Inter- and intracellular signaling in amyotrophic lateral sclerosis: Role of p38 mitogen-activated protein kinase

Neurodegenerative Diseases

Volumn 2, Issue 3-4, 2006, Pages 128-134

  Bendotti, C ^a   Bao Cutrona, M ^a   Cheroni, C ^a   Grignaschi, G ^a   Lo Coco, D ^a,b   Peviani, M ^a   Tortarolo, M ^a   Veglianese, P ^a   Zennaro, E ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

Author keywords

Amyotrophic lateral sclerosis; Cytokines; Neuroinflammation; Nitric oxide; p38 mitogen activated protein kinase; Reactive oxygen species; SOD1 mutants; Tumor necrosis factor

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NITRIC OXIDE; OXYGENASE INHIBITOR; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2;

AMYOTROPHIC LATERAL SCLEROSIS; BINDING AFFINITY; CELL DEATH; CELL INTERACTION; DISEASE COURSE; ENZYME ACTIVITY; FAMILIAL DISEASE; GLIA CELL; HUMAN; MOTONEURON; MOTOR NEURON DISEASE; NERVE CELL DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NEUROPHYSIOLOGY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL COMMUNICATION; HUMANS; MOTOR NEURONS; NEUROGLIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTOR CROSS-TALK;

EID: 33744782374     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000089617     Document Type: Review

References (52)

