Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes

Human Molecular Genetics

Volumn 22, Issue 8, 2013, Pages 1539-1557

  Diaper, Danielle C ^a   Adachi, Yoshitsugu ^a   Sutcliffe, Ben ^b   Humphrey, Dickon M ^a   Elliott, Christopher J H ^c   Stepto, Alan ^a   Ludlow, Zoe N ^a   Broeck, Lies Vanden ^d   Callaerts, Patrick ^d   Dermaut, Bart ^d,e   Al Chalabi, Ammar ^a   Shaw, Christopher E ^a   Robinson, Iain M ^b   Hirth, Frank ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b PLYMOUTH UNIVERSITY PENINSULA SCHOOLS OF MEDICINE AND DENTISTRY   (United Kingdom)

^c UNIVERSITY OF YORK   (United Kingdom)

^d UNIVERSITY OF LEUVEN   (Belgium)

^e UNIV LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

TAR DNA BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DROSOPHILA; EMBRYO; FEMALE; GAIN OF FUNCTION MUTATION; GENE EXPRESSION; LOCOMOTION; LOSS OF FUNCTION MUTATION; MORPHOLOGY; MOTOR CONTROL; NERVE CELL; NERVE DEGENERATION; NEUROMUSCULAR SYNAPSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; SURVIVAL; SYNAPTIC EFFICACY; SYNAPTIC TRANSMISSION;

AGING; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; FRONTOTEMPORAL LOBAR DEGENERATION; LARVA; NERVE DEGENERATION; NEUROMUSCULAR JUNCTION; NEURONS; PHENOTYPE; SYNAPTIC TRANSMISSION;

EID: 84875771192     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddt005     Document Type: Article

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