Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

Nature Genetics

Volumn 46, Issue 2, 2014, Pages 152-160

  Kim, Hyung Jun ^a,e   Raphael, Alya R ^b   Ladow, Eva S ^c   Mcgurk, Leeanne ^a   Weber, Ross A ^a   Trojanowski, John Q ^d   Lee, Virginia M Y ^d   Finkbeiner, Steven ^c   Gitler, Aaron D ^b   Bonini, Nancy M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GLADSTONE INSTITUTE OF NEUROLOGICAL DISEASE   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e Korea Brain Research Institute (KBRI)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

7 METHYL 5 [1 [[3 (TRIFLUOROMETHYL)PHENYL]ACETYL] 2,3 DIHYDRO 1H INDOL 5 YL] 7H PYRROLO[2,3 D]PYRIMIDIN 4 AMINE; ATAXIN 2; BINDING PROTEIN; CYTOPLASM PROTEIN; GSK 2606414; INITIATION FACTOR 2ALPHA; PROTEIN KINASE INHIBITOR; PROTEIN PABPC1; PYRROLO[2,3 D]PYRIMIDINE DERIVATIVE; TAR DNA BINDING PROTEIN; UNCLASSIFIED DRUG;

ADULT; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DROSOPHILA; DRUG EFFICACY; ENHANCER REGION; GENE FUNCTION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; SCREENING; SPINAL CORD MOTONEURON; SUPPRESSOR GENE; TDP 43 PROTEINOPATHY;

DROSOPHILA MELANOGASTER; MAMMALIA; SACCHAROMYCES CEREVISIAE;

ADENINE; AMYOTROPHIC LATERAL SCLEROSIS; ANALYSIS OF VARIANCE; ANIMALS; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; EUKARYOTIC INITIATION FACTOR-2; GENE ONTOLOGY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INDOLES; LUMINESCENT PROTEINS; MOTOR NEURONS; NERVE TISSUE PROTEINS; PHOSPHORYLATION; POLY(A)-BINDING PROTEINS; RETINA; RNA INTERFERENCE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SMALL MOLECULE LIBRARIES; SPINAL CORD;

EID: 84895822652     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.2853     Document Type: Article

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