-
1
-
-
0027401203
-
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
-
Rosen D, Siddique T, Patterson D, Figlewicz D, Sapp P, et al. (1993) Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362: 59-62.
-
(1993)
Nature
, vol.362
, pp. 59-62
-
-
Rosen, D.1
Siddique, T.2
Patterson, D.3
Figlewicz, D.4
Sapp, P.5
-
2
-
-
33749056809
-
ALS: a disease of motor neurons and their nonneuronal neighbors
-
Boillée S, Vande Velde C, Cleveland D, (2006) ALS: a disease of motor neurons and their nonneuronal neighbors. Neuron 52: 39-59.
-
(2006)
Neuron
, vol.52
, pp. 39-59
-
-
Boillée, S.1
Vande Velde, C.2
Cleveland, D.3
-
3
-
-
61349162349
-
Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6
-
Vance C, Rogelj B, Hortobagyi T, De Vos KJ, Nishimura AL, et al. (2009) Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. Science 323: 1208-1211.
-
(2009)
Science
, vol.323
, pp. 1208-1211
-
-
Vance, C.1
Rogelj, B.2
Hortobagyi, T.3
De Vos, K.J.4
Nishimura, A.L.5
-
4
-
-
61349156118
-
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis
-
Kwiatkowski TJ Jr, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, et al. (2009) Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science 323: 1205-1208.
-
(2009)
Science
, vol.323
, pp. 1205-1208
-
-
Kwiatkowski Jr., T.J.1
Bosco, D.A.2
Leclerc, A.L.3
Tamrazian, E.4
Vanderburg, C.R.5
-
5
-
-
42949094584
-
TDP-43 mutation in familial amyotrophic lateral sclerosis
-
Yokoseki A, Shiga A, Tan CF, Tagawa A, Kaneko H, et al. (2008) TDP-43 mutation in familial amyotrophic lateral sclerosis. Ann Neurol 63: 538-542.
-
(2008)
Ann Neurol
, vol.63
, pp. 538-542
-
-
Yokoseki, A.1
Shiga, A.2
Tan, C.F.3
Tagawa, A.4
Kaneko, H.5
-
6
-
-
41949100148
-
TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis
-
Van Deerlin VM, Leverenz JB, Bekris LM, Bird TD, Yuan W, et al. (2008) TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis. Lancet Neurol 7: 409-416.
-
(2008)
Lancet Neurol
, vol.7
, pp. 409-416
-
-
Van Deerlin, V.M.1
Leverenz, J.B.2
Bekris, L.M.3
Bird, T.D.4
Yuan, W.5
-
7
-
-
41149180753
-
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
-
Sreedharan J, Blair IP, Tripathi VB, Hu X, Vance C, et al. (2008) TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis. Science 319: 1668-1672.
-
(2008)
Science
, vol.319
, pp. 1668-1672
-
-
Sreedharan, J.1
Blair, I.P.2
Tripathi, V.B.3
Hu, X.4
Vance, C.5
-
8
-
-
52949094629
-
Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis
-
Rutherford NJ, Zhang YJ, Baker M, Gass JM, Finch NA, et al. (2008) Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis. PLoS Genet 4: e1000193.
-
(2008)
PLoS Genet
, vol.4
-
-
Rutherford, N.J.1
Zhang, Y.J.2
Baker, M.3
Gass, J.M.4
Finch, N.A.5
-
9
-
-
42649120983
-
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
-
Kabashi E, Valdmanis P, Dion P, Spiegelman D, McConkey B, et al. (2008) TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis. Nat Genet 40: 572-574.
-
(2008)
Nat Genet
, vol.40
, pp. 572-574
-
-
Kabashi, E.1
Valdmanis, P.2
Dion, P.3
Spiegelman, D.4
McConkey, B.5
-
10
-
-
41949119043
-
TDP-43 A315T mutation in familial motor neuron disease
-
Gitcho MA, Baloh RH, Chakraverty S, Mayo K, Norton JB, et al. (2008) TDP-43 A315T mutation in familial motor neuron disease. Ann Neurol 63: 535-538.
