C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins

Science

Volumn , Issue 6201, 2014, Pages 1192-1194

  Mizielinska, Sarah ^a   Grönke, Sebastian ^b   Niccoli, Teresa ^b,c   Ridler, Charlotte E ^a   Clayton, Emma L ^a   Devoy, Anny ^a   Moens, Thomas ^a,c   Norona, Frances E ^a   Woollacott, Ione O C ^a   Pietrzyk, Julian ^a   Cleverley, Karen ^a   Nicoll, Andrew J ^a   Pickering Brown, Stuart ^d   Dols, Jacqueline ^b   Cabecinha, Melissa ^c   Hendrich, Oliver ^b   Fratta, Pietro ^a   Fisher, Elizabeth M C ^a   Partridge, Linda ^b,c   Isaacs, Adrian M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b MAX PLANCK INSTITUTE FOR BIOLOGY OF AGEING   (Germany)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE CONTAINING DIPEPTIDE REPEAT PROTEIN; DIPEPTIDE; DIPEPTIDE REPEAT PROTEIN; GLYCINE ALANINE DIPEPTIDE PROTEIN; GLYCINE ARGININE DIPEPTIDE REPEAT PROTEIN; PROLINE ALANINE DIPEPTIDE PROTEIN; PROLINE ARGININE DIPEPTIDE REPEAT PROTEIN; RNA; RNA BINDING PROTEIN; UNCLASSIFIED DRUG; C9ORF72 PROTEIN, HUMAN; PROTEIN; REPETITIVE DNA;

AMINO ACID; FLY; GENE EXPRESSION; LYME DISEASE; NEUROLOGY; PROTEIN; RNA; TOXICITY;

ADULT; ARTICLE; BRAIN REGION; CIRCULAR DICHROISM; DROSOPHILA MELANOGASTER; ESCHERICHIA COLI; FLUORESCENCE IN SITU HYBRIDIZATION; GENE MUTATION; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; NERVE CELL; NERVE DEGENERATION; NEUROBLASTOMA CELL LINE; NEUROTOXICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RNA SEQUENCE; STOP CODON; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL; DISEASE MODEL; FRONTOTEMPORAL DEMENTIA; GENETICS; HUMAN; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL LINE, TUMOR; DIPEPTIDES; DISEASE MODELS, ANIMAL; DNA REPEAT EXPANSION; DROSOPHILA MELANOGASTER; ESCHERICHIA COLI; FRONTOTEMPORAL DEMENTIA; HUMANS; NEURONS; PROTEINS;

EID: 84907188956     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1256800     Document Type: Article

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