Insect-protected event DAS-81419-2 soybean (Glycine max L.) grown in the united states and brazil is compositionally equivalent to nontransgenic soybean

Journal of Agricultural and Food Chemistry

Volumn 63, Issue 7, 2015, Pages 2063-2073

  Fast, Brandon J ^a   Schafer, Ariane C ^b   Johnson, Tempest Y ^a   Potts, Brian L ^c   Herman, Rod A ^a  

^a DOW AGROSCIENCES LLC   (United States)

^b Dow AgroSciences Industrial Ltda   (Brazil)

^c 206 Carnegie Center   (United States)

Author keywords

crop composition; DAS 81419 2; risk assessment; safety evaluation; soybean

Indexed keywords

AMINO ACIDS; CROPS; PLANTS (BOTANY); RISK ASSESSMENT; SAFETY ENGINEERING;

DAS-81419-2; GLYCINE MAX; LEPIDOPTERAN INSECTS; REGULATORY REQUIREMENTS; SAFETY EVALUATIONS; SOYBEAN; TRANSGENIC CROPS; TRANSGENIC SOYBEAN;

NITROGEN FIXATION;

GLYCINE MAX; HEXAPODA;

ANIMAL; BRAZIL; CHEMISTRY; COMPARATIVE STUDY; FOOD SAFETY; GENETICALLY MODIFIED FOOD; GENETICS; GROWTH, DEVELOPMENT AND AGING; INSECT; NUTRITIONAL VALUE; PARASITOLOGY; PHYSIOLOGY; SOYBEAN; TRANSGENIC PLANT; UNITED STATES;

ANIMALS; BRAZIL; FOOD SAFETY; FOOD, GENETICALLY MODIFIED; INSECTS; NUTRITIVE VALUE; PLANTS, GENETICALLY MODIFIED; SOYBEANS; UNITED STATES;

EID: 84923378413     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf505015y     Document Type: Article

References (110)