1. Ackerley S, Grierson AJ, Banner S, Perkinton MS, Brownlees J, Byers HL, Ward M, Thornhill P, Hussain K, Waby JS, Anderton BH, Cooper JD, Dingwall C, Leigh PN, Shaw CE, Miller CC: p38α stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis. Mol Cell Neurosci 2004;26:354-364.
2. Alexianu ME, Kozovska M, Appel SH: Immune reactivity in a mouse model of familial ALS correlates with disease progression. Neurology 2001;57:1282-1289.
3. Almer G, Vukosavic S, Romero N, Przedborski S: Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem 1999;72:2415-2425.
4. Ameloot P, Fiers W, De Bleser P, Ware CF, Vandenabeele P, Brouckaert P: Identification of tumor necrosis factor (TNF) amino acids crucial for binding to the murine p75 TNF receptor and construction of receptor-selective mutants. J Biol Chem 2001;276:37426-37430.
5. Beckman JS: Protein tyrosine nitration and peroxynitrite. Faseb J 2002;16:1144.
6. Bendotti C, Atzori C, Piva R, Tortarolo M, Strong MJ, DeBiasi S, Migheli A: Activated p38MAPK is a novel component of the intracellular inclusions found in human amyotrophic lateral sclerosis and mutant SOD1 transgenic mice. J Neuropathol Exp Neurol 2004;63:113-119.
7. Bendotti C, Calvaresi N, Chiveri L, Prelle A, Moggio M, Braga M, Silani V, De Biasi S: Early vacuolization and mitochondrial damage in motor neurons of FALS mice are not associated with apoptosis or with changes in cytochrome oxidase histochemical reactivity. J Neurol Sci 2001;191:25-33.
8. Bendotti C Carri MT: Lessons from models of SOD1-linked familial ALS. Trends Mol Med 2004;10:393-400.
9. Bendotti C, Tortarolo M, Suchak SK, Calvaresi N, Carvelli L, Bastone A, Rizzi M, Rattray M, Mennini T: Transgenic SOD1 G93A mice develop reduced GLT-1 in spinal cord without alterations in cerebrospinal fluid glutamate levels. J Neurochem 2001;79:737-746.
10. Bezzi P, Domercq M, Brambilla L, Galli R, Schols D, De Clercq E, Vescovi A, Bagetta G, Kollias G, Meldolesi J, Volterra A: CXCR4-activated astrocyte glutamate release via TNF-α: amplification by microglia triggers neurotoxicity. Nat Neurosci 2001;4:702-710.
11. Bruijn LI, Becher MW, Lee MK, Anderson KL, Jenkins NA, Copeland NG, Sisodia SS, Rothstein JD, Borchelt DR, Price DL, Cleveland DW: ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron 1997;18:327-338.
12. Casoni F, Basso M, Massignan T, Gianazza E, Cheroni C, Salmona M, Bendotti C, Bonetto V: Protein nitration in a mouse model of familial amyotrophic lateral sclerosis: possible multifunctional role in the pathogenesis. J Biol Chem 2005;280:16295-162304.
13. Clement AM, Nguyen MD, Roberts EA, Garcia ML, Boillee S, Rule M, McMahon AP, Doucette W, Siwek D, Ferrante RJ, Brown RH Jr, Julien JP, Goldstein LS, Cleveland DW: Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science 2003;302:113-117.
14. Cleveland DW, Bruijn LI, Wong PC, Marszalek JR, Vechio JD, Lee MK, Xu XS, Borchelt DR, Sisodia SS, Price DL: Mechanisms of selective motor neuron death in transgenic mouse models of motor neuron disease. Neurology 1996;47:S54-S62.
15. Cookson MR, Shaw PJ: Oxidative stress and motor neurone disease. Brain Pathol 1999;9:165-186.
16. Ferri A, Nencini M, Casciati A, Cozzolino M, Angelini DF, Longone P, Spalloni A, Rotilio G, Carri MT: Cell death in amyotrophic lateral sclerosis: interplay between neuronal and glial cells. Faseb J 2004;18:1261-1263.
17. Friedlander RM: Apoptosis and caspases in neurodegenerative diseases. N Engl J Med 2003;348:1365-1375.
18. Ghatan S, Larner S, Kinoshita Y, Hetman M, Patel L, Xia Z, Youle RJ, Morrison RS: p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. J Cell Biol 2000;150:335-347.
19. Ghezzi P, Mennini T: Tumor necrosis factor and motoneuronal degeneration: an open problem. Neuroimmunomodulation 2001;9:178-182.
20. Gong YH, Parsadanian AS, Andreeva A, Snider WD, Elliott JL: Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration. J Neurosci 2000;20:660-665.
21. Hall ED, Oostveen JA, Gurney ME: Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS. Glia 1998;23:249-256.
22. Hensley K, Fedynyshyn J, Ferrell S, Floyd RA, Gordon B, Grammas P, Hamdheydari L, Mhatre M, Mou S, Pye QN, Stewart C, West M, West S, Williamson KS: Message and protein-level elevation of tumor necrosis factor-α (TNF-α) and TNF-α-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis. Neurobiol Dis 2003;14:74-80.
23. Hensley K, Floyd RA, Gordon B, Mou S, Pye QN, Stewart C, West M, Williamson K: Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. J Neurochem 2002;82:365-374.
24. Kang SJ, Sanchez I, Jing N, Yuan J: Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis. J Neurosci 2003;23:5455-5460.
25. Kong J, Xu Z: Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1. J Neurosci 1998;18:3241-3250.
26. Levine JB, Kong J, Nadler M Xu Z: Astrocytes interact intimately with degenerating motor neurons in mouse amyotrophic lateral sclerosis. Glia 1999;28:215-224.
27. Liu J, Lillo C, Jonsson PA, Vande Velde C, Ward CM, Miller TM, Subramaniam JR, Rothstein JD, Marklund S, Andersen PM, Brannstrom T, Gredal O, Wong PC, Williams DS, Cleveland DW: Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria. Neuron 2004;43:5-17.
