-
1
-
-
5644283296
-
Role of chemopreventive agents in cancer therapy
-
Dorai,T. et al. (2004) Role of chemopreventive agents in cancer therapy. Cancer Lett., 215, 129-140.
-
(2004)
Cancer Lett
, vol.215
, pp. 129-140
-
-
Dorai, T.1
-
2
-
-
33646028804
-
Molecular targets of dietary agents for prevention and therapy of cancer
-
Aggarwal,B.B. et al. (2006) Molecular targets of dietary agents for prevention and therapy of cancer. Biochem. Pharmacol., 71 1397-1421.
-
(2006)
Biochem. Pharmacol
, vol.71
, pp. 1397-1421
-
-
Aggarwal, B.B.1
-
3
-
-
0031561513
-
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
-
Jang,M. et al. (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science, 275, 218-220.
-
(1997)
Science
, vol.275
, pp. 218-220
-
-
Jang, M.1
-
4
-
-
20344394925
-
Resveratrol and breast cancer chemoprevention: Molecular mechanisms
-
Le Corre,L. et al. (2005) Resveratrol and breast cancer chemoprevention: Molecular mechanisms. Mol. Nutr. Food Res., 49 462-471.
-
(2005)
Mol. Nutr. Food Res
, vol.49
, pp. 462-471
-
-
Le Corre, L.1
-
5
-
-
22844450866
-
Resveratrol as an anticancer nutrient: Molecular basis, open questions and promises
-
Signorelli,P. et al. (2005) Resveratrol as an anticancer nutrient: molecular basis, open questions and promises. J. Nutr. Biochem., 16, 449-466.
-
(2005)
J. Nutr. Biochem
, vol.16
, pp. 449-466
-
-
Signorelli, P.1
-
6
-
-
1642576201
-
Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol
-
Fulda,S. et al. (2004) Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol. Cancer Res., 64, 337-346.
-
(2004)
Cancer Res
, vol.64
, pp. 337-346
-
-
Fulda, S.1
-
7
-
-
0036733776
-
Suppression of 7,12-dimethylbenz(a anthracene-induced mammary carcinogenesis in rats by resveratrol: Role of nuclear factor-κB, cyclooxygenase 2, and matrix metalloprotease 9
-
Banerjee,S. et al. (2002) Suppression of 7,12-dimethylbenz(a anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-κB, cyclooxygenase 2, and matrix metalloprotease 9. Cancer Res., 62, 4945-4954.
-
(2002)
Cancer Res
, vol.62
, pp. 4945-4954
-
-
Banerjee, S.1
-
8
-
-
19444362368
-
Genotoxicity of phytoestrogens
-
Stopper,H. et al. (2005) Genotoxicity of phytoestrogens. Mutat. Res., 574, 139-155.
-
(2005)
Mutat. Res
, vol.574
, pp. 139-155
-
-
Stopper, H.1
-
9
-
-
1542375450
-
Correlation of sister chromatid exchange formation through homologous recombination with ribonucleotide reductase inhibition
-
Matsuoka,A. et al. (2004) Correlation of sister chromatid exchange formation through homologous recombination with ribonucleotide reductase inhibition. Mutat. Res., 547, 101-107.
-
(2004)
Mutat. Res
, vol.547
, pp. 101-107
-
-
Matsuoka, A.1
-
10
-
-
0036337997
-
DNA substrate dependence of p53-mediated regulation of double-strand break repair
-
Akyüz,N. et al. (2002) DNA substrate dependence of p53-mediated regulation of double-strand break repair. Mol. Cell. Biol., 22 6306-6317.
-
(2002)
Mol. Cell. Biol
, vol.22
, pp. 6306-6317
-
-
Akyüz, N.1
-
11
-
-
0032076190
-
Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
-
Varon,R. et al. (1998) Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell, 93, 467-476.
-
(1998)
Cell
, vol.93
, pp. 467-476
-
-
Varon, R.1
-
12
-
-
2442477786
-
P53's double life: Transactivation-independent repression of homologous recombination
-
Bertrand,P. et al. (2004) P53's double life: transactivation-independent repression of homologous recombination. Trends Genet., 20, 235-243.
-
(2004)
Trends Genet
, vol.20
, pp. 235-243
-
-
Bertrand, P.1
-
13
-
-
11244344381
-
P53: Traffic cop at the crossroads of DNA repair and recombination
-
Sengupta,S. et al. (2005) P53: Traffic cop at the crossroads of DNA repair and recombination. Nat. Rev. Mol. Cell Biol., 6, 44-55.
-
(2005)
Nat. Rev. Mol. Cell Biol
, vol.6
, pp. 44-55
-
-
Sengupta, S.1
-
14
-
-
33644927601
-
P53 in recombination and repair
-
Gatz,S.A. et al. (2006) P53 in recombination and repair. Cell Death Differ., 13, 1003-1016.
