilbert, K.S.; Ray, Y.S.; Brand, H.; Paton, A.W.; Paton, J.C.; Backer, M.V. Chaperone-targeting cytotoxin and endoplasmic reticulum stress-inducing drug synergize to kill cancer cells. Neoplasia 2009, 11, 1165–1173
-
(2009)
Neoplasia
, vol.11
, pp. 1165-1173
-
-
Backer, J.M.1
Krivoshein, A.V.2
Hamby, C.V.3
Pizzonia, J.4
Gilbert, K.S.5
Ray, Y.S.6
Brand, H.7
Paton, A.W.8
Paton, J.C.9
Backer, M.V.10
-
233
-
-
70450270900
-
Awakening guardian angels: Drugging the p53 pathway
-
Brown, C.J.; Lain, S.; Verma, C.S.; Fersht, A.R.; Lane, D.P. Awakening guardian angels: Drugging the p53 pathway. Nat. Rev. Cancer 2009, 12, 862–873
-
(2009)
Nat. Rev. Cancer
, vol.12
, pp. 862-873
-
-
Brown, C.J.1
Lain, S.2
Verma, C.S.3
Fersht, A.R.4
Lane, D.P.5
-
234
-
-
77955363995
-
TP53 mutations in human cancers: Origins, consequences, and clinical use
-
Olivier, M.; Hollstein, M.; Hainaut, P. TP53 mutations in human cancers: Origins, consequences, and clinical use. Cold Spring Harb. Perspect. Biol. 2010, 1, a001008
-
(2010)
Cold Spring Harb. Perspect. Biol
, vol.1
-
-
Olivier, M.1
Hollstein, M.2
Hainaut, P.3
-
235
-
-
0027983669
-
Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
-
Cho, Y.; Gorina, S.; Jeffrey, P.D.; Pavletich, N.P. Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations. Science 1994, 265, 346–355
-
(1994)
Science
, vol.265
, pp. 346-355
-
-
Cho, Y.1
Gorina, S.2
Jeffrey, P.D.3
Pavletich, N.P.4
-
236
-
-
34547689085
-
Loss-of-function genetic diseases and the concept of pharmaceutical targets
-
Segalat, L. Loss-of-function genetic diseases and the concept of pharmaceutical targets Orphanet. J. Rare Dis. 2007, 2, 30–36
-
(2007)
Orphanet. J. Rare Dis
, vol.2
, pp. 30-36
-
-
Segalat, L.1
-
237
-
-
0037192628
-
Characterization of the p53-rescue drug CP-31398 in vitro and in living cells
-
Rippin, T.M.; Bykov, V.J.; Freund, S.M.; Selivanova, G.; Wiman, K.G.; Fersht, A.R Characterization of the p53-rescue drug CP-31398 in vitro and in living cells. Oncogene 2002, 21, 2119–2129.
-
(2002)
Oncogene
, vol.21
, pp. 2119-2129
-
-
Rippin, T.M.1
Bykov, V.J.2
Freund, S.M.3
Selivanova, G.4
Wiman, K.G.5
Fersht, A.R.6
-
238
-
-
0037154149
-
A peptide that binds and stabilizes p53 core domain: Chaperone strategy for rescue of oncogenic mutants
-
Friedler, A.; Hansson, L.O.; Veprintsev, D.B.; Freund, S.M.; Rippin, T.M.; Nikolova, P.V.; Proctor, M.R.; Rüdiger, S.; Fersht, A.R. A peptide that binds and stabilizes p53 core domain: Chaperone strategy for rescue of oncogenic mutants. Proc. Natl. Acad. Sci. USA 2002, 99, 937–942
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 937-942
-
-
Friedler, A.1
Hansson, L.O.2
Veprintsev, D.B.3
Freund, S.M.4
Rippin, T.M.5
Nikolova, P.V.6
Proctor, M.R.7
Rüdiger, S.8
Fersht, A.R.9
-
239
-
