-
1
-
-
0035478585
-
Macromolecular crowding: Obvious but underappreciated
-
R.J. Ellis Macromolecular crowding: obvious but underappreciated Trends Biochem.Sci. 26 2001 597 604
-
(2001)
Trends Biochem.Sci.
, vol.26
, pp. 597-604
-
-
Ellis, R.J.1
-
2
-
-
0033969150
-
Implications of macromolecular crowding for protein assembly
-
A.P. Minton Implications of macromolecular crowding for protein assembly Curr. Opin. Struct. Biol. 10 2000 34 39
-
(2000)
Curr. Opin. Struct. Biol.
, vol.10
, pp. 34-39
-
-
Minton, A.P.1
-
3
-
-
0033200063
-
Protein misfolding, evolution and disease
-
C.M. Dobson Protein misfolding, evolution and disease Trends Biochem. Sci. 24 1999 329 332
-
(1999)
Trends Biochem. Sci.
, vol.24
, pp. 329-332
-
-
Dobson, C.M.1
-
4
-
-
0043236283
-
Protein folding and misfolding: A paradigm of self-assembly and regulation in complex biological systems
-
M. Vendruscolo, J. Zurdo, C.E. MacPhee, and C.M. Dobson Protein folding and misfolding: a paradigm of self-assembly and regulation in complex biological systems Phil. Trans. Roy. Soc. ser. A 361 2003 1205 1222
-
(2003)
Phil. Trans. Roy. Soc. Ser. a
, vol.361
, pp. 1205-1222
-
-
Vendruscolo, M.1
Zurdo, J.2
MacPhee, C.E.3
Dobson, C.M.4
-
5
-
-
0035961329
-
The structural basis of protein folding and its links with human disease
-
C.M. Dobson The structural basis of protein folding and its links with human disease Phil. Trans. Roy. Soc. ser. B 356 2001 133 145
-
(2001)
Phil. Trans. Roy. Soc. Ser. B
, vol.356
, pp. 133-145
-
-
Dobson, C.M.1
-
6
-
-
0030728039
-
Deadly conformations - Protein misfolding in prion disease
-
A.L. Horwich, and J.S. Weissman Deadly conformations - protein misfolding in prion disease Cell 89 1997 499 510
-
(1997)
Cell
, vol.89
, pp. 499-510
-
-
Horwich, A.L.1
Weissman, J.S.2
-
7
-
-
0032006678
-
The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways
-
J.W. Kelly The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways Curr. Opin. Struct. Biol. 8 1998 101 106
-
(1998)
Curr. Opin. Struct. Biol.
, vol.8
, pp. 101-106
-
-
Kelly, J.W.1
-
9
-
-
0037174618
-
Alzheimer's disease is a synaptic failure
-
D.J. Selkoe Alzheimer's disease is a synaptic failure Science 298 2002 789 791
-
(2002)
Science
, vol.298
, pp. 789-791
-
-
Selkoe, D.J.1
-
10
-
-
0344944630
-
Protein aggregation and aggregate toxicity: New insights into protein folding, misfolding diseases and biological evolution
-
M. Stefani, and C.M. Dobson Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution J. Mol. Med. 81 2003 678 699
-
(2003)
J. Mol. Med.
, vol.81
, pp. 678-699
-
-
Stefani, M.1
Dobson, C.M.2
-
11
-
-
0033616575
-
Designing conditions for in vitro formation of amyloid protofilaments and fibrils
-
F. Chiti, P. Webster, N. Taddei, A. Clark, M. Stefani, G. Ramponi, and C.M. Dobson Designing conditions for in vitro formation of amyloid protofilaments and fibrils Proc. Natl Acad. Sci. USA 96 1999 3590 3594
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 3590-3594
-
-
Chiti, F.1
Webster, P.2
Taddei, N.3
Clark, A.4
Stefani, M.5
Ramponi, G.6
Dobson, C.M.7
-
12
-
-
13144259646
-
Amyloid fibril formation by an SH3 domain
-
J.I. Guijarro, M. Sunde, J.A. Jones, I.D. Campbell, and C.M. Dobson Amyloid fibril formation by an SH3 domain Proc. Natl Acad. Sci. USA 95 1998 4224 4228
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 4224-4228
-
-
Guijarro, J.I.1
Sunde, M.2
Jones, J.A.3
Campbell, I.D.4
Dobson, C.M.5
-
13
-
-
2342569618
-
Conformational constraints for amyloid fibrillation: The importance of being unfolded
-
V.N. Uversky, and A.L. Fink Conformational constraints for amyloid fibrillation: the importance of being unfolded BBA-Proteins Proteomics 1698 2004 131 153
-
(2004)
BBA-Proteins Proteomics
, vol.1698
, pp. 131-153
-
-
Uversky, V.N.1
Fink, A.L.2
-
14
-
-
0037014426
-
Protein misfolding, amyloid formation, and neurodegeneration: A critical role for molecular chaperones?
-
P.J. Muchowski Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones? Neuron 35 2002 9 12
-
(2002)
Neuron
, vol.35
, pp. 9-12
-
-
Muchowski, P.J.1
-
15
-
-
16944362157
-
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
-
M. Citron, D. Westaway, W.M. Xia, G. Carlson, T. Diehl, and G. Levesque Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice Nature Med. 3 1997 67 72
-
(1997)
Nature Med.
, vol.3
, pp. 67-72
-
-
Citron, M.1
Westaway, D.2
Xia, W.M.3
Carlson, G.4
Diehl, T.5
Levesque, G.6
-
16
-
-
0035947372
-
Impairment of the ubiquitin-proteasome system by protein aggregation
-
N.F. Bence, R.M. Sampat, and R.R. Kopito Impairment of the ubiquitin-proteasome system by protein aggregation Science 292 2001 1552 1555
-
(2001)
Science
, vol.292
, pp. 1552-1555
-
-
Bence, N.F.1
Sampat, R.M.2
Kopito, R.R.3
-
17
-
-
0242666359
-
Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function
-
Tofaris, G. K., Razzaq, A., Ghetti, B., Lilley, K., Spillantini, M. G. (2003). Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function. J. Biol. Chem. 298, 44405-44411.
