Safety evaluations of the cry1Ia1 protein found in the transgenic potato 'SpuntaG2'

Journal of the American Society for Horticultural Science

Volumn 135, Issue 4, 2010, Pages 325-332

  Quemada, Hector ^a   Zarka, Kelly ^a   Pett, Walter ^a   Bothma, Gurling ^b   Felcher, Kimberly ^a   Mirendil, Hope ^c   Koch, Muffy ^d   Brink, Johan ^a   Douches, David ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b AGRICULTURAL RESEARCH COUNCIL   (South Africa)

^c CALVIN COLLEGE   (United States)

^d NONE   (Canada)

Author keywords

Bt; Insect resistance; NPTII; Phthorimaea operculella; Tuber moth

Indexed keywords

EID: 77954921893     PISSN: 00031062     EISSN: None     Source Type: Journal    
DOI: 10.21273/jashs.135.4.325     Document Type: Article

References (31)

1. AGBIOS. 2010. GM crop database. 1 Mar. 2010. http://www.agbios. com/dbase.php.
2. Altschul, S., T. Madden, A. Schä ffer, J. Zhang, Z. Zhang, W. Miller, and D. Lipman. 1997. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucleic Acids Res. 25:3389-3402.
3. Beck, E., G. Ludwig, E. Auerswald, B. Reiss, and H. Schaller. 1982. Nucleotide sequence and exact localization of the neomycin phosphotransferase gene from transposon Tn5. Genetics 19:327- 336.
4. Benford, D. 2000. The acceptable daily intake: A tool for ensuring food safety. International Life Sciences Institute, Washington, DC.
5. Codex Alimentarius. 2003. Guideline for the conduct of food safety assessment of foods derived from recombinant-DNA plants CAC/GL 45-2003. 1 Mar. 2010. http://www.codexalimentarius.net/web/ index_en.jsp.
6. Delaney, B., J. Astwood, H. Cunny, R. Conn, C. Herouet-Guicheney, S. MacIntosh, L. Meyer, L. Privalle, Y. Gao, J. Mattsson, and M. Levine. 2008. Evaluation of protein safety in the context of agricultural biotechnology. Food Chem. Toxicol. 46:S71-S97.
7. Douches, D., W. Li, K. Zarka, J. Coombs, W. Pett, E. Grafius, and T. El-Nasr. 2002. Development of Bt-cry5 insect resistant potato lines 'Spunta-G2' and 'Spunta-G3'. HortScience 37:1103-1107.
8. Douches, D., W. Pett, D. Visser, J. Coombs, K. Zarka, G. Bothma, J. Brink, K. Felcher, M. Koch, and H. Quemada. 2010. Field and storage evaluations of 'SpuntaG2' for resistance to potato tuber moth and agronomic performance. J. Amer. Soc. Hort. Sci. 135:333- 340.
9. European Food Safety Authority. 2007. Statement of the scientific panel on genetically modified organisms of the safe use of the nptII antibiotic resistance marker gene in genetically modified plants. 1 Mar. 2010. http://www.efsa.europa.eu/EFSA/Statement/gmo_ statement_nptII_,0.pdf.
10. Fu, T., U. Abbott, and C. Hatzos. 2002. Digestibility of food allergens and nonallergenic proteins in simulated gastric fluid and simulated in- testinal fluid: A comparative study. J. Agr. Food Chem. 50:7154-7160.
11. Fuchs, R., J. Ream, B. Hammond, M. Naylor, R. Leimgruber, and S. Berberich. 1993b. Safety assessment of the neomycin phosphotrans- ferase II (NPTII) protein. Nat. Biotechnol. 11:1543-1547.
12. Fuchs, R., M. Gustafson, G. Rogan, D. Bartnicki, R. Leimgruber, R. Finn, A. Hershmn, and S. Berberich. 1993a. Purification and characterization of microbially expressed neomycin phosphotrans- ferase II (NPTII) protein and its equivalence to the plant expressed protein. Nat. Biotechnol. 11:1537-1542.
13. Gill, S., E. Cowles, and P. Pietrantonio. 1992. The mode of action of Bacillus thuringiensis endotoxins. Annu. Rev. Entomol. 37:615-636.
14. International Conference on Harmonisation of Technical Require- ments for Registration of Pharmaceuticals for Human Use. 1997. Preclinical safety evaluation of biotechnology-derived pharmaceu- ticals. ICH S6. 1 Mar. 2010. http://www.ich.org/cache/compo/276- 254-1.html.