1. Aronson, A. I. Why Bacillus thuringiensis insecticidal toxins are so effective: unique features of their mode of action FEMS Microbiol. Lett. 2001, 195, 1-8
2. Höfte, H.; Whiteley, H. R. Insecticidal Crystal Proteins of Bacillus thuringiensis Microbiol. Rev. 1989, 53, 242-255
3. Schnepf, E.; Crickmore, N.; Van Rie, J.; Lereclus, D.; Baum, J.; Feitelson, J.; Zeigler, D. R.; Dean, D. H. Bacillus thuringiensis and its pesticidal crystal proteins Microbiol. Mol. Biol. Rev. 1998, 62, 775-806
4. Dröge, W.; Broer, I.; Pühler, A. Transgenic plants containing the phosphinothricin- N -acetyltransferase gene metabolize the herbicide l -phosphinothricin (glufosinate) differently from untransformed plants Planta 1992, 187, 142-151
5. Weber, N.; Halpin, C.; Hannah, L. C.; Jez, J. M.; Kough, J.; Parrott, W. Crop genome plasticity and its relevance to food and feed safety of genetically engineered breeding stacks Plant Physiol. 2012, 160, 1842-1853
6. Schnell, J.; Steele, M.; Bean, J.; Neuspiel, M.; Girard, C.; Dormann, N.; Pearson, C.; Savoie, A.; Bourbonnière, L.; MacDonald, P. A comparative analysis of insertional effects in genetically engineered plants: considerations for pre-market assessments Transgenic Res. 2014, 1-17
7. Herman, R. A.; Phillips, A. M.; Lepping, M. D.; Fast, B. J.; Sabbatini, J. Compositional safety of event DAS-40278-9 (AAD-1) herbicide-tolerant maize GM Crops Food: Biotechnol. Agric. 2010, 1, 294-311
8. Abdeen, A.; Schnell, J.; Miki, B. Transcriptome analysis reveals absence of unintended effects in drought-tolerant transgenic plants overexpressing the transcription factor ABF3 BMC Genomics 2010, 11, 69
9. Baker, J.; Hawkins, N.; Ward, J.; Lovegrove, A.; Napier, J.; Shewry, P.; Beale, M. A metabolomic study of substantial equivalence of field-grown genetically modified wheat Plant Biotechnol. J. 2006, 4, 381-392
10. Berberich, S. A.; Ream, J. E.; Jackson, T. L.; Wood, R.; Stipanovic, R.; Harvey, P.; Patzer, S.; Fuchs, R. L. The composition of insect-protected cottonseed is equivalent to that of conventional cottonseed J. Agric. Food Chem. 1996, 44, 365-371
11. Berman, K. H.; Harrigan, G. G.; Riordan, S. G.; Nemeth, M. A.; Hanson, C.; Smith, M.; Sorbet, R.; Zhu, E.; Ridley, W. P. Compositions of seed, forage, and processed fractions from insect-protected soybean MON 87701 are equivalent to those of conventional soybean J. Agric. Food Chem. 2009, 57, 11360-11369
12. Catchpole, G.; Beckmann, M.; Enot, D.; Mondhe, M.; Zywicki, B.; Taylor, J.; Hardy, N.; Smith, A.; King, R.; Kell, D. Hierarchical metabolomics demonstrates substantial compositional similarity between genetically modified and conventional potato crops Proc. Natl. Acad. Sci. U. S. A. 2005, 102, 14458-14462
13. Coll, A.; Nadal, A.; Collado, R.; Capellades, G.; Kubista, M.; Messeguer, J.; Pla, M. Natural variation explains most transcriptomic changes among maize plants of MON810 and comparable non-GM varieties subjected to two N-fertilization farming practices Plant Mol. Biol. 2010, 73, 349-362
14. Drury, S. M.; Reynolds, T. L.; Ridley, W. P.; Bogdanova, N.; Riordan, S.; Nemeth, M. A.; Sorbet, R.; Trujillo, W. A.; Breeze, M. L. Composition of forage and grain from second-generation insect-protected corn MON 89034 is equivalent to that of conventional corn (Zea mays L.) J. Agric. Food Chem. 2008, 56, 4623-4630
15. El-Khishin, D. A. A. H.; Amina; El Moghazy, G.; Metry, E. A. Assessment of genetically modified potato lines resistant to potato virus Y using compositional analysis and molecular markers Res. J. Agric. Biol. Sci. 2009, 5, 261-271
16. Esposito, F.; Fogliano, V.; Cardi, T.; Carputo, D.; Filippone, E. Glycoalkaloid content and chemical composition of potatoes improved with nonconventional breeding approaches J. Agric. Food Chem. 2002, 50, 1553-1561