-
(2008)
Ann Neurol
, vol.63
, pp. 535-538
-
-
Gitcho, M.A.1
Baloh, R.H.2
Chakraverty, S.3
Mayo, K.4
Norton, J.B.5
-
11
-
-
33749632259
-
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
Neumann M, Sampathu D, Kwong L, Truax A, Micsenyi M, et al. (2006) Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 314: 130-133.
-
(2006)
Science
, vol.314
, pp. 130-133
-
-
Neumann, M.1
Sampathu, D.2
Kwong, L.3
Truax, A.4
Micsenyi, M.5
-
12
-
-
77953890823
-
TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration
-
Lagier-Tourenne C, Polymenidou M, Cleveland DW, (2010) TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration. Hum Mol Genet 19: R46-64.
-
(2010)
Hum Mol Genet
, vol.19
-
-
Lagier-Tourenne, C.1
Polymenidou, M.2
Cleveland, D.W.3
-
13
-
-
77951183978
-
Prion-like disorders: blurring the divide between transmissibility and infectivity
-
Cushman M, Johnson BS, King OD, Gitler AD, Shorter J, (2010) Prion-like disorders: blurring the divide between transmissibility and infectivity. J Cell Sci 123: 1191-1201.
-
(2010)
J Cell Sci
, vol.123
, pp. 1191-1201
-
-
Cushman, M.1
Johnson, B.S.2
King, O.D.3
Gitler, A.D.4
Shorter, J.5
-
14
-
-
67749133873
-
TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity
-
Johnson BS, Snead D, Lee JJ, McCaffery JM, Shorter J, et al. (2009) TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity. J Biol Chem 284: 20329-20339.
-
(2009)
J Biol Chem
, vol.284
, pp. 20329-20339
-
-
Johnson, B.S.1
Snead, D.2
Lee, J.J.3
McCaffery, J.M.4
Shorter, J.5
-
15
-
-
79960040173
-
An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity
-
Guo W, Chen Y, Zhou X, Kar A, Ray P, et al. (2011) An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity. Nat Struct Mol Biol 18: 822-830.
-
(2011)
Nat Struct Mol Biol
, vol.18
, pp. 822-830
-
-
Guo, W.1
Chen, Y.2
Zhou, X.3
Kar, A.4
Ray, P.5
-
16
-
-
79955502687
-
Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS
-
Sun Z, Diaz Z, Fang X, Hart MP, Chesi A, et al. (2011) Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS. PLoS Biol 9: e1000614.
-
(2011)
PLoS Biol
, vol.9
-
-
Sun, Z.1
Diaz, Z.2
Fang, X.3
Hart, M.P.4
Chesi, A.5
-
17
-
-
79953183632
-
Expression of human FUS/TLS in yeast leads to protein aggregation and cytotoxicity, recapitulating key features of FUS proteinopathy
-
Fushimi K, Long C, Jayaram N, Chen X, Li L, et al. (2011) Expression of human FUS/TLS in yeast leads to protein aggregation and cytotoxicity, recapitulating key features of FUS proteinopathy. Protein Cell 2: 141-149.
-
(2011)
Protein Cell
, vol.2
, pp. 141-149
-
-
Fushimi, K.1
Long, C.2
Jayaram, N.3
Chen, X.4
Li, L.5
-
18
-
-
79959869692
-
FUS/TLS forms cytoplasmic aggregates, inhibits cell growth and interacts with TDP-43 in a yeast model of amyotrophic lateral sclerosis
-
Kryndushkin D, Wickner RB, Shewmaker F, (2011) FUS/TLS forms cytoplasmic aggregates, inhibits cell growth and interacts with TDP-43 in a yeast model of amyotrophic lateral sclerosis. Protein Cell 2: 223-236.
-
(2011)
Protein Cell
, vol.2
, pp. 223-236
-
-
Kryndushkin, D.1
Wickner, R.B.2
Shewmaker, F.3
-
19
-
-
77955792022
-
ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
-
Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, et al. (2010) ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import. EMBO J 29: 2841-2857.
-
(2010)
EMBO J
, vol.29
, pp. 2841-2857
-
-
Dormann, D.1
Rodde, R.2
Edbauer, D.3
Bentmann, E.4
Fischer, I.5
-
20
-
-
2442676753
-
Nuclear factor TDP-43 binds to the polymorphic TG repeats in CFTR intron 8 and causes skipping of exon 9: a functional link with disease penetrance
-
Buratti E, Brindisi A, Pagani F, Baralle FE, (2004) Nuclear factor TDP-43 binds to the polymorphic TG repeats in CFTR intron 8 and causes skipping of exon 9: a functional link with disease penetrance. Am J Hum Genet 74: 1322-1325.
