-
1
-
-
4644362726
-
P38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis
-
S. Ackerley, A.J. Grierson, S. Banner, M.S. Perkinton, J. Brownlees, H.L. Byers, M. Ward, P. Thornhill, K. Hussain, J.S. Waby, B.H. Anderton, J.D. Cooper, C. Dingwall, P.N. Leigh, C.E. Shaw, and C.C. Miller P38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis Mol. Cell Neurosci. 26 2004 354 364
-
(2004)
Mol. Cell Neurosci.
, vol.26
, pp. 354-364
-
-
Ackerley, S.1
Grierson, A.J.2
Banner, S.3
Perkinton, M.S.4
Brownlees, J.5
Byers, H.L.6
Ward, M.7
Thornhill, P.8
Hussain, K.9
Waby, J.S.10
Anderton, B.H.11
Cooper, J.D.12
Dingwall, C.13
Leigh, P.N.14
Shaw, C.E.15
Miller, C.C.16
-
2
-
-
0034708480
-
The genome sequence of Drosophila melanogaster
-
M.D. Adams, S.E. Celniker, R.A. Holt, C.A. Evans, J.D. Gocayne, P.G. Amanatides, S.E. Scherer, P.W. Li, R.A. Hoskins, R.F. Galle, R.A. George, S.E. Lewis, S. Richards, M. Ashburner, S.N. Henderson, G.G. Sutton, J.R. Wortman, M.D. Yandell, Q. Zhang, L.X. Chen, R.C. Brandon, Y.H. Rogers, R.G. Blazej, M. Champe, B.D. Pfeiffer, K.H. Wan, C. Doyle, E.G. Baxter, G. Helt, C.R. Nelson, G.L. Gabor, J.F. Abril, A. Agbayani, H.J. An, C. Andrews-Pfannkoch, D. Baldwin, R.M. Ballew, A. Basu, J. Baxendale, L. Bayraktaroglu, E.M. Beasley, K.Y. Beeson, P.V. Benos, B.P. Berman, D. Bhandari, S. Bolshakov, D. Borkova, M.R. Botchan, J. Bouck, P. Brokstein, P. Brottier, K.C. Burtis, D.A. Busam, H. Butler, E. Cadieu, A. Center, I. Chandra, J.M. Cherry, S. Cawley, C. Dahlke, L.B. Davenport, P. Davies, P.B. de, A. Delcher, Z. Deng, A.D. Mays, I. Dew, S.M. Dietz, K. Dodson, L.E. Doup, M. Downes, S. Dugan-Rocha, B.C. Dunkov, P. Dunn, K.J. Durbin, C.C. Evangelista, C. Ferraz, S. Ferriera, W. Fleischmann, C. Fosler, A.E. Gabrielian, N.S. Garg, W.M. Gelbart, K. Glasser, A. Glodek, F. Gong, J.H. Gorrell, Z. Gu, P. Guan, M. Harris, N.L. Harris, D. Harvey, T.J. Heiman, J.R. Hernandez, J. Houck, D. Hostin, K.A. Houston, T.J. Howland, M.H. Wei, C. Ibegwam, M. Jalali, F. Kalush, G.H. Karpen, Z. Ke, J.A. Kennison, K.A. Ketchum, B.E. Kimmel, C.D. Kodira, C. Kraft, S. Kravitz, D. Kulp, Z. Lai, P. Lasko, Y. Lei, A.A. Levitsky, J. Li, Z. Li, Y. Liang, X. Lin, X. Liu, B. Mattei, T.C. McIntosh, M.P. McLeod, D. McPherson, G. Merkulov, N.V. Milshina, C. Mobarry, J. Morris, A. Moshrefi, S.M. Mount, M. Moy, B. Murphy, L. Murphy, D.M. Muzny, D.L. Nelson, D.R. Nelson, K.A. Nelson, K. Nixon, D.R. Nusskern, J.M. Pacleb, M. Palazzolo, G.S. Pittman, S. Pan, J. Pollard, V. Puri, M.G. Reese, K. Reinert, K. Remington, R.D. Saunders, F. Scheeler, H. Shen, B.C. Shue, I. Siden-Kiamos, M. Simpson, M.P. Skupski, T. Smith, E. Spier, A.C. Spradling, M. Stapleton, R. Strong, E. Sun, R. Svirskas, C. Tector, R. Turner, E. Venter, A.H. Wang, X. Wang, Z.Y. Wang, D.A. Wassarman, G.M. Weinstock, J. Weissenbach, S.M. Williams, T. Woodage, K.C. Worley, D. Wu, S. Yang, Q.A. Yao, J. Ye, R.F. Yeh, J.S. Zaveri, M. Zhan, G. Zhang, Q. Zhao, L. Zheng, X.H. Zheng, F.N. Zhong, W. Zhong, X. Zhou, S. Zhu, X. Zhu, H.O. Smith, R.A. Gibbs, E.W. Myers, G.M. Rubin, and J.C. Venter The genome sequence of Drosophila melanogaster Science 287 2000 2185 2195
-
(2000)
Science
, vol.287
, pp. 2185-2195
-
-
Adams, M.D.1
Celniker, S.E.2
Holt, R.A.3
Evans, C.A.4
Gocayne, J.D.5
Amanatides, P.G.6
Scherer, S.E.7
Li, P.W.8
Hoskins, R.A.9
Galle, R.F.10
George, R.A.11
Lewis, S.E.12
Richards, S.13
Ashburner, M.14
Henderson, S.N.15
Sutton, G.G.16
Wortman, J.R.17
Yandell, M.D.18
Zhang, Q.19
Chen, L.X.20
Brandon, R.C.21
Rogers, Y.H.22
Blazej, R.G.23
Champe, M.24
Pfeiffer, B.D.25
Wan, K.H.26
Doyle, C.27
Baxter, E.G.28
Helt, G.29
Nelson, C.R.30
Gabor, G.L.31
Abril, J.F.32
Agbayani, A.33
An, H.J.34
Andrews-Pfannkoch, C.35
Baldwin, D.36
Ballew, R.M.37
Basu, A.38
Baxendale, J.39
Bayraktaroglu, L.40
Beasley, E.M.41
Beeson, K.Y.42
Benos, P.V.43
Berman, B.P.44
Bhandari, D.45
Bolshakov, S.46
Borkova, D.47
Botchan, M.R.48
Bouck, J.49
Brokstein, P.50
Brottier, P.51
Burtis, K.C.52
Busam, D.A.53
Butler, H.54
Cadieu, E.55
Center, A.56
Chandra, I.57
Cherry, J.M.58
Cawley, S.59
Dahlke, C.60
Davenport, L.B.61
Davies, P.62
De, P.B.63
Delcher, A.64
Deng, Z.65
Mays, A.D.66
Dew, I.67
Dietz, S.M.68
Dodson, K.69
Doup, L.E.70
Downes, M.71
Dugan-Rocha, S.72
Dunkov, B.C.73
Dunn, P.74
Durbin, K.J.75
Evangelista, C.C.76
Ferraz, C.77
Ferriera, S.78
Fleischmann, W.79
Fosler, C.80
Gabrielian, A.E.81
Garg, N.S.82
Gelbart, W.M.83
Glasser, K.84
Glodek, A.85
Gong, F.86
Gorrell, J.H.87
Gu, Z.88
Guan, P.89
Harris, M.90
Harris, N.L.91
Harvey, D.92
Heiman, T.J.93
Hernandez, J.R.94
Houck, J.95
Hostin, D.96
Houston, K.A.97
Howland, T.J.98
Wei, M.H.99
more..
-
3
-
-
84893508018
-
Axonal transport of TDP-43 MRNA granules is impaired by ALS-causing mutations
-
N.H. Alami, R.B. Smith, M.A. Carrasco, L.A. Williams, C.S. Winborn, S.S. Han, E. Kiskinis, B. Winborn, B.D. Freibaum, A. Kanagaraj, A.J. Clare, N.M. Badders, B. Bilican, E. Chaum, S. Chandran, C.E. Shaw, K.C. Eggan, T. Maniatis, and J.P. Taylor Axonal transport of TDP-43 MRNA granules is impaired by ALS-causing mutations Neuron 81 2014 536 543
-
(2014)
Neuron
, vol.81
, pp. 536-543
-
-
Alami, N.H.1
Smith, R.B.2
Carrasco, M.A.3
Williams, L.A.4
Winborn, C.S.5
Han, S.S.6
Kiskinis, E.7
Winborn, B.8
Freibaum, B.D.9
Kanagaraj, A.10
Clare, A.J.11
Badders, N.M.12
Bilican, B.13
Chaum, E.14
Chandran, S.15
Shaw, C.E.16
Eggan, K.C.17
Maniatis, T.18
Taylor, J.P.19
-
4
-
-
65449123115
-
Incidence and lifetime risk of motor neuron disease in the United Kingdom: A population-based study
-
A. Alonso, G. Logroscino, S.S. Jick, and M.A. Hernan Incidence and lifetime risk of motor neuron disease in the United Kingdom: a population-based study Eur. J. Neurol. 16 2009 745 751
-
(2009)
Eur. J. Neurol.
, vol.16
, pp. 745-751
-
-
Alonso, A.1
Logroscino, G.2
Jick, S.S.3
Hernan, M.A.4
-
5
-
-
33750716074
-
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
T. Arai, M. Hasegawa, H. Akiyama, K. Ikeda, T. Nonaka, H. Mori, D. Mann, K. Tsuchiya, M. Yoshida, Y. Hashizume, and T. Oda TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis Biochem. Biophys. Res. Commun. 351 2006 602 611
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.351
, pp. 602-611
-
-
Arai, T.1
Hasegawa, M.2
Akiyama, H.3
Ikeda, K.4
Nonaka, T.5
Mori, H.6
Mann, D.7
Tsuchiya, K.8
Yoshida, M.9
Hashizume, Y.10
Oda, T.11
-
6
-
-
49649118218
-
Drosophila melanogaster and the development of biology in the 20th century
-
A.M. Arias Drosophila melanogaster and the development of biology in the 20th century Methods Mol. Biol. 420 2008 1 25
-
(2008)
Methods Mol. Biol.
, vol.420
, pp. 1-25
-
-
Arias, A.M.1
-
7
-
-
84874272095
-
Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to C9FTD/ALS
-
P.E. Ash, K.F. Bieniek, T.F. Gendron, T. Caulfield, W.L. Lin, M. DeJesus-Hernandez, M.M. van Blitterswijk, K. Jansen-West, J.W. Paul III, R. Rademakers, K.B. Boylan, D.W. Dickson, and L. Petrucelli Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to C9FTD/ALS Neuron 77 2013 639 646
-
(2013)
Neuron
, vol.77
, pp. 639-646
-
-
Ash, P.E.1
Bieniek, K.F.2
Gendron, T.F.3
Caulfield, T.4
Lin, W.L.5
Dejesus-Hernandez, M.6
Van Blitterswijk, M.M.7
Jansen-West, K.8
Paul, J.W.9
Rademakers, R.10
Boylan, K.B.11
Dickson, D.W.12
Petrucelli, L.13
-
8
-
-
0033539906
-
Identification of a novel fusion gene involving HTAFII68 and CHN from a T(9; 17)(Q22; Q11.2) translocation in an extraskeletal myxoid chondrosarcoma
-
C. Attwooll, M. Tariq, M. Harris, J.D. Coyne, N. Telford, and J.M. Varley Identification of a novel fusion gene involving HTAFII68 and CHN from a T(9; 17)(Q22; Q11.2) translocation in an extraskeletal myxoid chondrosarcoma Oncogene 18 1999 7599 7601
-
(1999)
Oncogene
, vol.18
, pp. 7599-7601
-
-
Attwooll, C.1
Tariq, M.2
Harris, M.3
Coyne, J.D.4
Telford, N.5
Varley, J.M.6
-
9
-
-
84902312349
-
Identification of Ter94, drosophila VCP, as a strong modulator of motor neuron degeneration induced by knockdown of Caz, drosophila FUS
-
Y. Azuma, T. Tokuda, M. Shimamura, A. Kyotani, H. Sasayama, T. Yoshida, I. Mizuta, T. Mizuno, M. Nakagawa, N. Fujikake, M. Ueyama, Y. Nagai, and M. Yamaguchi Identification of Ter94, drosophila VCP, as a strong modulator of motor neuron degeneration induced by knockdown of Caz, drosophila FUS Hum. Mol. Genet. 23 13 2014 3467 3480
-
(2014)
Hum. Mol. Genet.
, vol.23
, Issue.13
, pp. 3467-3480
-
-
Azuma, Y.1
Tokuda, T.2
Shimamura, M.3
Kyotani, A.4
Sasayama, H.5
Yoshida, T.6
Mizuta, I.7
Mizuno, T.8
Nakagawa, M.9
Fujikake, N.10
Ueyama, M.11
Nagai, Y.12
Yamaguchi, M.13
-
10
-
-
84922871119
-
Accumulation of dipeptide repeat proteins predates that of TDP-43 in frontotemporal lobar degeneration associated with hexanucleotide repeat expansions in C9ORF72 gene
-
A. Baborie, T.D. Griffiths, E. Jaros, R. Perry, I.G. McKeith, D.J. Burn, M. Masuda-Suzukake, M. Hasegawa, S. Rollinson, S. Pickering-Brown, A.C. Robinson, Y.S. Davidson, and D.M. Mann Accumulation of dipeptide repeat proteins predates that of TDP-43 in frontotemporal lobar degeneration associated with hexanucleotide repeat expansions in C9ORF72 gene Neuropathol. Appl. Neurobiol 2014
-
(2014)
Neuropathol. Appl. Neurobiol
-
-
Baborie, A.1
Griffiths, T.D.2
Jaros, E.3
Perry, R.4
McKeith, I.G.5
Burn, D.J.6
Masuda-Suzukake, M.7
Hasegawa, M.8
Rollinson, S.9
Pickering-Brown, S.10
Robinson, A.C.11
Davidson, Y.S.12
Mann, D.M.13
-
11
-
-
0033607753
-
Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation
-
H. Baechtold, M. Kuroda, J. Sok, D. Ron, B.S. Lopez, and A.T. Akhmedov Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation J. Biol. Chem. 274 1999 34337 34342
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 34337-34342
-
-
Baechtold, H.1
Kuroda, M.2
Sok, J.3
Ron, D.4
Lopez, B.S.5
Akhmedov, A.T.6
-
12
-
-
84879885490
-
Expression of zinc-deficient human superoxide dismutase in drosophila neurons produces a locomotor defect linked to mitochondrial dysfunction
-
S. Bahadorani, S.T. Mukai, J. Rabie, J.S. Beckman, J.P. Phillips, and A.J. Hilliker Expression of zinc-deficient human superoxide dismutase in drosophila neurons produces a locomotor defect linked to mitochondrial dysfunction Neurobiol. Aging 34 2013 2322 2330
-
(2013)
Neurobiol. Aging
, vol.34
, pp. 2322-2330
-
-
Bahadorani, S.1
Mukai, S.T.2
Rabie, J.3
Beckman, J.S.4
Phillips, J.P.5
Hilliker, A.J.6
-
13
-
-
74949135753
-
Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis
-
S.J. Barmada, G. Skibinski, E. Korb, E.J. Rao, J.Y. Wu, and S. Finkbeiner Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis J. Neurosci. 30 2010 639 649
-
(2010)
J. Neurosci.
, vol.30
, pp. 639-649
-
-
Barmada, S.J.1
Skibinski, G.2
Korb, E.3
Rao, E.J.4
Wu, J.Y.5
Finkbeiner, S.6
-
14
-
-
76249112500
-
Dynein light chain 1 is required for autophagy, protein clearance, and cell death in drosophila
-
Y. Batlevi, D.N. Martin, U.B. Pandey, C.R. Simon, C.M. Powers, J.P. Taylor, and E.H. Baehrecke Dynein light chain 1 is required for autophagy, protein clearance, and cell death in drosophila Proc. Natl. Acad. Sci. USA 107 2010 742 747
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 742-747
-
-
Batlevi, Y.1
Martin, D.N.2
Pandey, U.B.3
Simon, C.R.4
Powers, C.M.5
Taylor, J.P.6
Baehrecke, E.H.7
-
15
-
-
20844450998
-
Arginine methylation an emerging regulator of protein function
-
M.T. Bedford, and S. Richard Arginine methylation an emerging regulator of protein function Mol. Cell 18 2005 263 272
-
(2005)
Mol. Cell
, vol.18
, pp. 263-272
-
-
Bedford, M.T.1
Richard, S.2
-
16
-
-
77953812408
-
100 years of drosophila research and its impact on vertebrate neuroscience: A history lesson for the future
-
H.J. Bellen, C. Tong, and H. Tsuda 100 years of drosophila research and its impact on vertebrate neuroscience: a history lesson for the future Nat. Rev. Neurosci. 11 2010 514 522
-
(2010)
Nat. Rev. Neurosci.
, vol.11
, pp. 514-522
-
-
Bellen, H.J.1
Tong, C.2
Tsuda, H.3
-
17
-
-
70350045802
-
Mutations in FUS cause FALS and SALS in French and French Canadian populations
-
V.V. Belzil, P.N. Valdmanis, P.A. Dion, H. Daoud, E. Kabashi, A. Noreau, J. Gauthier, P. Hince, A. Desjarlais, J.P. Bouchard, L. Lacomblez, F. Salachas, P.F. Pradat, W. Camu, V. Meininger, N. Dupre, and G.A. Rouleau Mutations in FUS cause FALS and SALS in French and French Canadian populations Neurology 73 2009 1176 1179
-
(2009)
Neurology
, vol.73
, pp. 1176-1179
-
-
Belzil, V.V.1
Valdmanis, P.N.2
Dion, P.A.3
Daoud, H.4
Kabashi, E.5
Noreau, A.6
Gauthier, J.7
Hince, P.8
Desjarlais, A.9
Bouchard, J.P.10
Lacomblez, L.11
Salachas, F.12
Pradat, P.F.13
Camu, W.14
Meininger, V.15
Dupre, N.16
Rouleau, G.A.17
-
18
-
-
0842288215
-
Activated P38MAPK is a novel component of the intracellular inclusions found in human amyotrophic lateral sclerosis and mutant SOD1 transgenic mice
-
C. Bendotti, C. Atzori, R. Piva, M. Tortarolo, M.J. Strong, S. DeBiasi, and A. Migheli Activated P38MAPK is a novel component of the intracellular inclusions found in human amyotrophic lateral sclerosis and mutant SOD1 transgenic mice J. Neuropathol. Exp. Neurol. 63 2004 113 119
-
(2004)
J. Neuropathol. Exp. Neurol.
, vol.63
, pp. 113-119
-
-
Bendotti, C.1
Atzori, C.2
Piva, R.3
Tortarolo, M.4
Strong, M.J.5
Debiasi, S.6
Migheli, A.7
-
19
-
-
33744782374
-
Inter- and intracellular signaling in amyotrophic lateral sclerosis: Role of P38 mitogen-activated protein kinase
-
C. Bendotti, C.M. Bao, C. Cheroni, G. Grignaschi, C.D. Lo, M. Peviani, M. Tortarolo, P. Veglianese, and E. Zennaro Inter- and intracellular signaling in amyotrophic lateral sclerosis: role of P38 mitogen-activated protein kinase Neurodegener. Dis. 2 2005 128 134
-
(2005)
Neurodegener. Dis.
, vol.2
, pp. 128-134
-
-
Bendotti, C.1
Bao, C.M.2
Cheroni, C.3
Grignaschi, G.4
Lo, C.D.5
Peviani, M.6
Tortarolo, M.7
Veglianese, P.8
Zennaro, E.9
-
20
-
-
0029812470
-
HTAF(II)68, a novel RNA/SsDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II
-
A. Bertolotti, Y. Lutz, D.J. Heard, P. Chambon, and L. Tora HTAF(II)68, a novel RNA/SsDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II EMBO J. 15 1996 5022 5031
-
(1996)
EMBO J.
, vol.15
, pp. 5022-5031
-
-
Bertolotti, A.1
Lutz, Y.2
Heard, D.J.3
Chambon, P.4
Tora, L.5
-
21
-
-
33749056809
-
ALS: A disease of motor neurons and their nonneuronal neighbors
-
S. Boillee, V.C. Vande, and D.W. Cleveland ALS: a disease of motor neurons and their nonneuronal neighbors Neuron 52 2006 39 59
-
(2006)
Neuron
, vol.52
, pp. 39-59
-
-
Boillee, S.1
Vande, V.C.2
Cleveland, D.W.3
-
22
-
-
0033614771
-
A genetic model for human polyglutamine-repeat disease in Drosophila melanogaster
-
N.M. Bonini A genetic model for human polyglutamine-repeat disease in Drosophila melanogaster Philos. Trans. R. Soc. Lond. B: Biol. Sci. 354 1999 1057 1060
-
(1999)
Philos. Trans. R. Soc. Lond. B: Biol. Sci.
, vol.354
, pp. 1057-1060
-
-
Bonini, N.M.1
-
23
-
-
0027359334
-
Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis
-
A.C. Bowling, J.B. Schulz, R.H. Brown Jr., and M.F. Beal Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis J. Neurochem. 61 1993 2322 2325
-
(1993)
J. Neurochem.
, vol.61
, pp. 2322-2325
-
-
Bowling, A.C.1
Schulz, J.B.2
Brown, Jr.R.H.3
Beal, M.F.4
-
24
-
-
0027160708
-
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
-
A.H. Brand, and N. Perrimon Targeted gene expression as a means of altering cell fates and generating dominant phenotypes Development 118 1993 401 415
-
(1993)
Development
, vol.118
, pp. 401-415
-
-
Brand, A.H.1
Perrimon, N.2
-
25
-
-
0027265545
-
The developmentally-regulated drosophila gene Rox8 encodes an RRM-type RNA binding protein structurally related to human TIA-1-type nucleolysins
-
S. Brand, and H.M. Bourbon The developmentally-regulated drosophila gene Rox8 encodes an RRM-type RNA binding protein structurally related to human TIA-1-type nucleolysins Nucl. Acids Res. 21 1993 3699 3704
-
(1993)
Nucl. Acids Res.
, vol.21
, pp. 3699-3704
-
-
Brand, S.1
Bourbon, H.M.2
-
26
-
-
0001178038
-
Direct proof through non-disjunction that the sex-linked genes of drosophila are borne by the X-chromosome
-
C.B. Bridges Direct proof through non-disjunction that the sex-linked genes of drosophila are borne by the X-chromosome Science 40 1914 107 109
-
(1914)
Science
, vol.40
, pp. 107-109
-
-
Bridges, C.B.1
-
27
-
-
0031051485
-
ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions
-
L.I. Bruijn, M.W. Becher, M.K. Lee, K.L. Anderson, N.A. Jenkins, N.G. Copeland, S.S. Sisodia, J.D. Rothstein, D.R. Borchelt, D.L. Price, and D.W. Cleveland ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions Neuron 18 1997 327 338
-
(1997)
Neuron
, vol.18
, pp. 327-338
-
-
Bruijn, L.I.1
Becher, M.W.2
Lee, M.K.3
Anderson, K.L.4
Jenkins, N.A.5
Copeland, N.G.6
Sisodia, S.S.7
Rothstein, J.D.8
Borchelt, D.R.9
Price, D.L.10
Cleveland, D.W.11
-
28
-
-
0032544674
-
Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1
-
L.I. Bruijn, M.K. Houseweart, S. Kato, K.L. Anderson, S.D. Anderson, E. Ohama, A.G. Reaume, R.W. Scott, and D.W. Cleveland Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1 Science 281 1998 1851 1854
-
(1998)
Science
, vol.281
, pp. 1851-1854
-
-
Bruijn, L.I.1
Houseweart, M.K.2
Kato, S.3
Anderson, K.L.4
Anderson, S.D.5
Ohama, E.6
Reaume, A.G.7
Scott, R.W.8
Cleveland, D.W.9
-
29
-
-
0026744303
-
The small GTPase Rab5 functions as a regulatory factor in the early endocytic pathway
-
C. Bucci, R.G. Parton, I.H. Mather, H. Stunnenberg, K. Simons, B. Hoflack, and M. Zerial The small GTPase Rab5 functions as a regulatory factor in the early endocytic pathway Cell 70 1992 715 728
-
(1992)
Cell
, vol.70
, pp. 715-728
-
-
Bucci, C.1
Parton, R.G.2
Mather, I.H.3
Stunnenberg, H.4
Simons, K.5
Hoflack, B.6
Zerial, M.7
-
30
-
-
27844514227
-
TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: An important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing
-
E. Buratti, A. Brindisi, M. Giombi, S. Tisminetzky, Y.M. Ayala, and F.E. Baralle TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing J. Biol. Chem. 280 2005 37572 37584
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 37572-37584
-
-
Buratti, E.1
Brindisi, A.2
Giombi, M.3
Tisminetzky, S.4
Ayala, Y.M.5
Baralle, F.E.6
-
31
-
-
0035794665
-
Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping
-
E. Buratti, T. Dork, E. Zuccato, F. Pagani, M. Romano, and F.E. Baralle Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping EMBO J. 20 2001 1774 1784
-
(2001)
EMBO J.
, vol.20
, pp. 1774-1784
-
-
Buratti, E.1
Dork, T.2
Zuccato, E.3
Pagani, F.4
Romano, M.5
Baralle, F.E.6
-
32
-
-
84857050135
-
Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: A population-based cohort study
-
S. Byrne, M. Elamin, P. Bede, A. Shatunov, C. Walsh, B. Corr, M. Heverin, N. Jordan, K. Kenna, C. Lynch, R.L. McLaughlin, P.M. Iyer, C. O'Brien, J. Phukan, B. Wynne, A.L. Bokde, D.G. Bradley, N. Pender, A. Al-Chalabi, and O. Hardiman Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: a population-based cohort study Lancet Neurol. 11 2012 232 240
-
(2012)
Lancet Neurol.
, vol.11
, pp. 232-240
-
-
Byrne, S.1
Elamin, M.2
Bede, P.3
Shatunov, A.4
Walsh, C.5
Corr, B.6
Heverin, M.7
Jordan, N.8
Kenna, K.9
Lynch, C.10
McLaughlin, R.L.11
Iyer, P.M.12
O'Brien, C.13
Phukan, J.14
Wynne, B.15
Bokde, A.L.16
Bradley, D.G.17
Pender, N.18
Al-Chalabi, A.19
Hardiman, O.20
more..
