Opposing activities protect against age-onset proteotoxicity

Science

Volumn 313, Issue 5793, 2006, Pages 1604-1610

  Cohen, Ehud ^a   Bieschke, Jan ^b   Perciavalle, Rhonda M ^a   Kelly, Jeffery W ^b   Dillin, Andrew ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; BIOCOMMUNICATIONS; BIODIVERSITY; INSULIN; POLYPEPTIDES; TOXICITY;

ALZHEIMER'S DISEASE; MAMMALS; NEURODEGENERATIVE DISEASES; PROTEOTOXICITY;

PROTEINS;

AMYLOID BETA PROTEIN[1-42]; HEAT SHOCK FACTOR 1; HEAT SHOCK PROTEIN; INSULIN; SOMATOMEDIN C; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DAF 16; UNCLASSIFIED DRUG;

AGGREGATION; HEAT SHOCK; HORMONE; NEMATODE; NERVOUS SYSTEM DISORDER; PEPTIDE; PROTEIN; TOXICITY;

AGING; ALZHEIMER DISEASE; ARTICLE; CAENORHABDITIS ELEGANS; CELL SURVIVAL; DEGENERATIVE DISEASE; FLY; LONGEVITY; MAMMAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; WORM;

AGING; AMYLOID BETA-PROTEIN; ANIMALS; BIOPOLYMERS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL SURVIVAL; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MODELS, BIOLOGICAL; MOLECULAR WEIGHT; MOVEMENT; MUSCLES; PC12 CELLS; PEPTIDE FRAGMENTS; RATS; RECEPTOR, INSULIN; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

MAMMALIA;

EID: 33748792821     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1124646     Document Type: Article

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35. This study was generously supported by grants provided by the Backus and Ellison Medical Foundations (A.D.), NIH (DK 46335 and NS 50636), the Skaggs Institute of Chemical Biology, the Bundy Foundation, the Lita Annenberg Hazen Foundation, and the Max Planck Society (J.W.K. and J.B.). E.C. is supported by the John Douglas French Alzheimer's Foundation. We gratefully acknowledge M. Wood and the Microscopy Core Facility at the Scripps Research Institute for the preparation of immuno-EM samples and pictures, M. R. Ghadiri for use of AFM, G. Herradon for the gift of PC12 cells, the Caenorhabditis Genetics Center for CL2006 worms, and Dillin and Kelly lab members and D. Selkoe for critical comments during the course of this work.