17. George, C.; Ridley, W.; Obert, J. Composition of grain and forage from corn rootworm-protected corn event MON 863 is equivalent to that of conventional corn (Zea mays L.) J. Agric. Food Chem. 2004, 52, 4149-4158
18. Hamilton, K. A.; Pyla, P. D.; Breeze, M.; Olson, T.; Li, M. H.; Robinson, E.; Gallagher, S. P.; Sorbet, R.; Chen, Y. Bollgard II cotton: compositional analysis and feeding studies of cottonseed from insect-protected cotton (Gossypium hirsutum L.) producing the Cry1Ac and Cry2Ab2 proteins J. Agric. Food Chem. 2004, 52, 6969-6976
19. Harrigan, G. G.; Ridley, W. P.; Miller, K. D.; Sorbet, R.; Riordan, S. G.; Nemeth, M. A.; Reeves, W.; Pestert, T. A. The forage and grain of MON 87460, a drought-tolerant corn hybrid, are compositionally equivalent to that of conventional corn J. Agric. Food Chem. 2009, 57, 9754-9763
20. Harrigan, G. G.; Ridley, W. P.; Riordan, S. G.; Nemeth, M. A.; Sorbet, R.; Trujillo, W. A.; Breeze, M. L.; Schneider, R. W. Chemical composition of glyphosate-tolerant soybean 40-3-2 grown in Europe remains equivalent with that of conventional soybean (Glycine max L.) J. Agric. Food Chem. 2007, 55, 6160-6168
21. Herman, R.; Storer, N.; Phillips, A.; Prochaska, L.; Windels, P. Compositional assessment of event DAS-59122-7 maize using substantial equivalence Regul. Toxicol. Pharmacol. 2007, 47, 37-47
22. Herman, R. A.; Phillips, A. M.; Collins, R. A.; Tagliani, L. A.; Claussen, F. A.; Graham, C. D.; Bickers, B. L.; Harris, T. A.; Prochaska, L. M. Compositional equivalency of Cry1F corn event TC6275 and conventional corn (Zea mays L.) J. Agric. Food Chem. 2004, 52, 2726-2734
23. Herman, R. A.; Phillips, A. M.; Lepping, M. D.; Sabbatini, J., Compositional safety of DAS-68416-4 (AAD-12) herbicide-tolerant soybean. J. Nutr. Food Sci. 2011, 1:2, DOI 10.4172/215-9600.1000103.
24. Jiao, Z.; Deng, J.; Li, G.; Zhang, Z.; Cai, Z. Study on the compositional differences between transgenic and non-transgenic papaya (Carica papaya L.) J. Food Compos. Anal. 2010, 23, 640-647
25. Khalf, M.; Goulet, C.; Vorster, J.; Brunelle, F.; Anguenot, R.; Fliss, I.; Michaud, D. Tubers from potato lines expressing a tomato Kunitz protease inhibitor are substantially equivalent to parental and transigenic controls Plant Biotechnol. J. 2010, 8, 155-169
26. Kim, J. K.; Chu, S. M.; Kim, S. J.; Lee, D. J.; Lee, S. Y.; Lim, S. H.; Ha, S.-H.; Kweon, S. J.; Cho, H. S. Variation of glucosinolates in vegetable crops of Brassica rapa L. ssp. pekinensis Food Chem. 2010, 119, 423-428
27. Lin, C. H.; Lu, C. T.; Lin, H. T.; Pan, T. M. Safety assessment and detection method of genetically modified Chinese kale (Brassica oleracea cv. alboglabra) J. Agric. Food Chem. 2009, 57, 1876-1881
28. Lundry, D. R.; Ridley, W. P.; Meyer, J. J.; Riordan, S. G.; Nemeth, M. A.; Trujillo, W. A.; Breeze, M. L.; Sorbet, R. Composition of grain, forage, and processed fractions from second-generation glyphosate-tolerant soybean, MON 89788, is equivalent to that of conventional soybean (Glycine max L.) J. Agric. Food Chem. 2008, 56, 4611-4622
29. Malowicki, S. M. M.; Martin, R.; Qian, M. C. Comparison of sugar, acids, and volatile composition in raspberry bushy dwarf virus-resistant transgenic raspberries and the wild type "Meeker" (Rubus idaeus L.) J. Agric. Food Chem. 2008, 56, 6648-6655
30. McCann, M. C.; Liu, K. S.; Trujillo, W. A.; Dobert, R. C. Glyphosate-tolerant soybeans remain compositionally equivalent to conventional soybeans (Glycine max L.) during three years of field testing J. Agric. Food Chem. 2005, 53, 5331-5335
31. McCann, M. C.; Rogan, G. J.; Fitzpatrick, S.; Trujillo, W. A.; Sorbet, R.; Hartnell, G. F.; Riodan, S. G.; Nemeth, M. A. Glyphosate-tolerant alfalfa is compositionally equivalent to conventional alfalfa (Medicago sativa L.) J. Agric. Food Chem. 2006, 54, 7187-7192