-
(2004)
Am J Hum Genet
, vol.74
, pp. 1322-1325
-
-
Buratti, E.1
Brindisi, A.2
Pagani, F.3
Baralle, F.E.4
-
21
-
-
79953185674
-
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
-
Polymenidou M, Lagier-Tourenne C, Hutt KR, Huelga SC, Moran J, et al. (2011) Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Nat Neurosci 14: 459-468.
-
(2011)
Nat Neurosci
, vol.14
, pp. 459-468
-
-
Polymenidou, M.1
Lagier-Tourenne, C.2
Hutt, K.R.3
Huelga, S.C.4
Moran, J.5
-
22
-
-
79953180492
-
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
-
Tollervey JR, Curk T, Rogelj B, Briese M, Cereda M, et al. (2011) Characterizing the RNA targets and position-dependent splicing regulation by TDP-43. Nat Neurosci 14: 452-458.
-
(2011)
Nat Neurosci
, vol.14
, pp. 452-458
-
-
Tollervey, J.R.1
Curk, T.2
Rogelj, B.3
Briese, M.4
Cereda, M.5
-
23
-
-
77956155794
-
Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43
-
Fuentealba RA, Udan M, Bell S, Wegorzewska I, Shao J, et al. (2010) Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43. J Biol Chem 285: 26304-26314.
-
(2010)
J Biol Chem
, vol.285
, pp. 26304-26314
-
-
Fuentealba, R.A.1
Udan, M.2
Bell, S.3
Wegorzewska, I.4
Shao, J.5
-
24
-
-
78751616191
-
TDP-43 regulates its mRNA levels through a negative feedback loop
-
Ayala YM, De Conti L, Avendano-Vazquez SE, Dhir A, Romano M, et al. (2011) TDP-43 regulates its mRNA levels through a negative feedback loop. EMBO J 30: 277-288.
-
(2011)
EMBO J
, vol.30
, pp. 277-288
-
-
Ayala, Y.M.1
De Conti, L.2
Avendano-Vazquez, S.E.3
Dhir, A.4
Romano, M.5
-
25
-
-
79551523377
-
Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice
-
Igaz LM, Kwong LK, Lee EB, Chen-Plotkin A, Swanson E, et al. (2011) Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. J Clin Invest 121: 726-738.
-
(2011)
J Clin Invest
, vol.121
, pp. 726-738
-
-
Igaz, L.M.1
Kwong, L.K.2
Lee, E.B.3
Chen-Plotkin, A.4
Swanson, E.5
-
26
-
-
84155167265
-
Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration
-
Lee EB, Lee VM, Trojanowski JQ, (2012) Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration. Nat Rev Neurosci 13: 38-50.
-
(2012)
Nat Rev Neurosci
, vol.13
, pp. 38-50
-
-
Lee, E.B.1
Lee, V.M.2
Trojanowski, J.Q.3
-
27
-
-
79955812764
-
TDP-43-Based Animal Models of Neurodegeneration: New Insights into ALS Pathology and Pathophysiology
-
Wegorzewska I, Baloh RH, (2011) TDP-43-Based Animal Models of Neurodegeneration: New Insights into ALS Pathology and Pathophysiology. Neurodegener Dis 8: 262-274.
-
(2011)
Neurodegener Dis
, vol.8
, pp. 262-274
-
-
Wegorzewska, I.1
Baloh, R.H.2
-
28
-
-
77957918535
-
TDP-43-mediated neuron loss in vivo requires RNA-binding activity
-
Voigt A, Herholz D, Fiesel FC, Kaur K, Muller D, et al. (2010) TDP-43-mediated neuron loss in vivo requires RNA-binding activity. PLoS One 5: e12247.
-
(2010)
PLoS One
, vol.5
-
-
Voigt, A.1
Herholz, D.2
Fiesel, F.C.3
Kaur, K.4
Muller, D.5
-
29
-
-
77953194507
-
TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97
-
Ritson GP, Custer SK, Freibaum BD, Guinto JB, Geffel D, et al. (2010) TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97. J Neurosci 30: 7729-7739.