-
(2003)
J. Biol. Chem.
, vol.298
, pp. 44405-44411
-
-
Tofaris, G.K.1
Razzaq, A.2
Ghetti, B.3
Lilley, K.4
Spillantini, M.G.5
-
18
-
-
0027976996
-
Increased body-temperature accelerates aggregation of the Leu-68-Gln mutant cystatin-C, the amyloid-forming protein in hereditary cystatin-C amyloid angiopathy
-
M. Abrahamson, and A. Grubb Increased body-temperature accelerates aggregation of the Leu-68-Gln mutant cystatin-C, the amyloid-forming protein in hereditary cystatin-C amyloid angiopathy Proc. Natl Acad. Sci. USA 91 1994 1416 1420
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 1416-1420
-
-
Abrahamson, M.1
Grubb, A.2
-
19
-
-
9044229145
-
On the nucleation and growth of amyloid beta-protein fibrils: Detection of nuclei and quantitation of rate constants
-
A. Lomakin, D.S. Chung, G.B. Benedek, D.A. Kirschner, and D.B. Teplow On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants Proc. Natl Acad. Sci. USA 93 1996 1125 1129
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 1125-1129
-
-
Lomakin, A.1
Chung, D.S.2
Benedek, G.B.3
Kirschner, D.A.4
Teplow, D.B.5
-
20
-
-
0030908095
-
Models of amyloid seeding in Alzheimier's disease and scrapie: Mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins
-
J.D. Harper, and P.T. Lansbury Models of amyloid seeding in Alzheimier's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins Annu. Rev. Biochem. 66 1997 385 407
-
(1997)
Annu. Rev. Biochem.
, vol.66
, pp. 385-407
-
-
Harper, J.D.1
Lansbury, P.T.2
-
22
-
-
0035793953
-
Acidic pH promotes the formation of toxic fibrils from beta-amyloid peptide
-
Y. Su, and P.T. Chang Acidic pH promotes the formation of toxic fibrils from beta-amyloid peptide Brain Res. 893 2001 287 291
-
(2001)
Brain Res.
, vol.893
, pp. 287-291
-
-
Su, Y.1
Chang, P.T.2
-
23
-
-
0035839035
-
Dependence on solution conditions of aggregation and amyloid formation by an SH3 domain
-
J. Zurdo, J.I. Guijarro, J.L. Jimenez, H.R. Saibil, and C.M. Dobson Dependence on solution conditions of aggregation and amyloid formation by an SH3 domain J. Mol. Biol. 311 2001 325 340
-
(2001)
J. Mol. Biol.
, vol.311
, pp. 325-340
-
-
Zurdo, J.1
Guijarro, J.I.2
Jimenez, J.L.3
Saibil, H.R.4
Dobson, C.M.5
-
24
-
-
0034599720
-
Mutational analysis of the propensity for amyloid formation by a globular protein
-
F. Chiti, N. Taddei, M. Bucciantini, P. White, G. Ramponi, and C.M. Dobson Mutational analysis of the propensity for amyloid formation by a globular protein EMBO J. 19 2000 1441 1449
-
(2000)
EMBO J.
, vol.19
, pp. 1441-1449
-
-
Chiti, F.1
Taddei, N.2
Bucciantini, M.3
White, P.4
Ramponi, G.5
Dobson, C.M.6
-
25
-
-
0034612254
-
The preaggregated state of an amyloidogenic protein: Hydrostatic pressure converts native transthyretin into the amyloidogenic state
-
A.D. Ferrao-Gonzales, S.O. Souto, J.L. Silva, and D. Foguel The preaggregated state of an amyloidogenic protein: hydrostatic pressure converts native transthyretin into the amyloidogenic state Proc. Natl Acad. Sci. USA 97 2000 6445 6450
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 6445-6450
-
-
Ferrao-Gonzales, A.D.1
Souto, S.O.2
Silva, J.L.3
Foguel, D.4
-
26
-
-
0035916279
-
Amyloid-induced aggregation and precipitation of soluble proteins: A electrostatic contribution of the Alzheimer's beta(25-35) amyloid fibril
-
T. Konno Amyloid-induced aggregation and precipitation of soluble proteins: a electrostatic contribution of the Alzheimer's beta(25-35) amyloid fibril Biochemistry 40 2001 2148 2154
-
(2001)
Biochemistry
, vol.40
, pp. 2148-2154
-
-
Konno, T.1
-
27
-
-
0037044732
-
Charge attraction and beta propensity are necessary for amyloid fibril formation from tetrapeptides
-
L. Tjernberg, W. Hosia, N. Bark, J. Thyberg, and J. Johansson Charge attraction and beta propensity are necessary for amyloid fibril formation from tetrapeptides J. Biol. Chem. 277 2002 43243 43246
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 43243-43246
-
-
Tjernberg, L.1
Hosia, W.2
Bark, N.3
Thyberg, J.4
Johansson, J.5
-
28
-
-
0037059069
-
Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases
-
F. Chiti, M. Calamai, N. Taddei, M. Stefani, G. Ramponi, and C.M. Dobson Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases Proc. Natl Acad. Sci. USA 99 2002 16419 16426
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 16419-16426
-
-
Chiti, F.1
Calamai, M.2
Taddei, N.3
Stefani, M.4
Ramponi, G.5
Dobson, C.M.6
-
29
-
-
0037059063
-
De novo designed peptide-based amyloid fibrils
-
M.L. de la Paz, K. Goldie, J. Zurdo, E. Lacroix, C.M. Dobson, A. Hoenger, and L. Serrano De novo designed peptide-based amyloid fibrils Proc. Natl Acad. Sci. USA 99 2002 16052 16057
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 16052-16057
-
-
De La Paz, M.L.1
Goldie, K.2
Zurdo, J.3
Lacroix, E.4
Dobson, C.M.5
Hoenger, A.6
Serrano, L.7
-
30
-
-
0034730203
-
Designed protein tetramer zipped together with a hydrophobic Alzheimer homology: A structural clue to amyloid assembly
-
D.E. Otzen, O. Kristensen, and M. Oliveberg Designed protein tetramer zipped together with a hydrophobic Alzheimer homology: a structural clue to amyloid assembly Proc. Natl Acad. Sci. USA 97 2000 9907 9912
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 9907-9912
-
-
Otzen, D.E.1
Kristensen, O.2
Oliveberg, M.3
-
31
-
-
0035055990
-
Frequencies of amino acid strings in globular protein sequences indicate suppression of blocks of consecutive hydrophobic residues
-
R. Schwartz, S. Istrail, and J. King Frequencies of amino acid strings in globular protein sequences indicate suppression of blocks of consecutive hydrophobic residues Protein Sci. 10 2001 1023 1031
-
(2001)
Protein Sci.