32. McCann, M. C.; Trujillo, W. A.; Riordan, S. G.; Sorbet, R.; Bogdanova, N. N.; Sidhu, R. S. Comparison of the forage and grain composition from insect-protected and glyphosate-tolerant MON 88017 corn to conventional corn (Zea mays L.) J. Agric. Food Chem. 2007, 55, 4034-4042
33. Oberdoerfer, R.; Shillito, R.; de Beuckeleer, M.; Mitten, D. Rice (Oryza sativa L.) containing the bar gene is compositionally equivalent to the nontransgenic counterpart J. Agric. Food Chem. 2005, 53, 1457-1465
34. Obert, J. C.; Ridley, W. P.; Schneider, R. W.; Riordan, S. G.; Nemeth, M. A.; Trujillo, W. A.; Breeze, M. L.; Sorbet, R.; Astwood, J. D. The composition of grain and forage from glyphosate tolerant wheat MON 71800 is equivalent to that of conventional wheat (Triticum aestivum L.) J. Agric. Food Chem. 2004, 52, 1375-1384
35. Padgette, S. R.; Taylor, N. B.; Nida, D. L.; Bailey, M. R.; MacDonald, J.; Holden, L. R.; Fuchs, R. L. The composition of glyphosate-tolerant soybean seeds is equivalent to that of conventional soybeans J. Nutr. 1996, 126, 702-716
36. Poerschmann, J.; Rauschen, S.; Langer, U.; Augustin, J.; Górecki, T. Fatty acid patterns of genetically modified Cry3Bb1 expressing Bt-maize MON88017 and its near-isogenic line J. Agric. Food Chem. 2008, 57, 127-132
37. Sidhu, R. S.; Hammond, B. G.; Fuchs, R. L.; Mutz, J.-N.; Holden, L. R.; George, B.; Olson, T. Glyphosate-tolerant corn: the composition and feeding value of grain from glyphosate-tolerant corn is equivalent to that of conventional corn (Zea mays L.) J. Agric. Food Chem. 2000, 48, 2305-2312
38. Tang, M. Z.; Huang, K. L.; Li, X.; Zhou, K.; He, X. Y.; Luo, Y. B. Absence of effect after introducing Bacillus thuringiensis gene on nutritional composition in cottonseed J. Food Sci. 2006, 71, S38-S41
39. Taylor, N. B.; Fuchs, R. L.; MacDonald, J.; Shariff, A. R.; Padgette, S. R. Compositional analysis of glyphosate-tolerant soybeans treated with glyphosate J. Agric. Food Chem. 1999, 47, 4469-4473
40. Venneria, E.; Fanasca, S.; Monastra, G.; Finotti, E.; Ambra, R.; Azzini, E.; Durazzo, A.; Foddai, M. S.; Maiani, G. Assessment of the nutritional values of genetically modified wheat, corn, and tomato crops J. Agric. Food Chem. 2008, 56, 9206-9214
41. Wang, J.; Guo, L. Q.; Lin, J. F. Composition of transgenic Volvariella volvacea tolerant to cold stress is equivalent to that of conventional control J. Agric. Food Chem. 2009, 57, 2392-2396
42. Xin, L.; Xiaoyun, H.; Yunbo, L.; Guoying, X.; Xianbin, J.; Kunlun, H. Comparative analysis of nutritional composition between herbicide-tolerant rice with bar gene and its non-transgenic counterpart J. Food Compos. Anal. 2008, 21, 535-539
43. Zhu, J.; Patzoldt, W. L.; Shealy, R. T.; Vodkin, L. O.; Clough, S. J.; Tranel, P. J. Transcriptome response to glyphosate in sensitive and resistant soybean J. Agric. Food Chem. 2008, 56, 6355-6363
44. Ridley, W. P.; Harrigan, G. G.; Breeze, M. L.; Nemeth, M. A.; Sidhu, R. S.; Glenn, K. C. Evaluation of compositional equivalence for multitrait biotechnology crops J. Agric. Food Chem. 2011, 5865-5876
45. Ridley, W. P.; Sidhu, R. S.; Pyla, P. D.; Nemeth, M. A.; Breeze, M. L.; Astwood, J. D. Comparison of the nutritional profile of glyphosate-tolerant corn event NK603 with that of conventional corn (Zea mays L.) J. Agric. Food Chem. 2002, 50, 7235-7243
46. Wang, Y.; Xu, W.; Zhao, W.; Hao, J.; Luo, Y.; Tang, X.; Zhang, Y.; Huang, K. Comparative analysis of the proteomic and nutritional composition of transgenic rice seeds with Cry1ab/ac genes and their non-transgenic counterparts J. Cereal Sci. 2012, 55, 226-233