-
(2010)
J Neurosci
, vol.30
, pp. 7729-7739
-
-
Ritson, G.P.1
Custer, S.K.2
Freibaum, B.D.3
Guinto, J.B.4
Geffel, D.5
-
30
-
-
79957488875
-
Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS
-
Estes PS, Boehringer A, Zwick R, Tang JE, Grigsby B, et al. (2011) Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS. Hum Mol Genet 20: 2308-2321.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 2308-2321
-
-
Estes, P.S.1
Boehringer, A.2
Zwick, R.3
Tang, J.E.4
Grigsby, B.5
-
31
-
-
77649258646
-
A Drosophila model for TDP-43 proteinopathy
-
Li Y, Ray P, Rao EJ, Shi C, Guo W, et al. (2010) A Drosophila model for TDP-43 proteinopathy. Proc Natl Acad Sci U S A.
-
(2010)
Proc Natl Acad Sci U S A
-
-
Li, Y.1
Ray, P.2
Rao, E.J.3
Shi, C.4
Guo, W.5
-
32
-
-
78650607406
-
Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies
-
Miguel L, Frebourg T, Campion D, Lecourtois M, (2011) Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies. Neurobiol Dis 41: 398-406.
-
(2011)
Neurobiol Dis
, vol.41
, pp. 398-406
-
-
Miguel, L.1
Frebourg, T.2
Campion, D.3
Lecourtois, M.4
-
33
-
-
79957801387
-
Neuronal Function and Dysfunction of Drosophila dTDP
-
Lin MJ, Cheng CW, Shen CK, (2011) Neuronal Function and Dysfunction of Drosophila dTDP. PLoS ONE 6: e20371.
-
(2011)
PLoS ONE
, vol.6
-
-
Lin, M.J.1
Cheng, C.W.2
Shen, C.K.3
-
34
-
-
77951236534
-
Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS)
-
Hanson KA, Kim SH, Wassarman DA, Tibbetts RS, (2010) Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS). J Biol Chem 285: 11068-11072.
-
(2010)
J Biol Chem
, vol.285
, pp. 11068-11072
-
-
Hanson, K.A.1
Kim, S.H.2
Wassarman, D.A.3
Tibbetts, R.S.4
-
35
-
-
65549084887
-
Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1
-
Kim SH, Shi Y, Hanson KA, Williams LM, Sakasai R, et al. (2009) Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1. J Biol Chem 284: 8083-8092.
-
(2009)
J Biol Chem
, vol.284
, pp. 8083-8092
-
-
Kim, S.H.1
Shi, Y.2
Hanson, K.A.3
Williams, L.M.4
Sakasai, R.5
-
36
-
-
70449723717
-
Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD
-
Lim PJ, Danner R, Liang J, Doong H, Harman C, et al. (2009) Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. J Cell Biol 187: 201-217.
-
(2009)
J Cell Biol
, vol.187
, pp. 201-217
-
-
Lim, P.J.1
Danner, R.2
Liang, J.3
Doong, H.4
Harman, C.5
-
37
-
-
59649110865
-
PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation
-
N'Diaye EN, Kajihara KK, Hsieh I, Morisaki H, Debnath J, et al. (2009) PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation. EMBO Rep 10: 173-179.
-
(2009)
EMBO Rep
, vol.10
, pp. 173-179
-
-
N'Diaye, E.N.1
Kajihara, K.K.2
Hsieh, I.3
Morisaki, H.4
Debnath, J.5
-
38
-
-
77957674939
-
Ubiquilin at a crossroads in protein degradation pathways
-
Rothenberg C, Monteiro MJ, (2010) Ubiquilin at a crossroads in protein degradation pathways. Autophagy 6: 979-980.
