Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: Conformational disorder mediates binding diversity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 21, 1996, Pages 11504-11509

  Kriwacki, Richard W ^a   Hengst, Ludger ^a   Tennant, Linda ^a   Reed, Steven I ^a   Wright, Peter E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Cell cycle regulation; Kinase inhibitor; MALDI mass spectrometry; NMR spectroscopy; Protein folding

Indexed keywords

CDK2 PROTEIN, HUMAN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; ENZYME INHIBITOR; PROTEIN SERINE THREONINE KINASE; RECOMBINANT PROTEIN; UREA; PROTEIN P21;

ARTICLE; BINDING SITE; BIOSYNTHESIS; CHEMISTRY; CIRCULAR DICHROISM; CODON; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; HUMAN; MASS SPECTROMETRY; METABOLISM; MOLECULAR CLONING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; SEQUENCE TAGGED SITE; THERMODYNAMICS; AMINO TERMINAL SEQUENCE; CELL CYCLE; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME STRUCTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BASE SEQUENCE; BINDING SITES; CDC2-CDC28 KINASES; CIRCULAR DICHROISM; CLONING, MOLECULAR; CODON; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; ENZYME INHIBITORS; ESCHERICHIA COLI; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MUTAGENESIS, INSERTIONAL; PROTEIN CONFORMATION; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; SEQUENCE TAGGED SITES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; THERMODYNAMICS; UREA;

EID: 0029662315     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.21.11504     Document Type: Article

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