-
2
-
-
36749022214
-
The DNA damage response: Ten years after
-
Harper JW, Elledge SJ. The DNA damage response: ten years after. Mol Cell 2007; 28:739-45.
-
(2007)
Mol Cell
, vol.28
, pp. 739-745
-
-
Harper, J.W.1
Elledge, S.J.2
-
3
-
-
0035941021
-
ATR and ATRIP: Partners in checkpoint signaling
-
Cortez D, Guntuku S, Qin J, Elledge SJ. ATR and ATRIP: partners in checkpoint signaling. Science 2001; 294:1713-6.
-
(2001)
Science
, vol.294
, pp. 1713-1716
-
-
Cortez, D.1
Guntuku, S.2
Qin, J.3
Elledge, S.J.4
-
4
-
-
18244385718
-
ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
-
Ball HL, Myers JS, Cortez D. ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. Mol Biol Cell 2005; 16:2372-81.
-
(2005)
Mol Biol Cell
, vol.16
, pp. 2372-2381
-
-
Ball, H.L.1
Myers, J.S.2
Cortez, D.3
-
5
-
-
34250705797
-
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1
-
Delacroix S, Wagner JM, Kobayashi M, Yamamoto K, Karnitz LM. The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. Genes Dev 2007; 21:1472-7.
-
(2007)
Genes Dev
, vol.21
, pp. 1472-1477
-
-
Delacroix, S.1
Wagner, J.M.2
Kobayashi, M.3
Yamamoto, K.4
Karnitz, L.M.5
-
6
-
-
34948889415
-
The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR
-
Lee J, Kumagai A, Dunphy WG. The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. J Biol Chem 2007; 282:28036-44.
-
(2007)
J Biol Chem
, vol.282
, pp. 28036-28044
-
-
Lee, J.1
Kumagai, A.2
Dunphy, W.G.3
-
8
-
-
44849093460
-
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
-
Mordes DA, Glick GG, Zhao R, Cortez D. TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev 2008; 22:1478-89.
-
(2008)
Genes Dev
, vol.22
, pp. 1478-1489
-
-
Mordes, D.A.1
Glick, G.G.2
Zhao, R.3
Cortez, D.4
-
9
-
-
3242708425
-
Regulation of DNA replication by ATR: Signaling in response to DNA intermediates
-
Shechter D, Costanzo V, Gautier J. Regulation of DNA replication by ATR: signaling in response to DNA intermediates. DNA Repair (Amst) 2004; 3:901-8.
-
(2004)
DNA Repair (Amst)
, vol.3
, pp. 901-908
-
-
Shechter, D.1
Costanzo, V.2
Gautier, J.3
-
10
-
-
27544460716
-
Identification and functional analysis of TopBP1 and its homologs
-
Garcia V, Furuya K, Carr AM. Identification and functional analysis of TopBP1 and its homologs. DNA Repair (Amst) 2005; 4:1227-39.
-
(2005)
DNA Repair (Amst)
, vol.4
, pp. 1227-1239
-
-
Garcia, V.1
Furuya, K.2
Carr, A.M.3
-
11
-
-
34547115962
-
Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM
-
Yoo HY, Kumagai A, Shevchenko A, Dunphy WG. Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM. J Biol Chem 2007; 282:17501-6.
-
(2007)
J Biol Chem
, vol.282
, pp. 17501-17506
-
-
Yoo, H.Y.1
Kumagai, A.2
Shevchenko, A.3
Dunphy, W.G.4
-
12
-
-
44849128194
-
How ATR turns on: TopBP1 goes on ATRIP with ATR
-
Burrows AE, Elledge SJ. How ATR turns on: TopBP1 goes on ATRIP with ATR. Genes Dev 2008; 22:1416-21.
-
(2008)
Genes Dev
, vol.22
, pp. 1416-1421
-
-
Burrows, A.E.1
Elledge, S.J.2
-
13
-
-
33845607102
-
The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint
-
Majka J, Niedziela-Majka A, Burgers PM. The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint. Mol Cell 2006; 24:891-901.