-
33
-
-
79955774490
-
Rate of familial amyotrophic lateral sclerosis: A systematic review and meta-analysis
-
S. Byrne, C. Walsh, C. Lynch, P. Bede, M. Elamin, K. Kenna, R. McLaughlin, and O. Hardiman Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis J. Neurol. Neurosurg. Psychiatry 82 2011 623 627
-
(2011)
J. Neurol. Neurosurg. Psychiatry
, vol.82
, pp. 623-627
-
-
Byrne, S.1
Walsh, C.2
Lynch, C.3
Bede, P.4
Elamin, M.5
Kenna, K.6
McLaughlin, R.7
Hardiman, O.8
-
34
-
-
37849053294
-
HVAPB, the causative gene of a heterogeneous group of motor neuron diseases in humans, is functionally interchangeable with its drosophila homologue DVAP-33A at the neuromuscular junction
-
A. Chai, J. Withers, Y.H. Koh, K. Parry, H. Bao, B. Zhang, V. Budnik, and G. Pennetta HVAPB, the causative gene of a heterogeneous group of motor neuron diseases in humans, is functionally interchangeable with its drosophila homologue DVAP-33A at the neuromuscular junction Hum. Mol. Genet. 17 2008 266 280
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 266-280
-
-
Chai, A.1
Withers, J.2
Koh, Y.H.3
Parry, K.4
Bao, H.5
Zhang, B.6
Budnik, V.7
Pennetta, G.8
-
35
-
-
84907697655
-
Motor neuron expression of the voltage-gated calcium channel cacophony restores locomotion defects in a drosophila, TDP-43 loss of function model of ALS
-
J.C. Chang, D.J. Hazelett, J.A. Stewart, and D.B. Morton Motor neuron expression of the voltage-gated calcium channel cacophony restores locomotion defects in a drosophila, TDP-43 loss of function model of ALS Brain Res. 1584 2014 39 51
-
(2014)
Brain Res.
, vol.1584
, pp. 39-51
-
-
Chang, J.C.1
Hazelett, D.J.2
Stewart, J.A.3
Morton, D.B.4
-
36
-
-
0000352320
-
De la sclérose latérale amyotrophique
-
J.M. Charcot De la sclérose latérale amyotrophique Prog. Méd. 2 1874 325
-
(1874)
Prog. Méd.
, vol.2
, pp. 325
-
-
Charcot, J.M.1
-
37
-
-
0000280462
-
Deux cas d'atrophie musculaire progressive avec lesion de la substance grise et des faisceaux antero-lateraux de la moelle epiniere
-
J.M. Charcot, and A. Joffroy Deux cas d'atrophie musculaire progressive avec lesion de la substance grise et des faisceaux antero-lateraux de la moelle epiniere Arch. Physiol. Neurol. Path. 2 1869 744 754
-
(1869)
Arch. Physiol. Neurol. Path.
, vol.2
, pp. 744-754
-
-
Charcot, J.M.1
Joffroy, A.2
-
38
-
-
78650048929
-
Characterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosis
-
H.J. Chen, G. Anagnostou, A. Chai, J. Withers, A. Morris, J. Adhikaree, G. Pennetta, and J.S. de Belleroche Characterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosis J. Biol. Chem. 285 2010 40266 40281
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 40266-40281
-
-
Chen, H.J.1
Anagnostou, G.2
Chai, A.3
Withers, J.4
Morris, A.5
Adhikaree, J.6
Pennetta, G.7
De Belleroche, J.S.8
-
39
-
-
80053087977
-
Expression of human FUS protein in drosophila leads to progressive neurodegeneration
-
Y. Chen, M. Yang, J. Deng, X. Chen, Y. Ye, L. Zhu, J. Liu, H. Ye, Y. Shen, Y. Li, E.J. Rao, K. Fushimi, X. Zhou, E.H. Bigio, M. Mesulam, Q. Xu, and J.Y. Wu Expression of human FUS protein in drosophila leads to progressive neurodegeneration Protein Cell 2 2011 477 486
-
(2011)
Protein Cell
, vol.2
, pp. 477-486
-
-
Chen, Y.1
Yang, M.2
Deng, J.3
Chen, X.4
Ye, Y.5
Zhu, L.6
Liu, J.7
Ye, H.8
Shen, Y.9
Li, Y.10
Rao, E.J.11
Fushimi, K.12
Zhou, X.13
Bigio, E.H.14
Mesulam, M.15
Xu, Q.16
Wu, J.Y.17
-
40
-
-
70450180994
-
Prognostic factors in ALS: A critical review
-
A. Chio, G. Logroscino, O. Hardiman, R. Swingler, D. Mitchell, E. Beghi, and B.G. Traynor Prognostic factors in ALS: a critical review Amyotroph. Lateral Scler. 10 2009 310 323
-
(2009)
Amyotroph. Lateral Scler.
, vol.10
, pp. 310-323
-
-
Chio, A.1
Logroscino, G.2
Hardiman, O.3
Swingler, R.4
Mitchell, D.5
Beghi, E.6
Traynor, B.G.7
-
41
-
-
84893012138
-
TDP-43 phosphorylation by casein kinase I{varepsilon} promotes oligomerization and enhances toxicity in vivo
-
D.K. Choksi, B. Roy, S. Chatterjee, T. Yusuff, M.F. Bakhoum, U. Sengupta, S. Ambegaokar, R. Kayed, and G.R. Jackson TDP-43 phosphorylation by casein kinase I{varepsilon} promotes oligomerization and enhances toxicity in vivo Hum. Mol. Genet. 23 2014 1025 1035
-
(2014)
Hum. Mol. Genet.
, vol.23
, pp. 1025-1035
-
-
Choksi, D.K.1
Roy, B.2
Chatterjee, S.3
Yusuff, T.4
Bakhoum, M.F.5
Sengupta, U.6
Ambegaokar, S.7
Kayed, R.8
Jackson, G.R.9
-
42
-
-
0029991827
-
Colocalization of NOS and SOD1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: An immunohistochemical study
-
S.M. Chou, H.S. Wang, and K. Komai Colocalization of NOS and SOD1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: an immunohistochemical study J. Chem. Neuroanat. 10 1996 249 258
-
(1996)
J. Chem. Neuroanat.
, vol.10
, pp. 249-258
-
-
Chou, S.M.1
Wang, H.S.2
Komai, K.3
-
43
-
-
0029840369
-
Role of SOD-1 and nitric oxide/cyclic GMP cascade on neurofilament aggregation in ALS/MND
-
S.M. Chou, H.S. Wang, and A. Taniguchi Role of SOD-1 and nitric oxide/cyclic GMP cascade on neurofilament aggregation in ALS/MND J. Neurol. Sci. 139 Suppl. 1996 S16 S26
-
(1996)
J. Neurol. Sci.
, vol.139
, pp. S16-S26
-
-
Chou, S.M.1
Wang, H.S.2
Taniguchi, A.3
-
44
-
-
33746533924
-
Alpha-synuclein blocks ER-golgi traffic and Rab1 rescues neuron loss in Parkinson's models
-
A.A. Cooper, A.D. Gitler, A. Cashikar, C.M. Haynes, K.J. Hill, B. Bhullar, K. Liu, K. Xu, K.E. Strathearn, F. Liu, S. Cao, K.A. Caldwell, G.A. Caldwell, G. Marsischky, R.D. Kolodner, J. Labaer, J.C. Rochet, N.M. Bonini, and S. Lindquist Alpha-synuclein blocks ER-golgi traffic and Rab1 rescues neuron loss in Parkinson's models Science 313 2006 324 328
-
(2006)
Science
, vol.313
, pp. 324-328
-
-
Cooper, A.A.1
Gitler, A.D.2
Cashikar, A.3
Haynes, C.M.4
Hill, K.J.5
Bhullar, B.6
Liu, K.7
Xu, K.8
Strathearn, K.E.9
Liu, F.10
Cao, S.11
Caldwell, K.A.12
Caldwell, G.A.13
Marsischky, G.14
Kolodner, R.D.15
Labaer, J.16
Rochet, J.C.17
Bonini, N.M.18
Lindquist, S.19
-
45
-
-
77949760219
-
Mutations of FUS gene in sporadic amyotrophic lateral sclerosis
-
L. Corrado, B.R. Del, B. Castellotti, A. Ratti, C. Cereda, S. Penco, G. Soraru, Y. Carlomagno, S. Ghezzi, V. Pensato, C. Colombrita, S. Gagliardi, L. Cozzi, V. Orsetti, M. Mancuso, G. Siciliano, L. Mazzini, G.P. Comi, C. Gellera, M. Ceroni, S. D'Alfonso, and V. Silani Mutations of FUS gene in sporadic amyotrophic lateral sclerosis J. Med. Genet. 47 2010 190 194
-
(2010)
J. Med. Genet.
, vol.47
, pp. 190-194
-
-
Corrado, L.1
Del, B.R.2
Castellotti, B.3
Ratti, A.4
Cereda, C.5
Penco, S.6
Soraru, G.7
Carlomagno, Y.8
Ghezzi, S.9
Pensato, V.10
Colombrita, C.11
Gagliardi, S.12
Cozzi, L.13
Orsetti, V.14
Mancuso, M.15
Siciliano, G.16
Mazzini, L.17
Comi, G.P.18
Gellera, C.19
Ceroni, M.20
D'Alfonso, S.21
Silani, V.22
more..
-
46
-
-
0027397195
-
Cell culture evidence for neuronal degeneration in amyotrophic lateral sclerosis being linked to glutamate AMPA/kainate receptors
-
P. Couratier, J. Hugon, P. Sindou, J.M. Vallat, and M. Dumas Cell culture evidence for neuronal degeneration in amyotrophic lateral sclerosis being linked to glutamate AMPA/kainate receptors Lancet 341 1993 265 268
-
(1993)
Lancet
, vol.341
, pp. 265-268
-
-
Couratier, P.1
Hugon, J.2
Sindou, P.3
Vallat, J.M.4
Dumas, M.5
-
47
-
-
84863507711
-
Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis
-
J. Couthouis, M.P. Hart, R. Erion, O.D. King, Z. Diaz, T. Nakaya, F. Ibrahim, H.J. Kim, J. Mojsilovic-Petrovic, S. Panossian, C.E. Kim, E.C. Frackelton, J.A. Solski, K.L. Williams, D. Clay-Falcone, L. Elman, L. McCluskey, R. Greene, H. Hakonarson, R.G. Kalb, V.M. Lee, J.Q. Trojanowski, G.A. Nicholson, I.P. Blair, N.M. Bonini, V.M. Van Deerlin, Z. Mourelatos, J. Shorter, and A.D. Gitler Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis Hum. Mol. Genet. 21 2012 2899 2911
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 2899-2911
-
-
Couthouis, J.1
Hart, M.P.2
Erion, R.3
King, O.D.4
Diaz, Z.5
Nakaya, T.6
Ibrahim, F.7
Kim, H.J.8
Mojsilovic-Petrovic, J.9
Panossian, S.10
Kim, C.E.11
Frackelton, E.C.12
Solski, J.A.13
Williams, K.L.14
Clay-Falcone, D.15
Elman, L.16
McCluskey, L.17
Greene, R.18
Hakonarson, H.19
Kalb, R.G.20
Lee, V.M.21
Trojanowski, J.Q.22
Nicholson, G.A.23
Blair, I.P.24
Bonini, N.M.25
Van Deerlin, V.M.26
Mourelatos, Z.27
Shorter, J.28
Gitler, A.D.29
more..
-
48
-
-
84862908655
-
A yeast functional screen predicts new candidate ALS disease genes
-
J. Couthouis, M.P. Hart, J. Shorter, M. DeJesus-Hernandez, R. Erion, R. Oristano, A.X. Liu, D. Ramos, N. Jethava, D. Hosangadi, J. Epstein, A. Chiang, Z. Diaz, T. Nakaya, F. Ibrahim, H.J. Kim, J.A. Solski, K.L. Williams, J. Mojsilovic-Petrovic, C. Ingre, K. Boylan, N.R. Graff-Radford, D.W. Dickson, D. Clay-Falcone, L. Elman, L. McCluskey, R. Greene, R.G. Kalb, V.M. Lee, J.Q. Trojanowski, A. Ludolph, W. Robberecht, P.M. Andersen, G.A. Nicholson, I.P. Blair, O.D. King, N.M. Bonini, D.,V. Van, R. Rademakers, Z. Mourelatos, and A.D. Gitler A yeast functional screen predicts new candidate ALS disease genes Proc. Natl. Acad. Sci. USA 108 2011 20881 20890
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 20881-20890
-
-
Couthouis, J.1
Hart, M.P.2
Shorter, J.3
Dejesus-Hernandez, M.4
Erion, R.5
Oristano, R.6
Liu, A.X.7
Ramos, D.8
Jethava, N.9
Hosangadi, D.10
Epstein, J.11
Chiang, A.12
Diaz, Z.13
Nakaya, T.14
Ibrahim, F.15
Kim, H.J.16
Solski, J.A.17
Williams, K.L.18
Mojsilovic-Petrovic, J.19
Ingre, C.20
Boylan, K.21
Graff-Radford, N.R.22
Dickson, D.W.23
Clay-Falcone, D.24
Elman, L.25
McCluskey, L.26
Greene, R.27
Kalb, R.G.28
Lee, V.M.29
Trojanowski, J.Q.30
Ludolph, A.31
Robberecht, W.32
Andersen, P.M.33
Nicholson, G.A.34
Blair, I.P.35
King, O.D.36
Bonini, N.M.37
Van, D.V.38
Rademakers, R.39
Mourelatos, Z.40
Gitler, A.D.41
more..
-
49
-
-
0030833449
-
Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite
-
J.P. Crow, J.B. Sampson, Y. Zhuang, J.A. Thompson, and J.S. Beckman Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite J. Neurochem. 69 1997 1936 1944
-
(1997)
J. Neurochem.
, vol.69
, pp. 1936-1944
-
-
Crow, J.P.1
Sampson, J.B.2
Zhuang, Y.3
Thompson, J.A.4
Beckman, J.S.5
-
50
-
-
0027227651
-
Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma
-
A. Crozat, P. Aman, N. Mandahl, and D. Ron Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma Nature 363 1993 640 644
-
(1993)
Nature
, vol.363
, pp. 640-644
-
-
Crozat, A.1
Aman, P.2
Mandahl, N.3
Ron, D.4
-
51
-
-
84884687047
-
Hsp104 suppresses polyglutamine-induced degeneration post onset in a drosophila MJD/SCA3 model
-
M. Cushman-Nick, N.M. Bonini, and J. Shorter Hsp104 suppresses polyglutamine-induced degeneration post onset in a drosophila MJD/SCA3 model PLoS Genet. 9 2013 e1003781
-
(2013)
PLoS Genet.
, vol.9
, pp. e1003781
-
-
Cushman-Nick, M.1
Bonini, N.M.2
Shorter, J.3
-
52
-
-
84874531814
-
RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations
-
J.G. Daigle, N.A. Lanson Jr., R.B. Smith, I. Casci, A. Maltare, J. Monaghan, C.D. Nichols, D. Kryndushkin, F. Shewmaker, and U.B. Pandey RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations Hum. Mol. Genet. 22 2013 1193 1205
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 1193-1205
-
-
Daigle, J.G.1
Lanson, Jr.N.A.2
Smith, R.B.3
Casci, I.4
Maltare, A.5
Monaghan, J.6
Nichols, C.D.7
Kryndushkin, D.8
Shewmaker, F.9
Pandey, U.B.10
-
53
-
-
84863393591
-
VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis
-
K.J. De Vos, G.M. Morotz, R. Stoica, E.L. Tudor, K.F. Lau, S. Ackerley, A. Warley, C.E. Shaw, and C.C. Miller VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis Hum. Mol. Genet. 21 2012 1299 1311
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 1299-1311
-
-
De Vos, K.J.1
Morotz, G.M.2
Stoica, R.3
Tudor, E.L.4
Lau, K.F.5
Ackerley, S.6
Warley, A.7
Shaw, C.E.8
Miller, C.C.9
-
54
-
-
77951784437
-
De novo truncating FUS gene mutation as a cause of sporadic amyotrophic lateral sclerosis
-
M. DeJesus-Hernandez, J. Kocerha, N. Finch, R. Crook, M. Baker, P. Desaro, A. Johnston, N. Rutherford, A. Wojtas, K. Kennelly, Z.K. Wszolek, N. Graff-Radford, K. Boylan, and R. Rademakers De novo truncating FUS gene mutation as a cause of sporadic amyotrophic lateral sclerosis Hum. Mutat. 31 2010 E1377 E1389
-
(2010)
Hum. Mutat.
, vol.31
, pp. E1377-E1389
-
-
Dejesus-Hernandez, M.1
Kocerha, J.2
Finch, N.3
Crook, R.4
Baker, M.5
Desaro, P.6
Johnston, A.7
Rutherford, N.8
Wojtas, A.9
Kennelly, K.10
Wszolek, Z.K.11
Graff-Radford, N.12
Boylan, K.13
Rademakers, R.14
-
55
-
-
80054832080
-
Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS
-
M. DeJesus-Hernandez, I.R. Mackenzie, B.F. Boeve, A.L. Boxer, M. Baker, N.J. Rutherford, A.M. Nicholson, N.A. Finch, H. Flynn, J. Adamson, N. Kouri, A. Wojtas, P. Sengdy, G.Y. Hsiung, A. Karydas, W.W. Seeley, K.A. Josephs, G. Coppola, D.H. Geschwind, Z.K. Wszolek, H. Feldman, D.S. Knopman, R.C. Petersen, B.L. Miller, D.W. Dickson, K.B. Boylan, N.R. Graff-Radford, and R. Rademakers Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS Neuron 72 2011 245 256
-
(2011)
Neuron
, vol.72
, pp. 245-256
-
-
Dejesus-Hernandez, M.1
MacKenzie, I.R.2
Boeve, B.F.3
Boxer, A.L.4
Baker, M.5
Rutherford, N.J.6
Nicholson, A.M.7
Finch, N.A.8
Flynn, H.9
Adamson, J.10
Kouri, N.11
Wojtas, A.12
Sengdy, P.13
Hsiung, G.Y.14
Karydas, A.15
Seeley, W.W.16
Josephs, K.A.17
Coppola, G.18
Geschwind, D.H.19
Wszolek, Z.K.20
Feldman, H.21
Knopman, D.S.22
Petersen, R.C.23
Miller, B.L.24
Dickson, D.W.25
Boylan, K.B.26
Graff-Radford, N.R.27
Rademakers, R.28
more..
-
56
-
-
80053629733
-
Novel optineurin mutations in patients with familial and sporadic amyotrophic lateral sclerosis
-
B.R. Del, C. Tiloca, V. Pensato, L. Corrado, A. Ratti, N. Ticozzi, S. Corti, B. Castellotti, L. Mazzini, G. Soraru, C. Cereda, S. D'Alfonso, C. Gellera, G.P. Comi, and V. Silani Novel optineurin mutations in patients with familial and sporadic amyotrophic lateral sclerosis J. Neurol. Neurosurg. Psychiatry 82 2011 1239 1243
-
(2011)
J. Neurol. Neurosurg. Psychiatry
, vol.82
, pp. 1239-1243
-
-
Del, B.R.1
Tiloca, C.2
Pensato, V.3
Corrado, L.4
Ratti, A.5
Ticozzi, N.6
Corti, S.7
Castellotti, B.8
Mazzini, L.9
Soraru, G.10
Cereda, C.11
D'Alfonso, S.12
Gellera, C.13
Comi, G.P.14
Silani, V.15
-
57
-
-
80052580969
-
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
-
H.X. Deng, W. Chen, S.T. Hong, K.M. Boycott, G.H. Gorrie, N. Siddique, Y. Yang, F. Fecto, Y. Shi, H. Zhai, H. Jiang, M. Hirano, E. Rampersaud, G.H. Jansen, S. Donkervoort, E.H. Bigio, B.R. Brooks, K. Ajroud, R.L. Sufit, J.L. Haines, E. Mugnaini, M.A. Pericak-Vance, and T. Siddique Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia Nature 477 2011 211 215
-
(2011)
Nature
, vol.477
, pp. 211-215
-
-
Deng, H.X.1
Chen, W.2
Hong, S.T.3
Boycott, K.M.4
Gorrie, G.H.5
Siddique, N.6
Yang, Y.7
Fecto, F.8
Shi, Y.9
Zhai, H.10
Jiang, H.11
Hirano, M.12
Rampersaud, E.13
Jansen, G.H.14
Donkervoort, S.15
Bigio, E.H.16
Brooks, B.R.17
Ajroud, K.18
Sufit, R.L.19
Haines, J.L.20
Mugnaini, E.21
Pericak-Vance, M.A.22
Siddique, T.23
more..
-
58
-
-
33646466296
-
Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria
-
H.X. Deng, Y. Shi, Y. Furukawa, H. Zhai, R. Fu, E. Liu, G.H. Gorrie, M.S. Khan, W.Y. Hung, E.H. Bigio, T. Lukas, M.C. Dal Canto, T.V. O'Halloran, and T. Siddique Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria Proc. Natl. Acad. Sci. USA 103 2006 7142 7147
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 7142-7147
-
-
Deng, H.X.1
Shi, Y.2
Furukawa, Y.3
Zhai, H.4
Fu, R.5
Liu, E.6
Gorrie, G.H.7
Khan, M.S.8
Hung, W.Y.9
Bigio, E.H.10
Lukas, T.11
Dal Canto, M.C.12
O'Halloran, T.V.13
Siddique, T.14
-
59
-
-
34147131311
-
Inhibition of P38 mitogen activated protein kinase activation and mutant SOD1(G93A)-induced motor neuron death
-
M. Dewil, V.F. dela Cruz, L. Van Den Bosch, and W. Robberecht Inhibition of P38 mitogen activated protein kinase activation and mutant SOD1(G93A)-induced motor neuron death Neurobiol. Dis. 26 2007 332 341
-
(2007)
Neurobiol. Dis.
, vol.26
, pp. 332-341
-
-
Dewil, M.1
Dela Cruz, V.F.2
Van Den Bosch, L.3
Robberecht, W.4
-
60
-
-
84888807206
-
Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLD
-
D.C. Diaper, Y. Adachi, L. Lazarou, M. Greenstein, F.A. Simoes, D.A. Di, D.A. Solomon, S. Lowe, R. Alsubaie, D. Cheng, S. Buckley, D.M. Humphrey, C.E. Shaw, and F. Hirth Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLD Hum. Mol. Genet. 22 2013 3883 3893
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 3883-3893
-
-
Diaper, D.C.1
Adachi, Y.2
Lazarou, L.3
Greenstein, M.4
Simoes, F.A.5
Di, D.A.6
Solomon, D.A.7
Lowe, S.8
Alsubaie, R.9
Cheng, D.10
Buckley, S.11
Humphrey, D.M.12
Shaw, C.E.13
Hirth, F.14
-
61
-
-
84875771192
-
Loss and gain of drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes
-
D.C. Diaper, Y. Adachi, B. Sutcliffe, D.M. Humphrey, C.J. Elliott, A. Stepto, Z.N. Ludlow, L. Vanden Broeck, P. Callaerts, B. Dermaut, A. Al-Chalabi, C.E. Shaw, I.M. Robinson, and F. Hirth Loss and gain of drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes Hum. Mol. Genet. 22 2013 1539 1557
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 1539-1557
-
-
Diaper, D.C.1
Adachi, Y.2
Sutcliffe, B.3
Humphrey, D.M.4
Elliott, C.J.5
Stepto, A.6
Ludlow, Z.N.7
Vanden Broeck, L.8
Callaerts, P.9
Dermaut, B.10
Al-Chalabi, A.11
Shaw, C.E.12
Robinson, I.M.13
Hirth, F.14
-
62
-
-
84869237956
-
Arginine methylation next to the PY-NLS modulates transportin binding and nuclear import of FUS
-
D. Dormann, T. Madl, C.F. Valori, E. Bentmann, S. Tahirovic, C. Abou-Ajram, E. Kremmer, O. Ansorge, I.R. Mackenzie, M. Neumann, and C. Haass Arginine methylation next to the PY-NLS modulates transportin binding and nuclear import of FUS EMBO J. 31 2012 4258 4275
-
(2012)
EMBO J.
, vol.31
, pp. 4258-4275
-
-
Dormann, D.1
Madl, T.2
Valori, C.F.3
Bentmann, E.4
Tahirovic, S.5
Abou-Ajram, C.6
Kremmer, E.7
Ansorge, O.8
MacKenzie, I.R.9
Neumann, M.10
Haass, C.11
-
63
-
-
79151471350
-
TLS and PRMT1 Synergistically coactivate transcription at the survivin promoter through TLS arginine methylation
-
K. Du, S. Arai, T. Kawamura, A. Matsushita, and R. Kurokawa TLS and PRMT1 Synergistically coactivate transcription at the survivin promoter through TLS arginine methylation Biochem. Biophys. Res. Commun. 404 2011 991 996
-
(2011)
Biochem. Biophys. Res. Commun.
, vol.404
, pp. 991-996
-
-
Du, K.1
Arai, S.2
Kawamura, T.3
Matsushita, A.4
Kurokawa, R.5
-
64
-
-
77956155218
-
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
-
A.C. Elden, H.J. Kim, M.P. Hart, A.S. Chen-Plotkin, B.S. Johnson, X. Fang, M. Armakola, F. Geser, R. Greene, M.M. Lu, A. Padmanabhan, D. Clay-Falcone, L. McCluskey, L. Elman, D. Juhr, P.J. Gruber, U. Rub, G. Auburger, J.Q. Trojanowski, V.M. Lee, V.M. Van Deerlin, N.M. Bonini, and A.D. Gitler Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS Nature 466 2010 1069 1075
-
(2010)
Nature
, vol.466
, pp. 1069-1075
-
-
Elden, A.C.1
Kim, H.J.2
Hart, M.P.3
Chen-Plotkin, A.S.4
Johnson, B.S.5
Fang, X.6
Armakola, M.7
Geser, F.8
Greene, R.9
Lu, M.M.10
Padmanabhan, A.11
Clay-Falcone, D.12
McCluskey, L.13
Elman, L.14
Juhr, D.15
Gruber, P.J.16
Rub, U.17
Auburger, G.18
Trojanowski, J.Q.19
Lee, V.M.20
Van Deerlin, V.M.21
Bonini, N.M.22
Gitler, A.D.23
more..
-
65
-
-
0032982007
-
Expression of human FALS SOD in motorneurons of drosophila
-
A.J. Elia, T.L. Parkes, K. Kirby St, P. George-Hyslop, G.L. Boulianne, J.P. Phillips, and A.J. Hilliker Expression of human FALS SOD in motorneurons of drosophila Free Radic. Biol. Med. 26 1999 1332 1338
-
(1999)
Free Radic. Biol. Med.