-
(2010)
Autophagy
, vol.6
, pp. 979-980
-
-
Rothenberg, C.1
Monteiro, M.J.2
-
39
-
-
77955023765
-
Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy
-
Rothenberg C, Srinivasan D, Mah L, Kaushik S, Peterhoff CM, et al. (2010) Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy. Hum Mol Genet 19: 3219-3232.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 3219-3232
-
-
Rothenberg, C.1
Srinivasan, D.2
Mah, L.3
Kaushik, S.4
Peterhoff, C.M.5
-
40
-
-
79952585752
-
TDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch/MAP1B levels and synaptic microtubules organization
-
Godena VK, Romano G, Romano M, Appocher C, Klima R, et al. (2011) TDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch/MAP1B levels and synaptic microtubules organization. PLoS One 6: e17808.
-
(2011)
PLoS One
, vol.6
-
-
Godena, V.K.1
Romano, G.2
Romano, M.3
Appocher, C.4
Klima, R.5
-
41
-
-
0027990727
-
Control of programmed cell death by the baculovirus genes p35 and iap
-
Clem RJ, Miller LK, (1994) Control of programmed cell death by the baculovirus genes p35 and iap. Mol Cell Biol 14: 5212-5222.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 5212-5222
-
-
Clem, R.J.1
Miller, L.K.2
-
42
-
-
43249103898
-
Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia
-
Rimkus SA, Katzenberger RJ, Trinh AT, Dodson GE, Tibbetts RS, et al. (2008) Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia. Genes Dev 22: 1205-1220.
-
(2008)
Genes Dev
, vol.22
, pp. 1205-1220
-
-
Rimkus, S.A.1
Katzenberger, R.J.2
Trinh, A.T.3
Dodson, G.E.4
Tibbetts, R.S.5
-
43
-
-
67349271683
-
Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior
-
Feiguin F, Godena VK, Romano G, D'Ambrogio A, Klima R, et al. (2009) Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior. FEBS Lett 583: 1586-1592.
-
(2009)
FEBS Lett
, vol.583
, pp. 1586-1592
-
-
Feiguin, F.1
Godena, V.K.2
Romano, G.3
D'Ambrogio, A.4
Klima, R.5
-
44
-
-
44849103119
-
Functional significance of allelic variation at methuselah, an aging gene in Drosophila
-
Paaby AB, Schmidt PS, (2008) Functional significance of allelic variation at methuselah, an aging gene in Drosophila. PLoS One 3: e1987.
-
(2008)
PLoS One
, vol.3
-
-
Paaby, A.B.1
Schmidt, P.S.2
-
45
-
-
65549121943
-
Notch signaling: the core pathway and its posttranslational regulation
-
Fortini ME, (2009) Notch signaling: the core pathway and its posttranslational regulation. Dev Cell 16: 633-647.
-
(2009)
Dev Cell
, vol.16
, pp. 633-647
-
-
Fortini, M.E.1
-
46
-
-
14144255573
-
Notch-1 activation and dendritic atrophy in prion disease
-
Ishikura N, Clever JL, Bouzamondo-Bernstein E, Samayoa E, Prusiner SB, et al. (2005) Notch-1 activation and dendritic atrophy in prion disease. Proc Natl Acad Sci U S A 102: 886-891.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 886-891
-
-
Ishikura, N.1
Clever, J.L.2
Bouzamondo-Bernstein, E.3
Samayoa, E.4
Prusiner, S.B.5
-
47
-
-
20544468497
-
The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain
-
Reeve SP, Bassetto L, Genova GK, Kleyner Y, Leyssen M, et al. (2005) The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain. Curr Biol 15: 1156-1163.
-
(2005)
Curr Biol
, vol.15
, pp. 1156-1163
-
-
Reeve, S.P.1
Bassetto, L.2
Genova, G.K.3
Kleyner, Y.4
Leyssen, M.5
-
48
-
-
84865235172
-
Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis
-
Wu CH, Fallini C, Ticozzi N, Keagle PJ, Sapp PC, et al. (2012) Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis. Nature 488: 499-503.
-
(2012)
Nature
, vol.488
, pp. 499-503
-
-
Wu, C.H.1
Fallini, C.2
Ticozzi, N.3
Keagle, P.J.4
Sapp, P.C.5
-
49
-
-
0035940416
-
A conditional tissue-specific transgene expression system using inducible GAL4
-
Osterwalder T, Yoon KS, White BH, Keshishian H, (2001) A conditional tissue-specific transgene expression system using inducible GAL4. Proc Natl Acad Sci U S A 98: 12596-12601.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 12596-12601
-
-
Osterwalder, T.1
Yoon, K.S.2
White, B.H.3
Keshishian, H.4
-
50
-
-
84874526109
-
The Greatwall kinase: a new pathway in the control of the cell cycle
-
Lorca T, Castro A (2012) The Greatwall kinase: a new pathway in the control of the cell cycle. Oncogene.
