Compartmentalization of superoxide dismutase 1 (SOD1G93A) aggregates determines their toxicity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 39, 2012, Pages 15811-15816

  Weisberg, Sarah J ^a   Lyakhovetsky, Roman ^b   Werdiger, Ayelet Chen ^b   Gitler, Aaron D ^c   Soen, Yoav ^a   Kaganovich, Daniel ^b  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aggregation quality control; ALS; Insoluble protein deposit; Protein folding

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; HEAT SHOCK PROTEIN 70; PROTEASOME;

ARTICLE; CELL AGGREGATION; CELL COMPARTMENTALIZATION; CELL STRUCTURE; CELL VIABILITY; CYTOTOXICITY; HUMAN; HUMAN CELL; JUXTANUCLEAR QUALITY CONTROL COMPARTMENT; NERVE CELL; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING;

AMYOTROPHIC LATERAL SCLEROSIS; CELL LINE; CELL SURVIVAL; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INCLUSION BODIES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN FOLDING; SUPEROXIDE DISMUTASE;

EID: 84866883258     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1205829109     Document Type: Article

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