The aggregation and neurotoxicity of TDP-43 and its als-associated 25 kDa fragment are differentially affected by molecular chaperones in drosophila

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Gregory, Jenna M ^a   Barros, Teresa P ^a   Meehan, Sarah ^a   Dobson, Christopher M ^a   Luheshi, Leila M ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; ATAXIN 7; CHAPERONE; GC 14207 PROTEIN; GELDANAMYCIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; SMALL HEAT SHOCK PROTEIN; TANESPIMYCIN; TAR DNA BINDING PROTEIN; TRANSCRIPTION FACTOR GAL4; UNCLASSIFIED DRUG; 17-(ALLYLAMINO)-17-DEMETHOXYGELDANAMYCIN; BENZOQUINONE DERIVATIVE; CG14207 PROTEIN, DROSOPHILA; DNA BINDING PROTEIN; DROSOPHILA PROTEIN; HEAT SHOCK PROTEIN; MACROCYCLIC LACTAM; PEPTIDE FRAGMENT; PROTEIN TDP-43; TDP 25 PROTEIN, HUMAN; TDP-25 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; DISEASE ASSOCIATION; DROSOPHILA; IMMUNOHISTOCHEMISTRY; MOTONEURON; NERVE DEGENERATION; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PHENOTYPE; PHOTORECEPTOR; PLEIOTROPY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PREVALENCE; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; SCANNING ELECTRON MICROSCOPY; STEADY STATE; TDP 43 PROTEINOPATHY; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; BRAIN; CHEMISTRY; DROSOPHILA MELANOGASTER; GENE EXPRESSION REGULATION; METABOLISM; METHODOLOGY; TRANSGENE; TRANSGENIC ANIMAL;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BENZOQUINONES; BRAIN; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; HEAT-SHOCK PROTEINS; HEAT-SHOCK PROTEINS, SMALL; LACTAMS, MACROCYCLIC; MICROSCOPY, ELECTRON, SCANNING; MODELS, BIOLOGICAL; MODELS, GENETIC; PEPTIDE FRAGMENTS; PHENOTYPE; TRANSGENES;

EID: 84857477831     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031899     Document Type: Article

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