, vol.26
, pp. 1332-1338
-
-
Elia, A.J.1
Parkes, T.L.2
Kirby St, K.3
George-Hyslop, P.4
Boulianne, G.L.5
Phillips, J.P.6
Hilliker, A.J.7
-
66
-
-
79957488875
-
Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a drosophila model of ALS
-
P.S. Estes, A. Boehringer, R. Zwick, J.E. Tang, B. Grigsby, and D.C. Zarnescu Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a drosophila model of ALS Hum. Mol. Genet. 20 2011 2308 2321
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 2308-2321
-
-
Estes, P.S.1
Boehringer, A.2
Zwick, R.3
Tang, J.E.4
Grigsby, B.5
Zarnescu, D.C.6
-
67
-
-
84877832189
-
Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a drosophila model of amyotrophic lateral sclerosis
-
P.S. Estes, S.G. Daniel, A.P. McCallum, A.V. Boehringer, A.S. Sukhina, R.A. Zwick, and D.C. Zarnescu Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a drosophila model of amyotrophic lateral sclerosis Dis. Model Mech. 6 2013 721 733
-
(2013)
Dis. Model Mech.
, vol.6
, pp. 721-733
-
-
Estes, P.S.1
Daniel, S.G.2
McCallum, A.P.3
Boehringer, A.V.4
Sukhina, A.S.5
Zwick, R.A.6
Zarnescu, D.C.7
-
68
-
-
27944460430
-
Protein arginine methyltransferases: Guardians of the Arg?
-
F.O. Fackelmayer Protein arginine methyltransferases: guardians of the Arg? Trends Biochem. Sci. 30 2005 666 671
-
(2005)
Trends Biochem. Sci.
, vol.30
, pp. 666-671
-
-
Fackelmayer, F.O.1
-
69
-
-
65249159101
-
Amyotrophic lateral sclerosis in Sweden, 1991-2005
-
F. Fang, U. Valdimarsdottir, R. Bellocco, L.O. Ronnevi, P. Sparen, K. Fall, and W. Ye Amyotrophic lateral sclerosis in Sweden, 1991-2005 Arch. Neurol. 66 2009 515 519
-
(2009)
Arch. Neurol.
, vol.66
, pp. 515-519
-
-
Fang, F.1
Valdimarsdottir, U.2
Bellocco, R.3
Ronnevi, L.O.4
Sparen, P.5
Fall, K.6
Ye, W.7
-
70
-
-
70349110554
-
Metazoan stress granule assembly is mediated by P-EIF2alpha-dependent and -independent mechanisms
-
N.G. Farny, N.L. Kedersha, and P.A. Silver Metazoan stress granule assembly is mediated by P-EIF2alpha-dependent and -independent mechanisms RNA 15 2009 1814 1821
-
(2009)
RNA
, vol.15
, pp. 1814-1821
-
-
Farny, N.G.1
Kedersha, N.L.2
Silver, P.A.3
-
71
-
-
80855150639
-
SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis
-
F. Fecto, J. Yan, S.P. Vemula, E. Liu, Y. Yang, W. Chen, J.G. Zheng, Y. Shi, N. Siddique, H. Arrat, S. Donkervoort, S. Ajroud-Driss, R.L. Sufit, S.L. Heller, H.X. Deng, and T. Siddique SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis Arch. Neurol. 68 2011 1440 1446
-
(2011)
Arch. Neurol.
, vol.68
, pp. 1440-1446
-
-
Fecto, F.1
Yan, J.2
Vemula, S.P.3
Liu, E.4
Yang, Y.5
Chen, W.6
Zheng, J.G.7
Shi, Y.8
Siddique, N.9
Arrat, H.10
Donkervoort, S.11
Ajroud-Driss, S.12
Sufit, R.L.13
Heller, S.L.14
Deng, H.X.15
Siddique, T.16
-
72
-
-
67349271683
-
Depletion of TDP-43 affects drosophila motoneurons terminal synapsis and locomotive behavior
-
F. Feiguin, V.K. Godena, G. Romano, A. D'Ambrogio, R. Klima, and F.E. Baralle Depletion of TDP-43 affects drosophila motoneurons terminal synapsis and locomotive behavior FEBS Lett. 583 2009 1586 1592
-
(2009)
FEBS Lett.
, vol.583
, pp. 1586-1592
-
-
Feiguin, F.1
Godena, V.K.2
Romano, G.3
D'Ambrogio, A.4
Klima, R.5
Baralle, F.E.6
-
73
-
-
0034597833
-
Identification of genes that modify ataxin-1-induced neurodegeneration
-
P. Fernandez-Funez, M.L. Nino-Rosales, G.B. de, W.C. She, J.M. Luchak, P. Martinez, E. Turiegano, J. Benito, M. Capovilla, P.J. Skinner, A. McCall, I. Canal, H.T. Orr, H.Y. Zoghbi, and J. Botas Identification of genes that modify ataxin-1-induced neurodegeneration Nature 408 2000 101 106
-
(2000)
Nature
, vol.408
, pp. 101-106
-
-
Fernandez-Funez, P.1
Nino-Rosales, M.L.2
De, G.B.3
She, W.C.4
Luchak, J.M.5
Martinez, P.6
Turiegano, E.7
Benito, J.8
Capovilla, M.9
Skinner, P.J.10
McCall, A.11
Canal, I.12
Orr, H.T.13
Zoghbi, H.Y.14
Botas, J.15
-
74
-
-
33748795566
-
Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials
-
A. Ferri, M. Cozzolino, C. Crosio, M. Nencini, A. Casciati, E.B. Gralla, G. Rotilio, J.S. Valentine, and M.T. Carri Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials Proc. Natl. Acad. Sci. USA 103 2006 13860 13865
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 13860-13865
-
-
Ferri, A.1
Cozzolino, M.2
Crosio, C.3
Nencini, M.4
Casciati, A.5
Gralla, E.B.6
Rotilio, G.7
Valentine, J.S.8
Carri, M.T.9
-
75
-
-
75649135319
-
Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6
-
F.C. Fiesel, A. Voigt, S.S. Weber, C. Van den Haute, A. Waldenmaier, K. Gorner, M. Walter, M.L. Anderson, J.V. Kern, T.M. Rasse, T. Schmidt, W. Springer, R. Kirchner, M. Bonin, M. Neumann, V. Baekelandt, M. Alunni-Fabbroni, J.B. Schulz, and P.J. Kahle Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6 EMBO J. 29 2010 209 221
-
(2010)
EMBO J.
, vol.29
, pp. 209-221
-
-
Fiesel, F.C.1
Voigt, A.2
Weber, S.S.3
Van Den Haute, C.4
Waldenmaier, A.5
Gorner, K.6
Walter, M.7
Anderson, M.L.8
Kern, J.V.9
Rasse, T.M.10
Schmidt, T.11
Springer, W.12
Kirchner, R.13
Bonin, M.14
Neumann, M.15
Baekelandt, V.16
Alunni-Fabbroni, M.17
Schulz, J.B.18
Kahle, P.J.19
-
76
-
-
84878906794
-
Increased levels of phosphoinositides cause neurodegeneration in a drosophila model of amyotrophic lateral sclerosis
-
S. Forrest, A. Chai, M. Sanhueza, M. Marescotti, K. Parry, A. Georgiev, V. Sahota, R. Mendez-Castro, and G. Pennetta Increased levels of phosphoinositides cause neurodegeneration in a drosophila model of amyotrophic lateral sclerosis Hum. Mol. Genet. 22 2013 2689 2704
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 2689-2704
-
-
Forrest, S.1
Chai, A.2
Sanhueza, M.3
Marescotti, M.4
Parry, K.5
Georgiev, A.6
Sahota, V.7
Mendez-Castro, R.8
Pennetta, G.9
-
78
-
-
83555166183
-
A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: A gene identification study
-
I. Gijselinck, L.T. Van, J. van der Zee, K. Sleegers, S. Philtjens, G. Kleinberger, J. Janssens, K. Bettens, C.C. Van, S. Pereson, S. Engelborghs, A. Sieben, J.P. De, R. Vandenberghe, P. Santens, B.J. De, G. Maes, V. Baumer, L. Dillen, G. Joris, I. Cuijt, E. Corsmit, E. Elinck, D.J. Van, S. Vermeulen, M. Van den Broeck, C. Vaerenberg, M. Mattheijssens, K. Peeters, W. Robberecht, P. Cras, J.J. Martin, P.P. De Deyn, M. Cruts, and B.C. Van A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study Lancet Neurol. 11 2012 54 65
-
(2012)
Lancet Neurol.
, vol.11
, pp. 54-65
-
-
Gijselinck, I.1
Van, L.T.2
Van Der Zee, J.3
Sleegers, K.4
Philtjens, S.5
Kleinberger, G.6
Janssens, J.7
Bettens, K.8
Van, C.C.9
Pereson, S.10
Engelborghs, S.11
Sieben, A.12
De, J.P.13
Vandenberghe, R.14
Santens, P.15
De, B.J.16
Maes, G.17
Baumer, V.18
Dillen, L.19
Joris, G.20
Cuijt, I.21
Corsmit, E.22
Elinck, E.23
Van, D.J.24
Vermeulen, S.25
Van Den Broeck, M.26
Vaerenberg, C.27
Mattheijssens, M.28
Peeters, K.29
Robberecht, W.30
Cras, P.31
Martin, J.J.32
De Deyn, P.P.33
Cruts, M.34
Van, B.C.35
more..
-
79
-
-
84895807660
-
Amyotrophic lateral sclerosis: An update for 2013 clinical features, pathophysiology, management and therapeutic trials
-
P.H. Gordon Amyotrophic lateral sclerosis: an update for 2013 clinical features, pathophysiology, management and therapeutic trials Aging Dis. 4 2013 295 310
-
(2013)
Aging Dis.
, vol.4
, pp. 295-310
-
-
Gordon, P.H.1
-
80
-
-
84857477831
-
The aggregation and neurotoxicity of TDP-43 and its ALS-associated 25 kDa fragment are differentially affected by molecular chaperones in drosophila
-
J.M. Gregory, T.P. Barros, S. Meehan, C.M. Dobson, and L.M. Luheshi The aggregation and neurotoxicity of TDP-43 and its ALS-associated 25 kDa fragment are differentially affected by molecular chaperones in drosophila PLoS One 7 2012 e31899
-
(2012)
PLoS One
, vol.7
, pp. e31899
-
-
Gregory, J.M.1
Barros, T.P.2
Meehan, S.3
Dobson, C.M.4
Luheshi, L.M.5
-
81
-
-
0033609055
-
Three proteins define a class of human histone deacetylases related to yeast Hda1p
-
C.M. Grozinger, C.A. Hassig, and S.L. Schreiber Three proteins define a class of human histone deacetylases related to yeast Hda1p Proc. Natl. Acad. Sci. USA 96 1999 4868 4873
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 4868-4873
-
-
Grozinger, C.M.1
Hassig, C.A.2
Schreiber, S.L.3
-
82
-
-
0034785483
-
A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2
-
S. Hadano, C.K. Hand, H. Osuga, Y. Yanagisawa, A. Otomo, R.S. Devon, N. Miyamoto, J. Showguchi-Miyata, Y. Okada, R. Singaraja, D.A. Figlewicz, T. Kwiatkowski, B.A. Hosler, T. Sagie, J. Skaug, J. Nasir, R.H. Brown Jr., S.W. Scherer, G.A. Rouleau, M.R. Hayden, and J.E. Ikeda A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2 Nat. Genet. 29 2001 166 173
-
(2001)
Nat. Genet.
, vol.29
, pp. 166-173
-
-
Hadano, S.1
Hand, C.K.2
Osuga, H.3
Yanagisawa, Y.4
Otomo, A.5
Devon, R.S.6
Miyamoto, N.7
Showguchi-Miyata, J.8
Okada, Y.9
Singaraja, R.10
Figlewicz, D.A.11
Kwiatkowski, T.12
Hosler, B.A.13
Sagie, T.14
Skaug, J.15
Nasir, J.16
Brown, Jr.R.H.17
Scherer, S.W.18
Rouleau, G.A.19
Hayden, M.R.20
Ikeda, J.E.21
more..
-
83
-
-
84862777321
-
Secreted VAPB/ALS8 major sperm protein domains modulate mitochondrial localization and morphology via growth cone guidance receptors
-
S.M. Han, H. Tsuda, Y. Yang, J. Vibbert, P. Cottee, S.J. Lee, J. Winek, C. Haueter, H.J. Bellen, and M.A. Miller Secreted VAPB/ALS8 major sperm protein domains modulate mitochondrial localization and morphology via growth cone guidance receptors Dev. Cell 22 2012 348 362
-
(2012)
Dev. Cell
, vol.22
, pp. 348-362
-
-
Han, S.M.1
Tsuda, H.2
Yang, Y.3
Vibbert, J.4
Cottee, P.5
Lee, S.J.6
Winek, J.7
Haueter, C.8
Bellen, H.J.9
Miller, M.A.10
-
84
-
-
77951236534
-
Ubiquilin modifies TDP-43 toxicity in a drosophila model of amyotrophic lateral sclerosis (ALS)
-
K.A. Hanson, S.H. Kim, D.A. Wassarman, and R.S. Tibbetts Ubiquilin modifies TDP-43 toxicity in a drosophila model of amyotrophic lateral sclerosis (ALS) J. Biol. Chem. 285 2010 11068 11072
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 11068-11072
-
-
Hanson, K.A.1
Kim, S.H.2
Wassarman, D.A.3
Tibbetts, R.S.4
-
85
-
-
80755128213
-
Clinical diagnosis and management of amyotrophic lateral sclerosis
-
O. Hardiman, L.H. van den Berg, and M.C. Kiernan Clinical diagnosis and management of amyotrophic lateral sclerosis Nat. Rev. Neurol. 7 2011 639 649
-
(2011)
Nat. Rev. Neurol.
, vol.7
, pp. 639-649
-
-
Hardiman, O.1
Van Den Berg, L.H.2
Kiernan, M.C.3
-
86
-
-
77049308856
-
Aging: A theory based on free radical and radiation chemistry
-
D. Harman Aging: a theory based on free radical and radiation chemistry J. Gerontol. 11 1956 298 300
-
(1956)
J. Gerontol.
, vol.11
, pp. 298-300
-
-
Harman, D.1
-
87
-
-
47949086625
-
Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
M. Hasegawa, T. Arai, T. Nonaka, F. Kametani, M. Yoshida, Y. Hashizume, T.G. Beach, E. Buratti, F. Baralle, M. Morita, I. Nakano, T. Oda, K. Tsuchiya, and H. Akiyama Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis Ann. Neurol. 64 2008 60 70
-
(2008)
Ann. Neurol.
, vol.64
, pp. 60-70
-
-
Hasegawa, M.1
Arai, T.2
Nonaka, T.3
Kametani, F.4
Yoshida, M.5
Hashizume, Y.6
Beach, T.G.7
Buratti, E.8
Baralle, F.9
Morita, M.10
Nakano, I.11
Oda, T.12
Tsuchiya, K.13
Akiyama, H.14
-
88
-
-
84883348833
-
Comparison of parallel high-throughput RNA sequencing between knockout of TDP-43 and its overexpression reveals primarily nonreciprocal and nonoverlapping gene expression changes in the central nervous system of drosophila
-
D.J. Hazelett, J.C. Chang, D.L. Lakeland, and D.B. Morton Comparison of parallel high-throughput RNA sequencing between knockout of TDP-43 and its overexpression reveals primarily nonreciprocal and nonoverlapping gene expression changes in the central nervous system of drosophila G3 (Bethesda) 2 2012 789 802
-
(2012)
G3 (Bethesda)
, vol.2
, pp. 789-802
-
-
Hazelett, D.J.1
Chang, J.C.2
Lakeland, D.L.3
Morton, D.B.4
-
89
-
-
84908323798
-
TDP-43 suppresses CGG repeat-induced neurotoxicity through interactions with HnRNP A2/B1
-
F. He, A. Krans, B.D. Freibaum, J.P. Taylor, and P.K. Todd TDP-43 suppresses CGG repeat-induced neurotoxicity through interactions with HnRNP A2/B1 Hum. Mol. Genet. 23 19 2014 5036 5051
-
(2014)
Hum. Mol. Genet.
, vol.23
, Issue.19
, pp. 5036-5051
-
-
He, F.1
Krans, A.2
Freibaum, B.D.3
Taylor, J.P.4
Todd, P.K.5
-
90
-
-
0036122933
-
Identification of Ter94, drosophila VCP, as a modulator of polyglutamine-induced neurodegeneration
-
H. Higashiyama, F. Hirose, M. Yamaguchi, Y.H. Inoue, N. Fujikake, A. Matsukage, and A. Kakizuka Identification of Ter94, drosophila VCP, as a modulator of polyglutamine-induced neurodegeneration Cell Death Differ. 9 2002 264 273
-
(2002)
Cell Death Differ.
, vol.9
, pp. 264-273
-
-
Higashiyama, H.1
Hirose, F.2
Yamaguchi, M.3
Inoue, Y.H.4
Fujikake, N.5
Matsukage, A.6
Kakizuka, A.7
-
91
-
-
84877891666
-
Dopaminergic expression of the parkinsonian gene LRRK2-G2019S leads to non-autonomous visual neurodegeneration, accelerated by increased neural demands for energy
-
S. Hindle, F. Afsari, M. Stark, C.A. Middleton, G.J. Evans, S.T. Sweeney, and C.J. Elliott Dopaminergic expression of the parkinsonian gene LRRK2-G2019S leads to non-autonomous visual neurodegeneration, accelerated by increased neural demands for energy Hum. Mol. Genet. 22 2013 2129 2140
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 2129-2140
-
-
Hindle, S.1
Afsari, F.2
Stark, M.3
Middleton, C.A.4
Evans, G.J.5
Sweeney, S.T.6
Elliott, C.J.7
-
92
-
-
0021167918
-
Fine structural observations of neurofilamentous changes in amyotrophic lateral sclerosis
-
A. Hirano, H. Donnenfeld, S. Sasaki, and I. Nakano Fine structural observations of neurofilamentous changes in amyotrophic lateral sclerosis J. Neuropathol. Exp. Neurol. 43 1984 461 470
-
(1984)
J. Neuropathol. Exp. Neurol.
, vol.43
, pp. 461-470
-
-
Hirano, A.1
Donnenfeld, H.2
Sasaki, S.3
Nakano, I.4
-
93
-
-
0021157469
-
Fine structural study of neurofibrillary changes in a family with amyotrophic lateral sclerosis
-
A. Hirano, I. Nakano, L.T. Kurland, D.W. Mulder, P.W. Holley, and G. Saccomanno Fine structural study of neurofibrillary changes in a family with amyotrophic lateral sclerosis J. Neuropathol. Exp. Neurol. 43 1984 471 480
-
(1984)
J. Neuropathol. Exp. Neurol.
, vol.43
, pp. 471-480
-
-
Hirano, A.1
Nakano, I.2
Kurland, L.T.3
Mulder, D.W.4
Holley, P.W.5
Saccomanno, G.6
-
94
-
-
19444374567
-
Activation of the stress-activated MAP kinase, P38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice
-
S.S. Holasek, T.M. Wengenack, K.K. Kandimalla, C. Montano, D.M. Gregor, G.L. Curran, and J.F. Poduslo Activation of the stress-activated MAP kinase, P38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice Brain Res. 1045 2005 185 198
-
(2005)
Brain Res.
, vol.1045
, pp. 185-198
-
-
Holasek, S.S.1
Wengenack, T.M.2
Kandimalla, K.K.3
Montano, C.4
Gregor, D.M.5
Curran, G.L.6
Poduslo, J.F.7
-
95
-
-
84867289496
-
Entorhinal cortical neurons are the primary targets of fus mislocalization and ubiquitin aggregation in FUS transgenic rats
-
C. Huang, J. Tong, F. Bi, Q. Wu, B. Huang, H. Zhou, and X.G. Xia Entorhinal cortical neurons are the primary targets of fus mislocalization and ubiquitin aggregation in FUS transgenic rats Hum. Mol. Genet. 21 2012 4602 4614
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 4602-4614
-
-
Huang, C.1
Tong, J.2
Bi, F.3
Wu, Q.4
Huang, B.5
Zhou, H.6
Xia, X.G.7
-
96
-
-
79953743204
-
FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration
-
C. Huang, H. Zhou, J. Tong, H. Chen, Y.J. Liu, D. Wang, X. Wei, and X.G. Xia FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration PLoS Genet. 7 2011 e1002011
-
(2011)
PLoS Genet.
, vol.7
, pp. e1002011
-
-
Huang, C.1
Zhou, H.2
Tong, J.3
Chen, H.4
Liu, Y.J.5
Wang, D.6
Wei, X.7
Xia, X.G.8
-
97
-
-
0037161744
-
HDAC6 is a microtubule-associated deacetylase
-
C. Hubbert, A. Guardiola, R. Shao, Y. Kawaguchi, A. Ito, A. Nixon, M. Yoshida, X.F. Wang, and T.P. Yao HDAC6 is a microtubule-associated deacetylase Nature 417 2002 455 458
-
(2002)
Nature
, vol.417
, pp. 455-458
-
-
Hubbert, C.1
Guardiola, A.2
Shao, R.3
Kawaguchi, Y.4
Ito, A.5
Nixon, A.6
Yoshida, M.7
Wang, X.F.8
Yao, T.P.9
-
98
-
-
80052628820
-
Population based epidemiology of amyotrophic lateral sclerosis using capture-recapture methodology
-
M.H. Huisman, S.W. de Jong, P.T. van Doormaal, S.S. Weinreich, H.J. Schelhaas, A.J. van der Kooi, V.M. de, J.H. Veldink, and L.H. van den Berg Population based epidemiology of amyotrophic lateral sclerosis using capture-recapture methodology J. Neurol. Neurosurg. Psychiatry 82 2011 1165 1170
-
(2011)
J. Neurol. Neurosurg. Psychiatry
, vol.82
, pp. 1165-1170
-
-
Huisman, M.H.1
De Jong, S.W.2
Van Doormaal, P.T.3
Weinreich, S.S.4
Schelhaas, H.J.5
Van Der Kooi, A.J.6
De, V.M.7
Veldink, J.H.8
Van Den Berg, L.H.9
-
99
-
-
0037119437
-
Distinct sets of adjacent heterogeneous nuclear ribonucleoprotein (HnRNP) A1/A2 binding sites control 5 splice site selection in the HnRNP A1 MRNA precursor
-
S. Hutchison, C. LeBel, M. Blanchette, and B. Chabot Distinct sets of adjacent heterogeneous nuclear ribonucleoprotein (HnRNP) A1/A2 binding sites control 5′ splice site selection in the HnRNP A1 MRNA precursor J. Biol. Chem. 277 2002 29745 29752
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 29745-29752
-
-
Hutchison, S.1
Lebel, C.2
Blanchette, M.3
Chabot, B.4
-
100
-
-
84874258638
-
Identification of in vivo, conserved, TAF15 RNA binding sites reveals the impact of TAF15 on the neuronal transcriptome
-
F. Ibrahim, M. Maragkakis, P. Alexiou, M.A. Maronski, M.A. Dichter, and Z. Mourelatos Identification of in vivo, conserved, TAF15 RNA binding sites reveals the impact of TAF15 on the neuronal transcriptome Cell Rep. 3 2013 301 308
-
(2013)
Cell Rep.
, vol.3
, pp. 301-308
-
-
Ibrahim, F.1
Maragkakis, M.2
Alexiou, P.3
Maronski, M.A.4
Dichter, M.A.5
Mourelatos, Z.6
-
101
-
-
67649797399
-
Expression of TDP-43 C-terminal fragments in vitro recapitulates pathological features of TDP-43 proteinopathies
-
L.M. Igaz, L.K. Kwong, A. Chen-Plotkin, M.J. Winton, T.L. Unger, Y. Xu, M. Neumann, J.Q. Trojanowski, and V.M. Lee Expression of TDP-43 C-terminal fragments in vitro recapitulates pathological features of TDP-43 proteinopathies J. Biol. Chem. 284 2009 8516 8524
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 8516-8524
-
-
Igaz, L.M.1
Kwong, L.K.2
Chen-Plotkin, A.3
Winton, M.J.4
Unger, T.L.5
Xu, Y.6
Neumann, M.7
Trojanowski, J.Q.8
Lee, V.M.9
-
102
-
-
79551523377
-
Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice
-
L.M. Igaz, L.K. Kwong, E.B. Lee, A. Chen-Plotkin, E. Swanson, T. Unger, J. Malunda, Y. Xu, M.J. Winton, J.Q. Trojanowski, and V.M. Lee Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice J. Clin. Invest. 121 2011 726 738
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 726-738
-
-
Igaz, L.M.1
Kwong, L.K.2
Lee, E.B.3
Chen-Plotkin, A.4
Swanson, E.5
Unger, T.6
Malunda, J.7
Xu, Y.8
Winton, M.J.9
Trojanowski, J.Q.10
Lee, V.M.11
-
103
-
-
46749138739
-
Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
L.M. Igaz, L.K. Kwong, Y. Xu, A.C. Truax, K. Uryu, M. Neumann, C.M. Clark, L.B. Elman, B.L. Miller, M. Grossman, L.F. McCluskey, J.Q. Trojanowski, and V.M. Lee Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis Am. J. Pathol. 173 2008 182 194
-
(2008)
Am. J. Pathol.
, vol.173
, pp. 182-194
-
-
Igaz, L.M.1
Kwong, L.K.2
Xu, Y.3
Truax, A.C.4
Uryu, K.5
Neumann, M.6
Clark, C.M.7
Elman, L.B.8
Miller, B.L.9
Grossman, M.10
McCluskey, L.F.11
Trojanowski, J.Q.12
Lee, V.M.13
-
104
-
-
84887011964
-
RNA binding mediates neurotoxicity in the transgenic drosophila model of TDP-43 proteinopathy
-
R. Ihara, K. Matsukawa, Y. Nagata, H. Kunugi, S. Tsuji, T. Chihara, E. Kuranaga, M. Miura, T. Wakabayashi, T. Hashimoto, and T. Iwatsubo RNA binding mediates neurotoxicity in the transgenic drosophila model of TDP-43 proteinopathy Hum. Mol. Genet. 22 2013 4474 4484
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 4474-4484
-
-
Ihara, R.1
Matsukawa, K.2
Nagata, Y.3
Kunugi, H.4
Tsuji, S.5
Chihara, T.6
Kuranaga, E.7
Miura, M.8
Wakabayashi, T.9
Hashimoto, T.10
Iwatsubo, T.11
-
105
-
-
84855582418
-
Optineurin mutations in japanese amyotrophic lateral sclerosis
-
A. Iida, N. Hosono, M. Sano, T. Kamei, S. Oshima, T. Tokuda, M. Kubo, Y. Nakamura, and S. Ikegawa Optineurin mutations in japanese amyotrophic lateral sclerosis J. Neurol. Neurosurg. Psychiatry 83 2012 233 235
-
(2012)
J. Neurol. Neurosurg. Psychiatry
, vol.83
, pp. 233-235
-
-
Iida, A.1
Hosono, N.2
Sano, M.3
Kamei, T.4
Oshima, S.5
Tokuda, T.6
Kubo, M.7
Nakamura, Y.8
Ikegawa, S.9
-
106
-
-
0030294345
-
Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats
-
G. Imbert, F. Saudou, G. Yvert, D. Devys, Y. Trottier, J.M. Garnier, C. Weber, J.L. Mandel, G. Cancel, N. Abbas, A. Durr, O. Didierjean, G. Stevanin, Y. Agid, and A. Brice Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats Nat. Genet. 14 1996 285 291
-
(1996)
Nat. Genet.