47. Frank, T.; Röhlig, R. M.; Davies, H. V.; Barros, E.; Engel, K.-H. Metabolite profiling of maize kernels-genetic modification versus environmental influence J. Agric. Food Chem. 2012, 60, 3005-3012
48. Barros, E.; Lezar, S.; Anttonen, M. J.; Van Dijk, J. P.; Röhlig, R. M.; Kok, E. J.; Engel, K.-H. Comparison of two GM maize varieties with a near-isogenic non-GM variety using transcriptomics, proteomics and metabolomics Plant Biotechnol. J. 2010, 8, 436-451
49. Baudo, M. M.; Lyons, R.; Powers, S.; Pastori, G. M.; Edwards, K. J.; Holdsworth, M. J.; Shewry, P. R. Transgenesis has less impact on the transcriptome of wheat grain than conventional breeding Plant Biotechnol. J. 2006, 4, 369-380
50. Coll, A.; Nadal, A.; Collado, R.; Capellades, G.; Messeguer, J.; Melé, E.; Palaudelmàs, M.; Pla, M. Gene expression profiles of MON810 and comparable non-GM maize varieties cultured in the field are more similar than are those of conventional lines Transgenic Res. 2009, 18, 801-808
51. Coll, A.; Nadal, A.; Palaudelmàs, M.; Messeguer, J.; Melé, E.; Puigdomènech, P.; Pla, M. Lack of repeatable differential expression patterns between MON810 and comparable commercial varieties of maize Plant Mol. Biol. 2008, 68, 105-117
52. Harrigan, G. G.; Lundry, D.; Drury, S.; Berman, K.; Riordan, S. G.; Nemeth, M. A.; Ridley, W. P.; Glenn, K. C. Natural variation in crop composition and the impact of transgenesis Nature Biotechnol. 2010, 28, 402-404
53. Lehesranta, S.; Davies, H.; Shepherd, L.; Nunan, N.; McNicol, J.; Auriola, S.; Koistinen, K.; Suomalainen, S.; Kokko, H.; Karenlampi, S. Comparison of tuber proteomes of potato varieties, landraces, and genetically modified lines Plant Physiol. 2005, 138, 1690-1699
54. Park, H.; Lee, S.; Jeong, H.; Cho, S.; Chun, H.; Back, O.; Kim, D.; Lillehoj, H. The nutrient composition of the herbicide-tolerant green pepper is equivalent to that of the conventional green pepper Nutr. Res. (N. Y.) 2006, 26, 546-548
55. Ricroch, A. E.; Berge, J. B.; Kuntz, M. Evaluation of genetically engineered crops using transcriptomic, proteomic and metabolomic profiling techniques Plant Physiol. 2011, 155, 1752-1761
56. Kim, J.; Ryu, T.; Sohn, S.; Kim, J.; Chu, S.; Yu, C.; Baek, H. Metabolic fingerprinting study on the substantial equivalence of genetically modified (GM) chinese cabbage to non-GM cabbage J. Korean Soc. Appl. Biol. Chem. 2009, 52, 186-192
57. Tripathi, S.; Suzuki, J. Y.; Carr, J. B.; McQuate, G. T.; Ferreira, S. A.; Manshardt, R. M.; Pitz, K. Y.; Wall, M. M.; Gonsalves, D. Nutritional composition of Rainbow papaya, the first commercialized transgenic fruit crop J. Food Compos. Anal. 2011, 24, 140-147
58. Quemada, H.; Zarka, K.; Pett, W.; Bothma, G.; Felcher, K.; Mirendil, H.; Koch, M.; Brink, J.; Douches, D. Safety evaluations of the Cry1Ia1 protein found in the transgenic potato "SpuntaG2" J. Am. Soc. Hortic. Sci. 2010, 135, 325-332
59. Berman, K. H.; Harrigan, G. G.; Riordan, S. G.; Nemeth, M. A.; Hanson, C.; Smith, M.; Sorbet, R.; Zhu, E.; Ridley, W. P. Compositions of forage and seed from second-generation glyphosate-tolerant soybean MON 89788 and insect-protected soybean MON 87701 from Brazil are equivalent to those of conventional soybean (Glycine max) J. Agric. Food Chem. 2010, 58, 6270-6276
60. Zhou, J.; Harrigan, G. G.; Berman, K. H.; Webb, E. G.; Klusmeyer, T. H.; Nemeth, M. A. Stability in the composition equivalence of grain from insect-protected maize and seed from glyphosate-tolerant soybean to conventional counterparts over multiple seasons, locations, and breeding germplasms J. Agric. Food Chem. 2011, 59, 8822-8828
