Competition between NBS1 and ATMIN Controls ATM Signaling Pathway Choice

Cell Reports

Volumn 2, Issue 6, 2012, Pages 1498-1504

  Zhang, Tianyi ^a   Penicud, Kay ^a   Bruhn, Christopher ^b   Loizou, Joanna I ^a   Kanu, Nnennaya ^a   Wang, Zhao Qi ^b,c   Behrens, Axel ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b FRITZ LIPMANN INSTITUTE   (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ATM INTERACTOR PROTEIN; ATM PROTEIN; MRE11 PROTEIN; MULTIPROTEIN COMPLEX; NIBRIN; PROTEIN; RAD50 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MUTANT; CHROMATIN STRUCTURE; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; EMBRYO; ENZYME ACTIVITY; ENZYME BINDING; ENZYME PHOSPHORYLATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFECT; RADIOSENSITIVITY; SIGNAL TRANSDUCTION;

ANIMALS; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELL LINE; DNA BREAKS, DOUBLE-STRANDED; DNA-BINDING PROTEINS; HUMANS; MICE; MICE, MUTANT STRAINS; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

ATAXIA TELANGIECTASIA;

EID: 84871692987     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2012.11.002     Document Type: Article

References (21)

1. Dar I., Yosha G., Elfassy R., Galron R., Wang Z.Q., Shiloh Y., Barzilai A. Investigation of the functional link between ATM and NBS1 in the DNA damage response in the mouse cerebellum. J. Biol. Chem. 2011, 286:15361-15376.
2. Deng Y., Guo X., Ferguson D.O., Chang S. Multiple roles for MRE11 at uncapped telomeres. Nature 2009, 460:914-918.
3. Derheimer F.A., Kastan M.B. Multiple roles of ATM in monitoring and maintaining DNA integrity. FEBS Lett. 2010, 584:3675-3681.
4. el Marjou F., Janssen K.P., Chang B.H., Li M., Hindie V., Chan L., Louvard D., Chambon P., Metzger D., Robine S. Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis 2004, 39:186-193.
5. Falck J., Coates J., Jackson S.P. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 2005, 434:605-611.
6. Frappart P.O., Tong W.M., Demuth I., Radovanovic I., Herceg Z., Aguzzi A., Digweed M., Wang Z.Q. An essential function for NBS1 in the prevention of ataxia and cerebellar defects. Nat. Med. 2005, 11:538-544.
7. Guo Z., Kozlov S., Lavin M.F., Person M.D., Paull T.T. ATM activation by oxidative stress. Science 2010, 330:517-521.
8. Haigis K., Sage J., Glickman J., Shafer S., Jacks T. The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium. J. Biol. Chem. 2006, 281:638-647.
9. Kanu N., Behrens A. ATMIN defines an NBS1-independent pathway of ATM signalling. EMBO J. 2007, 26:2933-2941.
10. Kanu N., Behrens A. ATMINistrating ATM signalling: regulation of ATM by ATMIN. Cell Cycle 2008, 7:3483-3486.
11. Kanu N., Penicud K., Hristova M., Wong B., Irvine E., Plattner F., Raivich G., Behrens A. The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain. J. Biol. Chem. 2010, 285:38534-38542.
12. Lee J.H., Paull T.T. Activation and regulation of ATM kinase activity in response to DNA double-strand breaks. Oncogene 2007, 26:7741-7748.
13. Loizou J.I., Sancho R., Kanu N., Bolland D.J., Yang F., Rada C., Corcoran A.E., Behrens A. ATMIN is required for maintenance of genomic stability and suppression of B cell lymphoma. Cancer Cell 2011, 19:587-600.
14. Lukas J., Lukas C., Bartek J. More than just a focus: the chromatin response to DNA damage and its role in genome integrity maintenance. Nat. Cell Biol. 2011, 13:1161-1169.
15. McKinnon P.J. ATM and ataxia telangiectasia. EMBO Rep. 2004, 5:772-776.
16. Parrinello S., Samper E., Krtolica A., Goldstein J., Melov S., Campisi J. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat. Cell Biol. 2003, 5:741-747.
17. Sancho R., Jandke A., Davis H., Diefenbacher M.E., Tomlinson I., Behrens A. F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor. Gastroenterology 2010, 139:929-941.
18. Savitsky K., Sfez S., Tagle D.A., Ziv Y., Sartiel A., Collins F.S., Shiloh Y., Rotman G. The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. Hum. Mol. Genet. 1995, 4:2025-2032.
19. Uziel T., Lerenthal Y., Moyal L., Andegeko Y., Mittelman L., Shiloh Y. Requirement of the MRN complex for ATM activation by DNA damage. EMBO J. 2003, 22:5612-5621.
20. Williams G.J., Lees-Miller S.P., Tainer J.A. Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks. DNA Repair (Amst.) 2010, 9:1299-1306.
21. Yang Y.G., Saidi A., Frappart P.O., Min W., Barrucand C., Dumon-Jones V., Michelon J., Herceg Z., Wang Z.Q. Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks. EMBO J. 2006, 25:5527-5538.