, vol.10
, pp. 1023-1031
-
-
Schwartz, R.1
Istrail, S.2
King, J.3
-
32
-
-
0036166319
-
Kinetic partitioning of protein folding and aggregation
-
F. Chiti, N. Taddei, F. Baroni, C. Capanni, M. Stefani, G. Ramponi, and C.M. Dobson Kinetic partitioning of protein folding and aggregation Nature Struct. Biol. 9 2002 137 143
-
(2002)
Nature Struct. Biol.
, vol.9
, pp. 137-143
-
-
Chiti, F.1
Taddei, N.2
Baroni, F.3
Capanni, C.4
Stefani, M.5
Ramponi, G.6
Dobson, C.M.7
-
33
-
-
0033613188
-
De novo amyloid proteins from designed combinatorial libraries
-
M.W. West, W.X. Wang, J. Patterson, J.D. Mancias, J.R. Beasley, and M.H. Hecht De novo amyloid proteins from designed combinatorial libraries Proc. Natl Acad. Sci. USA 96 1999 11211 11216
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 11211-11216
-
-
West, M.W.1
Wang, W.X.2
Patterson, J.3
Mancias, J.D.4
Beasley, J.R.5
Hecht, M.H.6
-
34
-
-
0033814617
-
Protein engineering as a strategy to avoid formation of amyloid fibrils
-
V. Villegas, J. Zurdo, V.V. Filimonov, F.X. Aviles, C.M. Dobson, and L. Serrano Protein engineering as a strategy to avoid formation of amyloid fibrils Protein Sci. 9 2000 1700 1708
-
(2000)
Protein Sci.
, vol.9
, pp. 1700-1708
-
-
Villegas, V.1
Zurdo, J.2
Filimonov, V.V.3
Aviles, F.X.4
Dobson, C.M.5
Serrano, L.6
-
35
-
-
0035918288
-
Prediction of amyloid fibril-forming proteins
-
Y. Kallberg, M. Gustafsson, B. Persson, J. Thyberg, and J. Johansson Prediction of amyloid fibril-forming proteins J. Biol. Chem. 276 2001 12945 12950
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 12945-12950
-
-
Kallberg, Y.1
Gustafsson, M.2
Persson, B.3
Thyberg, J.4
Johansson, J.5
-
36
-
-
0028305304
-
A role for destabilizing amino-acid replacements in light-chain amyloidosis
-
M.R. Hurle, L.R. Helms, L. Li, W.N. Chan, and R. Wetzel A role for destabilizing amino-acid replacements in light-chain amyloidosis Proc. Natl Acad. Sci. USA 91 1994 5446 5450
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 5446-5450
-
-
Hurle, M.R.1
Helms, L.R.2
Li, L.3
Chan, W.N.4
Wetzel, R.5
-
37
-
-
0032725562
-
The tetrameric protein transthyretin dissociates to a non-native monomer in solution - A novel model for amyloidogenesis
-
A. Quintas, M.J.M. Saraiva, and R.M.M. Brito The tetrameric protein transthyretin dissociates to a non-native monomer in solution - a novel model for amyloidogenesis J. Biol. Chem. 274 1999 32943 32949
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 32943-32949
-
-
Quintas, A.1
Saraiva, M.J.M.2
Brito, R.M.M.3
-
38
-
-
0034255027
-
A systematic exploration of the influence of the protein stability on amyloid fibril formation in vitro
-
M. Ramirez-Alvarado, J.S. Merkel, and L. Regan A systematic exploration of the influence of the protein stability on amyloid fibril formation in vitro Proc. Natl Acad. Sci. USA 97 2000 8979 8984
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 8979-8984
-
-
Ramirez-Alvarado, M.1
Merkel, J.S.2
Regan, L.3
-
39
-
-
0036087114
-
The fibril_one on-line database: Mutations, experimental conditions, and trends associated with amyloid fibril formation
-
J.A. Siepen, and D.R. Westhead The fibril_one on-line database: mutations, experimental conditions, and trends associated with amyloid fibril formation Protein Sci. 11 2002 1862 1866
-
(2002)
Protein Sci.
, vol.11
, pp. 1862-1866
-
-
Siepen, J.A.1
Westhead, D.R.2
-
40
-
-
0038575395
-
A systematic investigation into the effect of protein destabilisation on beta 2-microglobulin amyloid formation
-
D.P. Smith, S. Jones, L.C. Serpell, M. Sunde, and S.E. Radford A systematic investigation into the effect of protein destabilisation on beta 2-microglobulin amyloid formation J. Mol. Biol. 330 2003 943 954
-
(2003)
