Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 32, Issue 9, 2012, Pages 2280-2288

  Noghero, Alessio ^a,b   Perino, Alessia ^b   Seano, Giorgio ^a,b   Saglio, Elisa ^c   Sasso, Giuseppe Lo ^d   Veglio, Franco ^b   Primo, Luca ^a,b   Hirsch, Emilio ^b   Bussolino, Federico ^a,b   Morello, Fulvio ^b,c  

^a CANDIOLO CANCER INSTITUTE   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c MOLINETTE HOSPITAL   (Italy)

^d Consorzio Mario Negri Sud ^*  (Italy)

Author keywords

angiogenesis; cholesterol; lipid rafts; liver X receptor; vascular endothelial growth factor

Indexed keywords

3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; CHOLESTEROL; LIVER X RECEPTOR; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; AORTA; ARTICLE; CAVEOLA; CELL COMPARTMENTALIZATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; HOMEOSTASIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEWIS CARCINOMA; LIPID RAFT; MORPHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUBULOGENESIS; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULARIZATION;

ANGIOGENESIS INHIBITORS; ANIMALS; AORTA, THORACIC; BENZOIC ACIDS; BENZYLAMINES; CARCINOMA, LEWIS LUNG; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; CHOLESTEROL; ENDOTHELIAL CELLS; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROCARBONS, FLUORINATED; MEMBRANE MICRODOMAINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOVASCULARIZATION, PHYSIOLOGIC; ORPHAN NUCLEAR RECEPTORS; PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SULFONAMIDES; TIME FACTORS; TRANSFECTION; TUMOR BURDEN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84865530278     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.112.250621     Document Type: Article

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