28. Migheli A, Atzori C, Piva R, Tortarolo M, Girelli M, Schiffer D, Bendotti C: Lack of apoptosis in mice with ALS. Nat Med 1999;5:966-967.
29. Migheli A, Piva R, Atzori C, Troost D, Schiffer D: c-Jun, JNK/SAPK kinases and transcription factor NF-κB are selectively activated in astrocytes, but not motor neurons, in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 1997;56:1314-1322.
30. Morrison BM, Morrison JH: Amyotrophic lateral sclerosis associated with mutations in superoxide dismutase: a putative mechanism of degeneration. Brain Res Brain Res Rev 1999;29:121-135.
31. Munoz-Fernandez MA, Fresno M: The role of tumour necrosis factor, interleukin-6, interferon-γ and inducible nitric oxide synthase in the development and pathology of the nervous system. Prog Neurobiol 1998;56:307-340.
32. Nguyen MD, D'Aigle T, Gowing G, Julien JP, Rivest S: Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis. J Neurosci 2004;24:1340-1349.
33. Nguyen MD, Julien JP, Rivest S: Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic rnterleukin-1β in neurodegeneration. Ann Neurol 2001;50:630-639.
34. Ono K, Han J: The p38 signal transduction pathway: activation and function. Cell Signal 2000;12:1-13.
35. Pasinelli P, Belford ME, Lennon N, Bacskai BJ, Hyman BT, Trotti D, Brown RH Jr: Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria. Neuron 2004;43:19-30.
36. Pehar M, Cassina P, Vargas MR, Castellanos R, Viera L, Beckman JS, Estevez AG, Barbeito L: Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis. J Neurochem 2004;89:464-473.
37. Poloni M, Facchetti D, Mai R, Micheli A, Agnoletti L, Francolini G, Mora G, Camana C, Mazzini L, Bachetti T: Circulating levels of tumour necrosis factor-α and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis. Neurosci Lett 2000;287:211-214.
38. Pramatarova A, Laganiere J, Roussel J, Brisebois K, Rouleau GA: Neuron-specific expression of mutant superoxide dismutase-1 in transgenic mice does not lead to motor impairment. J Neurosci 2001;21:3369-3374.
39. Raivich G, Liu ZQ, Kloss CU, Labow M, Bluethmann H, Bohatschek M: Cytotoxic potential of proinflammatory cytokines: combined deletion of TNF receptors TNFR1 and TNFR2 prevents motoneuron cell death after facial axotomy in adult mouse. Exp Neurol 2002;178:186-193.
40. Raoul C, Estevez AG, Nishimune H, Cleveland DW, deLapeyriere O, Henderson CE, Haase G, Pettmann B: Motoneuron death triggered by a specific pathway downstream of Fas potentiation by ALS-linked SOD1 mutations. Neuron 2002;35:1067-1083.
41. Robertson J, Beaulieu JM, Doroudchi MM, Durham HD, Julien JP, Mushynski WE: Apoptotic death of neurons exhibiting peripherin aggregates is mediated by the proinflammatory cytokine tumor necrosis factor-α. J Cell Biol 2001;155:217-226.
42. Rothstein JD, Van Kammen M, Levey AI, Martin LJ, Kuncl RW: Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann Neurol 1995;38:73-84.
43. Schiffer D, Fiano V: Astrogliosis in ALS: Possible interpretations according to pathogenetic hypotheses. Amyotroph Lateral Scler Other Motor Neuron Disord 2004;5:22-25.
44. Seeburger JL, Tarras S, Natter H, Springer JE: Spinal cord motoneurons express p75NTRR and p145trkB mRNA in amyotrophic lateral sclerosis. Brain Res 1993;621:111-115.
45. Son M, Fathallah-Shaykh HM, Elliott JL: Survival in a transgenic model of FALS is independent of iNOS expression. Ann Neurol 2001;50:273.
46. Torcia M, De Chiara G, Nencioni L, Ammendola S, Labardi D, Lucibello M, Rosini P, Marlier LN, Bonini P, Dello Sbarba P, Palamara AT, Zambrano N, Russo T, Garaci E, Cozzolino F: Nerve growth factor inhibits apoptosis in memory B lymphocytes via inactivation of p38 MAPK, prevention of Bcl-2 phosphorylation, and cytochrome c release. J Biol Chem 2001;276:39027-39036.
47. Tortarolo M, Veglianese P, Calvaresi N, Botturi A, Rossi C, Giorgini A, Migheli A, Bendotti C: Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression. Mol Cell Neurosci 2003;23:180-192.
48. 11C](R)-PK11195 positron emission tomography study. Neurobiol Dis 2004;15:601-609.
49. Wengenack TM, Holasek SS, Montano CM, Gregor D, Curran GL, Poduslo JF: Activation of programmed cell death markers in ventral horn motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in a transgenic mouse model. Brain Res 2004;1027:73-86.
50. West M, Mhatre M, Ceballos A, Floyd RA, Grammas P, Gabbita SP, Hamdheydari L, Mai T, Mou S, Pye QN, Stewart C, West S, Williamson KS, Zemlan F, Hensley K: The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor-α activation of microglia and extends survival of G93A-SOD1 transgenic mice. J Neurochem 2004;91:133-143.
51. Williamson AJ, Dibling BC, Boyne JR, Selby P, Burchill SA: Basic fibroblast growth factor-induced cell death is effected through sustained activation of p38MAPK and up-regulation of the death receptor p75NTR. J Biol Chem 2004;279:47912-47928.
52. Xie Z, Smith CJ, Van Eldik LJ: Activated glia induce neuron death via MAP kinase signaling pathways involving JNK and p38. Glia 2004;45:170-179.