Identification of ter94, Drosophila VCP, as a modulator of polyglutamine-induced neurodegeneration

Cell Death and Differentiation

Volumn 9, Issue 3, 2002, Pages 264-273

  Higashiyama, H ^a,c,f   Hirose, F ^e   Yamaguchi, M ^e   Inoue, Y H ^e   Fujikake, N ^a,b   Matsukage, A ^e   Kakizuka, A ^a,c,d  

^a OSAKA BIOSCIENCE INSTITUTE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d Aichi Cancer Center Research Institute ^*

^e AICHI CANCER CENTER HOSPITAL   (Japan)

^f Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

Misfold protein; Neurodegeneration; Polyglutamine; Protein accumulation; Ter94 VCP

Indexed keywords

ADENOSINE TRIPHOSPHATASE; MEMBRANE PROTEIN; POLYGLUTAMINE; PROTEIN P53; PROTEIN TER94; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; COMPOUND EYE; CONTROLLED STUDY; CORRELATION FUNCTION; DROSOPHILA; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC CODE; GENETIC SCREENING; HOMOZYGOTE; LARVAL STAGE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FAMILY; SEQUENCE HOMOLOGY; SUPPRESSOR GENE; TRANSGENE;

ANIMALS; APOPTOSIS; CELL CYCLE PROTEINS; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EYE; MUTATION; NEURODEGENERATIVE DISEASES; PEPTIDES; PHENOTYPE; TRINUCLEOTIDE REPEATS;

ANIMALIA;

EID: 0036122933     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400955     Document Type: Article

References (42)

1. Protein precipitation: A common etiology in neurodegenerative disorders?
2. Polyglutamine disease and neuronal cell death
3. Glutamine repeats and neurodegeneration
4. Protein fate in neurodegenerative proteinopathies: Polyglutamine diseases join the (mis)fold
5. Ataxin-1 nuclear localization and aggregation: Role in polyglutamine-induced disease in SCA1 transgenic mice
6. Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions
7. Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation
8. Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin
9. Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells
10. Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone
11. Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription
12. The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
13. The Gln-Ala repeat transcriptional activator CA 150 interacts with huntingtin: Neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis
14. Interference by huntingtin and atrophin-1 with CBP-mediated transcription leading to cellular toxicity
15. Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila
16. Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons
17. Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila
18. Identification of genes that modify ataxin-1-induced neurodegeneration
19. Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70
20. Mechanisms of chaperone suppression of polyglutamine disease: Selectivity, synergy and modulation of protein solubility in Drosophila
21. Genetic suppression of polyglutamine toxicity in Drosophila
22. Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1
23. TER94, a Drosophila homolog of the membrane fusion protein CDC48/p97, is accumulated in nonproliferating cells: In the reproductive organs and in the brain of the imago
24. Membrane fusion proteins are required for oskar mRNA localization in the Drosophila egg chamber
25. Grim, a novel cell death gene in Drosophila
26. Genetic control of programmed cell death in Drosophila
27. The head involution defective gene of Drosophila melanogaster functions in programmed cell death
28. Proapoptotic activity of Caenorhabditis elegans CED-4 protein in Drosophila: Implicated mechanisms for caspase activation
29. Ectopic expression of human p53 inhibits entry into S phase and induces apoptosis in the Drosophila eye imaginal disc
30. The AAA team: Related ATPases with diverse functions
31. Involvement of Valosin-containing Protein, an ATPase Co-purified with ΙκBα and 26 S Proteasome, in Ubiquitin-Proteasome-mediated Degradation of ΙκBα
32. Identification of TER94, an AAA ATPase protein, as a Bam-independent component of the Drosophila fusome
33. A yeast mutant showing diagnostic markers of early and late apoptosis
34. Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis
35. VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration
36. Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes
37. Tyrosine phosphorylation regulates cell cycle-dependent nuclear localization of Cdc48p
38. An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments
39. Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo
40. Triggering of neuronal cell death by accumulation of activated SEK1 on nuclear polyglutamine aggregations in PML bodies
41. Expression of baculovirus P35 prevents cell death in Drosophila