J. Mol. Biol.
, vol.330
, pp. 943-954
-
-
Smith, D.P.1
Jones, S.2
Serpell, L.C.3
Sunde, M.4
Radford, S.E.5
-
41
-
-
0031056829
-
Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis
-
D.R. Booth, M. Sunde, V. Bellotti, C.V. Robinson, W.L. Hutchinson, and P.E. Fraser Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis Nature 385 1997 787 793
-
(1997)
Nature
, vol.385
, pp. 787-793
-
-
Booth, D.R.1
Sunde, M.2
Bellotti, V.3
Robinson, C.V.4
Hutchinson, W.L.5
Fraser, P.E.6
-
42
-
-
0037795635
-
Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis show enhanced formation of aggregates in vitro
-
P.B. Stathopulos, J.A.O. Rumfeldt, G.A. Scholz, R.A. Irani, H.E. Frey, and R.A. Hallewell Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis show enhanced formation of aggregates in vitro Proc. Natl Acad. Sci. USA 100 2003 7021 7026
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 7021-7026
-
-
Stathopulos, P.B.1
Rumfeldt, J.A.O.2
Scholz, G.A.3
Irani, R.A.4
Frey, H.E.5
Hallewell, R.A.6
-
43
-
-
1542600164
-
Mapping a beta amyloid fibril secondary structure using scanning proline mutagenesis
-
A.D. Williams, E. Portelius, I. Kheterpal, J.T. Guo, K.D. Cook, Y. Xu, and R. Wetzel Mapping A beta amyloid fibril secondary structure using scanning proline mutagenesis J. Mol. Biol. 335 2004 833 842
-
(2004)
J. Mol. Biol.
, vol.335
, pp. 833-842
-
-
Williams, A.D.1
Portelius, E.2
Kheterpal, I.3
Guo, J.T.4
Cook, K.D.5
Xu, Y.6
Wetzel, R.7
-
44
-
-
0042467550
-
Rationalization of the effects of mutations on peptide and protein aggregation rates
-
F. Chiti, M. Stefani, N. Taddei, G. Ramponi, and C.M. Dobson Rationalization of the effects of mutations on peptide and protein aggregation rates Nature 424 2003 805 808
-
(2003)
Nature
, vol.424
, pp. 805-808
-
-
Chiti, F.1
Stefani, M.2
Taddei, N.3
Ramponi, G.4
Dobson, C.M.5
-
45
-
-
3242785264
-
Prediction of the absolute aggregation rates of amyloidogenic polypeptide chains
-
K.F. Dubay, A.P. Pawar, F. Chiti, J. Zurdo, C.M. Dobson, and M. Vendruscolo Prediction of the absolute aggregation rates of amyloidogenic polypeptide chains J. Mol. Biol. 341 2004 1317 1326
-
(2004)
J. Mol. Biol.
, vol.341
, pp. 1317-1326
-
-
Dubay, K.F.1
Pawar, A.P.2
Chiti, F.3
Zurdo, J.4
Dobson, C.M.5
Vendruscolo, M.6
-
46
-
-
5044235541
-
Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins
-
A.M. Fernandez-Escamilla, F. Rousseau, J. Schymkowitz, and L. Serrano Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins Nature Biotechnol. 22 2004 1302 1306
-
(2004)
Nature Biotechnol.
, vol.22
, pp. 1302-1306
-
-
Fernandez-Escamilla, A.M.1
Rousseau, F.2
Schymkowitz, J.3
Serrano, L.4
-
47
-
-
4143133235
-
A comparative study of the relationship between protein structure and beta-aggregation in globular and intrinsically disordered proteins
-
R. Linding, J. Schymkowitz, F. Rousseau, F. Diella, and L. Serrano A comparative study of the relationship between protein structure and beta-aggregation in globular and intrinsically disordered proteins J. Mol. Biol. 342 2004 345 353
-
(2004)
J. Mol. Biol.
, vol.342
, pp. 345-353
-
-
Linding, R.1
Schymkowitz, J.2
Rousseau, F.3
Diella, F.4
Serrano, L.5
-
48
-
-
3042584515
-
The role of aromaticity, exposed surface, and dipole moment in determining protein aggregation rates
-
G.G. Tartaglia, A. Cavalli, R. Pellarin, and A. Caflisch The role of aromaticity, exposed surface, and dipole moment in determining protein aggregation rates Protein Sci. 13 2004 1939 1941
-
(2004)
Protein Sci.
, vol.13
, pp. 1939-1941
-
-
Tartaglia, G.G.1
Cavalli, A.2
Pellarin, R.3
Caflisch, A.4
-
49
-
-
0025388957
-
Hydrophobicity indices for amino acid residues as determined by HPLC
-
R. Cowan, and R.G. Witthaker Hydrophobicity indices for amino acid residues as determined by HPLC Pept. Res. 3 1990 75 80
-
(1990)
Pept. Res.
, vol.3
, pp. 75-80
-
-
Cowan, R.1
Witthaker, R.G.2
-
50
-
-
0024278357
-
Hydrophilicity of polar amino-acid side-chains is markedly reduced by flanking peptide-bonds
-
M.A. Roseman Hydrophilicity of polar amino-acid side-chains is markedly reduced by flanking peptide-bonds J. Mol. Biol. 200 1988 513 522
-
(1988)
J. Mol. Biol.
, vol.200
, pp. 513-522
-
-
Roseman, M.A.1
-
51
-
-
0033607205
-
Structure-based conformational preferences of amino acids
-
P. Koehl, and M. Levitt Structure-based conformational preferences of amino acids Proc. Natl Acad. Sci. USA 96 1999 12524 12529
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 12524-12529
-
-
Koehl, P.1
Levitt, M.2
-
52
-
-
0034598954
-
Nature disfavors sequences of alternating polar and non-polar amino acids: Implications for amyloidogenesis
-
B.M. Broome, and M.H. Hecht Nature disfavors sequences of alternating polar and non-polar amino acids: implications for amyloidogenesis J. Mol. Biol. 296 2000 961 968
-
(2000)
