Inhibition of p38 mitogen activated protein kinase activation and mutant SOD1G93A-induced motor neuron death

Neurobiology of Disease

Volumn 26, Issue 2, 2007, Pages 332-341

  Dewil, Maarten ^a,b   dela Cruz, Vidal F ^c   Van Den Bosch, Ludo ^a   Robberecht, Wim ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^c Cytokine PharmaSciences Inc   (United States)

Author keywords

ALS; Apoptosis; CNI 1493; Glia; Inflammation; Microglia; Motoneuron; Neurodegeneration; p38 MAPK; Semapimod

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; COPPER ZINC SUPEROXIDE DISMUTASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MUTANT PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; MICROGLIA; MOUSE; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NEUROPATHOLOGY; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD MOTONEURON; TRANSGENIC MOUSE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AXONS; CELL DEATH; CELL SURVIVAL; ENZYME ACTIVATION; ENZYME INHIBITORS; HYDRAZONES; IMIDAZOLES; MICE; MICE, TRANSGENIC; MOTOR NEURONS; MUTATION; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; SUPEROXIDE DISMUTASE;

EID: 34147131311     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2006.12.023     Document Type: Article

References (40)

1. Akerlund K., Erlandsson Harris H., Tracey K.J., Wang H., Fehniger T., Klareskog L., Andersson J., and Andersson U. Anti-inflammatory effects of a new tumour necrosis factor-alpha (TNF-alpha) inhibitor (CNI-1493) in collagen-induced arthritis (CIA) in rats. Clin. Exp. Immunol. 115 (1999) 32-41
2. Amin A.R., Attur M.G., Thakker G.D., Patel P.D., Vyas P.R., Patel R.N., Patel I.R., and Abramson S.B. A novel mechanism of action of tetracyclines: effects on nitric oxide synthases. Proc. Natl. Acad Sci. U. S. A. 93 (1996) 14014-14019
3. Bendotti C., Atzori C., Piva R., Tortarolo M., Strong M.J., DeBiasi S., and Migheli A. Activated p38MAPK is a novel component of the intracellular inclusions found in human amyotrophic lateral sclerosis and mutant SOD1 transgenic mice. J. Neuropathol. Exp. Neurol. 63 (2004) 113-119
4. Chen M., Ona V.O., Li M., Ferrante R.J., Fink K.B., Zhu S., Bian J., Guo L., Farrell L.A., Hersch S.M., Hobbs W., Vonsattel J.P., Cha J.H., and Friedlander R.M. Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat. Med. 6 (2000) 797-801
5. Cohen P.S., Nakshatri H., Dennis J., Caragine T., Bianchi M., Cerami A., and Tracey K.J. CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency. Proc. Natl. Acad Sci. U. S. A. 93 (1996) 3967-3971
6. Cuenda A., Rouse J., Doza Y.N., Meier R., Cohen P., Gallagher T.F., Young P.R., and Lee J.C. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364 (1995) 229-233
7. Denham W., Yang J., Wang H., Botchkina G., Tracey K.J., and Norman J. Inhibition of p38 mitogen activate kinase attenuates the severity of pancreatitis-induced adult respiratory distress syndrome. Crit. Care Med. 28 (2000) 2567-2572
8. Du Y., Ma Z., Lin S., Dodel R.C., Gao F., Bales K.R., Triarhou L.C., Chernet E., Perry K.W., Nelson D.L., Luecke S., Phebus L.A., Bymaster F.P., and Paul S.M. Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Proc. Natl. Acad Sci. U. S. A. 98 (2001) 14669-14674
9. Feijoo C., Campbell D.G., Jakes R., Goedert M., and Cuenda A. Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly. J. Cell Sci. 118 (2005) 397-408
10. Ferrer I. Stress kinases involved in tau phosphorylation in Alzheimer's disease, tauopathies and APP transgenic mice. Neurotox. Res. 6 (2004) 469-475
11. Fischer L.R., Culver D.G., Tennant P., Davis A.A., Wang M., Castellano-Sanchez A., Khan J., Polak M.A., and Glass J.D. Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man. Exp. Neurol. 185 (2004) 232-240
12. Gabler W.L., and Creamer H.R. Suppression of human neutrophil functions by tetracyclines. J. Periodontal. Res. 26 (1991) 52-58
13. Gould T.W., Buss R.R., Vinsant S., Prevette D., Sun W., Knudson C.M., Milligan C.E., and Oppenheim R.W. Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS. J. Neurosci. 26 (2006) 8774-8786
14. Gurney M.E., Pu H., Chiu A.Y., DalCanto M.C., Polchow C.Y., Alexander D.D., Caliendo J., Hentati A., Kwon Y.W., Deng H.X., et al. Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation. Science 264 (1994) 1772-1775
15. Holasek S.S., Wengenack T.M., Kandimalla K.K., Montano C., Gregor D.M., Curran G.L., and Poduslo J.F. Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice. Brain Res. 1045 (2005) 185-198
16. Hommes D., van den Blink B., Plasse T., Bartelsman J., Xu C., Macpherson B., Tytgat G., Peppelenbosch M., and Van Deventer S. Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease. Gastroenterology 122 (2002) 7-14
17. Jaarsma D., Holstege J.C., Troost D., Davis M., Kennis J., Haasdijk E.D., and de Jong V.J. Induction of c-Jun immunoreactivity in spinal cord and brainstem neurons in a transgenic mouse model for amyotrophic lateral sclerosis. Neurosci. Lett. 219 (1996) 179-182