-
0035253217
-
Macromolecular crowding: An important but neglected aspect of the intracellular environment
-
Ellis, R.J. Macromolecular crowding: An important but neglected aspect of the intracellular environment. Curr. Opin. Struct. Biol. 2001, 11, 114–119
-
(2001)
Curr. Opin. Struct. Biol
, vol.11
, pp. 114-119
-
-
Ellis, R.J.1
-
241
-
-
26244432388
-
-
Baigent, C.; Keech, A.; Kearney, P.M.; Blackwell, L.; Buck, G.; Pollicino, C.; Kirby, A.; Sourjina, T.; Peto, R.; Collins, R. et al. Efficacy and safety of cholesterol lowering treatment: Prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins Lancet 2005, 366, 1267–1278
-
(2005)
Lancet
, vol.366
, pp. 1267-1278
-
-
Baigent, C.1
Keech, A.2
Kearney, P.M.3
Blackwell, L.4
Buck, G.5
Pollicino, C.6
Kirby, A.7
Sourjina, T.8
Peto, R.9
Collins, R.10
-
242
-
-
0037117499
-
Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine rich domains of Sup35 and of the amyloid β-peptide of amyloid plaques
-
Perutz, M.F.; Pope, B.J.; Owen, D.; Wanker, E.E.; Scherzinger, E. Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine rich domains of Sup35 and of the amyloid β-peptide of amyloid plaques. Proc. Natl. Acad. Sci. USA 2002, 99, 5596–5600
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 5596-5600
-
-
Perutz, M.F.1
Pope, B.J.2
Owen, D.3
Wanker, E.E.4
Scherzinger, E.5
-
243
-
-
13144259646
-
. Amyloid fibril formation by an SH3 domain
-
Guijarro, J.I.; Sunde, M.; Jones, J.A.; Campbell, I.D.; Dobson. C.M. Amyloid fibril formation by an SH3 domain. Proc. Natl. Acad. Sci. USA 1998, 95, 4224–4228
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 4224-4228
-
-
Guijarro, J.I.1
Sunde, M.2
Jones, J.A.3
Campbell, I.D.4
Dobson, C.M.5
-
244
-
-
70350211836
-
The molecular organization of the fungal prion HET-s in its amyloid form
-
Wasmer, C.; Schütz, A.; Loquet, A.; Buhtz, C.; Greenwald, J.; Riek, R.; Böckmann, A.; Meier, B.H The molecular organization of the fungal prion HET-s in its amyloid form. J. Mol. Biol. 2009, 394, 119–127
-
(2009)
J. Mol. Biol
, vol.394
, pp. 119-127
-
-
Wasmer, C.1
Schütz, A.2
Loquet, A.3
Buhtz, C.4
Greenwald, J.5
Riek, R.6
Böckmann, A.7
Meier, B.H.8
-
245
-
-
28244502156
-
Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: A focus on the transthyretin amyloidoses
-
Johnson, S.M.; Wiseman, R.L.; Sekijima, Y.; Green, N.S.; Adamski-Werner, S.L.; Kelly, J.W Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: A focus on the transthyretin amyloidoses. Acc. Chem. Res.2005, 38, 911–921
-
(2005)
Acc. Chem. Res
, vol.38
, pp. 911-921
-
-
Johnson, S.M.1
Wiseman, R.L.2
Sekijima, Y.3
Green, N.S.4
Adamski-Werner, S.L.5
Kelly, J.W.6
-
246
-
-
0033616682
-
Evolution of amyloid: What normal protein folding may tell us about fibrillogenesis and disease?
