Expression of zinc-deficient human superoxide dismutase in Drosophila neurons produces a locomotor defect linked to mitochondrial dysfunction

Neurobiology of Aging

Volumn 34, Issue 10, 2013, Pages 2322-2330

  Bahadorani, Sepehr ^a,b   Mukai, Spencer T ^b   Rabie, Jason ^a   Beckman, Joseph S ^c   Phillips, John P ^d   Hilliker, Arthur J ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b YORK UNIVERSITY   (Canada)

^c OREGON STATE UNIVERSITY   (United States)

^d UNIVERSITY OF GUELPH   (Canada)

Author keywords

Amyotrophic lateral sclerosis (ALS); Fly; Mitochondria; Ndi1; Paraquat; Respiration; Superoxide dismutase (SOD1)

Indexed keywords

ADENOSINE TRIPHOSPHATE; COPPER ZINC SUPEROXIDE DISMUTASE; PARAQUAT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ZINC;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DROSOPHILA; ELECTRON MICROSCOPY; ENZYME ACTIVITY; GENE EXPRESSION; IN VIVO STUDY; LIFESPAN; LOCOMOTION; MALE; MOTOR DYSFUNCTION; NERVE CELL; NERVE DEGENERATION; NONHUMAN; PATHOGENESIS; PHENOTYPE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY CHAIN; SOD1 GENE; WESTERN BLOTTING; ZINC DEFICIENCY;

AMYOTROPHIC LATERAL SCLEROSIS (ALS); FLY; MITOCHONDRIA; NDI1; PARAQUAT; RESPIRATION; SUPEROXIDE DISMUTASE (SOD1);

ADENOSINE TRIPHOSPHATE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DROSOPHILA; FEMALE; GENE EXPRESSION; MALE; MITOCHONDRIA; MITOCHONDRIAL DISEASES; MOTOR ACTIVITY; MOVEMENT DISORDERS; MUTATION; SUPEROXIDE DISMUTASE; VACUOLES; ZINC;

EID: 84879885490     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2013.03.024     Document Type: Article

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