-
(2012)
Oncogene
-
-
Lorca, T.1
Castro, A.2
-
51
-
-
33744981148
-
Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke
-
Arumugam TV, Chan SL, Jo DG, Yilmaz G, Tang SC, et al. (2006) Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nat Med 12: 621-623.
-
(2006)
Nat Med
, vol.12
, pp. 621-623
-
-
Arumugam, T.V.1
Chan, S.L.2
Jo, D.G.3
Yilmaz, G.4
Tang, S.C.5
-
52
-
-
84856242233
-
Notch signaling inhibits axon regeneration
-
El Bejjani R, Hammarlund M, (2012) Notch signaling inhibits axon regeneration. Neuron 73: 268-278.
-
(2012)
Neuron
, vol.73
, pp. 268-278
-
-
El Bejjani, R.1
Hammarlund, M.2
-
53
-
-
75649135319
-
Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6
-
Fiesel FC, Voigt A, Weber SS, Van den Haute C, Waldenmaier A, et al. (2009) Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6. EMBO J 29: 209-221.
-
(2009)
EMBO J
, vol.29
, pp. 209-221
-
-
Fiesel, F.C.1
Voigt, A.2
Weber, S.S.3
Van den Haute, C.4
Waldenmaier, A.5
-
54
-
-
0032522803
-
Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage
-
Zeng C, Younger-Shepherd S, Jan LY, Jan YN, (1998) Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage. Genes Dev 12: 1086-1091.
-
(1998)
Genes Dev
, vol.12
, pp. 1086-1091
-
-
Zeng, C.1
Younger-Shepherd, S.2
Jan, L.Y.3
Jan, Y.N.4
-
55
-
-
0023187831
-
The enhancer of split locus and neurogenesis in Drosophila melanogaster
-
Knust E, Bremer KA, Vassin H, Ziemer A, Tepass U, et al. (1987) The enhancer of split locus and neurogenesis in Drosophila melanogaster. Dev Biol 122: 262-273.
-
(1987)
Dev Biol
, vol.122
, pp. 262-273
-
-
Knust, E.1
Bremer, K.A.2
Vassin, H.3
Ziemer, A.4
Tepass, U.5
-
56
-
-
73649105844
-
Drosophila Hey is a target of Notch in asymmetric divisions during embryonic and larval neurogenesis
-
Monastirioti M, Giagtzoglou N, Koumbanakis KA, Zacharioudaki E, Deligiannaki M, et al. (2010) Drosophila Hey is a target of Notch in asymmetric divisions during embryonic and larval neurogenesis. Development 137: 191-201.
-
(2010)
Development
, vol.137
, pp. 191-201
-
-
Monastirioti, M.1
Giagtzoglou, N.2
Koumbanakis, K.A.3
Zacharioudaki, E.4
Deligiannaki, M.5
-
57
-
-
77958604956
-
Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA
-
Kim SH, Shanware NP, Bowler MJ, Tibbetts RS, (2010) Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA. J Biol Chem 285: 34097-34105.
-
(2010)
J Biol Chem
, vol.285
, pp. 34097-34105
-
-
Kim, S.H.1
Shanware, N.P.2
Bowler, M.J.3
Tibbetts, R.S.4
-
58
-
-
84868088848
-
High-content RNAi screening identifies the Type 1 inositol triphosphate receptor as a modifier of TDP-43 localization and neurotoxicity
-
Kim SH, Zhan L, Hanson KA, Tibbetts RS (2012) High-content RNAi screening identifies the Type 1 inositol triphosphate receptor as a modifier of TDP-43 localization and neurotoxicity. Hum Mol Genet.
-
(2012)
Hum Mol Genet
-
-
Kim, S.H.1
Zhan, L.2
Hanson, K.A.3
Tibbetts, R.S.4
-
59
-
-
0032168160
-
Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons
-
Jackson GR, Salecker I, Dong X, Yao X, Arnheim N, et al. (1998) Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons. Neuron 21: 633-642.