15. Laemmli, U. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
16. 0 coat protein gene and cryV-Bt genes in potato (Solanum tuberosum L.). J. Amer. Soc. Hort. Sci. 124:218-223.
17. Mendelsohn, M., J. Kough, V. Zigfridais, and K. Matthews. 2003. Are Bt crops safe? Nat. Biotechnol. 21:1003-1009.
18. MPI Research, Inc. 2008. Acute oral toxicity study of Cry1IA1 protein in mice. Study number 1466-001. MPI Research, Inc., Mattawan, MI.
19. National Center for Biotechnology Information, U.S. National Library of Medicine. 2010. Basic local alignment search tool. Protein BLAST. 1 Mar. 2010. http://blast.ncbi.nlm.nih.gov/Blast.cgi.
20. Organization for Economic Co-operation and Development. 2002. Consensus document on compositional considerations for new culti- vars of potatoes: Key food and feed nutrients, anti-nutrients and tox- icants. 1 Mar. 2010. http://www.olis.oecd.org/olis/2002doc.nsf/ LinkTo/env-jm-mono%282002%294.
21. Pearson, W. 2000. Flexible sequence similarity searching with the FASTA3 program package. Methods Mol. Biol. 132:185-219.
22. Rice, E., T. Lee, G. Rogan, and G. Bannon. 2008. Safety assessment of proteins used in crops developed through agricultural biotechnology. Industry perspective, p. 237-258. In: B.C. Hammond (ed.). Food safety of proteins in agricultural biotechnology. CRC Press, Boca Raton, FL.
23. Rogan, G., J. Bookout, D. Duncan, R. Fuchs, P. Lavrik, S. Love, M. Mueth, T. Olson, E. Owens, P. Raymond, and J. Zalewski. 2000. Compositional analysis of tubers from insect and virus resistant potato plants. J. Agr. Food Chem. 48:5936-5945.
24. South African Medical Research Council. 2002. Report on South African food consumption studies undertaken amongst different population groups (1983-2000): Average intakes of foods most commonly consumed. Table 44: Summary of food items commonly consumed by children and adults in South Africa. 5 Apr. 2010. http://www.mrc.ac.za/chronic/foodstudy.pdf.
25. Stone, T. and P. Lavrik. 1994. Petition for determination of non- regulated status. Potatoes expressing the colorado potato beetle control protein of Bacillus thuringiensis subsp. tenebrionis. USDA/ Aphis Petition 94-257-01. 1 Mar. 2010. http://www.aphis.usda.gov/ brs/aphisdocs/94_25701p.pdf.
26. U.S. Food and Drug Administration. 1994. Secondary food additives permitted in food for human consumption: Food additives permitted in feed and drinking water of animals; aminoglycoside 3#-phosphotransferaseII. Final rule. Fed. Regist. 59:26700-26711.
27. U.S. Food and Drug Administration. 2004. Toxicological principles for the safety assessment of food ingredients. Redbook 2000. 5 Apr. 2010. http://www.fda.gov/Food/GuidanceComplianceRegulatory Information/GuidanceDocuments/FoodIngredientsandPackaging/ Redbook/default.htm.
28. U.S. Food and Drug Administration. 2008. Good laboratory practices for nonclinical laboratory studies. Title 21, code of federal regula- tions part 58. U.S. Food and Drug Administration, Washington, DC.
29. University of Nebraska-Lincoln. 2010. AllergenOnline. 1 Mar. 2010. http://www.allergenonline.com.
30. Wilson, C., J. Kreychman, and M. Gerstein. 2000. Assessing annota- tion transfer for genomics: Quantifying the relations between protein sequence, structure and function through traditional and probabilistic scores. J. Mol. Biol. 297:233-249.
31. Zarka, K., R. Greyling, I. Gazendam, D. Olefse, K. Felcher, G. Bothma, J. Brink, H. Quemada, and D.S. Douches. 2010. Insertion and characterization of the cry1Ia1 gene in the potato cultivar Spunta for resistance to potato tuber moth. J. Amer. Soc. Hort. Sci. 135:317- 324.