-
(2006)
Mol Cell
, vol.24
, pp. 891-901
-
-
Majka, J.1
Niedziela-Majka, A.2
Burgers, P.M.3
-
14
-
-
0032508504
-
Enhanced phosphorylation of p53 by ATM in response to DNA damage
-
Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L, Smorodinsky NI, Prives C, Reiss Y, Shiloh Y, Ziv Y. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 1998; 281:1674-7.
-
(1998)
Science
, vol.281
, pp. 1674-1677
-
-
Banin, S.1
Moyal, L.2
Shieh, S.3
Taya, Y.4
Anderson, C.W.5
Chessa, L.6
Smorodinsky, N.I.7
Prives, C.8
Reiss, Y.9
Shiloh, Y.10
Ziv, Y.11
-
15
-
-
18144452815
-
Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20
-
Priestley A, Beamish HJ, Gell D, Amatucci AG, Muhlmann-Diaz MC, Singleton BK, Smith GC, Blunt T, Schalkwyk LC, Bedford JS, Jackson SP, Jeggo PA, Taccioli GE. Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20. Nucleic Acids Res 1998; 26:1965-73.
-
(1998)
Nucleic Acids Res
, vol.26
, pp. 1965-1973
-
-
Priestley, A.1
Beamish, H.J.2
Gell, D.3
Amatucci, A.G.4
Muhlmann-Diaz, M.C.5
Singleton, B.K.6
Smith, G.C.7
Blunt, T.8
Schalkwyk, L.C.9
Bedford, J.S.10
Jackson, S.P.11
Jeggo, P.A.12
Taccioli, G.E.13
-
16
-
-
0033833810
-
Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro
-
Takahashi T, Hara K, Inoue H, Kawa Y, Tokunaga C, Hidayat S, Yoshino K, Kuroda Y, Yonezawa K. Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro. Genes Cells 2000; 5:765-75.
-
(2000)
Genes Cells
, vol.5
, pp. 765-775
-
-
Takahashi, T.1
Hara, K.2
Inoue, H.3
Kawa, Y.4
Tokunaga, C.5
Hidayat, S.6
Yoshino, K.7
Kuroda, Y.8
Yonezawa, K.9
-
17
-
-
34247260964
-
Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay
-
Morita T, Yamashita A, Kashima I, Ogata K, Ishiura S, Ohno S. Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay. J Biol Chem 2007; 282:7799-808.
-
(2007)
J Biol Chem
, vol.282
, pp. 7799-7808
-
-
Morita, T.1
Yamashita, A.2
Kashima, I.3
Ogata, K.4
Ishiura, S.5
Ohno, S.6
-
18
-
-
15844394846
-
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
-
Falck J, Coates J, Jackson SP. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 2005; 434:605-11.
-
(2005)
Nature
, vol.434
, pp. 605-611
-
-
Falck, J.1
Coates, J.2
Jackson, S.P.3
-
19
-
-
45849105156
-
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
-
Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 2008; 320:1496-501.
-
(2008)
Science
, vol.320
, pp. 1496-1501
-
-
Sancak, Y.1
Peterson, T.R.2
Shaul, Y.D.3
Lindquist, R.A.4
Thoreen, C.C.5
Bar-Peled, L.6
Sabatini, D.M.7
-
20
-
-
1842431822
-
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex
-
Lee JH, Paull TT. Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science 2004; 304:93-6.
-
(2004)
Science
, vol.304
, pp. 93-96
-
-
Lee, J.H.1
Paull, T.T.2
-
21
-
-
0033560796
-
The DNA-dependent protein kinase
-
Smith GC, Jackson SP. The DNA-dependent protein kinase. Genes Dev 1999; 13:916-34.
-
(1999)
Genes Dev
, vol.13
, pp. 916-934
-
-
Smith, G.C.1
Jackson, S.P.2
-
22
-
-
18044381192
-
Rheb binds and regulates the mTOR kinase
-
Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J. Rheb binds and regulates the mTOR kinase. Curr Biol 2005; 15:702-13.