18. Krishnan J., Lemmens R., Robberecht W., and Van Den Bosch L. Role of heat shock response and Hsp27 in mutant SOD1-dependent cell death. Exp. Neurol. 200 (2006) 301-310
19. Kriz J., Nguyen M.D., and Julien J.P. Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis. Neurobiol. Dis. 10 (2002) 268-278
20. Lowenberg M., Verhaar A., van den Blink B., ten Kate F., van Deventer S., Peppelenbosch M., and Hommes D. Specific inhibition of c-Raf activity by semapimod induces clinical remission in severe Crohn's disease. J. Immunol. 175 (2005) 2293-2300
21. Martiney J.A., Rajan A.J., Charles P.C., Cerami A., Ulrich P.C., Macphail S., Tracey K.J., and Brosnan C.F. Prevention and treatment of experimental autoimmune encephalomyelitis by CNI-1493, a macrophage-deactivating agent. J. Immunol. 160 (1998) 5588-5595
22. Migheli A., Piva R., Atzori C., Troost D., and Schiffer D. c-Jun, JNK/SAPK kinases and transcription factor NF-kappa B are selectively activated in astrocytes, but not motor neurons, in amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol. 56 (1997) 1314-1322
23. Milligan E.D., O'Connor K.A., Armstrong C.B., Hansen M.K., Martin D., Tracey K.J., Maier S.F., and Watkins L.R. Systemic administration of CNI-1493, a p38 mitogen-activated protein kinase inhibitor, blocks intrathecal human immunodeficiency virus-1 gp120-induced enhanced pain states in rats. J. Pain 2 (2001) 326-333
24. Pasinelli P., and Brown R.H. Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nat. Rev., Neurosci. 7 (2006) 710-723
25. Raoul C., Estevez A.G., Nishimune H., Cleveland D.W., deLapeyriere O., Henderson C.E., Haase G., and Pettmann B. Motoneuron death triggered by a specific pathway downstream of Fas potentiation by ALS-linked SOD1 mutations. Neuron 35 (2002) 1067-1083
26. Raoul C., Barthelemy C., Couzinet A., Hancock D., Pettmann B., and Hueber A.O. Expression of a dominant negative form of Daxx in vivo rescues motoneurons from Fas (CD95)-induced cell death. J. Neurobiol. 62 (2005) 178-188
27. Reis K., Halldin J., Fernaeus S., Pettersson C., and Land T. NADPH oxidase inhibitor diphenyliodonium abolishes lipopolysaccharide-induced down-regulation of transferrin receptor expression in N2a and BV-2 cells. J. Neurosci. Res. 84 5 (2006) 1047-1052
28. Sagot Y., Dubois-Dauphin M., Tan S.A., de Bilbao F., Aebischer P., Martinou J.C., and Kato A.C. Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease. J. Neurosci. 15 (1995) 7727-7733
29. Tikka T., Fiebich B.L., Goldsteins G., Keinanen R., and Koistinaho J. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J. Neurosci. 21 (2001) 2580-2588
30. Tortarolo M., Veglianese P., Calvaresi N., Botturi A., Rossi C., Giorgini A., Migheli A., and Bendotti C. Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression. Mol. Cell. Neurosci. 23 (2003) 180-192
31. Van Den Bosch L., Schwaller B., Vleminckx V., Meijers B., Stork S., Ruehlicke T., Van Houtte E., Klaassen H., Celio M.R., Missiaen L., Robberecht W., and Berchtold M.W. Protective effect of parvalbumin on excitotoxic motor neuron death. Exp. Neurol. 174 (2002) 150-161
32. Van Den Bosch L., Tilkin P., Lemmens G., and Robberecht W. Minocycline delays disease onset and mortality in a transgenic model of ALS. NeuroReport 13 (2002) 1067-1070
33. Van Den Bosch L., Storkebaum E., Vleminckx V., Moons L., Vanopdenbosch L., Scheveneels W., Carmeliet P., and Robberecht W. Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration. Neurobiol. Dis. 17 (2004) 21-28
34. Veglianese P., Lo Coco D., Bao Cutrona M., Magnoni R., Pennacchini D., Pozzi B., Gowing G., Julien J.P., Tortarolo M., and Bendotti C. Activation of the p38MAPK cascade is associated with upregulation of TNF alpha receptors in the spinal motor neurons of mouse models of familial ALS. Mol. Cell. Neurosci. 31 (2006) 218-231
35. Virgo L., and de Belleroche J. Induction of the immediate early gene c-jun in human spinal cord in amyotrophic lateral sclerosis with concomitant loss of NMDA receptor NR-1 and glycine transporter mRNA. Brain Res. 676 (1995) 196-204
36. Wu Q., Chen M., Buchwald M., and Phillips R.A. A simple, rapid method for isolation of high quality genomic DNA from animal tissues. Nucleic Acids Res. 23 (1995) 5087-5088
37. Yrjanheikki J., Keinanen R., Pellikka M., Hokfelt T., and Koistinaho J. Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc. Natl. Acad Sci. U. S. A. 95 (1998) 15769-15774
38. Yrjanheikki J., Tikka T., Keinanen R., Goldsteins G., Chan P.H., and Koistinaho J. A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc. Natl. Acad Sci. U. S. A. 96 (1999) 13496-13500
39. Zhu S., Stavrovskaya I.G., Drozda M., Kim B.Y., Ona V., Li M., Sarang S., Liu A.S., Hartley D.M., Wu du C., Gullans S., Ferrante R.J., Przedborski S., Kristal B.S., and Friedlander R.M. Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature 417 (2002) 74-78
40. Zinser E., Turza N., and Steinkasserer A. CNI-1493 mediated suppression of dendritic cell activation in vitro and in vivo. Immunobiology 209 (2004) 89-97