Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease

EMBO Molecular Medicine

Volumn 6, Issue 9, 2014, Pages 1105-1120

  Goveia, Jermaine ^a,b   Stapor, Peter ^a,b   Carmeliet, Peter ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

Angiogenesis; Endothelial cell dysfunction; Metabolism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); 6 N,N' DIMETHYLARGININE; 6 PHOSPHOFRUCTOKINASE; ADENOSINE TRIPHOSPHATE; ADVANCED GLYCATION END PRODUCT; ARGINASE; ARGININE; CARBON; DIHYDROXYACETONE PHOSPHATE; DIMETHYLARGININASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FRUCTOSE 1,6 BISPHOSPHATE; FRUCTOSE 2,6 BISPHOSPHATE; FRUCTOSE 6 PHOSPHATE; GERANYLGERANYL PYROPHOSPHATE; GLUTAMINE; GLYCERALDEHYDE 3 PHOSPHATE; HEXOSAMINE; METHYLGLYOXAL; MEVALONIC ACID; N(G),N(G) DIMETHYLARGININE; ORNITHINE; PENTOSE PHOSPHATE; POLYAMINE; POLYOL; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; TRANSKETOLASE; URIC ACID; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE;

AEROBIC METABOLISM; AMINO ACID METABOLISM; ANGIOGENESIS; ATHEROSCLEROSIS; CARBON METABOLISM; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CELL METABOLISM; CELL PROLIFERATION; CITRIC ACID CYCLE; DIABETES MELLITUS; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; FATTY ACID OXIDATION; FOLATE METABOLISM; GLUCOSE METABOLISM; GLYCOLYSIS; GLYCOSYLATION; HUMAN; HYPERGLYCEMIA; HYPERHOMOCYSTEINEMIA; HYPERTENSION; HYPERURICEMIA; INFLAMMATION; NEOPLASM; NONHUMAN; NUCLEOTIDE METABOLISM; PATHOGENESIS; PENTOSE PHOSPHATE CYCLE; POLYAMINE SYNTHESIS; PROTEIN METABOLISM; PULMONARY HYPERTENSION; REVIEW; VASCULAR ENDOTHELIUM; APOPTOSIS; BIOLOGICAL MODEL; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; SIGNAL TRANSDUCTION;

APOPTOSIS; ATHEROSCLEROSIS; CELL PROLIFERATION; DIABETES MELLITUS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GLYCOLYSIS; HUMANS; METABOLIC NETWORKS AND PATHWAYS; MODELS, BIOLOGICAL; NEOVASCULARIZATION, PATHOLOGIC; SIGNAL TRANSDUCTION;

EID: 84916931723     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.15252/emmm.201404156     Document Type: Review

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