61. Noteborn, H. P. J. M.; Bienenmann-Ploum, M. E.; van den Berg, J. H. J.; Alink, G. M.; Zolla, L.; Reynaerts, A.; Pensa, M.; Kuiper, H. A., Safety assessment of the Bacillus thuringiensis insecticidal crystal protein CRYIA(b) expressed in transgenic tomatoesGenetically Modified Foods; American Chemical Society: Washington, DC, 1995; Vol. 605, pp 134-147.
62. Qin, F.; Kang, L.; Guo, L.; Lin, J.; Song, J.; Zhao, Y. Composition of transgenic soybean seeds with higher γ-linolenic acid content is equivalent to that of conventional control J. Agric. Food Chem. 2012, 60, 2200-2204
63. Kim, J.; Park, S.-Y.; Lee, S.; Lim, S.-H.; Kim, H.; Oh, S.-D.; Yeo, Y.; Cho, H.; Ha, S.-H. Unintended polar metabolite profiling of carotenoid-biofortified transgenic rice reveals substantial equivalence to its non-transgenic counterpart Plant Biotechnol. Rep. 2012, 19-26
64. Cheng, K.; Beaulieu, J.; Iquira, E.; Belzile, F.; Fortin, M.; Stromvik, M. Effect of transgenes on global gene expression in soybean is within the natural range of variation of conventional cultivars J. Agric. Food Chem. 2008, 56, 3057-3067
65. Duke, S. O.; Rimando, A. M.; Pace, P. F.; Reddy, K. N.; Smeda, R. J. Isoflavone, glyphosate, and aminomethylphosphonic acid levels in seeds of glyphosate-treated, glyphosate-resistant soybean J. Agric. Food Chem. 2002, 51, 340-344
66. Reuter, T.; Aulrich, K.; Berk, A.; Flachowsky, G. Investigations on genetically modified maize (Bt-maize) in pig nutrition: chemical composition and nutritional evaluation Arch. Tierernahrung 2002, 56, 23-31
67. Beckles, D. M.; Tananuwong, K.; Shoemaker, C. F. Starch characteristics of transgenic wheat (Triticum aestivum L.) overexpressing the Dx5 high molecular weight glutenin subunit are substantially equivalent to those in nonmodified wheat J. Food Sci. 2012, 77, C437-C442
68. Rogan, G. J.; Bookout, J. T.; Duncan, D. R.; Fuchs, R. L.; Lavrik, P. B.; Love, S. L.; Mueth, M.; Olson, T.; Owens, E. D.; Raymond, P. J.; Zalewski, J. Compositional analysis of tubers from insect and virus resistant potato plants J. Agric. Food Chem. 2000, 48, 5936-5945
69. Roberts, M.; Minott, D. A.; Tennant, P. F.; Jackson, J. C. Assessment of compositional changes during ripening of transgenic papaya modified for protection against papaya ringspot virus J. Sci. Food Agric. 2008, 88, 1911-1920
70. Park, S.-Y.; Lee, S.; Lee, J.-H.; Ko, H.-S.; Kweon, S.; Suh, S.-C.; Shin, K.-S.; Kim, J. Compositional comparative analysis between insect-resistant rice (Oryza sativa L.) with a synthetic cry1Ac gene and its non-transgenic counterpart Plant Biotechnol. Rep. 2012, 6, 29-37
71. Nida, D. L.; Patzer, S.; Harvey, P.; Stipanovic, R.; Wood, R.; Fuchs, R. L. Glyphosate-tolerant cotton: the composition of the cottonseed is equivalent to that of conventional cottonseed J. Agric. Food Chem. 1996, 44, 1967-1974
72. Cromwell, G. L.; Henry, B. J.; Scott, A. L.; Gerngross, M. F.; Dusek, D. L.; Fletcher, D. W. Glufosinate herbicide-tolerant (LibertyLink) rice vs. conventional rice in diets for growing-finishing swine J. Animal Sci. 2005, 83, 1068-1074
73. Calsamiglia, S.; Hernandez, B.; Hartnell, G. F.; Phipps, R. Effects of corn silage derived from a genetically modified variety containing two transgenes on feed intake, milk production, and composition, and the absence of detectable transgenic deoxyribonucleic acid in milk in holstein dairy cows J. Dairy Sci. 2007, 90, 4718-4723
74. Böhme, H.; Aulrich, K.; Daenicke, R.; Flachowsky, G. Genetically modified feeds in animal nutrition. 2nd communication: glufosinate tolerant sugar beets (roots and silage) and maize grains for ruminants and pigs Arch. Tierernahrung 2001, 54, 197-207
75. Li, X.; Huang, K.; He, X.; Zhu, B.; Liang, Z.; Li, H.; Luo, Y. Comparison of nutritional quality between Chinese indica rice with sck and cry1Ac genes and its nontransgenic counterpart J. Food Sci. 2007, 72, S420-S424