J. Mol. Biol.
, vol.296
, pp. 961-968
-
-
Broome, B.M.1
Hecht, M.H.2
-
53
-
-
12244285938
-
Molecular basis for amyloid fibril formation and stability
-
O.S. Makin, E. Atkins, P. Sikorski, J. Johansson, and L.C. Serpell Molecular basis for amyloid fibril formation and stability Proc. Natl Acad. Sci. USA 102 2005 315 320
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 315-320
-
-
Makin, O.S.1
Atkins, E.2
Sikorski, P.3
Johansson, J.4
Serpell, L.C.5
-
54
-
-
10844254749
-
Role of aromatic interactions in amyloid formation by peptides derived from human amylin
-
S.M. Tracz, A. Abedini, M. Driscoll, and D.P. Raleigh Role of aromatic interactions in amyloid formation by peptides derived from human amylin Biochemistry 43 2004 15901 15908
-
(2004)
Biochemistry
, vol.43
, pp. 15901-15908
-
-
Tracz, S.M.1
Abedini, A.2
Driscoll, M.3
Raleigh, D.P.4
-
55
-
-
0035823520
-
Analysis of the minimal amyloid-forming fragment of the islet amyloid polypeptide - An experimental support for the key role of the phenylalanine residue in amyloid formation
-
R. Azriel, and E. Gazit Analysis of the minimal amyloid-forming fragment of the islet amyloid polypeptide - an experimental support for the key role of the phenylalanine residue in amyloid formation J. Biol. Chem. 276 2001 34156 34161
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 34156-34161
-
-
Azriel, R.1
Gazit, E.2
-
56
-
-
0033617220
-
A molecular model of Alzheimer amyloid beta-peptide fibril formation
-
L.O. Tjernberg, D.J.E. Callaway, A. Tjernberg, S. Hahne, C. Lilliehook, and L. Terenius A molecular model of Alzheimer amyloid beta-peptide fibril formation J. Biol. Chem. 274 1999 12619 12625
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 12619-12625
-
-
Tjernberg, L.O.1
Callaway, D.J.E.2
Tjernberg, A.3
Hahne, S.4
Lilliehook, C.5
Terenius, L.6
-
57
-
-
0034649352
-
Amyloid fibril formation by a beta(16-22), a seven-residue fragment of the Alzheimer's beta-amyloid peptide, and structural characterization by solid state NMR
-
J.J. Balbach, Y. Ishii, O.N. Antzutkin, R.D. Leapman, N.W. Rizzo, and F. Dyda Amyloid fibril formation by A beta(16-22), a seven-residue fragment of the Alzheimer's beta-amyloid peptide, and structural characterization by solid state NMR Biochemistry 39 2000 13748 13759
-
(2000)
Biochemistry
, vol.39
, pp. 13748-13759
-
-
Balbach, J.J.1
Ishii, Y.2
Antzutkin, O.N.3
Leapman, R.D.4
Rizzo, N.W.5
Dyda, F.6
-
58
-
-
0037168655
-
A structural model for Alzheimer's beta-amyloid fibrils based on experimental constraints from solid state NMR
-
A.T. Petkova, Y. Ishii, J.J. Balbach, O.N. Antzutkin, R.D. Leapman, F. Delaglio, and R. Tycko A structural model for Alzheimer's beta-amyloid fibrils based on experimental constraints from solid state NMR Proc. Natl Acad. Sci. USA 99 2002 16742 16747
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 16742-16747
-
-
Petkova, A.T.1
Ishii, Y.2
Balbach, J.J.3
Antzutkin, O.N.4
Leapman, R.D.5
Delaglio, F.6
Tycko, R.7
-
59
-
-
0037174998
-
Structural and dynamic features of Alzheimer's a beta peptide in amyloid fibrils studied by site-directed spin labeling
-
M. Torok, S. Milton, R. Kayed, P. Wu, T. McIntire, C.G. Glabe, and R. Langen Structural and dynamic features of Alzheimer's A beta peptide in amyloid fibrils studied by site-directed spin labeling J. Biol. Chem. 277 2002 40810 40815
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 40810-40815
-
-
Torok, M.1
Milton, S.2
Kayed, R.3
Wu, P.4
McIntire, T.5
Glabe, C.G.6
Langen, R.7
-
60
-
-
0028804827
-
Structural model for the beta-amyloid fibril based on interstrand alignment of an antiparallel-sheet comprising a C-terminal peptide
-
P.T. Lansbury, P.R. Costa, J.M. Griffiths, E.J. Simon, M. Auger, and K.J. Halverson Structural model for the beta-amyloid fibril based on interstrand alignment of an antiparallel-sheet comprising a C-terminal peptide Nature Struct. Biol. 2 1995 990 998
-
(1995)
Nature Struct. Biol.
, vol.2
, pp. 990-998
-
-
Lansbury, P.T.1
Costa, P.R.2
Griffiths, J.M.3
Simon, E.J.4
Auger, M.5
Halverson, K.J.6
-
61
-
-
0036308719
-
Mutations that reduce aggregation of the Alzheimer's a beta 42 peptide: An unbiased search for the sequence determinants of a beta amyloidogenesis
-
C. Wurth, N.K. Guimard, and M.H. Hecht Mutations that reduce aggregation of the Alzheimer's A beta 42 peptide: an unbiased search for the sequence determinants of A beta amyloidogenesis J. Mol. Biol. 319 2002 1279 1290
-
(2002)
J. Mol. Biol.
, vol.319
, pp. 1279-1290
-
-
Wurth, C.1
Guimard, N.K.2
Hecht, M.H.3
-
62
-
-
0041816383
-
Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization
-
G. Bitan, S.S. Vollers, and D.B. Teplow Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization J. Biol. Chem. 278 2003 34882 34889
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 34882-34889
-
-
Bitan, G.1
Vollers, S.S.2
Teplow, D.B.3
-
63
-
-
0035860781
-
Amyloid beta-protein oligomerization - Prenucleation interactions revealed by photo-induced cross-linking of unmodified proteins
-
G. Bitan, A. Lomakin, and D.B. Teplow Amyloid beta-protein oligomerization - prenucleation interactions revealed by photo-induced cross-linking of unmodified proteins J. Biol. Chem. 276 2001 35176 35184
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 35176-35184
-
-
Bitan, G.1
Lomakin, A.2
Teplow, D.B.3
-
64
-
-
17944368176
-
The "arctic" APP mutation (E693G) causes Alzheimer's disease by enhanced a beta protofibril formation
-
C. Nilsberth, A. Westlind-Danielsson, C.B. Eckman, M.M. Condron, K. Axelman, and C. Forsell The "Arctic" APP mutation (E693G) causes Alzheimer's disease by enhanced A beta protofibril formation Nature Neurosci. 4 2001 887 893
-
(2001)
Nature Neurosci.