-
(2005)
Curr Biol
, vol.15
, pp. 702-713
-
-
Long, X.1
Lin, Y.2
Ortiz-Vega, S.3
Yonezawa, K.4
Avruch, J.5
-
23
-
-
37549028411
-
DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity
-
Sun Y, Xu Y, Roy K, Price BD. DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity. Mol Cell Biol 2007; 27:8502-9.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 8502-8509
-
-
Sun, Y.1
Xu, Y.2
Roy, K.3
Price, B.D.4
-
24
-
-
45849103487
-
Aven-Dependent Activation of ATM Following DNA Damage
-
Guo JY, Yamada A, Kajino T, Wu JQ, Tang W, Freel CD, Feng J, Chau BN, Wang MZ, Margolis SS, Yoo HY, Wang XF, Dunphy WG, Irusta PM, Hardwick JM, Kornbluth S. Aven-Dependent Activation of ATM Following DNA Damage. Curr Biol 2008; 18:933-42.
-
(2008)
Curr Biol
, vol.18
, pp. 933-942
-
-
Guo, J.Y.1
Yamada, A.2
Kajino, T.3
Wu, J.Q.4
Tang, W.5
Freel, C.D.6
Feng, J.7
Chau, B.N.8
Wang, M.Z.9
Margolis, S.S.10
Yoo, H.Y.11
Wang, X.F.12
Dunphy, W.G.13
Irusta, P.M.14
Hardwick, J.M.15
Kornbluth, S.16
-
25
-
-
0034234924
-
A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells
-
Sekulic A, Hudson CC, Homme JL, Yin P, Otterness DM, Karnitz LM, Abraham RT. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res 2000; 60:3504-13.
-
(2000)
Cancer Res
, vol.60
, pp. 3504-3513
-
-
Sekulic, A.1
Hudson, C.C.2
Homme, J.L.3
Yin, P.4
Otterness, D.M.5
Karnitz, L.M.6
Abraham, R.T.7
-
26
-
-
34447503808
-
Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit
-
Miled N, Yan Y, Hon WC, Perisic O, Zvelebil M, Inbar Y, Schneidman-Duhovny D, Wolfson HJ, Backer JM, Williams RL. Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science 2007; 317:239-42.
-
(2007)
Science
, vol.317
, pp. 239-242
-
-
Miled, N.1
Yan, Y.2
Hon, W.C.3
Perisic, O.4
Zvelebil, M.5
Inbar, Y.6
Schneidman-Duhovny, D.7
Wolfson, H.J.8
Backer, J.M.9
Williams, R.L.10
-
27
-
-
28844448182
-
Oncogenic PI3K deregulates transcription and translation
-
Bader AG, Kang S, Zhao L, Vogt PK. Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 2005; 5:921-9.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 921-929
-
-
Bader, A.G.1
Kang, S.2
Zhao, L.3
Vogt, P.K.4
-
28
-
-
34247877694
-
Function of a conserved checkpoint recruitment domain in ATRIP proteins
-
Ball HL, Ehrhardt MR, Mordes DA, Glick GG, Chazin WJ, Cortez D. Function of a conserved checkpoint recruitment domain in ATRIP proteins. Mol Cell Biol 2007; 27:3367-77.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 3367-3377
-
-
Ball, H.L.1
Ehrhardt, M.R.2
Mordes, D.A.3
Glick, G.G.4
Chazin, W.J.5
Cortez, D.6
-
29
-
-
24744448894
-
ATRIP oligomerization is required for ATR-dependent checkpoint signaling
-
Ball HL, Cortez D. ATRIP oligomerization is required for ATR-dependent checkpoint signaling. J Biol Chem 2005; 280:31390-6.
-
(2005)
J Biol Chem
, vol.280
, pp. 31390-31396
-
-
Ball, H.L.1
Cortez, D.2
-
30
-
-
0037462453
-
The ATRs, ATMs and TORs are giant HEAT repeat proteins
-
Perry J, Kleckner N. The ATRs, ATMs and TORs are giant HEAT repeat proteins. Cell 2003; 112:151-5.
-
(2003)
Cell
, vol.112
, pp. 151-155
-
-
Perry, J.1
Kleckner, N.2
-
31
-
-
33744942683
-
The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM
-
Jiang X, Sun Y, Chen S, Roy K, Price BD. The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM. The Journal of biological chemistry 2006; 281:15741-6.
-
(2006)
The Journal of biological chemistry
, vol.281
, pp. 15741-15746
-
-
Jiang, X.1
Sun, Y.2
Chen, S.3
Roy, K.4
Price, B.D.5
|