, vol.14
, pp. 285-291
-
-
Imbert, G.1
Saudou, F.2
Yvert, G.3
Devys, D.4
Trottier, Y.5
Garnier, J.M.6
Weber, C.7
Mandel, J.L.8
Cancel, G.9
Abbas, N.10
Durr, A.11
Didierjean, O.12
Stevanin, G.13
Agid, Y.14
Brice, A.15
-
107
-
-
48749088629
-
Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS
-
Y. Inukai, T. Nonaka, T. Arai, M. Yoshida, Y. Hashizume, T.G. Beach, E. Buratti, F.E. Baralle, H. Akiyama, S. Hisanaga, and M. Hasegawa Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS FEBS Lett. 582 2008 2899 2904
-
(2008)
FEBS Lett.
, vol.582
, pp. 2899-2904
-
-
Inukai, Y.1
Nonaka, T.2
Arai, T.3
Yoshida, M.4
Hashizume, Y.5
Beach, T.G.6
Buratti, E.7
Baralle, F.E.8
Akiyama, H.9
Hisanaga, S.10
Hasegawa, M.11
-
108
-
-
84899955855
-
ALS-linked SOD1 in glial cells enhances β-N-methylamino l-alanine (BMAA)-induced toxicity in drosophila
-
R. Islam, E.L. Kumimoto, H. Bao, and B. Zhang ALS-linked SOD1 in glial cells enhances β-N-methylamino l-alanine (BMAA)-induced toxicity in drosophila F1000 Research 1 2012 47
-
(2012)
F1000 Research
, vol.1
, pp. 47
-
-
Islam, R.1
Kumimoto, E.L.2
Bao, H.3
Zhang, B.4
-
109
-
-
0032168160
-
Polyglutamine-expanded human huntingtin transgenes induce degeneration of drosophila photoreceptor Neurons
-
G.R. Jackson, I. Salecker, X. Dong, X. Yao, N. Arnheim, P.W. Faber, M.E. MacDonald, and S.L. Zipursky Polyglutamine-expanded human huntingtin transgenes induce degeneration of drosophila photoreceptor Neurons Neuron 21 1998 633 642
-
(1998)
Neuron
, vol.21
, pp. 633-642
-
-
Jackson, G.R.1
Salecker, I.2
Dong, X.3
Yao, X.4
Arnheim, N.5
Faber, P.W.6
MacDonald, M.E.7
Zipursky, S.L.8
-
110
-
-
0041880131
-
RNA-mediated neurodegeneration caused by the fragile X premutation RCGG repeats in drosophila
-
P. Jin, D.C. Zarnescu, F. Zhang, C.E. Pearson, J.C. Lucchesi, K. Moses, and S.T. Warren RNA-mediated neurodegeneration caused by the fragile X premutation RCGG repeats in drosophila Neuron 39 2003 739 747
-
(2003)
Neuron
, vol.39
, pp. 739-747
-
-
Jin, P.1
Zarnescu, D.C.2
Zhang, F.3
Pearson, C.E.4
Lucchesi, J.C.5
Moses, K.6
Warren, S.T.7
-
111
-
-
78649941297
-
Exome sequencing reveals VCP mutations as a cause of familial ALS
-
J.O. Johnson, J. Mandrioli, M. Benatar, Y. Abramzon, V.M. Van Deerlin, J.Q. Trojanowski, J.R. Gibbs, M. Brunetti, S. Gronka, J. Wuu, J. Ding, L. McCluskey, M. Martinez-Lage, D. Falcone, D.G. Hernandez, S. Arepalli, S. Chong, J.C. Schymick, J. Rothstein, F. Landi, Y.D. Wang, A. Calvo, G. Mora, M. Sabatelli, M.R. Monsurro, S. Battistini, F. Salvi, R. Spataro, P. Sola, G. Borghero, G. Galassi, S.W. Scholz, J.P. Taylor, G. Restagno, A. Chio, and B.J. Traynor Exome sequencing reveals VCP mutations as a cause of familial ALS Neuron 68 2010 857 864
-
(2010)
Neuron
, vol.68
, pp. 857-864
-
-
Johnson, J.O.1
Mandrioli, J.2
Benatar, M.3
Abramzon, Y.4
Van Deerlin, V.M.5
Trojanowski, J.Q.6
Gibbs, J.R.7
Brunetti, M.8
Gronka, S.9
Wuu, J.10
Ding, J.11
McCluskey, L.12
Martinez-Lage, M.13
Falcone, D.14
Hernandez, D.G.15
Arepalli, S.16
Chong, S.17
Schymick, J.C.18
Rothstein, J.19
Landi, F.20
Wang, Y.D.21
Calvo, A.22
Mora, G.23
Sabatelli, M.24
Monsurro, M.R.25
Battistini, S.26
Salvi, F.27
Spataro, R.28
Sola, P.29
Borghero, G.30
Galassi, G.31
Scholz, S.W.32
Taylor, J.P.33
Restagno, G.34
Chio, A.35
Traynor, B.J.36
more..
-
112
-
-
84899644069
-
Mutations in the matrin 3 gene cause familial amyotrophic lateral sclerosis
-
J.O. Johnson, E.P. Pioro, A. Boehringer, R. Chia, H. Feit, A.E. Renton, H.A. Pliner, Y. Abramzon, G. Marangi, B.J. Winborn, J.R. Gibbs, M.A. Nalls, S. Morgan, M. Shoai, J. Hardy, A. Pittman, R.W. Orrell, A. Malaspina, K.C. Sidle, P. Fratta, M.B. Harms, R.H. Baloh, A. Pestronk, C.C. Weihl, E. Rogaeva, L. Zinman, V.E. Drory, G. Borghero, G. Mora, A. Calvo, J.D. Rothstein, C. Drepper, M. Sendtner, A.B. Singleton, J.P. Taylor, M.R. Cookson, G. Restagno, M. Sabatelli, R. Bowser, A. Chio, and B.J. Traynor Mutations in the matrin 3 gene cause familial amyotrophic lateral sclerosis Nat. Neurosci. 17 2014 664 666
-
(2014)
Nat. Neurosci.
, vol.17
, pp. 664-666
-
-
Johnson, J.O.1
Pioro, E.P.2
Boehringer, A.3
Chia, R.4
Feit, H.5
Renton, A.E.6
Pliner, H.A.7
Abramzon, Y.8
Marangi, G.9
Winborn, B.J.10
Gibbs, J.R.11
Nalls, M.A.12
Morgan, S.13
Shoai, M.14
Hardy, J.15
Pittman, A.16
Orrell, R.W.17
Malaspina, A.18
Sidle, K.C.19
Fratta, P.20
Harms, M.B.21
Baloh, R.H.22
Pestronk, A.23
Weihl, C.C.24
Rogaeva, E.25
Zinman, L.26
Drory, V.E.27
Borghero, G.28
Mora, G.29
Calvo, A.30
Rothstein, J.D.31
Drepper, C.32
Sendtner, M.33
Singleton, A.B.34
Taylor, J.P.35
Cookson, M.R.36
Restagno, G.37
Sabatelli, M.38
Bowser, R.39
Chio, A.40
Traynor, B.J.41
more..
-
113
-
-
33846295930
-
Amyotrophic lateral sclerosis in an urban setting: A population based study of inner city London
-
C.A. Johnston, B.R. Stanton, M.R. Turner, R. Gray, A.H. Blunt, D. Butt, M.A. Ampong, C.E. Shaw, P.N. Leigh, and A. Al-Chalabi Amyotrophic lateral sclerosis in an urban setting: a population based study of inner city London J. Neurol. 253 2006 1642 1643
-
(2006)
J. Neurol.
, vol.253
, pp. 1642-1643
-
-
Johnston, C.A.1
Stanton, B.R.2
Turner, M.R.3
Gray, R.4
Blunt, A.H.5
Butt, D.6
Ampong, M.A.7
Shaw, C.E.8
Leigh, P.N.9
Al-Chalabi, A.10
-
114
-
-
0027944708
-
Identification of a novel exon 4 SOD1 mutation in a sporadic amyotrophic lateral sclerosis patient
-
C.T. Jones, P.J. Shaw, G. Chari, and D.J. Brock Identification of a novel exon 4 SOD1 mutation in a sporadic amyotrophic lateral sclerosis patient Mol. Cell. Probes 8 1994 329 330
-
(1994)
Mol. Cell. Probes
, vol.8
, pp. 329-330
-
-
Jones, C.T.1
Shaw, P.J.2
Chari, G.3
Brock, D.J.4
-
115
-
-
0028273306
-
Identification of a novel SOD1 mutation in an apparently sporadic amyotrophic lateral sclerosis patient and the detection of Ile113Thr in three others
-
C.T. Jones, R.J. Swingler, and D.J. Brock Identification of a novel SOD1 mutation in an apparently sporadic amyotrophic lateral sclerosis patient and the detection of Ile113Thr in three others Hum. Mol. Genet. 3 1994 649 650
-
(1994)
Hum. Mol. Genet.
, vol.3
, pp. 649-650
-
-
Jones, C.T.1
Swingler, R.J.2
Brock, D.J.3
-
116
-
-
84979788598
-
Genetic studies in drosophila and humans support a model for the concerted function of CISD2, PPT1 and CLN3 in disease
-
M.A. Jones, S. Amr, A. Ferebee, P. Huynh, J.A. Rosenfeld, M.F. Miles, A.G. Davies, C.A. Korey, J.M. Warrick, R. Shiang, S.H. Elsea, S. Girirajan, and M. Grotewiel Genetic studies in drosophila and humans support a model for the concerted function of CISD2, PPT1 and CLN3 in disease Biol. Open 3 5 2014 342 352
-
(2014)
Biol. Open
, vol.3
, Issue.5
, pp. 342-352
-
-
Jones, M.A.1
Amr, S.2
Ferebee, A.3
Huynh, P.4
Rosenfeld, J.A.5
Miles, M.F.6
Davies, A.G.7
Korey, C.A.8
Warrick, J.M.9
Shiang, R.10
Elsea, S.H.11
Girirajan, S.12
Grotewiel, M.13
-
117
-
-
80051551180
-
SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: Recent advances in understanding disease toward the development of clinical treatments
-
P.I. Joyce, P. Fratta, E.M. Fisher, and A. Acevedo-Arozena SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments Mamm. Genome 22 2011 420 448
-
(2011)
Mamm. Genome
, vol.22
, pp. 420-448
-
-
Joyce, P.I.1
Fratta, P.2
Fisher, E.M.3
Acevedo-Arozena, A.4
-
118
-
-
42649120983
-
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
-
E. Kabashi, P.N. Valdmanis, P. Dion, D. Spiegelman, B.J. McConkey, V.C. Vande, J.P. Bouchard, L. Lacomblez, K. Pochigaeva, F. Salachas, P.F. Pradat, W. Camu, V. Meininger, N. Dupre, and G.A. Rouleau TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis Nat. Genet. 40 2008 572 574
-
(2008)
Nat. Genet.
, vol.40
, pp. 572-574
-
-
Kabashi, E.1
Valdmanis, P.N.2
Dion, P.3
Spiegelman, D.4
McConkey, B.J.5
Vande, V.C.6
Bouchard, J.P.7
Lacomblez, L.8
Pochigaeva, K.9
Salachas, F.10
Pradat, P.F.11
Camu, W.12
Meininger, V.13
Dupre, N.14
Rouleau, G.A.15
-
119
-
-
33749554133
-
Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8)
-
K. Kanekura, I. Nishimoto, S. Aiso, and M. Matsuoka Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8) J. Biol. Chem. 281 2006 30223 30233
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 30223-30233
-
-
Kanekura, K.1
Nishimoto, I.2
Aiso, S.3
Matsuoka, M.4
-
120
-
-
0030797166
-
Pathological characterization of astrocytic hyaline inclusions in familial amyotrophic lateral sclerosis
-
S. Kato, H. Hayashi, K. Nakashima, E. Nanba, M. Kato, A. Hirano, I. Nakano, K. Asayama, and E. Ohama Pathological characterization of astrocytic hyaline inclusions in familial amyotrophic lateral sclerosis Am. J. Pathol. 151 1997 611 620
-
(1997)
Am. J. Pathol.
, vol.151
, pp. 611-620
-
-
Kato, S.1
Hayashi, H.2
Nakashima, K.3
Nanba, E.4
Kato, M.5
Hirano, A.6
Nakano, I.7
Asayama, K.8
Ohama, E.9
-
121
-
-
0346020435
-
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
-
Y. Kawaguchi, J.J. Kovacs, A. McLaurin, J.M. Vance, A. Ito, and T.P. Yao The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress Cell 115 2003 727 738
-
(2003)
Cell
, vol.115
, pp. 727-738
-
-
Kawaguchi, Y.1
Kovacs, J.J.2
McLaurin, A.3
Vance, J.M.4
Ito, A.5
Yao, T.P.6
-
122
-
-
1542378930
-
Glutamate receptors: RNA editing and death of motor neurons
-
Y. Kawahara, K. Ito, H. Sun, H. Aizawa, I. Kanazawa, and S. Kwak Glutamate receptors: RNA editing and death of motor neurons Nature 427 2004 801
-
(2004)
Nature
, vol.427
, pp. 801
-
-
Kawahara, Y.1
Ito, K.2
Sun, H.3
Aizawa, H.4
Kanazawa, I.5
Kwak, S.6
-
123
-
-
0842301324
-
Active zone localization of presynaptic calcium channels encoded by the cacophony locus of drosophila
-
F. Kawasaki, B. Zou, X. Xu, and R.W. Ordway Active zone localization of presynaptic calcium channels encoded by the cacophony locus of drosophila J. Neurosci. 24 2004 282 285
-
(2004)
J. Neurosci.
, vol.24
, pp. 282-285
-
-
Kawasaki, F.1
Zou, B.2
Xu, X.3
Ordway, R.W.4
-
124
-
-
0034629073
-
Genetic suppression of polyglutamine toxicity in drosophila
-
P. Kazemi-Esfarjani, and S. Benzer Genetic suppression of polyglutamine toxicity in drosophila Science 287 2000 1837 1840
-
(2000)
Science
, vol.287
, pp. 1837-1840
-
-
Kazemi-Esfarjani, P.1
Benzer, S.2
-
125
-
-
76749088358
-
Pathological roles of MAPK signaling pathways in human diseases
-
E.K. Kim, and E.J. Choi Pathological roles of MAPK signaling pathways in human diseases Biochim. Biophys. Acta 1802 2010 396 405
-
(2010)
Biochim. Biophys. Acta
, vol.1802
, pp. 396-405
-
-
Kim, E.K.1
Choi, E.J.2
-
126
-
-
84875605133
-
Mutations in prion-like domains in HnRNPA2B1 and HnRNPA1 cause multisystem proteinopathy and ALS
-
H.J. Kim, N.C. Kim, Y.D. Wang, E.A. Scarborough, J. Moore, Z. Diaz, K.S. MacLea, B. Freibaum, S. Li, A. Molliex, A.P. Kanagaraj, R. Carter, K.B. Boylan, A.M. Wojtas, R. Rademakers, J.L. Pinkus, S.A. Greenberg, J.Q. Trojanowski, B.J. Traynor, B.N. Smith, S. Topp, A.S. Gkazi, J. Miller, C.E. Shaw, M. Kottlors, J. Kirschner, A. Pestronk, Y.R. Li, A.F. Ford, A.D. Gitler, M. Benatar, O.D. King, V.E. Kimonis, E.D. Ross, C.C. Weihl, J. Shorter, and J.P. Taylor Mutations in prion-like domains in HnRNPA2B1 and HnRNPA1 cause multisystem proteinopathy and ALS Nature 495 2013 467 473
-
(2013)
Nature
, vol.495
, pp. 467-473
-
-
Kim, H.J.1
Kim, N.C.2
Wang, Y.D.3
Scarborough, E.A.4
Moore, J.5
Diaz, Z.6
MacLea, K.S.7
Freibaum, B.8
Li, S.9
Molliex, A.10
Kanagaraj, A.P.11
Carter, R.12
Boylan, K.B.13
Wojtas, A.M.14
Rademakers, R.15
Pinkus, J.L.16
Greenberg, S.A.17
Trojanowski, J.Q.18
Traynor, B.J.19
Smith, B.N.20
Topp, S.21
Gkazi, A.S.22
Miller, J.23
Shaw, C.E.24
Kottlors, M.25
Kirschner, J.26
Pestronk, A.27
Li, Y.R.28
Ford, A.F.29
Gitler, A.D.30
Benatar, M.31
King, O.D.32
Kimonis, V.E.33
Ross, E.D.34
Weihl, C.C.35
Shorter, J.36
Taylor, J.P.37
more..
-
127
-
-
84895822652
-
Therapeutic modulation of EIF2alpha phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models
-
H.J. Kim, A.R. Raphael, E.S. Ladow, L. McGurk, R.A. Weber, J.Q. Trojanowski, V.M. Lee, S. Finkbeiner, A.D. Gitler, and N.M. Bonini Therapeutic modulation of EIF2alpha phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models Nat. Genet. 46 2014 152 160
-
(2014)
Nat. Genet.
, vol.46
, pp. 152-160
-
-
Kim, H.J.1
Raphael, A.R.2
Ladow, E.S.3
McGurk, L.4
Weber, R.A.5
Trojanowski, J.Q.6
Lee, V.M.7
Finkbeiner, S.8
Gitler, A.D.9
Bonini, N.M.10
-
128
-
-
77958604956
-
Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 MRNA
-
S.H. Kim, N.P. Shanware, M.J. Bowler, and R.S. Tibbetts Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 MRNA J. Biol. Chem. 285 2010 34097 34105
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 34097-34105
-
-
Kim, S.H.1
Shanware, N.P.2
Bowler, M.J.3
Tibbetts, R.S.4
-
129
-
-
84868088848
-
High-content RNAi screening identifies the type 1 Inositol triphosphate receptor as a modifier of TDP-43 localization and neurotoxicity
-
S.H. Kim, L. Zhan, K.A. Hanson, and R.S. Tibbetts High-content RNAi screening identifies the type 1 Inositol triphosphate receptor as a modifier of TDP-43 localization and neurotoxicity Hum. Mol. Genet. 21 2012 4845 4856
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 4845-4856
-
-
Kim, S.H.1
Zhan, L.2
Hanson, K.A.3
Tibbetts, R.S.4
-
130
-
-
0033407473
-
CuZn-SOD promoter-driven expression in the drosophila central nervous system
-
V.I. Klichko, S.N. Radyuk, and W.C. Orr CuZn-SOD promoter-driven expression in the drosophila central nervous system Neurobiol. Aging 20 1999 537 543
-
(1999)
Neurobiol. Aging
, vol.20
, pp. 537-543
-
-
Klichko, V.I.1
Radyuk, S.N.2
Orr, W.C.3
-
131
-
-
2442520399
-
Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains
-
H.S. Ko, T. Uehara, K. Tsuruma, and Y. Nomura Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains FEBS Lett. 566 2004 110 114
-
(2004)
FEBS Lett.
, vol.566
, pp. 110-114
-
-
Ko, H.S.1
Uehara, T.2
Tsuruma, K.3
Nomura, Y.4
-
132
-
-
51649124062
-
Two German kindreds with familial amyotrophic lateral sclerosis due to TARDBP mutations
-
P. Kuhnlein, A.D. Sperfeld, B. Vanmassenhove, D.,V. Van, V.M. Lee, J.Q. Trojanowski, H.A. Kretzschmar, A.C. Ludolph, and M. Neumann Two German kindreds with familial amyotrophic lateral sclerosis due to TARDBP mutations Arch. Neurol. 65 2008 1185 1189
-
(2008)
Arch. Neurol.
, vol.65
, pp. 1185-1189
-
-
Kuhnlein, P.1
Sperfeld, A.D.2
Vanmassenhove, B.3
Van, D.V.4
Lee, V.M.5
Trojanowski, J.Q.6
Kretzschmar, H.A.7
Ludolph, A.C.8
Neumann, M.9
-
133
-
-
84890891751
-
Transcriptome profiling following neuronal and glial expression of ALS-linked SOD1 in drosophila
-
E.L. Kumimoto, T.R. Fore, and B. Zhang Transcriptome profiling following neuronal and glial expression of ALS-linked SOD1 in drosophila G3 (Bethesda) 2013 pii: g3113.005850v1
-
(2013)
G3 (Bethesda)
-
-
Kumimoto, E.L.1
Fore, T.R.2
Zhang, B.3
-
134
-
-
61349156118
-
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis
-
T.J. Kwiatkowski Jr., D.A. Bosco, A.L. Leclerc, E. Tamrazian, C.R. Vanderburg, C. Russ, A. Davis, J. Gilchrist, E.J. Kasarskis, T. Munsat, P. Valdmanis, G.A. Rouleau, B.A. Hosler, P. Cortelli, P.J. de Jong, Y. Yoshinaga, J.L. Haines, M.A. Pericak-Vance, J. Yan, N. Ticozzi, T. Siddique, D. McKenna-Yasek, P.C. Sapp, H.R. Horvitz, J.E. Landers, and R.H. Brown Jr. Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis Science 323 2009 1205 1208
-
(2009)
Science
, vol.323
, pp. 1205-1208
-
-
Kwiatkowski, Jr.T.J.1
Bosco, D.A.2
Leclerc, A.L.3
Tamrazian, E.4
Vanderburg, C.R.5
Russ, C.6
Davis, A.7
Gilchrist, J.8
Kasarskis, E.J.9
Munsat, T.10
Valdmanis, P.11
Rouleau, G.A.12
Hosler, B.A.13
Cortelli, P.14
De Jong, P.J.15
Yoshinaga, Y.16
Haines, J.L.17
Pericak-Vance, M.A.18
Yan, J.19
Ticozzi, N.20
Siddique, T.21
McKenna-Yasek, D.22
Sapp, P.C.23
Horvitz, H.R.24
Landers, J.E.25
Brown, Jr.R.H.26
more..
-
135
-
-
84907221451
-
Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells
-
I. Kwon, S. Xiang, M. Kato, L. Wu, P. Theodoropoulos, T. Wang, J. Kim, J. Yun, Y. Xie, and S.L. McKnight Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells Science 345 2014 1139 1145
-
(2014)
Science
, vol.345
, pp. 1139-1145
-
-
Kwon, I.1
Xiang, S.2
Kato, M.3
Wu, L.4
Theodoropoulos, P.5
Wang, T.6
Kim, J.7
Yun, J.8
Xie, Y.9
McKnight, S.L.10
-
136
-
-
0028895196
-
Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation
-
Y. Labelle, J. Zucman, G. Stenman, L.G. Kindblom, J. Knight, C. Turc-Carel, B. Dockhorn-Dworniczak, N. Mandahl, C. Desmaze, and M. Peter Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation Hum. Mol. Genet. 4 1995 2219 2226
-
(1995)
Hum. Mol. Genet.
, vol.4
, pp. 2219-2226
-
-
Labelle, Y.1
Zucman, J.2
Stenman, G.3
Kindblom, L.G.4
Knight, J.5
Turc-Carel, C.6
Dockhorn-Dworniczak, B.7
Mandahl, N.8
Desmaze, C.9
Peter, M.10
-
137
-
-
62149141328
-
Rethinking ALS: The FUS about TDP-43
-
C. Lagier-Tourenne, and D.W. Cleveland Rethinking ALS: the FUS about TDP-43 Cell 136 2009 1001 1004
-
(2009)
Cell
, vol.136
, pp. 1001-1004
-
-
Lagier-Tourenne, C.1
Cleveland, D.W.2
-
138
-
-
84868152371
-
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-MRNAs
-
C. Lagier-Tourenne, M. Polymenidou, K.R. Hutt, A.Q. Vu, M. Baughn, S.C. Huelga, K.M. Clutario, S.C. Ling, T.Y. Liang, C. Mazur, E. Wancewicz, A.S. Kim, A. Watt, S. Freier, G.G. Hicks, J.P. Donohue, L. Shiue, C.F. Bennett, J. Ravits, D.W. Cleveland, and G.W. Yeo Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-MRNAs Nat. Neurosci. 15 2012 1488 1497
-
(2012)
Nat. Neurosci.
, vol.15
, pp. 1488-1497
-
-
Lagier-Tourenne, C.1
Polymenidou, M.2
Hutt, K.R.3
Vu, A.Q.4
Baughn, M.5
Huelga, S.C.6
Clutario, K.M.7
Ling, S.C.8
Liang, T.Y.9
Mazur, C.10
Wancewicz, E.11
Kim, A.S.12
Watt, A.13
Freier, S.14
Hicks, G.G.15
Donohue, J.P.16
Shiue, L.17
Bennett, C.F.18
Ravits, J.19
Cleveland, D.W.20
Yeo, G.W.21
more..
-
139
-
-
79958720175
-
A drosophila model of fus-related neurodegeneration reveals genetic interaction between FUS and TDP-43
-
N.A. Lanson Jr., A. Maltare, H. King, R. Smith, J.H. Kim, J.P. Taylor, T.E. Lloyd, and U.B. Pandey A drosophila model of fus-related neurodegeneration reveals genetic interaction between FUS and TDP-43 Hum. Mol. Genet. 20 2011 2510 2523
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 2510-2523
-
-
Lanson, Jr.N.A.1
Maltare, A.2
King, H.3
Smith, R.4
Kim, J.H.5
Taylor, J.P.6
Lloyd, T.E.7
Pandey, U.B.8
-
140
-
-
84878131682
-
TARDBP and FUS mutations associated with amyotrophic lateral sclerosis: Summary and update
-
S. Lattante, G.A. Rouleau, and E. Kabashi TARDBP and FUS mutations associated with amyotrophic lateral sclerosis: summary and update Hum. Mutat. 34 2013 812 826
-
(2013)
Hum. Mutat.