76. Choi, H.; Moon, J.-K.; Park, B.-S.; Park, H.-W.; Park, S.-Y.; Kim, T.-S.; Kim, D.-H.; Ryu, T.-H.; Kweon, S.-J.; Kim, J.-H. Comparative nutritional analysis for genetically modified rice, Iksan483 and Milyang204, and nontransgenic counterparts J. Korean Soc. Appl. Biol. Chem. 2012, 55, 19-26
77. Chang, Y.; Zhao, C.; Zhu, Z.; Wu, Z.; Zhou, J.; Zhao, Y.; Lu, X.; Xu, G. Metabolic profiling based on LC/MS to evaluate unintended effects of transgenic rice with cry1Ac and sck genes Plant Mol. Biol. 2012, 78, 477-487
78. Kim, J. K.; Park, S.-Y.; Ha, S.-H.; Lee, S. M.; Lim, S.-H.; Kim, H. J.; Ko, H.-S.; Oh, S.-D.; Park, J.-S.; Suh, S.-C. Compositional assessment of carotenoid-biofortified rice using substantial equivalence Afr. J. Biotechnol. 2012, 11, 9330-9335
79. El Sanhoty, R.; Abd El-Rahman, A. A.; Bögl, K. W. Quality and safety evaluation of genetically modified potatoes Spunta with Cry V gene: compositional analysis, determination of some toxins, antinutrients compounds and feeding study in rats Food/Nahrung 2004, 48, 13-18
80. Langkilde, S.; Schrøder, M.; Frank, T.; Shepherd, L. V. T.; Conner, S.; Davies, H. V.; Meyer, O.; Danier, J.; Rychlik, M.; Belknap, W. R.; McCue, K. F.; Engel, K.-H.; Stewart, D.; Knudsen, I.; Poulsen, M. Compositional and toxicological analysis of a GM potato line with reduced α-solanine content-a 90-day feeding study in the Syrian Golden hamster Regul. Toxicol. Pharmacol. 2012, 64, 177-185
81. Duke, S. O.; Lydon, J.; Koskinen, W. C.; Moorman, T. B.; Chaney, R. L.; Hammerschmidt, R. Glyphosate effects on plant mineral nutrition, crop rhizosphere microbiota, and plant disease in glyphosate-resistant crops J. Agric. Food Chem. 2012, 60, 10375-10397
82. Bhandari, S.; Basnet, S.; Chung, K.; Ryu, K.-H.; Lee, Y.-S. Comparisons of nutritional and phytochemical property of genetically modified CMV-resistant red pepper and its parental cultivar Hortic., Environ. Biotechnol. 2012, 53, 151-157
83. Corpillo, D.; Gardini, G.; Vaira, A. M.; Basso, M.; Aime, S.; Accotto, G. P.; Fasano, M. Proteomics as a tool to improve investigation of substantial equivalence in genetically modified organisms: The case of a virus-resistant tomato Proteomics 2004, 4, 193-200
84. Shepherd, L.; McNicol, J.; Razzo, R.; Taylor, M.; Davies, H. Assessing the potential for unintended effects in genetically modified potatoes perturbed in metabolic and developmental processes. Targeted analysis of key nutrients and anti-nutrients Transgenic Res. 2006, 15, 409-425
85. Berman, K. H.; Harrigan, G. G.; Nemeth, M. A.; Oliveira, W. S.; Berger, G. U.; Tagliaferro, F. S. Compositional equivalence of insect-protected glyphosate-tolerant soybean MON 87701 × MON 89788 to conventional soybean extends across different world regions and multiple growing seasons J. Agric. Food Chem. 2011, 59, 11643-11651
86. Takagi, H.; Hirose, S.; Yasuda, H.; Takaiwa, F. Biochemical safety evaluation of transgenic rice seeds expressing T cell epitopes of Japanese cedar pollen allergens J. Agric. Food Chem. 2006, 54, 9901-9905
87. Ricroch, A. E. Assessment of GE food safety using "-omics" techniques and long-term animal feeding studies New Biotechnol. 2013, 30, 349-354
88. Gayen, D.; Sarkar, S. N.; Datta, S. K.; Datta, K. Comparative analysis of nutritional compositions of transgenic high iron rice with its non-transgenic counterpart Food Chem. 2013, 138, 835-840
89. Lundry, D. R.; Burns, J. A.; Nemeth, M. A.; Riordan, S. G. Composition of Grain and Forage from Insect-Protected and Herbicide-Tolerant Corn, MON 89034 × TC1507 × MON 88017 × DAS-59122-7 (SmartStax) is Equivalent to That of Conventional Corn (Zea mays L) J. Agric. Food Chem. 2013, 61, 1991-1998
90. Herman, R. A.; Fast, B. J.; Johnson, T. Y.; Sabbatini, J.; Rudgers, G. W. Compositional Safety of Herbicide-Tolerant DAS-81910-7 Cotton J. Agric. Food Chem. 2013, 61, 11683-11692