-
(2006)
Cell Death Differ
, vol.13
, pp. 1003-1016
-
-
Gatz, S.A.1
-
15
-
-
3242883729
-
The p53 response to DNA damage
-
Meek,D.W. (2004) The p53 response to DNA damage. DNA Repair (Amst. 3, 1049-1056.
-
(2004)
DNA Repair (Amst
, vol.3
, pp. 1049-1056
-
-
Meek, D.W.1
-
16
-
-
25144469291
-
The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM
-
Paull,T.T. et al. (2005) The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM. Cell Cycle, 4, 737-740.
-
(2005)
Cell Cycle
, vol.4
, pp. 737-740
-
-
Paull, T.T.1
-
17
-
-
33645814188
-
P53 modulates homologous recombination by transcriptional regulation of the Rad51 gene
-
Arias-Lopez,C. et al. (2006) P53 modulates homologous recombination by transcriptional regulation of the Rad51 gene. EMBO Rep., 7, 219-224.
-
(2006)
EMBO Rep
, vol.7
, pp. 219-224
-
-
Arias-Lopez, C.1
-
18
-
-
0033199892
-
Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine
-
Sarkaria,J.N. et al. (1999) Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res., 59, 4375-4382.
-
(1999)
Cancer Res
, vol.59
, pp. 4375-4382
-
-
Sarkaria, J.N.1
-
19
-
-
2442555209
-
Double strand break repair by homologous recombination is regulated by cell cycle-independent signaling via ATM in human glioma cells
-
Golding,S.E. et al. (2004) Double strand break repair by homologous recombination is regulated by cell cycle-independent signaling via ATM in human glioma cells. J. Biol. Chem., 279 15402-15410.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 15402-15410
-
-
Golding, S.E.1
-
20
-
-
1242317867
-
Caffeine inhibits homology-directed repair of I-SceI-induced DNA double-strand breaks
-
Wang,H. et al. (2004) Caffeine inhibits homology-directed repair of I-SceI-induced DNA double-strand breaks. Oncogene, 23, 824-834.
-
(2004)
Oncogene
, vol.23
, pp. 824-834
-
-
Wang, H.1
-
21
-
-
0034650582
-
Atm deficiency causes increased frequency of intra-chromosomal homologous recombination in mice
-
Bishop,A.J. et al. (2000) Atm deficiency causes increased frequency of intra-chromosomal homologous recombination in mice. Cancer Res., 60, 395-399.
-
(2000)
Cancer Res
, vol.60
, pp. 395-399
-
-
Bishop, A.J.1
-
22
-
-
4444313808
-
The rate of extrachromosomal homologous recombination within a novel reporter plasmid is elevated in cells lacking functional ATM protein
-
Drexler,G.A. et al. (2004) The rate of extrachromosomal homologous recombination within a novel reporter plasmid is elevated in cells lacking functional ATM protein. DNA Repair (Amst.), 3, 1345-1353.
-
(2004)
DNA Repair (Amst.)
, vol.3
, pp. 1345-1353
-
-
Drexler, G.A.1
-
23
-
-
0034141562
-
The controlling role of ATM in homologous recombinational repair of DNA damage
-
Morrison,C. et al. (2000) The controlling role of ATM in homologous recombinational repair of DNA damage. EMBO J., 19 463-471.
-
(2000)
EMBO J
, vol.19
, pp. 463-471
-
-
Morrison, C.1
-
24
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
Satoh,Y. (2003) ATM and related protein kinases: Safeguarding genome integrity. Nat. Rev. Cancer, 3, 155-168.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 155-168
-
-
Satoh, Y.1
-
25
-
-
29144450333
-
s allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: Implications for the Mre11 complex as a DNA damage sensor
-
s allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. Genes Dev. 19, 3043-3054.
-
(2005)
Genes Dev
, vol.19
, pp. 3043-3054
-
-
Morales, M.1
-
26
-
-
13944277701
-
The life and death of DNA-PK
-
Collis,S.J. et al. (2004) The life and death of DNA-PK. Oncogene, 24, 949-961.
-
(2004)
Oncogene
, vol.24
, pp. 949-961
-
-
Collis, S.J.1
-
27
-
-
17244367849
-
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
-
Bartkova,J. et al. (2005) DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature, 434 864-870.
-
(2005)
Nature
, vol.434
, pp. 864-870
-
-
Bartkova, J.1
-
28
-
-
30344463835
-
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
-
Jazayeri,A. et al. (2006) ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat. Cell Biol., 8, 37-45.