, vol.34
, pp. 812-826
-
-
Lattante, S.1
Rouleau, G.A.2
Kabashi, E.3
-
141
-
-
33745945163
-
TLS, EWS and TAF15: A model for transcriptional integration of gene expression
-
W.J. Law, K.L. Cann, and G.G. Hicks TLS, EWS and TAF15: a model for transcriptional integration of gene expression Brief Funct. Genomic Proteomic 5 2006 8 14
-
(2006)
Brief Funct. Genomic Proteomic
, vol.5
, pp. 8-14
-
-
Law, W.J.1
Cann, K.L.2
Hicks, G.G.3
-
142
-
-
84922481787
-
Dissection of genetic factors associated with amyotrophic lateral sclerosis
-
Leblond, C.S., Kaneb, H.M., Dion, P.A., Rouleau, G.A., 2014. Dissection of genetic factors associated with amyotrophic lateral sclerosis. Exp. Neurol. pii: S0014-4886(14)00115-0.
-
(2014)
Exp. Neurol.
-
-
Leblond, C.S.1
Kaneb, H.M.2
Dion, P.A.3
Rouleau, G.A.4
-
143
-
-
84874680813
-
Riluzole and prognostic factors in amyotrophic lateral sclerosis long-term and short-term survival: A population-based study of 1149 cases in Taiwan
-
C.T. Lee, Y.W. Chiu, K.C. Wang, C.S. Hwang, K.H. Lin, I.T. Lee, and C.P. Tsai Riluzole and prognostic factors in amyotrophic lateral sclerosis long-term and short-term survival: a population-based study of 1149 cases in Taiwan J. Epidemiol. 23 2013 35 40
-
(2013)
J. Epidemiol.
, vol.23
, pp. 35-40
-
-
Lee, C.T.1
Chiu, Y.W.2
Wang, K.C.3
Hwang, C.S.4
Lin, K.H.5
Lee, I.T.6
Tsai, C.P.7
-
144
-
-
1842839807
-
Stimulation of HTAFII68 (NTD)-mediated transactivation by V-Src
-
H.J. Lee, S. Kim, J. Pelletier, and J. Kim Stimulation of HTAFII68 (NTD)-mediated transactivation by V-Src FEBS Lett. 564 2004 188 198
-
(2004)
FEBS Lett.
, vol.564
, pp. 188-198
-
-
Lee, H.J.1
Kim, S.2
Pelletier, J.3
Kim, J.4
-
145
-
-
79961148135
-
Hyperphosphorylation as a defense mechanism to reduce tdp-43 aggregation
-
H.Y. Li, P.A. Yeh, H.C. Chiu, C.Y. Tang, and B.P. Tu Hyperphosphorylation as a defense mechanism to reduce tdp-43 aggregation PLoS One 6 2011 e23075
-
(2011)
PLoS One
, vol.6
, pp. e23075
-
-
Li, H.Y.1
Yeh, P.A.2
Chiu, H.C.3
Tang, C.Y.4
Tu, B.P.5
-
146
-
-
45749147456
-
RNA toxicity is a component of ataxin-3 degeneration in drosophila
-
L.B. Li, Z. Yu, X. Teng, and N.M. Bonini RNA toxicity is a component of ataxin-3 degeneration in drosophila Nature 453 2008 1107 1111
-
(2008)
Nature
, vol.453
, pp. 1107-1111
-
-
Li, L.B.1
Yu, Z.2
Teng, X.3
Bonini, N.M.4
-
147
-
-
84893306964
-
The ADAR RNA editing enzyme controls neuronal excitability in Drosophila melanogaster
-
X. Li, I.M. Overton, R.A. Baines, L.P. Keegan, and M.A. O'Connell The ADAR RNA editing enzyme controls neuronal excitability in Drosophila melanogaster Nucl. Acids Res. 42 2014 1139 1151
-
(2014)
Nucl. Acids Res.
, vol.42
, pp. 1139-1151
-
-
Li, X.1
Overton, I.M.2
Baines, R.A.3
Keegan, L.P.4
O'Connell, M.A.5
-
148
-
-
77649258646
-
A drosophila model for TDP-43 proteinopathy
-
Y. Li, P. Ray, E.J. Rao, C. Shi, W. Guo, X. Chen, E.A. Woodruff III, K. Fushimi, and J.Y. Wu A drosophila model for TDP-43 proteinopathy Proc. Natl. Acad. Sci. USA 107 2010 3169 3174
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 3169-3174
-
-
Li, Y.1
Ray, P.2
Rao, E.J.3
Shi, C.4
Guo, W.5
Chen, X.6
Woodruff, E.A.7
Fushimi, K.8
Wu, J.Y.9
-
149
-
-
84871590013
-
The FTD/ALS-associated rna-binding protein TDP-43 regulates the robustness of neuronal specification through MicroRNA-9a in drosophila
-
Z. Li, Y. Lu, X.L. Xu, and F.B. Gao The FTD/ALS-associated rna-binding protein TDP-43 regulates the robustness of neuronal specification through MicroRNA-9a in drosophila Hum. Mol. Genet. 22 2013 218 225
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 218-225
-
-
Li, Z.1
Lu, Y.2
Xu, X.L.3
Gao, F.B.4
-
150
-
-
79957801387
-
Neuronal function and dysfunction of drosophila DTDP
-
M.J. Lin, C.W. Cheng, and C.K. Shen Neuronal function and dysfunction of drosophila DTDP PLoS One 6 2011 e20371
-
(2011)
PLoS One
, vol.6
, pp. e20371
-
-
Lin, M.J.1
Cheng, C.W.2
Shen, C.K.3
-
151
-
-
77955784599
-
ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS
-
S.C. Ling, C.P. Albuquerque, J.S. Han, C. Lagier-Tourenne, S. Tokunaga, H. Zhou, and D.W. Cleveland ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS Proc. Natl. Acad. Sci. USA 107 2010 13318 13323
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 13318-13323
-
-
Ling, S.C.1
Albuquerque, C.P.2
Han, J.S.3
Lagier-Tourenne, C.4
Tokunaga, S.5
Zhou, H.6
Cleveland, D.W.7
-
152
-
-
3242701496
-
Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria
-
J. Liu, C. Lillo, P.A. Jonsson, V.C. Vande, C.M. Ward, T.M. Miller, J.R. Subramaniam, J.D. Rothstein, S. Marklund, P.M. Andersen, T. Brannstrom, O. Gredal, P.C. Wong, D.S. Williams, and D.W. Cleveland Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria Neuron 43 2004 5 17
-
(2004)
Neuron
, vol.43
, pp. 5-17
-
-
Liu, J.1
Lillo, C.2
Jonsson, P.A.3
Vande, V.C.4
Ward, C.M.5
Miller, T.M.6
Subramaniam, J.R.7
Rothstein, J.D.8
Marklund, S.9
Andersen, P.M.10
Brannstrom, T.11
Gredal, O.12
Wong, P.C.13
Williams, D.S.14
Cleveland, D.W.15
-
153
-
-
77949899075
-
Flightless flies: Drosophila models of neuromuscular disease
-
T.E. Lloyd, and J.P. Taylor Flightless flies: drosophila models of neuromuscular disease Ann. N. Y. Acad. Sci. 1184 2010 e1 20
-
(2010)
Ann. N. Y. Acad. Sci.
, vol.1184
, pp. e1-20
-
-
Lloyd, T.E.1
Taylor, J.P.2
-
154
-
-
37749020600
-
Descriptive epidemiology of amyotrophic lateral sclerosis: New evidence and unsolved issues
-
G. Logroscino, B.J. Traynor, O. Hardiman, A. Chio′, P. Couratier, J.D. Mitchell, R.J. Swingler, and E. Beghi Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues J. Neurol. Neurosurg. Psychiatry 79 2008 6 11
-
(2008)
J. Neurol. Neurosurg. Psychiatry
, vol.79
, pp. 6-11
-
-
Logroscino, G.1
Traynor, B.J.2
Hardiman, O.3
Chio, A.4
Couratier, P.5
Mitchell, J.D.6
Swingler, R.J.7
Beghi, E.8
-
155
-
-
77950612903
-
Incidence of amyotrophic lateral sclerosis in Europe
-
G. Logroscino, B.J. Traynor, O. Hardiman, A. Chio, D. Mitchell, R.J. Swingler, A. Millul, E. Benn, and E. Beghi Incidence of amyotrophic lateral sclerosis in Europe J. Neurol. Neurosurg. Psychiatry 81 2010 385 390
-
(2010)
J. Neurol. Neurosurg. Psychiatry
, vol.81
, pp. 385-390
-
-
Logroscino, G.1
Traynor, B.J.2
Hardiman, O.3
Chio, A.4
Mitchell, D.5
Swingler, R.J.6
Millul, A.7
Benn, E.8
Beghi, E.9
-
156
-
-
0030668895
-
The expansion of the CAG repeat in ataxin-2 is a frequent cause of autosomal dominant spinocerebellar ataxia
-
D. Lorenzetti, S. Bohlega, and H.Y. Zoghbi The expansion of the CAG repeat in ataxin-2 is a frequent cause of autosomal dominant spinocerebellar ataxia Neurology 49 1997 1009 1013
-
(1997)
Neurology
, vol.49
, pp. 1009-1013
-
-
Lorenzetti, D.1
Bohlega, S.2
Zoghbi, H.Y.3
-
157
-
-
70350356317
-
Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching
-
Y. Lu, J. Ferris, and F.B. Gao Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching Mol. Brain 2 2009 30
-
(2009)
Mol. Brain
, vol.2
, pp. 30
-
-
Lu, Y.1
Ferris, J.2
Gao, F.B.3
-
158
-
-
16044366720
-
Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein
-
T.J. Lyons, H. Liu, J.J. Goto, A. Nersissian, J.A. Roe, J.A. Graden, C. Cafe, L.M. Ellerby, D.E. Bredesen, E.B. Gralla, and J.S. Valentine Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein Proc. Natl. Acad. Sci. USA 93 1996 12240 12244
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 12240-12244
-
-
Lyons, T.J.1
Liu, H.2
Goto, J.J.3
Nersissian, A.4
Roe, J.A.5
Graden, J.A.6
Cafe, C.7
Ellerby, L.M.8
Bredesen, D.E.9
Gralla, E.B.10
Valentine, J.S.11
-
159
-
-
34249946466
-
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations
-
I.R. Mackenzie, E.H. Bigio, P.G. Ince, F. Geser, M. Neumann, N.J. Cairns, L.K. Kwong, M.S. Forman, J. Ravits, H. Stewart, A. Eisen, L. McClusky, H.A. Kretzschmar, C.M. Monoranu, J.R. Highley, J. Kirby, T. Siddique, P.J. Shaw, V.M. Lee, and J.Q. Trojanowski Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations Ann. Neurol. 61 2007 427 434
-
(2007)
Ann. Neurol.
, vol.61
, pp. 427-434
-
-
MacKenzie, I.R.1
Bigio, E.H.2
Ince, P.G.3
Geser, F.4
Neumann, M.5
Cairns, N.J.6
Kwong, L.K.7
Forman, M.S.8
Ravits, J.9
Stewart, H.10
Eisen, A.11
McClusky, L.12
Kretzschmar, H.A.13
Monoranu, C.M.14
Highley, J.R.15
Kirby, J.16
Siddique, T.17
Shaw, P.J.18
Lee, V.M.19
Trojanowski, J.Q.20
more..
-
160
-
-
84858622829
-
Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: A cross-sectional study
-
E. Majounie, A.E. Renton, K. Mok, E.G. Dopper, A. Waite, S. Rollinson, A. Chio, G. Restagno, N. Nicolaou, J. Simon-Sanchez, J.C. van Swieten, Y. Abramzon, J.O. Johnson, M. Sendtner, R. Pamphlett, R.W. Orrell, S. Mead, K.C. Sidle, H. Houlden, J.D. Rohrer, K.E. Morrison, H. Pall, K. Talbot, O. Ansorge, D.G. Hernandez, S. Arepalli, M. Sabatelli, G. Mora, M. Corbo, F. Giannini, A. Calvo, E. Englund, G. Borghero, G.L. Floris, A.M. Remes, H. Laaksovirta, L. McCluskey, J.Q. Trojanowski, V.M. Van Deerlin, G.D. Schellenberg, M.A. Nalls, V.E. Drory, C.S. Lu, T.H. Yeh, H. Ishiura, Y. Takahashi, S. Tsuji, B.,I. Le, A. Brice, C. Drepper, N. Williams, J. Kirby, P. Shaw, J. Hardy, P.J. Tienari, P. Heutink, H.R. Morris, S. Pickering-Brown, and B.J. Traynor Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study Lancet Neurol. 11 2012 323 330
-
(2012)
Lancet Neurol.
, vol.11
, pp. 323-330
-
-
Majounie, E.1
Renton, A.E.2
Mok, K.3
Dopper, E.G.4
Waite, A.5
Rollinson, S.6
Chio, A.7
Restagno, G.8
Nicolaou, N.9
Simon-Sanchez, J.10
Van Swieten, J.C.11
Abramzon, Y.12
Johnson, J.O.13
Sendtner, M.14
Pamphlett, R.15
Orrell, R.W.16
Mead, S.17
Sidle, K.C.18
Houlden, H.19
Rohrer, J.D.20
Morrison, K.E.21
Pall, H.22
Talbot, K.23
Ansorge, O.24
Hernandez, D.G.25
Arepalli, S.26
Sabatelli, M.27
Mora, G.28
Corbo, M.29
Giannini, F.30
Calvo, A.31
Englund, E.32
Borghero, G.33
Floris, G.L.34
Remes, A.M.35
Laaksovirta, H.36
McCluskey, L.37
Trojanowski, J.Q.38
Van Deerlin, V.M.39
Schellenberg, G.D.40
Nalls, M.A.41
Drory, V.E.42
Lu, C.S.43
Yeh, T.H.44
Ishiura, H.45
Takahashi, Y.46
Tsuji, S.47
Le, B.I.48
Brice, A.49
Drepper, C.50
Williams, N.51
Kirby, J.52
Shaw, P.53
Hardy, J.54
Tienari, P.J.55
Heutink, P.56
Morris, H.R.57
Pickering-Brown, S.58
Traynor, B.J.59
more..
-
161
-
-
67649336230
-
Manipulation of Sod1 expression ubiquitously, but not in the nervous system or muscle, impacts age-related parameters in drosophila
-
I. Martin, M.A. Jones, and M. Grotewiel Manipulation of Sod1 expression ubiquitously, but not in the nervous system or muscle, impacts age-related parameters in drosophila FEBS Lett. 583 2009 2308 2314
-
(2009)
FEBS Lett.
, vol.583
, pp. 2308-2314
-
-
Martin, I.1
Jones, M.A.2
Grotewiel, M.3
-
162
-
-
0036791118
-
Recurrent rearrangement of the Ewing's sarcoma gene, EWSR1, or its homologue, TAF15, with the transcription factor CIZ/NMP4 in acute leukemia
-
A. Martini, S.R. La, H. Janssen, C. Bilhou-Nabera, A. Corveleyn, R. Somers, A. Aventin, R. Foa, A. Hagemeijer, C. Mecucci, and P. Marynen Recurrent rearrangement of the Ewing's sarcoma gene, EWSR1, or its homologue, TAF15, with the transcription factor CIZ/NMP4 in acute leukemia Cancer Res. 62 2002 5408 5412
-
(2002)
Cancer Res.
, vol.62
, pp. 5408-5412
-
-
Martini, A.1
La, S.R.2
Janssen, H.3
Bilhou-Nabera, C.4
Corveleyn, A.5
Somers, R.6
Aventin, A.7
Foa, R.8
Hagemeijer, A.9
Mecucci, C.10
Marynen, P.11
-
163
-
-
77952419246
-
Mutations of optineurin in amyotrophic lateral sclerosis
-
H. Maruyama, H. Morino, H. Ito, Y. Izumi, H. Kato, Y. Watanabe, Y. Kinoshita, M. Kamada, H. Nodera, H. Suzuki, O. Komure, S. Matsuura, K. Kobatake, N. Morimoto, K. Abe, N. Suzuki, M. Aoki, A. Kawata, T. Hirai, T. Kato, K. Ogasawara, A. Hirano, T. Takumi, H. Kusaka, K. Hagiwara, R. Kaji, and H. Kawakami Mutations of optineurin in amyotrophic lateral sclerosis Nature 465 2010 223 226
-
(2010)
Nature
, vol.465
, pp. 223-226
-
-
Maruyama, H.1
Morino, H.2
Ito, H.3
Izumi, Y.4
Kato, H.5
Watanabe, Y.6
Kinoshita, Y.7
Kamada, M.8
Nodera, H.9
Suzuki, H.10
Komure, O.11
Matsuura, S.12
Kobatake, K.13
Morimoto, N.14
Abe, K.15
Suzuki, N.16
Aoki, M.17
Kawata, A.18
Hirai, T.19
Kato, T.20
Ogasawara, K.21
Hirano, A.22
Takumi, T.23
Kusaka, H.24
Hagiwara, K.25
Kaji, R.26
Kawakami, H.27
more..
-
164
-
-
0027362619
-
The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1
-
W.A. May, S.L. Lessnick, B.S. Braun, M. Klemsz, B.C. Lewis, L.B. Lunsford, R. Hromas, and C.T. Denny The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1 Mol. Cell Biol. 13 1993 7393 7398
-
(1993)
Mol. Cell Biol.
, vol.13
, pp. 7393-7398
-
-
May, W.A.1
Lessnick, S.L.2
Braun, B.S.3
Klemsz, M.4
Lewis, B.C.5
Lunsford, L.B.6
Hromas, R.7
Denny, C.T.8
-
165
-
-
3242677215
-
Gene expression systems in drosophila: A synthesis of time and space
-
S.E. McGuire, G. Roman, and R.L. Davis Gene expression systems in drosophila: a synthesis of time and space Trends Genet. 20 2004 384 391
-
(2004)
Trends Genet.
, vol.20
, pp. 384-391
-
-
McGuire, S.E.1
Roman, G.2
Davis, R.L.3
-
166
-
-
84858334440
-
Accumulation of insoluble forms of FUS protein correlates with toxicity in drosophila
-
L. Miguel, T. Avequin, M. Delarue, S. Feuillette, T. Frebourg, D. Campion, and M. Lecourtois Accumulation of insoluble forms of FUS protein correlates with toxicity in drosophila Neurobiol. Aging 33 2012 1008 1015
-
(2012)
Neurobiol. Aging
, vol.33
, pp. 1008-1015
-
-
Miguel, L.1
Avequin, T.2
Delarue, M.3
Feuillette, S.4
Frebourg, T.5
Campion, D.6
Lecourtois, M.7
-
167
-
-
78650607406
-
Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in drosophila models of TDP-43 proteinopathies
-
L. Miguel, T. Frebourg, D. Campion, and M. Lecourtois Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in drosophila models of TDP-43 proteinopathies Neurobiol. Dis. 41 2011 398 406
-
(2011)
Neurobiol. Dis.
, vol.41
, pp. 398-406
-
-
Miguel, L.1
Frebourg, T.2
Campion, D.3
Lecourtois, M.4
-
168
-
-
0031282443
-
Spongecake and eggroll: Two hereditary diseases in drosophila resemble patterns of human brain degeneration
-
K.T. Min, and S. Benzer Spongecake and eggroll: two hereditary diseases in drosophila resemble patterns of human brain degeneration Curr. Biol. 7 1997 885 888
-
(1997)
Curr. Biol.
, vol.7
, pp. 885-888
-
-
Min, K.T.1
Benzer, S.2
-
169
-
-
84904068578
-
HDAC6 is a bruchpilot deacetylase that facilitates neurotransmitter release
-
K. Miskiewicz, L.E. Jose, W.M. Yeshaw, J.S. Valadas, J. Swerts, S. Munck, F. Feiguin, B. Dermaut, and P. Verstreken HDAC6 is a bruchpilot deacetylase that facilitates neurotransmitter release Cell Rep. 8 2014 94 102
-
(2014)
Cell Rep.
, vol.8
, pp. 94-102
-
-
Miskiewicz, K.1
Jose, L.E.2
Yeshaw, W.M.3
Valadas, J.S.4
Swerts, J.5
Munck, S.6
Feiguin, F.7
Dermaut, B.8
Verstreken, P.9
-
170
-
-
84907188956
-
C9orf72 repeat expansions cause neurodegeneration in drosophila through arginine-rich proteins
-
S. Mizielinska, S. Gronke, T. Niccoli, C.E. Ridler, E.L. Clayton, A. Devoy, T. Moens, F.E. Norona, I.O. Woollacott, J. Pietrzyk, K. Cleverley, A.J. Nicoll, S. Pickering-Brown, J. Dols, M. Cabecinha, O. Hendrich, P. Fratta, E.M. Fisher, L. Partridge, and A.M. Isaacs C9orf72 repeat expansions cause neurodegeneration in drosophila through arginine-rich proteins Science 345 2014 1192 1194
-
(2014)
Science
, vol.345
, pp. 1192-1194
-
-
Mizielinska, S.1
Gronke, S.2
Niccoli, T.3
Ridler, C.E.4
Clayton, E.L.5
Devoy, A.6
Moens, T.7
Norona, F.E.8
Woollacott, I.O.9
Pietrzyk, J.10
Cleverley, K.11
Nicoll, A.J.12
Pickering-Brown, S.13
Dols, J.14
Cabecinha, M.15
Hendrich, O.16
Fratta, P.17
Fisher, E.M.18
Partridge, L.19
Isaacs, A.M.20
more..
-
171
-
-
84893434633
-
Loss of drosophila ataxin-7, a SAGA subunit, reduces H2B ubiquitination and leads to neural and retinal degeneration
-
R.D. Mohan, G. Dialynas, V.M. Weake, J. Liu, S. Martin-Brown, L. Florens, M.P. Washburn, J.L. Workman, and S.M. Abmayr Loss of drosophila ataxin-7, a SAGA subunit, reduces H2B ubiquitination and leads to neural and retinal degeneration Genes Dev. 28 2014 259 272
-
(2014)
Genes Dev.
, vol.28
, pp. 259-272
-
-
Mohan, R.D.1
Dialynas, G.2
Weake, V.M.3
Liu, J.4
Martin-Brown, S.5
Florens, L.6
Washburn, M.P.7
Workman, J.L.8
Abmayr, S.M.9
-
172
-
-
84896722337
-
Homeotic gene teashirt (Tsh) has a neuroprotective function in amyloid-beta 42 mediated neurodegeneration
-
M.T. Moran, M. Tare, M. Kango-Singh, and A. Singh Homeotic gene teashirt (Tsh) has a neuroprotective function in amyloid-beta 42 mediated neurodegeneration PLoS One 8 2013 e80829
-
(2013)
PLoS One
, vol.8
, pp. e80829
-
-
Moran, M.T.1
Tare, M.2
Kango-Singh, M.3
Singh, A.4
-
173
-
-
84874962380
-
The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS
-
K. Mori, S.M. Weng, T. Arzberger, S. May, K. Rentzsch, E. Kremmer, B. Schmid, H.A. Kretzschmar, M. Cruts, B.C. Van, C. Haass, and D. Edbauer The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS Science 339 2013 1335 1338
-
(2013)
Science
, vol.339
, pp. 1335-1338
-
-
Mori, K.1
Weng, S.M.2
Arzberger, T.3
May, S.4
Rentzsch, K.5
Kremmer, E.6
Schmid, B.7
Kretzschmar, H.A.8
Cruts, M.9
Van, B.C.10
Haass, C.11
Edbauer, D.12
-
174
-
-
0021713250
-
Motor neuron disease in the province of Turin, Italy, 1966-1980. Survival analysis in an unselected population
-
P. Mortara, A. Chio, M.G. Rosso, M. Leone, and D. Schiffer Motor neuron disease in the province of Turin, Italy, 1966-1980. survival analysis in an unselected population J. Neurol. Sci. 66 1984 165 173
-
(1984)
J. Neurol. Sci.
, vol.66
, pp. 165-173
-
-
Mortara, P.1
Chio, A.2
Rosso, M.G.3
Leone, M.4
Schiffer, D.5
-
175
-
-
84897865656
-
The amyotrophic lateral sclerosis 8 protein, VAP, is required for er protein quality control
-
A. Moustaqim-Barrette, Y.Q. Lin, S. Pradhan, G.G. Neely, H.J. Bellen, and H. Tsuda The amyotrophic lateral sclerosis 8 protein, VAP, is required for er protein quality control Hum. Mol. Genet. 23 2014 1975 1989
-
(2014)
Hum. Mol. Genet.
, vol.23
, pp. 1975-1989
-
-
Moustaqim-Barrette, A.1
Lin, Y.Q.2
Pradhan, S.3
Neely, G.G.4
Bellen, H.J.5
Tsuda, H.6
-
176
-
-
0001250446
-
Genetic variability, twin hybrids and constant hybrids, in a case of balanced lethal factors
-
H.J. Muller Genetic variability, twin hybrids and constant hybrids, in a case of balanced lethal factors Genetics 3 1918 422 499
-
(1918)
Genetics
, vol.3
, pp. 422-499
-
-
Muller, H.J.1
-
177
-
-
33747830026
-
Artificial transmutation of the gene
-
H.J. Muller Artificial transmutation of the gene Science 66 1927 84 87
-
(1927)
Science
, vol.66
, pp. 84-87
-
-
Muller, H.J.1
-
178
-
-
0034708758
-
A whole-genome assembly of drosophila
-
E.W. Myers, G.G. Sutton, A.L. Delcher, I.M. Dew, D.P. Fasulo, M.J. Flanigan, S.A. Kravitz, C.M. Mobarry, K.H. Reinert, K.A. Remington, E.L. Anson, R.A. Bolanos, H.H. Chou, C.M. Jordan, A.L. Halpern, S. Lonardi, E.M. Beasley, R.C. Brandon, L. Chen, P.J. Dunn, Z. Lai, Y. Liang, D.R. Nusskern, M. Zhan, Q. Zhang, X. Zheng, G.M. Rubin, M.D. Adams, and J.C. Venter A whole-genome assembly of drosophila Science 287 2000 2196 2204
-
(2000)
Science
, vol.287
, pp. 2196-2204
-
-
Myers, E.W.1
Sutton, G.G.2
Delcher, A.L.3
Dew, I.M.4
Fasulo, D.P.5
Flanigan, M.J.6
Kravitz, S.A.7
Mobarry, C.M.8
Reinert, K.H.9
Remington, K.A.10
Anson, E.L.11
Bolanos, R.A.12
Chou, H.H.13
Jordan, C.M.14
Halpern, A.L.15
Lonardi, S.16
Beasley, E.M.17
Brandon, R.C.18
Chen, L.19
Dunn, P.J.20
Lai, Z.21
Liang, Y.22
Nusskern, D.R.23
Zhan, M.24
Zhang, Q.25
Zheng, X.26
Rubin, G.M.27
Adams, M.D.28
Venter, J.C.29
more..