91. Lepping, M. D.; Herman, R. A.; Potts, B. L. Compositional Equivalence of DAS-44406-6 (AAD-12 + 2mEPSPS + PAT) Herbicide-Tolerant Soybean and Nontransgenic Soybean J. Agric. Food Chem. 2013, 61, 11180-11190
92. Venkatesh, T.; Breeze, M. L.; Liu, K.; Harrigan, G. G.; Culler, A. H. Compositional Analysis of Grain and Forage from MON 87427, an Inducible Male Sterile and Tissue Selective Glyphosate-Tolerant Maize Product for Hybrid Seed Production J. Agric. Food Chem. 2014, 62, 1964-1973
93. EFSA Panel on Genetically Modified Organisms (GMO), Guidance for RiskAssessment of Food and Feed from Genetically Modified Plants. EFSA J. 2011, 9, 2150-2186.
94. Commission Implementing Regulation (EU) No 503/2013 on Applications for Authorisation of Genetically Modified Food and Feed in Accordance with Regulation (EC) No 1829/2003. Official J. Eur Union 2013, 56.
95. Application for Commodity Clearance of DAS-24236-5 × DAS-21023-5 (WideStrike) Cotton in the Republic of South Africa; Dow AgroSciences LLC: Indianapolis, IN, 2013.
96. SAS/STAT 9.3 User"s Guide; SAS Institute Inc.: Cary, NC, 2011.
97. Curran-Everett, D. Multiple comparisons: philosophies and illustrations Am. J. Physiol.: Regul., Integr. Compar. Physiol. 2000, 279, R1-R8
98. Benjamini, Y.; Hochberg, Y. Controlling the false discovery rate-a practical and powerful approach to multiple testing J. R. Stat. Soc. Ser. B: Methodological 1995, 57, 289-300
99. Colquhoun, D. An investigation of the false discovery rate and the misinterpretation of p -values R. Soc. Open Sci. 2014, 1, 140216
100. Zhou, J.; Berman, K. H.; Breeze, M. L.; Nemeth, M. A.; Oliveira, W. S.; Braga, D. P. V.; Berger, G. U.; Harrigan, G. G. Compositional variability in conventional and glyphosate-tolerant soybean (Glycine max L.) varieties grown in different regions in Brazil J. Agric. Food Chem. 2011, 59, 11652-11656
101. Bilyeu, K. D.; Zeng, P.; Coello, P.; Zhang, Z. J.; Krishnan, H. B.; Bailey, A.; Beuselinck, P. R.; Polacco, J. C. Quantitative Conversion of Phytate to Inorganic Phosphorus in Soybean Seeds Expressing a Bacterial Phytase Plant Physiol. 2008, 146, 468-477
102. Hartwig, E. E.; Kilen, T. C. Yield and Composition of Soybean Seed from Parents with Different Protein, Similar Yield Crop Sci. 1991, 31, 290-292
103. Iskander, F. Y. Maturation Stage and Mineral Content in Soybeans Food Chem. 1987, 24, 29-35
104. Kakade, M. L.; Simons, N. R.; Liener, I. E.; Lambert, J. W. Biochemical and Nutritional Assessment of Different Varieties of Soybeans J. Agric. Food Chem. 1972, 20, 87-90
105. Environmental Health and Safety, Concensus Document on Compositional Considerations for New Varieties of Soybean: Key Food and Feed Nutrients and Anti-nutrients; OECD: Paris, 2001; Vol. 15, p 30.
106. International Life Sciences Institute Crop Composition Database, version 4.2; International Life Sciences Institute: Washington, DC, 2011; www.cropcomposition.org.
107. Herman, R. A.; Dunville, C. M.; Juberg, D. R.; Fletcher, D. W.; Cromwell, G. L. Performance of broiler chickens fed diets containing DAS-68416-4 soybean meal GM Crops 2011, 2, 169-175
108. Harrigan, G. G.; Glenn, K. C.; Ridley, W. P. Assessing the natural variability in crop composition Regul. Toxicol. Pharmacol. 2010, 58, S13-S20
109. Harrigan, G. G.; Culler, A. H.; Culler, M.; Breeze, M. L.; Berman, K. H.; Halls, S. C.; Harrison, J. M. Investigation of Biochemical Diversity in a Soybean Lineage Representing 35 Years of Breeding J. Agric. Food Chem. 2013, 61, 6412-6422
110. Herman, R. A.; Price, W. D. Unintended Compositional Changes in Genetically Modified (GM) Crops: 20 Years of Research J. Agric. Food Chem. 2013, 61, 11695-11701