-
(2006)
Nat. Cell Biol
, vol.8
, pp. 37-45
-
-
Jazayeri, A.1
-
29
-
-
0035933774
-
Specific structural determinants are responsible for the antioxidant activity and cell cycle effects of resveratrol
-
Stivala,L.A. et al. (2001) Specific structural determinants are responsible for the antioxidant activity and cell cycle effects of resveratrol. J. Biol. Chem., 276, 22586-22594.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 22586-22594
-
-
Stivala, L.A.1
-
30
-
-
22544463089
-
Inhibition of mammalian DNA polymerases by resveratrol: Mechanism and structural determinants
-
Locatelli,G.A. et al. (2005) Inhibition of mammalian DNA polymerases by resveratrol: Mechanism and structural determinants. Biochem J., 389, 259-268.
-
(2005)
Biochem J
, vol.389
, pp. 259-268
-
-
Locatelli, G.A.1
-
31
-
-
9744220428
-
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to γH2AX foci
-
Riballo,E. et al. (2004) A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to γH2AX foci. Mol. Cell, 16, 715-724.
-
(2004)
Mol. Cell
, vol.16
, pp. 715-724
-
-
Riballo, E.1
-
32
-
-
0242576442
-
Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells
-
O'Prey,J. et al. (2003) Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells. Biochem. Pharmacol., 66, 2075-2088.
-
(2003)
Biochem. Pharmacol
, vol.66
, pp. 2075-2088
-
-
O'Prey, J.1
-
33
-
-
0842303315
-
The isoflavonoids genistein and quercetin activate different stress signalling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX
-
Ye,R. et al. (2004) The isoflavonoids genistein and quercetin activate different stress signalling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. DNA Repair (Amst.), 3, 235-244.
-
(2004)
DNA Repair (Amst.)
, vol.3
, pp. 235-244
-
-
Ye, R.1
-
34
-
-
27744485649
-
Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-chk1/2-Cdc25C pathway as a central mechanism for S-phase arrest in human ovarian carcinoma Ovcar-3 cells
-
Tyagi,A. et al. (2005) Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-chk1/2-Cdc25C pathway as a central mechanism for S-phase arrest in human ovarian carcinoma Ovcar-3 cells. Carcinogenesis, 26, 1978-1987.
-
(2005)
Carcinogenesis
, vol.26
, pp. 1978-1987
-
-
Tyagi, A.1
-
35
-
-
13244287780
-
Nbs1 is required for ATR-dependent phosphorylation events
-
Stiff,T. et al. (2005) Nbs1 is required for ATR-dependent phosphorylation events. EMBO J., 24, 199-208.
-
(2005)
EMBO J
, vol.24
, pp. 199-208
-
-
Stiff, T.1
-
36
-
-
24944576230
-
Rad50 depletion impacts upon ATR-dependent DNA damage response
-
Zhong,H. et al. (2005) Rad50 depletion impacts upon ATR-dependent DNA damage response. Hum Mol. Genet., 14, 2685-2693.
-
(2005)
Hum Mol. Genet
, vol.14
, pp. 2685-2693
-
-
Zhong, H.1
-
37
-
-
10344263324
-
Recombination proteins in yeast
-
Krogh,B.O. et al. (2004) Recombination proteins in yeast. Annu. Rev. Genet., 38, 233-271.
-
(2004)
Annu. Rev. Genet
, vol.38
, pp. 233-271
-
-
Krogh, B.O.1
-
38
-
-
0037038362
-
Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells
-
Tauchi,H. et al. (2002) Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells. Nature, 420, 93-98.
-
(2002)
Nature
, vol.420
, pp. 93-98
-
-
Tauchi, H.1
-
39
-
-
30344432122
-
Impaired DNA double strand break repair in cells from Nijmegen breakage syndrome patients
-
Howlett,N.G. et al. (2006) Impaired DNA double strand break repair in cells from Nijmegen breakage syndrome patients. DNA Repair (Amst 5, 251-257.
-
(2006)
DNA Repair (Amst
, vol.5
, pp. 251-257
-
-
Howlett, N.G.1
-
40
-
-
33751583362
-
Conditional deletion of Nbs1 in routine cells reveals its role in branching repair pathways of DNA double-strand breaks
-
Yang,Y.G. et al. (2006) Conditional deletion of Nbs1 in routine cells reveals its role in branching repair pathways of DNA double-strand breaks. EMBO J., 25, 5527-5538.
-
(2006)
EMBO J
, vol.25
, pp. 5527-5538
-
-
Yang, Y.G.1
-
41
-
-
34548496891
-
Homologous recombination repairis regulated by domains at the N- and C-terminus of NBSl and is dissociated with ATM functions
-
Sakamoto,S. et al. (2007) Homologous recombination repairis regulated by domains at the N- and C-terminus of NBSl and is dissociated with ATM functions. Oncogene, 26, 6002-6009.