, vol.4
, pp. 887-893
-
-
Nilsberth, C.1
Westlind-Danielsson, A.2
Eckman, C.B.3
Condron, M.M.4
Axelman, K.5
Forsell, C.6
-
65
-
-
0034282630
-
Substitutions at codon 22 of Alzheimer's a beta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells
-
L. Miravalle, T. Tokuda, R. Chiarle, G. Giaccone, O. Bugiani, and F. Tagliavini Substitutions at codon 22 of Alzheimer's A beta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells J. Biol. Chem. 275 2000 27110 27116
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 27110-27116
-
-
Miravalle, L.1
Tokuda, T.2
Chiarle, R.3
Giaccone, G.4
Bugiani, O.5
Tagliavini, F.6
-
66
-
-
0035980088
-
Pathogenic effects of D23N Iowa mutant amyloid beta-protein
-
W.E. Van Nostrand, J.P. Melchor, H.S. Cho, S.M. Greenberg, and G.W. Rebeck Pathogenic effects of D23N Iowa mutant amyloid beta-protein J. Biol. Chem. 276 2001 32860 32866
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 32860-32866
-
-
Van Nostrand, W.E.1
Melchor, J.P.2
Cho, H.S.3
Greenberg, S.M.4
Rebeck, G.W.5
-
67
-
-
0029854533
-
Point substitution in the central hydrophobic cluster of a human beta-amyloid congener disrupts peptide folding and abolishes plaque competence
-
W.P. Esler, E.R. Stimson, J.R. Ghilardi, Y.A. Lu, A.M. Felix, and H.V. Vinters Point substitution in the central hydrophobic cluster of a human beta-amyloid congener disrupts peptide folding and abolishes plaque competence Biochemistry 35 1996 13914 13921
-
(1996)
Biochemistry
, vol.35
, pp. 13914-13921
-
-
Esler, W.P.1
Stimson, E.R.2
Ghilardi, J.R.3
Lu, Y.A.4
Felix, A.M.5
Vinters, H.V.6
-
68
-
-
0028920098
-
Prolines and amyloidogenicity in fragments of the Alzheimers peptide beta/A4
-
S.J. Wood, R. Wetzel, J.D. Martin, and M.R. Hurle Prolines and amyloidogenicity in fragments of the Alzheimers peptide beta/A4 Biochemistry 34 1995 724 730
-
(1995)
Biochemistry
, vol.34
, pp. 724-730
-
-
Wood, S.J.1
Wetzel, R.2
Martin, J.D.3
Hurle, M.R.4
-
69
-
-
0141499226
-
The role of alpha-synuclein in Parkinson's disease: Insights from animal models
-
E. Maries, B. Dass, T.J. Collier, J.H. Kordower, and K. Steece-Collier The role of alpha-synuclein in Parkinson's disease: insights from animal models Nature Rev. Neurosci. 4 2003 727 738
-
(2003)
Nature Rev. Neurosci.
, vol.4
, pp. 727-738
-
-
Maries, E.1
Dass, B.2
Collier, T.J.3
Kordower, J.H.4
Steece-Collier, K.5
-
70
-
-
0029257497
-
The core Alzheimers peptide Nac forms amyloid fibrils which seed and are seeded by beta-amyloid - Is Nac a common trigger or target in neurodegenerative disease
-
H.Y. Han, P.H. Weinreb, and P.T. Lansbury The core Alzheimers peptide Nac forms amyloid fibrils which seed and are seeded by beta-amyloid - is Nac a common trigger or target in neurodegenerative disease Chem. Biol. 2 1995 163 169
-
(1995)
Chem. Biol.
, vol.2
, pp. 163-169
-
-
Han, H.Y.1
Weinreb, P.H.2
Lansbury, P.T.3
-
71
-
-
0042848693
-
A peptide motif consisting of glycine, alanine, and valine is required for the fibrillization and cytotoxicity of human alpha-synuclein
-
H.N. Du, L. Tang, X.Y. Luo, H.T. Li, J. Hu, J.W. Zhou, and H.Y. Hu A peptide motif consisting of glycine, alanine, and valine is required for the fibrillization and cytotoxicity of human alpha-synuclein Biochemistry 42 2003 8870 8878
-
(2003)
Biochemistry
, vol.42
, pp. 8870-8878
-
-
Du, H.N.1
Tang, L.2
Luo, X.Y.3
Li, H.T.4
Hu, J.5
Zhou, J.W.6
Hu, H.Y.7
-
72
-
-
0036670712
-
Aggregation and neurotoxicity of alpha-synuclein and related peptides
-
O.M.A. El-Agnaf, and G.B. Irvine Aggregation and neurotoxicity of alpha-synuclein and related peptides Biochem. Soc. Trans. 30 2002 559 565
-
(2002)
Biochem. Soc. Trans.
