Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 9, 2007, Pages 3514-3519

  Urano, Jun ^a   Sato, Tatsuhiro ^a   Matsuo, Tomohiko ^b,c   Otsubo, Yoko ^b   Yamamoto, Masayuki ^b   Tamanoi, Fuyuhiko ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF GENEVA   (Switzerland)

^d 1602 Molecular Sciences Building ^*  (United States)

Author keywords

Constitutive active TOR; FAT domain; Kinase domain; Mating; TORC1

Indexed keywords

AMINO ACID DERIVATIVE; GUANINE NUCLEOTIDE BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHOTRANSFERASE; PROTEIN MLST8; PROTEIN RAPTOR; PROTEIN RHB1P; PROTEIN RICTOR; PROTEIN TOR2; RAPAMYCIN; RAS PROTEIN; RHEB PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; GENE; HUMAN; HUMAN CELL; MAMMAL CELL; MATING; MUTANT; NONHUMAN; NUTRIENT; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; RHB1 GENE; SIGNAL TRANSDUCTION; STRESS; WILD TYPE; YEAST;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; DIMERIZATION; GTP PHOSPHOHYDROLASES; HUMANS; IMMUNOPRECIPITATION; MOLECULAR SEQUENCE DATA; POINT MUTATION; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY;

MAMMALIA; RAPTORES; SCHIZOSACCHAROMYCETACEAE;

EID: 33847651745     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0608510104     Document Type: Article

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