-
(2007)
Oncogene
, vol.26
, pp. 6002-6009
-
-
Sakamoto, S.1
-
42
-
-
0037080679
-
Sensing of intermediates in V(D)J recombination by ATM
-
Perkins,E.J. et al. (2002) Sensing of intermediates in V(D)J recombination by ATM. Genes Dev., 16, 159-164.
-
(2002)
Genes Dev
, vol.16
, pp. 159-164
-
-
Perkins, E.J.1
-
43
-
-
0037379690
-
Resveratrol increases serine15-phosphorylated but transcriptionally impaired p53 and induces a reversible DNA replication block in serum-activated vascular smooth endothelial muscle cells
-
Haider,U.G.B. et al. (2003) Resveratrol increases serine15-phosphorylated but transcriptionally impaired p53 and induces a reversible DNA replication block in serum-activated vascular smooth endothelial muscle cells. Mol. Pharmacol., 63, 925-932.
-
(2003)
Mol. Pharmacol
, vol.63
, pp. 925-932
-
-
Haider, U.G.B.1
-
44
-
-
33644851083
-
Poly(ADP-RIBOSE) polymerase-1 (Parp-1) antagonizes topoisomerase I-dependent recombination stimulation by p53
-
Baumann,C. et al. (2006) Poly(ADP-RIBOSE) polymerase-1 (Parp-1) antagonizes topoisomerase I-dependent recombination stimulation by p53. Nucleic Acids Res., 34, 1036-1049.
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 1036-1049
-
-
Baumann, C.1
-
45
-
-
4344587175
-
Prevention and repair of DNA damage by selected phytochemicals as measured by single cell gel electrophoresis
-
Chakraborty,S. et al. (2004) Prevention and repair of DNA damage by selected phytochemicals as measured by single cell gel electrophoresis. J. Environ. Pathol. Toxicol. Oncol., 23, 215-226.
-
(2004)
J. Environ. Pathol. Toxicol. Oncol
, vol.23
, pp. 215-226
-
-
Chakraborty, S.1
-
46
-
-
30644475948
-
Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA-breakage: A putative mechanism for anticancer properties
-
Amzi,A.S. et al. (2006) Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA-breakage: A putative mechanism for anticancer properties. FEBS Lett., 580, 533-538.
-
(2006)
FEBS Lett
, vol.580
, pp. 533-538
-
-
Amzi, A.S.1
-
47
-
-
33745917711
-
Modulation of DNA intercalation by resveratrol and genistein
-
Usha,S. et al. (2006) Modulation of DNA intercalation by resveratrol and genistein. Mol. Cell Biochem. 284, 57-64.
-
(2006)
Mol. Cell Biochem
, vol.284
, pp. 57-64
-
-
Usha, S.1
-
48
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist,C.J. et al. (2003) DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature, 421, 499-506.
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
-
49
-
-
17244366865
-
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
-
Gorgoulis,V.G. et al. (2005) Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature, 434, 907-913.
-
(2005)
Nature
, vol.434
, pp. 907-913
-
-
Gorgoulis, V.G.1
-
50
-
-
34548438445
-
Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals
-
Howells,L.M. et al. (2007) Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals. Acta Pharmacol. Sin., 28, 1274-1304.
-
(2007)
Acta Pharmacol. Sin
, vol.28
, pp. 1274-1304
-
-
Howells, L.M.1
-
51
-
-
3042568754
-
Resveratrol-induced cellular apoptosis and cell cycle arrest in neuroblastoma cells and antitumor effects on neuroblastoma in mice
-
Chen,Y. et al. (2004) Resveratrol-induced cellular apoptosis and cell cycle arrest in neuroblastoma cells and antitumor effects on neuroblastoma in mice. Surgery, 136, 57-66.
-
(2004)
Surgery
, vol.136
, pp. 57-66
-
-
Chen, Y.1
-
52
-
-
12344284763
-
Anticancer activity of resveratrol on implanted human primary gastric carcinoma cells in nude mice
-
Zhou,H.B. et al. (2005) Anticancer activity of resveratrol on implanted human primary gastric carcinoma cells in nude mice. World J. Gastroenterol., 11, 280-284.
-
(2005)
World J. Gastroenterol
, vol.11
, pp. 280-284
-
-
Zhou, H.B.1
-
53
-
-
34547882115
-
Resveratrol: A review of preclinical studies for human cancer prevention
-
Athar,M. et al. (2007) Resveratrol: A review of preclinical studies for human cancer prevention. Toxicol. Appl. Pharmacol., 224, 274-283.
-
(2007)
Toxicol. Appl. Pharmacol
, vol.224
, pp. 274-283
-
-
Athar, M.1
|