, vol.30
, pp. 559-565
-
-
El-Agnaf, O.M.A.1
Irvine, G.B.2
-
73
-
-
0035951869
-
A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly
-
B.I. Giasson, I.V.J. Murray, J.Q. Trojanowski, and V.M.Y. Lee A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly J. Biol. Chem. 276 2001 2380 2386
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 2380-2386
-
-
Giasson, B.I.1
Murray, I.V.J.2
Trojanowski, J.Q.3
Lee, V.M.Y.4
-
74
-
-
0035022941
-
Intrinsically disordered protein
-
A.K. Dunker, J.D. Lawson, C.J. Brown, R.M. Williams, P. Romero, and J.S. Oh Intrinsically disordered protein J. Mol. Graph. 19 2001 26 59
-
(2001)
J. Mol. Graph.
, vol.19
, pp. 26-59
-
-
Dunker, A.K.1
Lawson, J.D.2
Brown, C.J.3
Williams, R.M.4
Romero, P.5
Oh, J.S.6
-
75
-
-
0141733169
-
Structural organization of alpha-synuclein fibrils studied by site-directed spin labeling
-
A. Der-Sarkissian, C.C. Jao, J. Chen, and R. Langen Structural organization of alpha-synuclein fibrils studied by site-directed spin labeling J. Biol. Chem. 278 2003 37530 37535
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 37530-37535
-
-
Der-Sarkissian, A.1
Jao, C.C.2
Chen, J.3
Langen, R.4
-
76
-
-
0037022661
-
Rationally designed mutations convert de novo amyloid-like fibrils into monomeric beta-sheet proteins
-
W.X. Wang, and M.H. Hecht Rationally designed mutations convert de novo amyloid-like fibrils into monomeric beta-sheet proteins Proc. Natl Acad. Sci. USA 99 2002 2760 2765
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 2760-2765
-
-
Wang, W.X.1
Hecht, M.H.2
-
77
-
-
0037022563
-
Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation
-
J.S. Richardson, and D.C. Richardson Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation Proc. Natl Acad. Sci. USA 99 2002 2754 2759
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 2754-2759
-
-
Richardson, J.S.1
Richardson, D.C.2
-
78
-
-
0032718386
-
Salt-induced detour through compact regions of the protein folding landscape
-
D.E. Otzen, and M. Oliveberg Salt-induced detour through compact regions of the protein folding landscape Proc. Natl Acad. Sci. USA 96 1999 11746 11751
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 11746-11751
-
-
Otzen, D.E.1
Oliveberg, M.2
-
79
-
-
0031990490
-
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
-
R. Kruger, W. Kuhn, T. Muller, D. Woitalla, M. Graeber, and S. Kosel Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease Nature Genet. 18 1998 106 108
-
(1998)
Nature Genet.
, vol.18
, pp. 106-108
-
-
Kruger, R.1
Kuhn, W.2
Muller, T.3
Woitalla, D.4
Graeber, M.5
Kosel, S.6
-
80
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
-
M.H. Polymeropoulos, C. Lavedan, E. Leroy, S.E. Ide, A. Dehejia, and A. Dutra Mutation in the alpha-synuclein gene identified in families with Parkinson's disease Science 276 1997 2045 2047
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
-
81
-
-
0031787871
-
Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease
-
K.A. Conway, J.D. Harper, and P.T. Lansbury Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease Nature Med. 4 1998 1318 1320
-
(1998)
Nature Med.
, vol.4
, pp. 1318-1320
-
-
Conway, K.A.1
Harper, J.D.2
Lansbury, P.T.3
-
82
-
-
11144353869
-
Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons
-
A.R. Saha, J. Hill, M.A. Utton, A.A. Asuni, S. Ackerley, and A.J. Grierson Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons J. Cell Sci. 117 2004 1017 1024
-
(2004)
J. Cell Sci.
, vol.117
, pp. 1017-1024
-
-
Saha, A.R.1
Hill, J.2
Utton, M.A.3
Asuni, A.A.4
Ackerley, S.5
Grierson, A.J.6
-
83
-
-
10744230149
-
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia
-
J.J. Zarranz, J. Alegre, J.C. Gomez-Esteban, E. Lezcano, R. Ros, and I. Ampuero The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia Ann. Neurol. 55 2004 164 173
-
(2004)
Ann. Neurol.
, vol.55
, pp. 164-173
-
-
Zarranz, J.J.1
Alegre, J.2
Gomez-Esteban, J.C.3
Lezcano, E.4
Ros, R.5
Ampuero, I.6
-
84
-
-
6344228684
-
Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein
-
W. Choi, S. Zibaee, R. Jakes, L.C. Serpell, B. Davletov, R.A. Crowther, and M. Goedert Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein FEBS Letters 576 2004 363 368
-
(2004)
FEBS Letters
, vol.576
, pp. 363-368
-
-
Choi, W.1
Zibaee, S.2
Jakes, R.3
Serpell, L.C.4
Davletov, B.5
Crowther, R.A.6
Goedert, M.7
-
85
-
-
0028618190
-
Tissue-dependent alternative splicing of messenger-Rna for Nacp, the precursor of non-A-beta component of Alzheimer's-disease amyloid
-
K. Ueda, T. Saitoh, and H. Mori Tissue-dependent alternative splicing of messenger-Rna For Nacp, the precursor of non-A-beta component of Alzheimer's-disease amyloid Biochem. Biophys. Res. Commun. 205 1994 1366 1372
-
(1994)
Biochem. Biophys. Res. Commun.
, vol.205
, pp. 1366-1372
-
-
Ueda, K.1
Saitoh, T.2
Mori, H.3
-
86
-
-
9444233904
-
Differential expression of alpha-synuclein isoforms in dementia with Lewy bodies
-
K. Beyer, J.I. Lao, C. Carrato, J.L. Mate, D. Lopez, I. Ferrer, and A. Ariza Differential expression of alpha-synuclein isoforms in dementia with Lewy bodies Neuropathol. Appl. Neurobiol. 30 2004 601 607
-
(2004)
Neuropathol. Appl. Neurobiol.