-
(1998)
Neuron
, vol.21
, pp. 633-642
-
-
Jackson, G.R.1
Salecker, I.2
Dong, X.3
Yao, X.4
Arnheim, N.5
-
60
-
-
75149155060
-
Oxidative stress in ALS: key role in motor neuron injury and therapeutic target
-
Barber SC, Shaw PJ, (2010) Oxidative stress in ALS: key role in motor neuron injury and therapeutic target. Free Radic Biol Med 48: 629-641.
-
(2010)
Free Radic Biol Med
, vol.48
, pp. 629-641
-
-
Barber, S.C.1
Shaw, P.J.2
-
61
-
-
34247508686
-
Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?
-
Herrup K, Yang Y, (2007) Cell cycle regulation in the postmitotic neuron: oxymoron or new biology? Nat Rev Neurosci 8: 368-378.
-
(2007)
Nat Rev Neurosci
, vol.8
, pp. 368-378
-
-
Herrup, K.1
Yang, Y.2
-
62
-
-
84883348833
-
Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila
-
Hazelett DJ, Chang JC, Lakeland DL, Morton DB, (2012) Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila. G3 (Bethesda) 2: 789-802.
-
(2012)
G3 (Bethesda)
, vol.2
, pp. 789-802
-
-
Hazelett, D.J.1
Chang, J.C.2
Lakeland, D.L.3
Morton, D.B.4
-
63
-
-
78651408754
-
Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes
-
Sephton CF, Cenik C, Kucukural A, Dammer EB, Cenik B, et al. (2011) Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes. J Biol Chem 286: 1204-1215.
-
(2011)
J Biol Chem
, vol.286
, pp. 1204-1215
-
-
Sephton, C.F.1
Cenik, C.2
Kucukural, A.3
Dammer, E.B.4
Cenik, B.5
-
64
-
-
79957646007
-
RNA targets of TDP-43 identified by UV-CLIP are deregulated in ALS
-
Xiao S, Sanelli T, Dib S, Sheps D, Findlater J, et al. (2011) RNA targets of TDP-43 identified by UV-CLIP are deregulated in ALS. Mol Cell Neurosci 47: 167-180.
-
(2011)
Mol Cell Neurosci
, vol.47
, pp. 167-180
-
-
Xiao, S.1
Sanelli, T.2
Dib, S.3
Sheps, D.4
Findlater, J.5
-
65
-
-
59649128891
-
Conditional inhibition of autophagy genes in adult Drosophila impairs immunity without compromising longevity
-
Ren C, Finkel SE, Tower J, (2009) Conditional inhibition of autophagy genes in adult Drosophila impairs immunity without compromising longevity. Exp Gerontol 44: 228-235.
-
(2009)
Exp Gerontol
, vol.44
, pp. 228-235
-
-
Ren, C.1
Finkel, S.E.2
Tower, J.3
-
66
-
-
0034100993
-
Barbu: an E(spl) m4/m(alpha)-related gene that antagonizes Notch signaling and is required for the establishment of ommatidial polarity
-
Zaffran S, Frasch M, (2000) Barbu: an E(spl) m4/m(alpha)-related gene that antagonizes Notch signaling and is required for the establishment of ommatidial polarity. Development 127: 1115-1130.
-
(2000)
Development
, vol.127
, pp. 1115-1130
-
-
Zaffran, S.1
Frasch, M.2
-
67
-
-
34548486689
-
Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon
-
Wang H, Ouyang Y, Somers WG, Chia W, Lu B, (2007) Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon. Nature 449: 96-100.
-
(2007)
Nature
, vol.449
, pp. 96-100
-
-
Wang, H.1
Ouyang, Y.2
Somers, W.G.3
Chia, W.4
Lu, B.5
-
68
-
-
34248652102
-
A protocol for dissecting Drosophila melanogaster brains for live imaging or immunostaining
-
Wu JS, Luo L, (2006) A protocol for dissecting Drosophila melanogaster brains for live imaging or immunostaining. Nat Protoc 1: 2110-2115.
-
(2006)
Nat Protoc
, vol.1
, pp. 2110-2115
-
-
Wu, J.S.1
Luo, L.2
|