-
179
-
-
0023270442
-
Hepatic ultrastructural changes and liver dysfunction in amyotrophic lateral sclerosis
-
Y. Nakano, K. Hirayama, and K. Terao Hepatic ultrastructural changes and liver dysfunction in amyotrophic lateral sclerosis Arch. Neurol. 44 1987 103 106
-
(1987)
Arch. Neurol.
, vol.44
, pp. 103-106
-
-
Nakano, Y.1
Hirayama, K.2
Terao, K.3
-
180
-
-
70350673956
-
A new subtype of frontotemporal lobar degeneration with FUS pathology
-
M. Neumann, R. Rademakers, S. Roeber, M. Baker, H.A. Kretzschmar, and I.R. Mackenzie A new subtype of frontotemporal lobar degeneration with FUS pathology Brain 132 2009 2922 2931
-
(2009)
Brain
, vol.132
, pp. 2922-2931
-
-
Neumann, M.1
Rademakers, R.2
Roeber, S.3
Baker, M.4
Kretzschmar, H.A.5
MacKenzie, I.R.6
-
181
-
-
33749632259
-
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
M. Neumann, D.M. Sampathu, L.K. Kwong, A.C. Truax, M.C. Micsenyi, T.T. Chou, J. Bruce, T. Schuck, M. Grossman, C.M. Clark, L.F. McCluskey, B.L. Miller, E. Masliah, I.R. Mackenzie, H. Feldman, W. Feiden, H.A. Kretzschmar, J.Q. Trojanowski, and V.M. Lee Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis Science 314 2006 130 133
-
(2006)
Science
, vol.314
, pp. 130-133
-
-
Neumann, M.1
Sampathu, D.M.2
Kwong, L.K.3
Truax, A.C.4
Micsenyi, M.C.5
Chou, T.T.6
Bruce, J.7
Schuck, T.8
Grossman, M.9
Clark, C.M.10
McCluskey, L.F.11
Miller, B.L.12
Masliah, E.13
MacKenzie, I.R.14
Feldman, H.15
Feiden, W.16
Kretzschmar, H.A.17
Trojanowski, J.Q.18
Lee, V.M.19
-
182
-
-
1942533604
-
A novel locus for late onset amyotrophic lateral sclerosis/motor neurone disease variant at 20q13
-
A.L. Nishimura, M. Mitne-Neto, H.C. Silva, J.R. Oliveira, M. Vainzof, and M. Zatz A novel locus for late onset amyotrophic lateral sclerosis/motor neurone disease variant at 20q13 J. Med. Genet. 41 2004 315 320
-
(2004)
J. Med. Genet.
, vol.41
, pp. 315-320
-
-
Nishimura, A.L.1
Mitne-Neto, M.2
Silva, H.C.3
Oliveira, J.R.4
Vainzof, M.5
Zatz, M.6
-
183
-
-
6344257200
-
A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis
-
A.L. Nishimura, M. Mitne-Neto, H.C. Silva, A. Richieri-Costa, S. Middleton, D. Cascio, F. Kok, J.R. Oliveira, T. Gillingwater, J. Webb, P. Skehel, and M. Zatz A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis Am. J. Hum. Genet. 75 2004 822 831
-
(2004)
Am. J. Hum. Genet.
, vol.75
, pp. 822-831
-
-
Nishimura, A.L.1
Mitne-Neto, M.2
Silva, H.C.3
Richieri-Costa, A.4
Middleton, S.5
Cascio, D.6
Kok, F.7
Oliveira, J.R.8
Gillingwater, T.9
Webb, J.10
Skehel, P.11
Zatz, M.12
-
184
-
-
0037184063
-
Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity
-
J. Niwa, S. Ishigaki, N. Hishikawa, M. Yamamoto, M. Doyu, S. Murata, K. Tanaka, N. Taniguchi, and G. Sobue Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity J. Biol. Chem. 277 2002 36793 36798
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 36793-36798
-
-
Niwa, J.1
Ishigaki, S.2
Hishikawa, N.3
Yamamoto, M.4
Doyu, M.5
Murata, S.6
Tanaka, K.7
Taniguchi, N.8
Sobue, G.9
-
185
-
-
0035947778
-
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of EIF2alpha
-
I. Novoa, H. Zeng, H.P. Harding, and D. Ron Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of EIF2alpha J. Cell Biol. 153 2001 1011 1022
-
(2001)
J. Cell Biol.
, vol.153
, pp. 1011-1022
-
-
Novoa, I.1
Zeng, H.2
Harding, H.P.3
Ron, D.4
-
186
-
-
0029081561
-
Molecular cloning of a CDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant
-
F.C. Nucifora Jr., S.H. Li, S. Danoff, A. Ullrich, and C.A. Ross Molecular cloning of a CDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant Brain Res. Mol. Brain Res. 32 1995 291 296
-
(1995)
Brain Res. Mol. Brain Res.
, vol.32
, pp. 291-296
-
-
Nucifora, Jr.F.C.1
Li, S.H.2
Danoff, S.3
Ullrich, A.4
Ross, C.A.5
-
187
-
-
37749032923
-
Epidemiology and clinical features of amyotrophic lateral sclerosis in Ireland between 1995 and 2004
-
O. O'Toole, B.J. Traynor, P. Brennan, C. Sheehan, E. Frost, B. Corr, and O. Hardiman Epidemiology and clinical features of amyotrophic lateral sclerosis in Ireland between 1995 and 2004 J. Neurol. Neurosurg. Psychiatry 79 2008 30 32
-
(2008)
J. Neurol. Neurosurg. Psychiatry
, vol.79
, pp. 30-32
-
-
O'Toole, O.1
Traynor, B.J.2
Brennan, P.3
Sheehan, C.4
Frost, E.5
Corr, B.6
Hardiman, O.7
-
188
-
-
0041308082
-
ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics
-
A. Otomo, S. Hadano, T. Okada, H. Mizumura, R. Kunita, H. Nishijima, J. Showguchi-Miyata, Y. Yanagisawa, E. Kohiki, E. Suga, M. Yasuda, H. Osuga, T. Nishimoto, S. Narumiya, and J.E. Ikeda ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics Hum. Mol. Genet. 12 2003 1671 1687
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 1671-1687
-
-
Otomo, A.1
Hadano, S.2
Okada, T.3
Mizumura, H.4
Kunita, R.5
Nishijima, H.6
Showguchi-Miyata, J.7
Yanagisawa, Y.8
Kohiki, E.9
Suga, E.10
Yasuda, M.11
Osuga, H.12
Nishimoto, T.13
Narumiya, S.14
Ikeda, J.E.15
-
189
-
-
0029066110
-
Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs
-
S.H. Ou, F. Wu, D. Harrich, L.F. Garcia-Martinez, and R.B. Gaynor Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs J. Virol. 69 1995 3584 3596
-
(1995)
J. Virol.
, vol.69
, pp. 3584-3596
-
-
Ou, S.H.1
Wu, F.2
Harrich, D.3
Garcia-Martinez, L.F.4
Gaynor, R.B.5
-
190
-
-
56549103118
-
Spinal anterior horn cells in sporadic amyotrophic lateral sclerosis show ribosomal detachment from, and cisternal distention of the rough endoplasmic reticulum
-
K. Oyanagi, M. Yamazaki, H. Takahashi, K. Watabe, M. Wada, T. Komori, T. Morita, and T. Mizutani Spinal anterior horn cells in sporadic amyotrophic lateral sclerosis show ribosomal detachment from, and cisternal distention of the rough endoplasmic reticulum Neuropathol. Appl. Neurobiol. 34 2008 650 658
-
(2008)
Neuropathol. Appl. Neurobiol.
, vol.34
, pp. 650-658
-
-
Oyanagi, K.1
Yamazaki, M.2
Takahashi, H.3
Watabe, K.4
Wada, M.5
Komori, T.6
Morita, T.7
Mizutani, T.8
-
191
-
-
79955749505
-
Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery
-
U.B. Pandey, and C.D. Nichols Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery Pharmacol. Rev. 63 2011 411 436
-
(2011)
Pharmacol. Rev.
, vol.63
, pp. 411-436
-
-
Pandey, U.B.1
Nichols, C.D.2
-
192
-
-
34250183177
-
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
-
U.B. Pandey, Z. Nie, Y. Batlevi, B.A. McCray, G.P. Ritson, N.B. Nedelsky, S.L. Schwartz, N.A. DiProspero, M.A. Knight, O. Schuldiner, R. Padmanabhan, M. Hild, D.L. Berry, D. Garza, C.C. Hubbert, T.P. Yao, E.H. Baehrecke, and J.P. Taylor HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS Nature 447 2007 859 863
-
(2007)
Nature
, vol.447
, pp. 859-863
-
-
Pandey, U.B.1
Nie, Z.2
Batlevi, Y.3
McCray, B.A.4
Ritson, G.P.5
Nedelsky, N.B.6
Schwartz, S.L.7
Diprospero, N.A.8
Knight, M.A.9
Schuldiner, O.10
Padmanabhan, R.11
Hild, M.12
Berry, D.L.13
Garza, D.14
Hubbert, C.C.15
Yao, T.P.16
Baehrecke, E.H.17
Taylor, J.P.18
-
193
-
-
1542408999
-
Decreased expression of Cu-Zn superoxide dismutase 1 in ants with extreme lifespan
-
J.D. Parker, K.M. Parker, B.H. Sohal, R.S. Sohal, and L. Keller Decreased expression of Cu-Zn superoxide dismutase 1 in ants with extreme lifespan Proc. Natl. Acad. Sci. USA 101 2004 3486 3489
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 3486-3489
-
-
Parker, J.D.1
Parker, K.M.2
Sohal, B.H.3
Sohal, R.S.4
Keller, L.5
-
194
-
-
0031864164
-
Extension of drosophila lifespan by overexpression of human SOD1 in motorneurons
-
T.L. Parkes, A.J. Elia, D. Dickinson, A.J. Hilliker, J.P. Phillips, and G.L. Boulianne Extension of drosophila lifespan by overexpression of human SOD1 in motorneurons Nat. Genet. 19 1998 171 174
-
(1998)
Nat. Genet.
, vol.19
, pp. 171-174
-
-
Parkes, T.L.1
Elia, A.J.2
Dickinson, D.3
Hilliker, A.J.4
Phillips, J.P.5
Boulianne, G.L.6
-
195
-
-
79960925229
-
The Ewing sarcoma protein regulates DNA damage-induced alternative splicing
-
M.P. Paronetto, B. Minana, and J. Valcarcel The Ewing sarcoma protein regulates DNA damage-induced alternative splicing Mol. Cell 43 2011 353 368
-
(2011)
Mol. Cell
, vol.43
, pp. 353-368
-
-
Paronetto, M.P.1
Minana, B.2
Valcarcel, J.3
-
196
-
-
3242703300
-
Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria
-
P. Pasinelli, M.E. Belford, N. Lennon, B.J. Bacskai, B.T. Hyman, D. Trotti, and R.H. Brown Jr. Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria Neuron 43 2004 19 30
-
(2004)
Neuron
, vol.43
, pp. 19-30
-
-
Pasinelli, P.1
Belford, M.E.2
Lennon, N.3
Bacskai, B.J.4
Hyman, B.T.5
Trotti, D.6
Brown, Jr.R.H.7
-
197
-
-
33846839142
-
+ channel homeostatic regulation
-
+ channel homeostatic regulation J. Neurosci. 27 2007 1072 1081
-
(2007)
J. Neurosci.
, vol.27
, pp. 1072-1081
-
-
Peng, I.F.1
Wu, C.F.2
-
198
-
-
0037130456
-
Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner
-
G. Pennetta, P.R. Hiesinger, R. Fabian-Fine, I.A. Meinertzhagen, and H.J. Bellen Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner Neuron 35 2002 291 306
-
(2002)
Neuron
, vol.35
, pp. 291-306
-
-
Pennetta, G.1
Hiesinger, P.R.2
Fabian-Fine, R.3
Meinertzhagen, I.A.4
Bellen, H.J.5
-
199
-
-
0029050058
-
Subunit-destabilizing mutations in drosophila copper/zinc superoxide dismutase: Neuropathology and a model of dimer dysequilibrium
-
J.P. Phillips, J.A. Tainer, E.D. Getzoff, G.L. Boulianne, K. Kirby, and A.J. Hilliker Subunit-destabilizing mutations in drosophila copper/zinc superoxide dismutase: neuropathology and a model of dimer dysequilibrium Proc. Natl. Acad. Sci. USA 92 1995 8574 8578
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 8574-8578
-
-
Phillips, J.P.1
Tainer, J.A.2
Getzoff, E.D.3
Boulianne, G.L.4
Kirby, K.5
Hilliker, A.J.6
-
200
-
-
0023617392
-
Abnormal glutamate metabolism in amyotrophic lateral sclerosis
-
A. Plaitakis, and J.T. Caroscio Abnormal glutamate metabolism in amyotrophic lateral sclerosis Ann. Neurol. 22 1987 575 579
-
(1987)
Ann. Neurol.
, vol.22
, pp. 575-579
-
-
Plaitakis, A.1
Caroscio, J.T.2
-
201
-
-
84878831487
-
Amyotrophic lateral sclerosis in Sardinia, Insular Italy, 1995-2009
-
M. Pugliatti, L.D. Parish, P. Cossu, S. Leoni, A. Ticca, M.V. Saddi, E. Ortu, S. Traccis, G. Borghero, R. Puddu, A. Chio, and P. Pirina Amyotrophic lateral sclerosis in Sardinia, Insular Italy, 1995-2009 J. Neurol. 260 2013 572 579
-
(2013)
J. Neurol.
, vol.260
, pp. 572-579
-
-
Pugliatti, M.1
Parish, L.D.2
Cossu, P.3
Leoni, S.4
Ticca, A.5
Saddi, M.V.6
Ortu, E.7
Traccis, S.8
Borghero, G.9
Puddu, R.10
Chio, A.11
Pirina, P.12
-
202
-
-
0030292488
-
Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2
-
S.M. Pulst, A. Nechiporuk, T. Nechiporuk, S. Gispert, X.N. Chen, I. Lopes-Cendes, S. Pearlman, S. Starkman, G. Orozco-Diaz, A. Lunkes, P. DeJong, G.A. Rouleau, G. Auburger, J.R. Korenberg, C. Figueroa, and S. Sahba Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2 Nat. Genet. 14 1996 269 276
-
(1996)
Nat. Genet.
, vol.14
, pp. 269-276
-
-
Pulst, S.M.1
Nechiporuk, A.2
Nechiporuk, T.3
Gispert, S.4
Chen, X.N.5
Lopes-Cendes, I.6
Pearlman, S.7
Starkman, S.8
Orozco-Diaz, G.9
Lunkes, A.10
Dejong, P.11
Rouleau, G.A.12
Auburger, G.13
Korenberg, J.R.14
Figueroa, C.15
Sahba, S.16
-
203
-
-
84896799718
-
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects
-
H. Qiu, S. Lee, Y. Shang, W.Y. Wang, K.F. Au, S. Kamiya, S.J. Barmada, S. Finkbeiner, H. Lui, C.E. Carlton, A.A. Tang, M.C. Oldham, H. Wang, J. Shorter, A.J. Filiano, E.D. Roberson, W.G. Tourtellotte, B. Chen, L.H. Tsai, and E.J. Huang ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects J. Clin. Invest. 124 2014 981 999
-
(2014)
J. Clin. Invest.
, vol.124
, pp. 981-999
-
-
Qiu, H.1
Lee, S.2
Shang, Y.3
Wang, W.Y.4
Au, K.F.5
Kamiya, S.6
Barmada, S.J.7
Finkbeiner, S.8
Lui, H.9
Carlton, C.E.10
Tang, A.A.11
Oldham, M.C.12
Wang, H.13
Shorter, J.14
Filiano, A.J.15
Roberson, E.D.16
Tourtellotte, W.G.17
Chen, B.18
Tsai, L.H.19
Huang, E.J.20
more..
-
204
-
-
0027276357
-
Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation T(12; 16) in malignant liposarcoma
-
T.H. Rabbitts, A. Forster, R. Larson, and P. Nathan Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation T(12; 16) in malignant liposarcoma Nat. Genet. 4 1993 175 180
-
(1993)
Nat. Genet.
, vol.4
, pp. 175-180
-
-
Rabbitts, T.H.1
Forster, A.2
Larson, R.3
Nathan, P.4
-
205
-
-
48449098142
-
A drosophila model of ALS: Human ALS-associated mutation in VAP33A suggests a dominant negative mechanism
-
A. Ratnaparkhi, G.M. Lawless, F.E. Schweizer, P. Golshani, and G.R. Jackson A drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanism PLoS One 3 2008 e2334
-
(2008)
PLoS One
, vol.3
, pp. e2334
-
-
Ratnaparkhi, A.1
Lawless, G.M.2
Schweizer, F.E.3
Golshani, P.4
Jackson, G.R.5
-
206
-
-
0034837386
-
A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster
-
L.T. Reiter, L. Potocki, S. Chien, M. Gribskov, and E. Bier A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster Genome Res. 11 2001 1114 1125
-
(2001)
Genome Res.
, vol.11
, pp. 1114-1125
-
-
Reiter, L.T.1
Potocki, L.2
Chien, S.3
Gribskov, M.4
Bier, E.5
-
207
-
-
80051704854
-
A drosophila model of the neurodegenerative disease SCA17 reveals a role of RBP-J/Su(H) in modulating the pathological outcome
-
J. Ren, A.G. Jegga, M. Zhang, J. Deng, J. Liu, C.B. Gordon, B.J. Aronow, L.J. Lu, B. Zhang, and J. Ma A drosophila model of the neurodegenerative disease SCA17 reveals a role of RBP-J/Su(H) in modulating the pathological outcome Hum. Mol. Genet. 20 2011 3424 3436
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 3424-3436
-
-
Ren, J.1
Jegga, A.G.2
Zhang, M.3
Deng, J.4
Liu, J.5
Gordon, C.B.6
Aronow, B.J.7
Lu, L.J.8
Zhang, B.9
Ma, J.10
-
208
-
-
84893649256
-
State of play in amyotrophic lateral sclerosis genetics
-
A.E. Renton, A. Chio, and B.J. Traynor State of play in amyotrophic lateral sclerosis genetics Nat. Neurosci. 17 2014 17 23
-
(2014)
Nat. Neurosci.
, vol.17
, pp. 17-23
-
-
Renton, A.E.1
Chio, A.2
Traynor, B.J.3
-
209
-
-
80054837386
-
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD
-
A.E. Renton, E. Majounie, A. Waite, J. Simon-Sanchez, S. Rollinson, J.R. Gibbs, J.C. Schymick, H. Laaksovirta, J.C. van Swieten, L. Myllykangas, H. Kalimo, A. Paetau, Y. Abramzon, A.M. Remes, A. Kaganovich, S.W. Scholz, J. Duckworth, J. Ding, D.W. Harmer, D.G. Hernandez, J.O. Johnson, K. Mok, M. Ryten, D. Trabzuni, R.J. Guerreiro, R.W. Orrell, J. Neal, A. Murray, J. Pearson, I.E. Jansen, D. Sondervan, H. Seelaar, D. Blake, K. Young, N. Halliwell, J.B. Callister, G. Toulson, A. Richardson, A. Gerhard, J. Snowden, D. Mann, D. Neary, M.A. Nalls, T. Peuralinna, L. Jansson, V.M. Isoviita, A.L. Kaivorinne, M. Holtta-Vuori, E. Ikonen, R. Sulkava, M. Benatar, J. Wuu, A. Chio, G. Restagno, G. Borghero, M. Sabatelli, D. Heckerman, E. Rogaeva, L. Zinman, J.D. Rothstein, M. Sendtner, C. Drepper, E.E. Eichler, C. Alkan, Z. Abdullaev, S.D. Pack, A. Dutra, E. Pak, J. Hardy, A. Singleton, N.M. Williams, P. Heutink, S. Pickering-Brown, H.R. Morris, P.J. Tienari, and B.J. Traynor A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD Neuron 72 2011 257 268
-
(2011)
Neuron
, vol.72
, pp. 257-268
-
-
Renton, A.E.1
Majounie, E.2
Waite, A.3
Simon-Sanchez, J.4
Rollinson, S.5
Gibbs, J.R.6
Schymick, J.C.7
Laaksovirta, H.8
Van Swieten, J.C.9
Myllykangas, L.10
Kalimo, H.11
Paetau, A.12
Abramzon, Y.13
Remes, A.M.14
Kaganovich, A.15
Scholz, S.W.16
Duckworth, J.17
Ding, J.18
Harmer, D.W.19
Hernandez, D.G.20
Johnson, J.O.21
Mok, K.22
Ryten, M.23
Trabzuni, D.24
Guerreiro, R.J.25
Orrell, R.W.26
Neal, J.27
Murray, A.28
Pearson, J.29
Jansen, I.E.30
Sondervan, D.31
Seelaar, H.32
Blake, D.33
Young, K.34
Halliwell, N.35
Callister, J.B.36
Toulson, G.37
Richardson, A.38
Gerhard, A.39
Snowden, J.40
Mann, D.41
Neary, D.42
Nalls, M.A.43
Peuralinna, T.44
Jansson, L.45
Isoviita, V.M.46
Kaivorinne, A.L.47
Holtta-Vuori, M.48
Ikonen, E.49
Sulkava, R.50
Benatar, M.51
Wuu, J.52
Chio, A.53
Restagno, G.54
Borghero, G.55
Sabatelli, M.56
Heckerman, D.57
Rogaeva, E.58
Zinman, L.59
Rothstein, J.D.60
Sendtner, M.61
Drepper, C.62
Eichler, E.E.63
Alkan, C.64
Abdullaev, Z.65
Pack, S.D.66
Dutra, A.67
Pak, E.68
Hardy, J.69
Singleton, A.70
Williams, N.M.71
Heutink, P.72
Pickering-Brown, S.73
Morris, H.R.74
Tienari, P.J.75
Traynor, B.J.76
more..
-
211
-
-
77953194507
-
TDP-43 mediates degeneration in a novel drosophila model of disease caused by mutations in VCP/P97
-
G.P. Ritson, S.K. Custer, B.D. Freibaum, J.B. Guinto, D. Geffel, J. Moore, W. Tang, M.J. Winton, M. Neumann, J.Q. Trojanowski, V.M. Lee, M.S. Forman, and J.P. Taylor TDP-43 mediates degeneration in a novel drosophila model of disease caused by mutations in VCP/P97 J. Neurosci. 30 2010 7729 7739
-
(2010)
J. Neurosci.
, vol.30
, pp. 7729-7739
-
-
Ritson, G.P.1
Custer, S.K.2
Freibaum, B.D.3
Guinto, J.B.4
Geffel, D.5
Moore, J.6
Tang, W.7
Winton, M.J.8
Neumann, M.9
Trojanowski, J.Q.10
Lee, V.M.11
Forman, M.S.12
Taylor, J.P.13
-
212
-
-
84866126892
-
Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain
-
B. Rogelj, L.E. Easton, G.K. Bogu, L.W. Stanton, G. Rot, T. Curk, B. Zupan, Y. Sugimoto, M. Modic, N. Haberman, J. Tollervey, R. Fujii, T. Takumi, C.E. Shaw, and J. Ule Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain Sci. Rep. 2 2012 603
-
(2012)
Sci. Rep.
, vol.2
, pp. 603
-
-
Rogelj, B.1
Easton, L.E.2
Bogu, G.K.3
Stanton, L.W.4
Rot, G.5
Curk, T.6
Zupan, B.7
Sugimoto, Y.8
Modic, M.9
Haberman, N.10
Tollervey, J.11
Fujii, R.12
Takumi, T.13
Shaw, C.E.14
Ule, J.15
-
213
-
-
0001532967
-
Systematic gain-of-function genetics in drosophila
-
P. Rorth, K. Szabo, A. Bailey, T. Laverty, J. Rehm, G.M. Rubin, K. Weigmann, M. Milan, V. Benes, W. Ansorge, and S.M. Cohen Systematic gain-of-function genetics in drosophila Development 125 1998 1049 1057
-
(1998)
Development
, vol.125
, pp. 1049-1057
-
-
Rorth, P.1
Szabo, K.2
Bailey, A.3
Laverty, T.4
Rehm, J.5
Rubin, G.M.6
Weigmann, K.7
Milan, M.8
Benes, V.9
Ansorge, W.10
Cohen, S.M.11
-
214
-
-
0027401203
-
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
-
D.R. Rosen, T. Siddique, D. Patterson, D.A. Figlewicz, P. Sapp, A. Hentati, D. Donaldson, J. Goto, J.P. O'Regan, and H.X. Deng Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis Nature 362 1993 59 62
-
(1993)
Nature
, vol.362
, pp. 59-62
-
-
Rosen, D.R.1
Siddique, T.2
Patterson, D.3
Figlewicz, D.A.4
Sapp, P.5
Hentati, A.6
Donaldson, D.7
Goto, J.8
O'Regan, J.P.9
Deng, H.X.10
-
215
-
-
0026597010
-
Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
-
J.D. Rothstein, L.J. Martin, and R.W. Kuncl Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis N. Engl. J. Med. 326 1992 1464 1468
-
(1992)
N. Engl. J. Med.
, vol.326
, pp. 1464-1468
-
-
Rothstein, J.D.1
Martin, L.J.2
Kuncl, R.W.3
-
216
-
-
0025299819
-
Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis
-
J.D. Rothstein, G. Tsai, R.W. Kuncl, L. Clawson, D.R. Cornblath, D.B. Drachman, A. Pestronk, B.L. Stauch, and J.T. Coyle Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis Ann. Neurol. 28 1990 18 25
-
(1990)
Ann. Neurol.
, vol.28
, pp. 18-25
-
-
Rothstein, J.D.1
Tsai, G.2
Kuncl, R.W.3
Clawson, L.4
Cornblath, D.R.5
Drachman, D.B.6
Pestronk, A.7
Stauch, B.L.8
Coyle, J.T.9
-
217
-
-
0029030610
-
Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
-
J.D. Rothstein, K.M. Van, A.I. Levey, L.J. Martin, and R.W. Kuncl Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis Ann. Neurol. 38 1995 73 84
-
(1995)
Ann. Neurol.