-
Lansbury, P. Evolution of amyloid: What normal protein folding may tell us about fibrillogenesis and disease? Proc. Natl. Acad. Sci. USA 1999, 96, 3342–3344
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 3342-3344
-
-
Lansbury, P.1
-
247
-
-
84883387793
-
Targeting the unfolded protein response in disease
-
Hetz, C.; Chevet, E.; Harding, H.P. Targeting the unfolded protein response in disease. Nat. Rev Drug Discov. 2013, 12, 703–719
-
(2013)
Nat. Rev Drug Discov
, vol.12
, pp. 703-719
-
-
Hetz, C.1
Chevet, E.2
Harding, H.P.3
-
249
-
-
84863903065
-
Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: Progress and prognosis
-
Lindquist, S.L.; Kelly, J.W. Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: Progress and prognosis. Cold Spring Harb. Perspect. Biol. 2011, 3, a004507
-
(2011)
Cold Spring Harb. Perspect. Biol
, vol.3
-
-
Lindquist, S.L.1
Kelly, J.W.2
-
250
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
-
Ozcan, U.; Yilmaz, E.; Ozcan, L.; Furuhashi, M.; Vaillancourt, E.; Smith, R.O.; Görgün, C.Z.; Hotamisligil, G.S. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006, 313, 1137–1140
-
(2006)
Science
, vol.313
, pp. 1137-1140
-
-
Ozcan, U.1
Yilmaz, E.2
Ozcan, L.3
Furuhashi, M.4
Vaillancourt, E.5
Smith, R.O.6
Görgün, C.Z.7
Hotamisligil, G.S.8
-
251
-
-
57849115277
-
Ozcan, U Endoplasmic reticulum stress plays a central role in development of leptin resistance
-
Ozcan, L.; Ergin, A.S.; Lu, A.; Chung, J.; Sarkar, S.; Nie, D.; Myers, M.G.,; Ozcan, U Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab 2009, 9, 35–51
-
(2009)
Cell Metab
, vol.9
, pp. 35-51
-
-
Ozcan, L.1
Ergin, A.S.2
Lu, A.3
Chung, J.4
Sarkar, S.5
Nie, D.6
Myers, M.G.7
-
252
-
-
79952410092
-
Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and β-cell dysfunction in humans
-
Xiao, C.; Giacca, A.; Lewis, G.F. Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and β-cell dysfunction in humans. Diabetes 2011, 60, 918–924.
-
(2011)
Diabetes
, vol.60
, pp. 918-924
-
-
Xiao, C.1
Giacca, A.2
Lewis, G.F.3
-
253
-
-
77955411159
-
-
Kars, M.; Yang, L.; Gregor, M.F.; Mohammed, B.S.; Pietka, T.A.; Finck, B.N.; Patterson, B.W.; Horton, J.D.; Mittendorfer, B.; Hotamisligil, G.S. et al. Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women Diabetes2010, 59, 1899–1905
-
(2010)
Diabetes
, vol.59
, pp. 1899-1905
-
-
Kars, M.1
Yang, L.2
Gregor, M.F.3
Mohammed, B.S.4
Pietka, T.A.5
Finck, B.N.6
Patterson, B.W.7
Horton, J.D.8
Mittendorfer, B.9
Hotamisligil, G.S.10
-
254
-
-
80052825784
-
-
Promlek, T.; Ishiwata-Kimata, Y.; Shido, M.; Sakuramoto, M.; Kohno, K.; Kimata, YMembrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways. Mol. Biol. Cell2011, 22, 3520–3532
-
(2011)
Mol. Biol. Cell
, vol.22
, pp. 3520-3532
-
-
Promlek, T.1
Ishiwata-Kimata, Y.2
Shido, M.3
Sakuramoto, M.4
Kohno, K.5
-
255
-
-
77950887221
-
Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1
-
Wiseman, R.L.; Zhang, Y.; Lee, K.P.; Harding, H.P.; Haynes, C.M.; Price, J.; Sicheri, F.; Ron, D. Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol. Cell2010, 38, 291–304
-
(2010)
Mol. Cell
, vol.38
, pp. 291-304
-
-
Wiseman, R.L.1
Zhang, Y.2
Lee, K.P.3
Harding, H.P.4
Haynes, C.M.5
Price, J.6
Sicheri, F.7
Ron, D.8
-
256
-
-
0033601370
-
Pharmacological rescue of mutant p53 conformation and function
-
Foster, B.A.; Coffey, H.A.; Morin, M.J.; Rastinejad, F. Pharmacological rescue of mutant p53 conformation and function. Science1999, 286, 2507–2510
-
(1999)
Science
, vol.286
, pp. 2507-2510
-
-
Foster, B.A.1
Coffey, H.A.2
Morin, M.J.3
Rastinejad, F.4
|