, vol.30
, pp. 601-607
-
-
Beyer, K.1
Lao, J.I.2
Carrato, C.3
Mate, J.L.4
Lopez, D.5
Ferrer, I.6
Ariza, A.7
-
87
-
-
0038116620
-
Role of alpha-synuclein carboxy-terminus on fibril formation in vitro
-
I.V.J. Murray, B.I. Giasson, S.M. Quinn, V. Koppaka, P.H. Axelsen, and H. Ischiropoulos Role of alpha-synuclein carboxy-terminus on fibril formation in vitro Biochemistry 42 2003 8530 8540
-
(2003)
Biochemistry
, vol.42
, pp. 8530-8540
-
-
Murray, I.V.J.1
Giasson, B.I.2
Quinn, S.M.3
Koppaka, V.4
Axelsen, P.H.5
Ischiropoulos, H.6
-
88
-
-
0034712918
-
Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation
-
L.C. Serpell, J. Berriman, R. Jakes, M. Goedert, and R.A. Crowther Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation Proc. Natl Acad. Sci. USA 97 2000 4897 4902
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 4897-4902
-
-
Serpell, L.C.1
Berriman, J.2
Jakes, R.3
Goedert, M.4
Crowther, R.A.5
-
89
-
-
12944304172
-
Mapping long-range interactions in alpha-synuclein using spin-label NMR and ensemble molecular dynamics simulations
-
M.M. Dedmon, K. Lindorff-Larsen, J. Christodoulou, M. Vendruscolo, and C.M. Dobson Mapping long-range interactions in alpha-synuclein using spin-label NMR and ensemble molecular dynamics simulations J. Am. Chem. Soc. 127 2005 476 477
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 476-477
-
-
Dedmon, M.M.1
Lindorff-Larsen, K.2
Christodoulou, J.3
Vendruscolo, M.4
Dobson, C.M.5
-
90
-
-
0347594304
-
Modeling Tau polymerization in vitro: A review and synthesis
-
T.C. Gamblin, R.W. Berry, and L.I. Binder Modeling Tau polymerization in vitro: a review and synthesis Biochemistry 42 2003 15009 15017
-
(2003)
Biochemistry
, vol.42
, pp. 15009-15017
-
-
Gamblin, T.C.1
Berry, R.W.2
Binder, L.I.3
-
91
-
-
0036892302
-
Tau gene mutations: Dissecting the pathogenesis of FTDP-17
-
E.M. Ingram, and M.G. Spillantini Tau gene mutations: dissecting the pathogenesis of FTDP-17 Trends Mol. Med. 8 2002 555 562
-
(2002)
Trends Mol. Med.
, vol.8
, pp. 555-562
-
-
Ingram, E.M.1
Spillantini, M.G.2
-
92
-
-
0024745894
-
Multiple isoforms of human microtubule-associated protein-Tau - Sequences and localization in neurofibrillary tangles of Alzheimers disease
-
M. Goedert, M.G. Spillantini, R. Jakes, D. Rutherford, and R.A. Crowther Multiple isoforms of human microtubule-associated protein-Tau - sequences and localization in neurofibrillary tangles of Alzheimers disease Neuron 3 1989 519 526
-
(1989)
Neuron
, vol.3
, pp. 519-526
-
-
Goedert, M.1
Spillantini, M.G.2
Jakes, R.3
Rutherford, D.4
Crowther, R.A.5
-
93
-
-
0035958642
-
Tauopathy in Drosophila: Neurodegeneration without neurofibrillary tangles
-
C.W. Wittmann, M.F. Wszolek, J.M. Shulman, P.M. Salvaterra, J. Lewis, M. Hutton, and M.B. Feany Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles Science 293 2001 711 714
-
(2001)
Science
, vol.293
, pp. 711-714
-
-
Wittmann, C.W.1
Wszolek, M.F.2
Shulman, J.M.3
Salvaterra, P.M.4
Lewis, J.5
Hutton, M.6
Feany, M.B.7
-
94
-
-
0037111833
-
Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's disease
-
T. Fath, J. Eidenmuller, and R. Brandt Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's disease J. Neurosci. 22 2002 9733 9741
-
(2002)
J. Neurosci.
, vol.22
, pp. 9733-9741
-
-
Fath, T.1
Eidenmuller, J.2
Brandt, R.3
-
95
-
-
0034528413
-
Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Their relevance for understanding the neurogenerative process
-
M. Goedert, B. Ghetti, and M.G. Spillantini Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Their relevance for understanding the neurogenerative process Ann. NY Acad. Sci. 920 2000 74 83
-
(2000)
Ann. NY Acad. Sci.
, vol.920
, pp. 74-83
-
-
Goedert, M.1
Ghetti, B.2
Spillantini, M.G.3
-
96
-
-
0034625060
-
Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure
-
M. von Bergen, P. Friedhoff, J. Biernat, J. Heberle, E.M. Mandelkow, and E. Mandelkow Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure Proc. Natl Acad. Sci. USA 97 2000 5129 5134
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 5129-5134
-
-
Von Bergen, M.1
Friedhoff, P.2
Biernat, J.3
Heberle, J.4
Mandelkow, E.M.5
Mandelkow, E.6
-
97
-
-
0036780877
-
Amyloid-beta immunotherapy for Alzheimer's disease: The end of the beginning
-
D. Schenk Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning Nature Rev. Neurosci. 3 2002 824 828
-
(2002)
Nature Rev. Neurosci.
, vol.3
, pp. 824-828
-
-
Schenk, D.1
-
98
-
-
0037264120
-
Unfolding the role of protein misfolding in neurodegenerative diseases
-
C. Soto Unfolding the role of protein misfolding in neurodegenerative diseases Nature Rev. Neurosci. 4 2003 49 60
-
(2003)
Nature Rev. Neurosci.
, vol.4
, pp. 49-60
-
-
Soto, C.1
-
99
-
-
2542530161
-
In the footsteps of alchemists
-
C.M. Dobson In the footsteps of alchemists Science 304 2004 1259
-
(2004)
Science
, vol.304
, pp. 1259
-
-
Dobson, C.M.1
-
100
-
-
0042467574
-
A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme
-
M. Dumoulin, A.M. Last, A. Desmyter, K. Decanniere, D. Canet, and G.R. Larsson A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme Nature 424 2003 783 788
-
(2003)
Nature
, vol.424
, pp. 783-788
-
-
Dumoulin, M.1
Last, A.M.2
Desmyter, A.3
Decanniere, K.4
Canet, D.5
Larsson, G.R.6
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