, vol.38
, pp. 73-84
-
-
Rothstein, J.D.1
Van, K.M.2
Levey, A.I.3
Martin, L.J.4
Kuncl, R.W.5
-
218
-
-
0031724091
-
Diagnosis of amyotrophic lateral sclerosis
-
L.P. Rowland Diagnosis of amyotrophic lateral sclerosis J. Neurol. Sci. 160 Suppl. 1 1998 S6 S24
-
(1998)
J. Neurol. Sci.
, vol.160
, pp. S6-S24
-
-
Rowland, L.P.1
-
219
-
-
0034708613
-
A brief history of drosophila's contributions to genome research
-
G.M. Rubin, and E.B. Lewis A brief history of drosophila's contributions to genome research Science 287 2000 2216 2218
-
(2000)
Science
, vol.287
, pp. 2216-2218
-
-
Rubin, G.M.1
Lewis, E.B.2
-
220
-
-
0019945644
-
Genetic transformation of drosophila with transposable element vectors
-
G.M. Rubin, and A.C. Spradling Genetic transformation of drosophila with transposable element vectors Science 218 1982 348 353
-
(1982)
Science
, vol.218
, pp. 348-353
-
-
Rubin, G.M.1
Spradling, A.C.2
-
221
-
-
52949094629
-
Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis
-
N.J. Rutherford, Y.J. Zhang, M. Baker, J.M. Gass, N.A. Finch, Y.F. Xu, H. Stewart, B.J. Kelley, K. Kuntz, R.J. Crook, J. Sreedharan, C. Vance, E. Sorenson, C. Lippa, E.H. Bigio, D.H. Geschwind, D.S. Knopman, H. Mitsumoto, R.C. Petersen, N.R. Cashman, M. Hutton, C.E. Shaw, K.B. Boylan, B. Boeve, N.R. Graff-Radford, Z.K. Wszolek, R.J. Caselli, D.W. Dickson, I.R. Mackenzie, L. Petrucelli, and R. Rademakers Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis PLoS Genet. 4 2008 e1000193
-
(2008)
PLoS Genet.
, vol.4
, pp. e1000193
-
-
Rutherford, N.J.1
Zhang, Y.J.2
Baker, M.3
Gass, J.M.4
Finch, N.A.5
Xu, Y.F.6
Stewart, H.7
Kelley, B.J.8
Kuntz, K.9
Crook, R.J.10
Sreedharan, J.11
Vance, C.12
Sorenson, E.13
Lippa, C.14
Bigio, E.H.15
Geschwind, D.H.16
Knopman, D.S.17
Mitsumoto, H.18
Petersen, R.C.19
Cashman, N.R.20
Hutton, M.21
Shaw, C.E.22
Boylan, K.B.23
Boeve, B.24
Graff-Radford, N.R.25
Wszolek, Z.K.26
Caselli, R.J.27
Dickson, D.W.28
MacKenzie, I.R.29
Petrucelli, L.30
Rademakers, R.31
more..
-
222
-
-
84887510924
-
Mutations in the 3′ untranslated region of FUS causing FUS overexpression are associated with amyotrophic lateral sclerosis
-
M. Sabatelli, A. Moncada, A. Conte, S. Lattante, G. Marangi, M. Luigetti, M. Lucchini, M. Mirabella, A. Romano, G.A. Del, G. Bisogni, P.N. Doronzio, P.M. Rossini, and M. Zollino Mutations in the 3′ untranslated region of FUS causing FUS overexpression are associated with amyotrophic lateral sclerosis Hum. Mol. Genet. 22 2013 4748 4755
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 4748-4755
-
-
Sabatelli, M.1
Moncada, A.2
Conte, A.3
Lattante, S.4
Marangi, G.5
Luigetti, M.6
Lucchini, M.7
Mirabella, M.8
Romano, A.9
Del, G.A.10
Bisogni, G.11
Doronzio, P.N.12
Rossini, P.M.13
Zollino, M.14
-
223
-
-
84901193085
-
Gain-of-function mutations in the ALS8 causative gene VAPB have detrimental effects on neurons and muscles
-
M. Sanhueza, L. Zechini, T. Gillespie, and G. Pennetta Gain-of-function mutations in the ALS8 causative gene VAPB have detrimental effects on neurons and muscles Biol. Open 3 2014 59 71
-
(2014)
Biol. Open
, vol.3
, pp. 59-71
-
-
Sanhueza, M.1
Zechini, L.2
Gillespie, T.3
Pennetta, G.4
-
224
-
-
0030292368
-
Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT
-
K. Sanpei, H. Takano, S. Igarashi, T. Sato, M. Oyake, H. Sasaki, A. Wakisaka, K. Tashiro, Y. Ishida, T. Ikeuchi, R. Koide, M. Saito, A. Sato, T. Tanaka, S. Hanyu, Y. Takiyama, M. Nishizawa, N. Shimizu, Y. Nomura, M. Segawa, K. Iwabuchi, I. Eguchi, H. Tanaka, H. Takahashi, and S. Tsuji Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT Nat. Genet. 14 1996 277 284
-
(1996)
Nat. Genet.
, vol.14
, pp. 277-284
-
-
Sanpei, K.1
Takano, H.2
Igarashi, S.3
Sato, T.4
Oyake, M.5
Sasaki, H.6
Wakisaka, A.7
Tashiro, K.8
Ishida, Y.9
Ikeuchi, T.10
Koide, R.11
Saito, M.12
Sato, A.13
Tanaka, T.14
Hanyu, S.15
Takiyama, Y.16
Nishizawa, M.17
Shimizu, N.18
Nomura, Y.19
Segawa, M.20
Iwabuchi, K.21
Eguchi, I.22
Tanaka, H.23
Takahashi, H.24
Tsuji, S.25
more..
-
225
-
-
0033546228
-
Ultrastructural change of synapses of betz cells in patients with amyotrophic lateral sclerosis
-
S. Sasaki, and M. Iwata Ultrastructural change of synapses of betz cells in patients with amyotrophic lateral sclerosis Neurosci. Lett. 268 1999 29 32
-
(1999)
Neurosci. Lett.
, vol.268
, pp. 29-32
-
-
Sasaki, S.1
Iwata, M.2
-
226
-
-
84862571269
-
Knockdown of the drosophila fused in sarcoma (FUS) homologue causes deficient locomotive behavior and shortening of motoneuron terminal branches
-
H. Sasayama, M. Shimamura, T. Tokuda, Y. Azuma, T. Yoshida, T. Mizuno, M. Nakagawa, N. Fujikake, Y. Nagai, and M. Yamaguchi Knockdown of the drosophila fused in sarcoma (FUS) homologue causes deficient locomotive behavior and shortening of motoneuron terminal branches PLoS One 7 2012 e39483
-
(2012)
PLoS One
, vol.7
, pp. e39483
-
-
Sasayama, H.1
Shimamura, M.2
Tokuda, T.3
Azuma, Y.4
Yoshida, T.5
Mizuno, T.6
Nakagawa, M.7
Fujikake, N.8
Nagai, Y.9
Yamaguchi, M.10
-
227
-
-
84876437828
-
Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo
-
C. Scaramuzzino, J. Monaghan, C. Milioto, N.A. Lanson Jr., A. Maltare, T. Aggarwal, I. Casci, F.O. Fackelmayer, M. Pennuto, and U.B. Pandey Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo PLoS One 8 2013 e61576
-
(2013)
PLoS One
, vol.8
, pp. e61576
-
-
Scaramuzzino, C.1
Monaghan, J.2
Milioto, C.3
Lanson, Jr.N.A.4
Maltare, A.5
Aggarwal, T.6
Casci, I.7
Fackelmayer, F.O.8
Pennuto, M.9
Pandey, U.B.10
-
228
-
-
78651408754
-
Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes
-
C.F. Sephton, C. Cenik, A. Kucukural, E.B. Dammer, B. Cenik, Y. Han, C.M. Dewey, F.P. Roth, J. Herz, J. Peng, M.J. Moore, and G. Yu Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes J. Biol. Chem. 286 2011 1204 1215
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 1204-1215
-
-
Sephton, C.F.1
Cenik, C.2
Kucukural, A.3
Dammer, E.B.4
Cenik, B.5
Han, Y.6
Dewey, C.M.7
Roth, F.P.8
Herz, J.9
Peng, J.10
Moore, M.J.11
Yu, G.12
-
229
-
-
84889826574
-
Defects in synapse structure and function precede motor neuron degeneration in drosophila models of FUS-related ALS
-
M. Shahidullah, S.J. Le Marchand, H. Fei, J. Zhang, U.B. Pandey, M.B. Dalva, P. Pasinelli, and I.B. Levitan Defects in synapse structure and function precede motor neuron degeneration in drosophila models of FUS-related ALS J. Neurosci. 33 2013 19590 19598
-
(2013)
J. Neurosci.
, vol.33
, pp. 19590-19598
-
-
Shahidullah, M.1
Le Marchand, S.J.2
Fei, H.3
Zhang, J.4
Pandey, U.B.5
Dalva, M.B.6
Pasinelli, P.7
Levitan, I.B.8
-
230
-
-
0029067210
-
CSF and plasma amino acid levels in motor neuron disease: Elevation of CSF glutamate in a subset of patients
-
P.J. Shaw, V. Forrest, P.G. Ince, J.P. Richardson, and H.J. Wastell CSF and plasma amino acid levels in motor neuron disease: elevation of CSF glutamate in a subset of patients Neurodegeneration 4 1995 209 216
-
(1995)
Neurodegeneration
, vol.4
, pp. 209-216
-
-
Shaw, P.J.1
Forrest, V.2
Ince, P.G.3
Richardson, J.P.4
Wastell, H.J.5
-
231
-
-
0029842923
-
Immunohistochemical study on superoxide dismutases in spinal cords from autopsied patients with amyotrophic lateral sclerosis
-
N. Shibata, K. Asayama, A. Hirano, and M. Kobayashi Immunohistochemical study on superoxide dismutases in spinal cords from autopsied patients with amyotrophic lateral sclerosis Dev. Neurosci. 18 1996 492 498
-
(1996)
Dev. Neurosci.
, vol.18
, pp. 492-498
-
-
Shibata, N.1
Asayama, K.2
Hirano, A.3
Kobayashi, M.4
-
232
-
-
0027966078
-
Cu/Zn superoxide dismutase-like immunoreactivity in lewy body-like inclusions of sporadic amyotrophic lateral sclerosis
-
N. Shibata, A. Hirano, M. Kobayashi, S. Sasaki, T. Kato, S. Matsumoto, Z. Shiozawa, T. Komori, A. Ikemoto, and T. Umahara Cu/Zn superoxide dismutase-like immunoreactivity in lewy body-like inclusions of sporadic amyotrophic lateral sclerosis Neurosci. Lett. 179 1994 149 152
-
(1994)
Neurosci. Lett.
, vol.179
, pp. 149-152
-
-
Shibata, N.1
Hirano, A.2
Kobayashi, M.3
Sasaki, S.4
Kato, T.5
Matsumoto, S.6
Shiozawa, Z.7
Komori, T.8
Ikemoto, A.9
Umahara, T.10
-
233
-
-
0029927679
-
Intense superoxide dismutase-1 immunoreactivity in intracytoplasmic hyaline inclusions of familial amyotrophic lateral sclerosis with posterior column involvement
-
N. Shibata, A. Hirano, M. Kobayashi, T. Siddique, H.X. Deng, W.Y. Hung, T. Kato, and K. Asayama Intense superoxide dismutase-1 immunoreactivity in intracytoplasmic hyaline inclusions of familial amyotrophic lateral sclerosis with posterior column involvement J. Neuropathol. Exp. Neurol. 55 1996 481 490
-
(1996)
J. Neuropathol. Exp. Neurol.
, vol.55
, pp. 481-490
-
-
Shibata, N.1
Hirano, A.2
Kobayashi, M.3
Siddique, T.4
Deng, H.X.5
Hung, W.Y.6
Kato, T.7
Asayama, K.8
-
234
-
-
81855206492
-
Genes and pathways affected by CAG-repeat RNA-based toxicity in drosophila
-
S.Y. Shieh, and N.M. Bonini Genes and pathways affected by CAG-repeat RNA-based toxicity in drosophila Hum. Mol. Genet. 20 2011 4810 4821
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 4810-4821
-
-
Shieh, S.Y.1
Bonini, N.M.2
-
235
-
-
84904392609
-
Genetic link between cabeza, a drosophila homologue of fused in sarcoma (FUS), and the EGFR signaling pathway
-
M. Shimamura, A. Kyotani, Y. Azuma, H. Yoshida, N.T. Binh, I. Mizuta, T. Yoshida, T. Mizuno, M. Nakagawa, T. Tokuda, and M. Yamaguchi Genetic link between cabeza, a drosophila homologue of fused in sarcoma (FUS), and the EGFR signaling pathway Exp. Cell Res. 326 2014 36 45
-
(2014)
Exp. Cell Res.
, vol.326
, pp. 36-45
-
-
Shimamura, M.1
Kyotani, A.2
Azuma, Y.3
Yoshida, H.4
Binh, N.T.5
Mizuta, I.6
Yoshida, T.7
Mizuno, T.8
Nakagawa, M.9
Tokuda, T.10
Yamaguchi, M.11
-
236
-
-
0346361872
-
Genetic modifiers of tauopathy in drosophila
-
J.M. Shulman, and M.B. Feany Genetic modifiers of tauopathy in drosophila Genetics 165 2003 1233 1242
-
(2003)
Genetics
, vol.165
, pp. 1233-1242
-
-
Shulman, J.M.1
Feany, M.B.2
-
237
-
-
34250728186
-
Genetic modifiers of the drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles
-
A. Simonsen, R.C. Cumming, K. Lindmo, V. Galaviz, S. Cheng, T.E. Rusten, and K.D. Finley Genetic modifiers of the drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles Genetics 176 2007 1283 1297
-
(2007)
Genetics
, vol.176
, pp. 1283-1297
-
-
Simonsen, A.1
Cumming, R.C.2
Lindmo, K.3
Galaviz, V.4
Cheng, S.5
Rusten, T.E.6
Finley, K.D.7
-
238
-
-
0019967916
-
Transposition of cloned P elements into drosophila germ line chromosomes
-
A.C. Spradling, and G.M. Rubin Transposition of cloned P elements into drosophila germ line chromosomes Science 218 1982 341 347
-
(1982)
Science
, vol.218
, pp. 341-347
-
-
Spradling, A.C.1
Rubin, G.M.2
-
239
-
-
0037081113
-
Glutamate levels in cerebrospinal fluid in amyotrophic lateral sclerosis: A reappraisal using a new HPLC method with coulometric detection in a large cohort of patients
-
O. Spreux-Varoquaux, G. Bensimon, L. Lacomblez, F. Salachas, P.F. Pradat, F.N. Le, A. Marouan, M. Dib, and V. Meininger Glutamate levels in cerebrospinal fluid in amyotrophic lateral sclerosis: a reappraisal using a new HPLC method with coulometric detection in a large cohort of patients J. Neurol. Sci. 193 2002 73 78
-
(2002)
J. Neurol. Sci.
, vol.193
, pp. 73-78
-
-
Spreux-Varoquaux, O.1
Bensimon, G.2
Lacomblez, L.3
Salachas, F.4
Pradat, P.F.5
Le, F.N.6
Marouan, A.7
Dib, M.8
Meininger, V.9
-
240
-
-
41149180753
-
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
-
J. Sreedharan, I.P. Blair, V.B. Tripathi, X. Hu, C. Vance, B. Rogelj, S. Ackerley, J.C. Durnall, K.L. Williams, E. Buratti, F. Baralle, B.J. de, J.D. Mitchell, P.N. Leigh, A. Al-Chalabi, C.C. Miller, G. Nicholson, and C.E. Shaw TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis Science 319 2008 1668 1672
-
(2008)
Science
, vol.319
, pp. 1668-1672
-
-
Sreedharan, J.1
Blair, I.P.2
Tripathi, V.B.3
Hu, X.4
Vance, C.5
Rogelj, B.6
Ackerley, S.7
Durnall, J.C.8
Williams, K.L.9
Buratti, E.10
Baralle, F.11
De, B.J.12
Mitchell, J.D.13
Leigh, P.N.14
Al-Chalabi, A.15
Miller, C.C.16
Nicholson, G.17
Shaw, C.E.18
-
241
-
-
0035909330
-
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in drosophila
-
J.S. Steffan, L. Bodai, J. Pallos, M. Poelman, A. McCampbell, B.L. Apostol, A. Kazantsev, E. Schmidt, Y.Z. Zhu, M. Greenwald, R. Kurokawa, D.E. Housman, G.R. Jackson, J.L. Marsh, and L.M. Thompson Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in drosophila Nature 413 2001 739 743
-
(2001)
Nature
, vol.413
, pp. 739-743
-
-
Steffan, J.S.1
Bodai, L.2
Pallos, J.3
Poelman, M.4
McCampbell, A.5
Apostol, B.L.6
Kazantsev, A.7
Schmidt, E.8
Zhu, Y.Z.9
Greenwald, M.10
Kurokawa, R.11
Housman, D.E.12
Jackson, G.R.13
Marsh, J.L.14
Thompson, L.M.15
-
242
-
-
0028968330
-
Cabeza, a drosophila gene encoding a novel RNA binding protein, shares homology with EWS and TLS, two genes involved in human sarcoma formation
-
D.T. Stolow, and S.R. Haynes Cabeza, a drosophila gene encoding a novel RNA binding protein, shares homology with EWS and TLS, two genes involved in human sarcoma formation Nucl. Acids Res. 23 1995 835 843
-
(1995)
Nucl. Acids Res.
, vol.23
, pp. 835-843
-
-
Stolow, D.T.1
Haynes, S.R.2
-
243
-
-
84956762643
-
The linear arrangement of six sex-linked factors in drosophila, as shown by their mode of association
-
A.H. Sturtevant The linear arrangement of six sex-linked factors in drosophila, as shown by their mode of association J. Exp. Zool. 14 1913 43 59
-
(1913)
J. Exp. Zool.
, vol.14
, pp. 43-59
-
-
Sturtevant, A.H.1
-
244
-
-
0003898626
-
-
Cold Spring Harbor Laboratory Press New York
-
A.H. Sturtevant A History of Genetics 1965 Cold Spring Harbor Laboratory Press New York
-
(1965)
A History of Genetics
-
-
Sturtevant, A.H.1
-
245
-
-
0032908347
-
FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies
-
J. Sun, and J. Tower FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies Mol. Cell Biol. 19 1999 216 228
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 216-228
-
-
Sun, J.1
Tower, J.2
-
246
-
-
0031716355
-
Mitochondria in sporadic amyotrophic lateral sclerosis
-
R.H. Swerdlow, J.K. Parks, D.S. Cassarino, P.A. Trimmer, S.W. Miller, D.J. Maguire, J.P. Sheehan, R.S. Maguire, G. Pattee, V.C. Juel, L.H. Phillips, J.B. Tuttle, J.P. Bennett Jr., R.E. Davis, and W.D. Parker Jr. Mitochondria in sporadic amyotrophic lateral sclerosis Exp. Neurol. 153 1998 135 142
-
(1998)
Exp. Neurol.
, vol.153
, pp. 135-142
-
-
Swerdlow, R.H.1
Parks, J.K.2
Cassarino, D.S.3
Trimmer, P.A.4
Miller, S.W.5
Maguire, D.J.6
Sheehan, J.P.7
Maguire, R.S.8
Pattee, G.9
Juel, V.C.10
Phillips, L.H.11
Tuttle, J.B.12
Bennett, Jr.J.P.13
Davis, R.E.14
Parker, Jr.W.D.15
-
247
-
-
84901255856
-
Age-dependent deterioration of locomotion in Drosophila melanogaster deficient in the homologue of amyotrophic lateral sclerosis 2
-
Y. Takayama, R.E. Itoh, T. Tsuyama, and T. Uemura Age-dependent deterioration of locomotion in Drosophila melanogaster deficient in the homologue of amyotrophic lateral sclerosis 2 Genes Cells 19 6 2014 464 477
-
(2014)
Genes Cells
, vol.19
, Issue.6
, pp. 464-477
-
-
Takayama, Y.1
Itoh, R.E.2
Tsuyama, T.3
Uemura, T.4
-
248
-
-
0032752054
-
Reduction of GluR2 RNA editing, a molecular change that increases calcium influx through AMPA receptors, selective in the spinal ventral gray of patients with amyotrophic lateral sclerosis
-
H. Takuma, S. Kwak, T. Yoshizawa, and I. Kanazawa Reduction of GluR2 RNA editing, a molecular change that increases calcium influx through AMPA receptors, selective in the spinal ventral gray of patients with amyotrophic lateral sclerosis Ann. Neurol. 46 1999 806 815
-
(1999)
Ann. Neurol.
, vol.46
, pp. 806-815
-
-
Takuma, H.1
Kwak, S.2
Yoshizawa, T.3
Kanazawa, I.4
-
249
-
-
73549089900
-
TLS inhibits RNA polymerase III transcription
-
A.Y. Tan, and J.L. Manley TLS inhibits RNA polymerase III transcription Mol. Cell Biol. 30 2010 186 196
-
(2010)
Mol. Cell Biol.
, vol.30
, pp. 186-196
-
-
Tan, A.Y.1
Manley, J.L.2
-
250
-
-
34247606414
-
TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation
-
C.F. Tan, H. Eguchi, A. Tagawa, O. Onodera, T. Iwasaki, A. Tsujino, M. Nishizawa, A. Kakita, and H. Takahashi TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation Acta Neuropathol. 113 2007 535 542
-
(2007)
Acta Neuropathol.
, vol.113
, pp. 535-542
-
-
Tan, C.F.1
Eguchi, H.2
Tagawa, A.3
Onodera, O.4
Iwasaki, T.5
Tsujino, A.6
Nishizawa, M.7
Kakita, A.8
Takahashi, H.9
-
251
-
-
79953180492
-
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
-
J.R. Tollervey, T. Curk, B. Rogelj, M. Briese, M. Cereda, M. Kayikci, J. Konig, T. Hortobagyi, A.L. Nishimura, V. Zupunski, R. Patani, S. Chandran, G. Rot, B. Zupan, C.E. Shaw, and J. Ule Characterizing the RNA targets and position-dependent splicing regulation by TDP-43 Nat. Neurosci. 14 2011 452 458
-
(2011)
Nat. Neurosci.
, vol.14
, pp. 452-458
-
-
Tollervey, J.R.1
Curk, T.2
Rogelj, B.3
Briese, M.4
Cereda, M.5
Kayikci, M.6
Konig, J.7
Hortobagyi, T.8
Nishimura, A.L.9
Zupunski, V.10
Patani, R.11
Chandran, S.12
Rot, G.13
Zupan, B.14
Shaw, C.E.15
Ule, J.16
-
252
-
-
0038383029
-
Persistent activation of P38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression
-
M. Tortarolo, P. Veglianese, N. Calvaresi, A. Botturi, C. Rossi, A. Giorgini, A. Migheli, and C. Bendotti Persistent activation of P38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression Mol. Cell Neurosci. 23 2003 180 192
-
(2003)
Mol. Cell Neurosci.
, vol.23
, pp. 180-192
-
-
Tortarolo, M.1
Veglianese, P.2
Calvaresi, N.3
Botturi, A.4
Rossi, C.5
Giorgini, A.6
Migheli, A.7
Bendotti, C.8
-
253
-
-
83455162720
-
Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations
-
M.L. Tradewell, Z. Yu, M. Tibshirani, M.C. Boulanger, H.D. Durham, and S. Richard Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations Hum. Mol. Genet. 21 2012 136 149
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 136-149
-
-
Tradewell, M.L.1
Yu, Z.2
Tibshirani, M.3
Boulanger, M.C.4
Durham, H.D.5
Richard, S.6
-
254
-
-
0035808437
-
Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity
-
D. Trotti, M. Aoki, P. Pasinelli, U.V. Berger, N.C. Danbolt, R.H. Brown Jr., and M.A. Hediger Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity J. Biol. Chem. 276 2001 576 582
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 576-582
-
-
Trotti, D.1
Aoki, M.2
Pasinelli, P.3
Berger, U.V.4
Danbolt, N.C.5
Brown, Jr.R.H.6
Hediger, M.A.7
-
255
-
-
0033366461
-
SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter
-
D. Trotti, A. Rolfs, N.C. Danbolt, R.H. Brown Jr., and M.A. Hediger SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter Nat. Neurosci. 2 1999 427 433
-
(1999)
Nat. Neurosci.
, vol.2
, pp. 427-433
-
-
Trotti, D.1
Rolfs, A.2
Danbolt, N.C.3
Brown, Jr.R.H.4
Hediger, M.A.5
-
256
-
-
43449099127
-
The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors
-
H. Tsuda, S.M. Han, Y. Yang, C. Tong, Y.Q. Lin, K. Mohan, C. Haueter, A. Zoghbi, Y. Harati, J. Kwan, M.A. Miller, and H.J. Bellen The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors Cell 133 2008 963 977
-
(2008)
Cell
, vol.133
, pp. 963-977
-
-
Tsuda, H.1
Han, S.M.2
Yang, Y.3
Tong, C.4
Lin, Y.Q.5
Mohan, K.6
Haueter, C.7
Zoghbi, A.8
Harati, Y.9
Kwan, J.10
Miller, M.A.11
Bellen, H.J.12
-
257
-
-
42249102078
-
Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS
-
B.J. Turner, and K. Talbot Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS Prog. Neurobiol. 85 2008 94 134
-
(2008)
Prog. Neurobiol.
, vol.85
, pp. 94-134
-
-
Turner, B.J.1
Talbot, K.2
-
258
-
-
0035918291
-
Involvement of the pro-oncoprotein TLS (translocated in liposarcoma) in nuclear factor-kappa B P65-mediated transcription as a coactivator
-
H. Uranishi, T. Tetsuka, M. Yamashita, K. Asamitsu, M. Shimizu, M. Itoh, and T. Okamoto Involvement of the pro-oncoprotein TLS (translocated in liposarcoma) in nuclear factor-kappa B P65-mediated transcription as a coactivator J. Biol. Chem. 276 2001 13395 13401
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 13395-13401
-
-
Uranishi, H.1
Tetsuka, T.2
Yamashita, M.3
Asamitsu, K.4
Shimizu, M.5
Itoh, M.6
Okamoto, T.7
-
259
-
-
41949100148
-
TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: A genetic and histopathological analysis
-
V.M. Van Deerlin, J.B. Leverenz, L.M. Bekris, T.D. Bird, W. Yuan, L.B. Elman, D. Clay, E.M. Wood, A.S. Chen-Plotkin, M. Martinez-Lage, E. Steinbart, L. McCluskey, M. Grossman, M. Neumann, I.L. Wu, W.S. Yang, R. Kalb, D.R. Galasko, T.J. Montine, J.Q. Trojanowski, V.M. Lee, G.D. Schellenberg, and C.E. Yu TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis Lancet Neurol. 7 2008 409 416
-
(2008)
Lancet Neurol.
