Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 19, 2013, Pages 7778-7783

  Xu, Zihui ^a,b   Poidevin, Mickael ^a   Li, Xuekun ^a   Li, Yujing ^a   Shu, Liqi ^a   Nelson, David L ^c   Li, He ^b   Hales, Chadwick M ^a   Gearing, Marla ^a   Wingo, Thomas S ^a,d   Jin, Peng ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d Department of Verterans Affairs Medical Center ^*  (United States)

Author keywords

Fly model; RNA mediated neurodegeneration

Indexed keywords

HEXANUCLEOTIDE; NUCLEOTIDE; RNA; RNA BINDING PROTEIN; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ARTICLE; CELL DEATH; CEREBELLUM; DROSOPHILA; FRONTOTEMPORAL DEMENTIA; MOUSE; NERVE CELL; NERVE DEGENERATION; NONHUMAN; NUCLEOTIDE REPEAT; PATHOGENESIS; PRIORITY JOURNAL;

FLY MODEL; RNA-MEDIATED NEURODEGENERATION;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BINDING SITES; BRAIN; DNA REPEAT EXPANSION; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EXONS; FRONTOTEMPORAL DEMENTIA; GREEN FLUORESCENT PROTEINS; HUMANS; INTRONS; MICE; MOTOR NEURONS; NERVE TISSUE PROTEINS; NEURONS; OLIGONUCLEOTIDES; OPEN READING FRAMES; PLASMIDS; RNA; RNA-BINDING PROTEINS; TRANSCRIPTION FACTORS;

EID: 84877342215     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1219643110     Document Type: Article

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