, vol.7
, pp. 409-416
-
-
Van Deerlin, V.M.1
Leverenz, J.B.2
Bekris, L.M.3
Bird, T.D.4
Yuan, W.5
Elman, L.B.6
Clay, D.7
Wood, E.M.8
Chen-Plotkin, A.S.9
Martinez-Lage, M.10
Steinbart, E.11
McCluskey, L.12
Grossman, M.13
Neumann, M.14
Wu, I.L.15
Yang, W.S.16
Kalb, R.17
Galasko, D.R.18
Montine, T.J.19
Trojanowski, J.Q.20
Lee, V.M.21
Schellenberg, G.D.22
Yu, C.E.23
more..
-
260
-
-
84866766416
-
VAPB and C9orf72 mutations in 1 familial amyotrophic lateral sclerosis patient
-
B.M. van, M.A. van Es, M. Koppers, R.W. van, J. Medic, H.J. Schelhaas, A.J. van der Kooi, V.M. de, J.H. Veldink, and L.H. van den Berg VAPB and C9orf72 mutations in 1 familial amyotrophic lateral sclerosis patient Neurobiol. Aging 33 2012 2950 2954
-
(2012)
Neurobiol. Aging
, vol.33
, pp. 2950-2954
-
-
Van, B.M.1
Van Es, M.A.2
Koppers, M.3
Van, R.W.4
Medic, J.5
Schelhaas, H.J.6
Van Der Kooi, A.J.7
De, V.M.8
Veldink, J.H.9
Van Den Berg, L.H.10
-
261
-
-
61349162349
-
Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6
-
C. Vance, B. Rogelj, T. Hortobagyi, K.J. De Vos, A.L. Nishimura, J. Sreedharan, X. Hu, B. Smith, D. Ruddy, P. Wright, J. Ganesalingam, K.L. Williams, V. Tripathi, S. Al-Saraj, A. Al-Chalabi, P.N. Leigh, I.P. Blair, G. Nicholson, B.J. de, J.M. Gallo, C.C. Miller, and C.E. Shaw Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6 Science 323 2009 1208 1211
-
(2009)
Science
, vol.323
, pp. 1208-1211
-
-
Vance, C.1
Rogelj, B.2
Hortobagyi, T.3
De Vos, K.J.4
Nishimura, A.L.5
Sreedharan, J.6
Hu, X.7
Smith, B.8
Ruddy, D.9
Wright, P.10
Ganesalingam, J.11
Williams, K.L.12
Tripathi, V.13
Al-Saraj, S.14
Al-Chalabi, A.15
Leigh, P.N.16
Blair, I.P.17
Nicholson, G.18
De, B. J.19
Gallo, J.M.20
Miller, C.C.21
Shaw, C.E.22
more..
-
262
-
-
84873166518
-
TDP-43 loss-of-function causes neuronal loss due to defective steroid receptor-mediated gene program switching in drosophila
-
L. Vanden Broeck, M. Naval-Sanchez, Y. Adachi, D. Diaper, P. Dourlen, J. Chapuis, G. Kleinberger, M. Gistelinck, B.C. Van, J.C. Lambert, F. Hirth, S. Aerts, P. Callaerts, and B. Dermaut TDP-43 loss-of-function causes neuronal loss due to defective steroid receptor-mediated gene program switching in drosophila Cell Rep. 3 2013 160 172
-
(2013)
Cell Rep.
, vol.3
, pp. 160-172
-
-
Vanden Broeck, L.1
Naval-Sanchez, M.2
Adachi, Y.3
Diaper, D.4
Dourlen, P.5
Chapuis, J.6
Kleinberger, G.7
Gistelinck, M.8
Van, B.C.9
Lambert, J.C.10
Hirth, F.11
Aerts, S.12
Callaerts, P.13
Dermaut, B.14
-
263
-
-
0034659405
-
Active maintenance of MHDA2/MHDAC6 histone-deacetylase in the cytoplasm
-
A. Verdel, S. Curtet, M.P. Brocard, S. Rousseaux, C. Lemercier, M. Yoshida, and S. Khochbin Active maintenance of MHDA2/MHDAC6 histone-deacetylase in the cytoplasm Curr. Biol. 10 2000 747 749
-
(2000)
Curr. Biol.
, vol.10
, pp. 747-749
-
-
Verdel, A.1
Curtet, S.2
Brocard, M.P.3
Rousseaux, S.4
Lemercier, C.5
Yoshida, M.6
Khochbin, S.7
-
264
-
-
77957918535
-
TDP-43-mediated neuron loss in vivo requires RNA-binding activity
-
A. Voigt, D. Herholz, F.C. Fiesel, K. Kaur, D. Muller, P. Karsten, S.S. Weber, P.J. Kahle, T. Marquardt, and J.B. Schulz TDP-43-mediated neuron loss in vivo requires RNA-binding activity PLoS One 5 2010 e12247
-
(2010)
PLoS One
, vol.5
, pp. e12247
-
-
Voigt, A.1
Herholz, D.2
Fiesel, F.C.3
Kaur, K.4
Muller, D.5
Karsten, P.6
Weber, S.S.7
Kahle, P.J.8
Marquardt, T.9
Schulz, J.B.10
-
265
-
-
73949134014
-
Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL MRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS)
-
K. Volkening, C. Leystra-Lantz, W. Yang, H. Jaffee, and M.J. Strong Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL MRNA stability. implications for altered RNA processing in amyotrophic lateral sclerosis (ALS) Brain Res. 1305 2009 168 182
-
(2009)
Brain Res.
, vol.1305
, pp. 168-182
-
-
Volkening, K.1
Leystra-Lantz, C.2
Yang, W.3
Jaffee, H.4
Strong, M.J.5
-
266
-
-
54249100481
-
TDP-43: An emerging new player in neurodegenerative diseases
-
I.F. Wang, L.S. Wu, and C.K. Shen TDP-43: an emerging new player in neurodegenerative diseases Trends Mol. Med. 14 2008 479 485
-
(2008)
Trends Mol. Med.
, vol.14
, pp. 479-485
-
-
Wang, I.F.1
Wu, L.S.2
Shen, C.K.3
-
267
-
-
80053424095
-
The ALS-associated proteins FUS and TDP-43 function together to affect drosophila locomotion and life span
-
J.W. Wang, J.R. Brent, A. Tomlinson, N.A. Shneider, and B.D. McCabe The ALS-associated proteins FUS and TDP-43 function together to affect drosophila locomotion and life span J. Clin. Invest. 121 2011 4118 4126
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 4118-4126
-
-
Wang, J.W.1
Brent, J.R.2
Tomlinson, A.3
Shneider, N.A.4
McCabe, B.D.5
-
268
-
-
64549124726
-
Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse
-
L. Wang, H.X. Deng, G. Grisotti, H. Zhai, T. Siddique, and R.P. Roos Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse Hum. Mol. Genet. 18 2009 1642 1651
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 1642-1651
-
-
Wang, L.1
Deng, H.X.2
Grisotti, G.3
Zhai, H.4
Siddique, T.5
Roos, R.P.6
-
269
-
-
46649093597
-
Induced NcRNAs allosterically modify RNA-binding proteins in Cis to inhibit transcription
-
X. Wang, S. Arai, X. Song, D. Reichart, K. Du, G. Pascual, P. Tempst, M.G. Rosenfeld, C.K. Glass, and R. Kurokawa Induced NcRNAs allosterically modify RNA-binding proteins in Cis to inhibit transcription Nature 454 2008 126 130
-
(2008)
Nature
, vol.454
, pp. 126-130
-
-
Wang, X.1
Arai, S.2
Song, X.3
Reichart, D.4
Du, K.5
Pascual, G.6
Tempst, P.7
Rosenfeld, M.G.8
Glass, C.K.9
Kurokawa, R.10
-
270
-
-
0032727617
-
Suppression of polyglutamine-mediated neurodegeneration in drosophila by the molecular chaperone HSP70
-
J.M. Warrick, H.Y. Chan, Gray-Board, Y. Chai, H.L. Paulson, and N.M. Bonini Suppression of polyglutamine-mediated neurodegeneration in drosophila by the molecular chaperone HSP70 Nat. Genet. 23 1999 425 428
-
(1999)
Nat. Genet.
, vol.23
, pp. 425-428
-
-
Warrick, J.M.1
Chan, H.Y.2
Gray-Board3
Chai, Y.4
Paulson, H.L.5
Bonini, N.M.6
-
271
-
-
18544392423
-
Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in drosophila
-
J.M. Warrick, H.L. Paulson, Gray-Board, Q.T. Bui, K.H. Fischbeck, R.N. Pittman, and N.M. Bonini Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in drosophila Cell 93 1998 939 949
-
(1998)
Cell
, vol.93
, pp. 939-949
-
-
Warrick, J.M.1
Paulson, H.L.2
Gray-Board3
Bui, Q.T.4
Fischbeck, K.H.5
Pittman, R.N.6
Bonini, N.M.7
-
272
-
-
0035664213
-
Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues
-
M. Watanabe, M. Dykes-Hoberg, V.C. Culotta, D.L. Price, P.C. Wong, and J.D. Rothstein Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues Neurobiol. Dis. 8 2001 933 941
-
(2001)
Neurobiol. Dis.
, vol.8
, pp. 933-941
-
-
Watanabe, M.1
Dykes-Hoberg, M.2
Culotta, V.C.3
Price, D.L.4
Wong, P.C.5
Rothstein, J.D.6
-
273
-
-
54049142949
-
A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1
-
M.R. Watson, R.D. Lagow, K. Xu, B. Zhang, and N.M. Bonini A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1 J. Biol. Chem. 283 2008 24972 24981
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 24972-24981
-
-
Watson, M.R.1
Lagow, R.D.2
Xu, K.3
Zhang, B.4
Bonini, N.M.5
-
274
-
-
1842483843
-
Inclusion body myopathy associated with paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein
-
G.D. Watts, J. Wymer, M.J. Kovach, S.G. Mehta, S. Mumm, D. Darvish, A. Pestronk, M.P. Whyte, and V.E. Kimonis Inclusion body myopathy associated with paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein Nat. Genet. 36 2004 377 381
-
(2004)
Nat. Genet.
, vol.36
, pp. 377-381
-
-
Watts, G.D.1
Wymer, J.2
Kovach, M.J.3
Mehta, S.G.4
Mumm, S.5
Darvish, D.6
Pestronk, A.7
Whyte, M.P.8
Kimonis, V.E.9
-
275
-
-
73249152831
-
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
-
I. Wegorzewska, S. Bell, N.J. Cairns, T.M. Miller, and R.H. Baloh TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration Proc. Natl. Acad. Sci. USA 106 2009 18809 18814
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 18809-18814
-
-
Wegorzewska, I.1
Bell, S.2
Cairns, N.J.3
Miller, T.M.4
Baloh, R.H.5
-
276
-
-
0036321382
-
Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients
-
F.R. Wiedemann, G. Manfredi, C. Mawrin, M.F. Beal, and E.A. Schon Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients J. Neurochem. 80 2002 616 625
-
(2002)
J. Neurochem.
, vol.80
, pp. 616-625
-
-
Wiedemann, F.R.1
Manfredi, G.2
Mawrin, C.3
Beal, M.F.4
Schon, E.A.5
-
277
-
-
0032539791
-
Impairment of mitochondrial function in skeletal muscle of patients with amyotrophic lateral sclerosis
-
F.R. Wiedemann, K. Winkler, A.V. Kuznetsov, C. Bartels, S. Vielhaber, H. Feistner, and W.S. Kunz Impairment of mitochondrial function in skeletal muscle of patients with amyotrophic lateral sclerosis J. Neurol. Sci. 156 1998 65 72
-
(1998)
J. Neurol. Sci.
, vol.156
, pp. 65-72
-
-
Wiedemann, F.R.1
Winkler, K.2
Kuznetsov, A.V.3
Bartels, C.4
Vielhaber, S.5
Feistner, H.6
Kunz, W.S.7
-
278
-
-
77649269011
-
TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration
-
H. Wils, G. Kleinberger, J. Janssens, S. Pereson, G. Joris, I. Cuijt, V. Smits, G.C. Ceuterick-de, B.C. Van, and S. Kumar-Singh TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration Proc. Natl. Acad. Sci. USA 107 2010 3858 3863
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 3858-3863
-
-
Wils, H.1
Kleinberger, G.2
Janssens, J.3
Pereson, S.4
Joris, G.5
Cuijt, I.6
Smits, V.7
Ceuterick-De, G.C.8
Van, B. C.9
Kumar-Singh, S.10
-
279
-
-
44749093657
-
A90V TDP-43 variant results in the aberrant localization of TDP-43 in vitro
-
M.J. Winton, V.M. Van Deerlin, L.K. Kwong, W. Yuan, E.M. Wood, C.E. Yu, G.D. Schellenberg, R. Rademakers, R. Caselli, A. Karydas, J.Q. Trojanowski, B.L. Miller, and V.M. Lee A90V TDP-43 variant results in the aberrant localization of TDP-43 in vitro FEBS Lett. 582 2008 2252 2256
-
(2008)
FEBS Lett.
, vol.582
, pp. 2252-2256
-
-
Winton, M.J.1
Van Deerlin, V.M.2
Kwong, L.K.3
Yuan, W.4
Wood, E.M.5
Yu, C.E.6
Schellenberg, G.D.7
Rademakers, R.8
Caselli, R.9
Karydas, A.10
Trojanowski, J.Q.11
Miller, B.L.12
Lee, V.M.13
-
280
-
-
84866175104
-
Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo
-
T.M. Wishart, T.M. Rooney, D.J. Lamont, A.K. Wright, A.J. Morton, M. Jackson, M.R. Freeman, and T.H. Gillingwater Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo PLoS Genet. 8 2012 e1002936
-
(2012)
PLoS Genet.
, vol.8
, pp. e1002936
-
-
Wishart, T.M.1
Rooney, T.M.2
Lamont, D.J.3
Wright, A.K.4
Morton, A.J.5
Jackson, M.6
Freeman, M.R.7
Gillingwater, T.H.8
-
281
-
-
84865235172
-
Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis
-
C.H. Wu, C. Fallini, N. Ticozzi, P.J. Keagle, P.C. Sapp, K. Piotrowska, P. Lowe, M. Koppers, D. McKenna-Yasek, D.M. Baron, J.E. Kost, P. Gonzalez-Perez, A.D. Fox, J. Adams, F. Taroni, C. Tiloca, A.L. Leclerc, S.C. Chafe, D. Mangroo, M.J. Moore, J.A. Zitzewitz, Z.S. Xu, L.H. van den Berg, J.D. Glass, G. Siciliano, E.T. Cirulli, D.B. Goldstein, F. Salachas, V. Meininger, W. Rossoll, A. Ratti, C. Gellera, D.A. Bosco, G.J. Bassell, V. Silani, V.E. Drory, R.H. Brown Jr., and J.E. Landers Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis Nature 488 2012 499 503
-
(2012)
Nature
, vol.488
, pp. 499-503
-
-
Wu, C.H.1
Fallini, C.2
Ticozzi, N.3
Keagle, P.J.4
Sapp, P.C.5
Piotrowska, K.6
Lowe, P.7
Koppers, M.8
McKenna-Yasek, D.9
Baron, D.M.10
Kost, J.E.11
Gonzalez-Perez, P.12
Fox, A.D.13
Adams, J.14
Taroni, F.15
Tiloca, C.16
Leclerc, A.L.17
Chafe, S.C.18
Mangroo, D.19
Moore, M.J.20
Zitzewitz, J.A.21
Xu, Z.S.22
Van Den Berg, L.H.23
Glass, J.D.24
Siciliano, G.25
Cirulli, E.T.26
Goldstein, D.B.27
Salachas, F.28
Meininger, V.29
Rossoll, W.30
Ratti, A.31
Gellera, C.32
Bosco, D.A.33
Bassell, G.J.34
Silani, V.35
Drory, V.E.36
Brown, Jr.R.H.37
Landers, J.E.38
more..
-
282
-
-
84865028374
-
Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice
-
L.S. Wu, W.C. Cheng, and C.K. Shen Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice J. Biol. Chem. 287 2012 27335 27344
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 27335-27344
-
-
Wu, L.S.1
Cheng, W.C.2
Shen, C.K.3
-
283
-
-
84858726202
-
Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a drosophila model of fus-mediated ALS
-
R. Xia, Y. Liu, L. Yang, J. Gal, H. Zhu, and J. Jia Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a drosophila model of fus-mediated ALS Mol. Neurodegener. 7 2012 10
-
(2012)
Mol. Neurodegener.
, vol.7
, pp. 10
-
-
Xia, R.1
Liu, Y.2
Yang, L.3
Gal, J.4
Zhu, H.5
Jia, J.6
-
284
-
-
84877342215
-
Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration
-
Z. Xu, M. Poidevin, X. Li, Y. Li, L. Shu, D.L. Nelson, H. Li, C.M. Hales, M. Gearing, T.S. Wingo, and P. Jin Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration Proc. Natl. Acad. Sci. USA 110 2013 7778 7783
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 7778-7783
-
-
Xu, Z.1
Poidevin, M.2
Li, X.3
Li, Y.4
Shu, L.5
Nelson, D.L.6
Li, H.7
Hales, C.M.8
Gearing, M.9
Wingo, T.S.10
Jin, P.11
-
285
-
-
84887073158
-
Neurodegeneration caused by polyglutamine expansion is regulated by P-glycoprotein in Drosophila melanogaster
-
S. Yadav, and M.G. Tapadia Neurodegeneration caused by polyglutamine expansion is regulated by P-glycoprotein in Drosophila melanogaster Genetics 195 2013 857 870
-
(2013)
Genetics
, vol.195
, pp. 857-870
-
-
Yadav, S.1
Tapadia, M.G.2
-
286
-
-
84869005887
-
The effect of PRMT1-mediated arginine methylation on the subcellular localization, stress granules, and detergent-insoluble aggregates of FUS/TLS
-
A. Yamaguchi, and K. Kitajo The effect of PRMT1-mediated arginine methylation on the subcellular localization, stress granules, and detergent-insoluble aggregates of FUS/TLS PLoS One 7 2012 e49267
-
(2012)
PLoS One
, vol.7
, pp. e49267
-
-
Yamaguchi, A.1
Kitajo, K.2
-
287
-
-
0346734108
-
Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease
-
K. Yamanaka, V.C. Vande, E. Eymard-Pierre, E. Bertini, O. Boespflug-Tanguy, and D.W. Cleveland Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease Proc. Natl. Acad. Sci. USA 100 2003 16041 16046
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 16041-16046
-
-
Yamanaka, K.1
Vande, V.C.2
Eymard-Pierre, E.3
Bertini, E.4
Boespflug-Tanguy, O.5
Cleveland, D.W.6
-
288
-
-
0032561190
-
Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing
-
L. Yang, L.J. Embree, S. Tsai, and D.D. Hickstein Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing J. Biol. Chem. 273 1998 27761 27764
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 27761-27764
-
-
Yang, L.1
Embree, L.J.2
Tsai, S.3
Hickstein, D.D.4
-
289
-
-
0034785509
-
The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis
-
Y. Yang, A. Hentati, H.X. Deng, O. Dabbagh, T. Sasaki, M. Hirano, W.Y. Hung, K. Ouahchi, J. Yan, A.C. Azim, N. Cole, G. Gascon, A. Yagmour, M. Ben-Hamida, M. Pericak-Vance, F. Hentati, and T. Siddique The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis Nat. Genet. 29 2001 160 165
-
(2001)
Nat. Genet.
, vol.29
, pp. 160-165
-
-
Yang, Y.1
Hentati, A.2
Deng, H.X.3
Dabbagh, O.4
Sasaki, T.5
Hirano, M.6
Hung, W.Y.7
Ouahchi, K.8
Yan, J.9
Azim, A.C.10
Cole, N.11
Gascon, G.12
Yagmour, A.13
Ben-Hamida, M.14
Pericak-Vance, M.15
Hentati, F.16
Siddique, T.17
-
290
-
-
84870188268
-
Drosophila Vap-33 is required for axonal localization of Dscam isoforms
-
Z. Yang, S.U. Huh, J.M. Drennan, H. Kathuria, J.S. Martinez, H. Tsuda, M.C. Hall, and J.C. Clemens Drosophila Vap-33 is required for axonal localization of Dscam isoforms J. Neurosci. 32 2012 17241 17250
-
(2012)
J. Neurosci.
, vol.32
, pp. 17241-17250
-
-
Yang, Z.1
Huh, S.U.2
Drennan, J.M.3
Kathuria, H.4
Martinez, J.S.5
Tsuda, H.6
Hall, M.C.7
Clemens, J.C.8
-
291
-
-
84874548947
-
Identification of genetic modifiers of TDP-43 neurotoxicity in drosophila
-
L. Zhan, K.A. Hanson, S.H. Kim, A. Tare, and R.S. Tibbetts Identification of genetic modifiers of TDP-43 neurotoxicity in drosophila PLoS One 8 2013 e57214
-
(2013)
PLoS One
, vol.8
, pp. e57214
-
-
Zhan, L.1
Hanson, K.A.2
Kim, S.H.3
Tare, A.4
Tibbetts, R.S.5
-
292
-
-
84919912448
-
Aggregation-prone C9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress
-
Y.J. Zhang, K. Jansen-West, Y.F. Xu, T.F. Gendron, K.F. Bieniek, W.L. Lin, H. Sasaguri, T. Caulfield, J. Hubbard, L. Daughrity, J. Chew, V.V. Belzil, M. Prudencio, J.N. Stankowski, M. Castanedes-Casey, E. Whitelaw, P.E. Ash, M. DeTure, R. Rademakers, K.B. Boylan, D.W. Dickson, and L. Petrucelli Aggregation-prone C9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress Acta Neuropathol. 128 2014 505 524
-
(2014)
Acta Neuropathol.
, vol.128
, pp. 505-524
-
-
Zhang, Y.J.1
Jansen-West, K.2
Xu, Y.F.3
Gendron, T.F.4
Bieniek, K.F.5
Lin, W.L.6
Sasaguri, H.7
Caulfield, T.8
Hubbard, J.9
Daughrity, L.10
Chew, J.11
Belzil, V.V.12
Prudencio, M.13
Stankowski, J.N.14
Castanedes-Casey, M.15
Whitelaw, E.16
Ash, P.E.17
Deture, M.18
Rademakers, R.19
Boylan, K.B.20
Dickson, D.W.21
Petrucelli, L.22
more..
-
293
-
-
66149114101
-
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
-
Y.J. Zhang, Y.F. Xu, C. Cook, T.F. Gendron, P. Roettges, C.D. Link, W.L. Lin, J. Tong, M. Castanedes-Casey, P. Ash, J. Gass, V. Rangachari, E. Buratti, F. Baralle, T.E. Golde, D.W. Dickson, and L. Petrucelli Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity Proc. Natl. Acad. Sci. USA 106 2009 7607 7612
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 7607-7612
-
-
Zhang, Y.J.1
Xu, Y.F.2
Cook, C.3
Gendron, T.F.4
Roettges, P.5
Link, C.D.6
Lin, W.L.7
Tong, J.8
Castanedes-Casey, M.9
Ash, P.10
Gass, J.11
Rangachari, V.12
Buratti, E.13
Baralle, F.14
Golde, T.E.15
Dickson, D.W.16
Petrucelli, L.17
-
294
-
-
77950421249
-
Transgenic rat model of neurodegeneration caused by mutation in the TDP gene
-
H. Zhou, C. Huang, H. Chen, D. Wang, C.P. Landel, P.Y. Xia, R. Bowser, Y.J. Liu, and X.G. Xia Transgenic rat model of neurodegeneration caused by mutation in the TDP gene PLoS Genet. 6 2010 e1000887
-
(2010)
PLoS Genet.
, vol.6
, pp. e1000887
-
-
Zhou, H.1
Huang, C.2
Chen, H.3
Wang, D.4
Landel, C.P.5
Xia, P.Y.6
Bowser, R.7
Liu, Y.J.8
Xia, X.G.9
-
295
-
-
0030746523
-
TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling
-
H. Zinszner, J. Sok, D. Immanuel, Y. Yin, and D. Ron TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling J Cell Sci 110 Part 15 1997 1741 1750
-
(1997)
J Cell Sci
, vol.110
, pp. 1741-1750
-
-
Zinszner, H.1
Sok, J.2
Immanuel, D.3
Yin, Y.4
Ron, D.5
-
296
-
-
78651105614
-
Non-ATG-initiated translation directed by microsatellite expansions
-
T. Zu, B. Gibbens, N.S. Doty, M. Gomes-Pereira, A. Huguet, M.D. Stone, J. Margolis, M. Peterson, T.W. Markowski, M.A. Ingram, Z. Nan, C. Forster, W.C. Low, B. Schoser, N.V. Somia, H.B. Clark, S. Schmechel, P.B. Bitterman, G. Gourdon, M.S. Swanson, M. Moseley, and L.P. Ranum Non-ATG-initiated translation directed by microsatellite expansions Proc. Natl. Acad. Sci. USA 108 2011 260 265
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 260-265
-
-
Zu, T.1
Gibbens, B.2
Doty, N.S.3
Gomes-Pereira, M.4
Huguet, A.5
Stone, M.D.6
Margolis, J.7
Peterson, M.8
Markowski, T.W.9
Ingram, M.A.10
Nan, Z.11
Forster, C.12
Low, W.C.13
Schoser, B.14
Somia, N.V.15
Clark, H.B.16
Schmechel, S.17
Bitterman, P.B.18
Gourdon, G.19
Swanson, M.S.20
Moseley, M.21
Ranum, L.P.22
more..
-
297
-
-
84890837640
-
RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia
-
T. Zu, Y. Liu, M. Banez-Coronel, T. Reid, O. Pletnikova, J. Lewis, T.M. Miller, M.B. Harms, A.E. Falchook, S.H. Subramony, L.W. Ostrow, J.D. Rothstein, J.C. Troncoso, and L.P. Ranum RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia Proc. Natl. Acad. Sci. USA 110 2013 E4968 E4977
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. E4968-E4977
-
-
Zu, T.1
Liu, Y.2
Banez-Coronel, M.3
Reid, T.4
Pletnikova, O.5
Lewis, J.6
Miller, T.M.7
Harms, M.B.8
Falchook, A.E.9
Subramony, S.H.10
Ostrow, L.W.11
Rothstein, J.D.12
Troncoso, J.C.13
Ranum, L.P.14
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