Advanced glycation end products induce apoptosis and procoagulant activity in cultured human umbilical vein endothelial cells

Diabetes Research and Clinical Practice

Volumn 46, Issue 3, 1999, Pages 197-202

  Min, Cheolhong ^a   Kang, Eungtaek ^a   Yu, Suk Hee ^a   Shinn, Soon Hyun ^a   Kim, Yong Seong ^b  

^a Chung Ang University   (South Korea)

^b Inha University School of Medicine   (South Korea)

Author keywords

AGEs; Apoptosis; Endothelial cells; HUVECs; Procoagulant activity (PCA)

Indexed keywords

GLYCOSYLATED PROTEIN;

APOPTOSIS; ARTICLE; BLOOD CLOTTING; CELL CULTURE; DIABETES MELLITUS; DIABETIC ANGIOPATHY; ENDOTHELIUM CELL; GLYCATION; HUMAN; HUMAN CELL; HUMAN TISSUE; PATHOGENESIS; UMBILICAL VEIN;

APOPTOSIS; BLOOD COAGULATION; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; PARTIAL THROMBOPLASTIN TIME; THROMBOPLASTIN; UMBILICAL VEINS;

EID: 0032752314     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8227(99)00094-7     Document Type: Article

References (19)

1. King G.L., Banskota N.K. Mechanisms of diabetic microvascular complications. Kahn C.R., Weir G.C. Joslin's diabetes mellitus. 13 Ed. 1994;631-642 Lea and Febiger, Pennsylvania.
2. Brownlee M., Vlassara H., Cerami A. Nonenzymatic glycosylation and the pathogenesis of diabetic complications. Annu. Intern. Med. 101:1984;527-537.
3. Brownlee M., Vlassara H., Kooney A. Aminoguanidine prevents diabetes-induced arterial wall protein cross linking. Science. 232:1986;1629-1632.
4. Brownlee M., Cerami A., Vlassara H. Advanced products of glycosylation and the pathogenesis of diabetic vascular disease. Diabetes Metab. Rev. 4:1988;437-451.
5. Brownlee M. Glycosylation products as toxic mediators of diabetic complications. Annu. Rev. Med. 42:1991;159-166.
6. Esposito C., Gerlach H., Brett J., Stern D., Vlassara H. Endothelial receptor-mediated binding of glucose modified albumin is associated with increased monolayer permeability and modulation of cell surface coagulant properties. J. Exp. Med. 170:1989;1387-1407.
7. Majno G., Joris I. Apoptosis, oncosis, and necrosis; An overview of cell death. Am. J. Pathol. 146:1995;3-15.
8. Baumgartner-Parzer S.M., Wagner L., Pettermann M., Grillari J., Gessl A., Walfhausl W. High glucose triggered apoptosis in cultured endothelial cells. Diabetes. 44:1995;1323-1327.
9. Jaffe E.A., Nachman R.L., Becker C.G., Minick C.R. Culture of human endothelial cells derived from umbilical veins. J. Clin. Invest. 52:1973;2745-2756.
10. Jaffe E.A., Hoyer L.W., Nachman R.L. Synthesis of von Willebrand factor by cultured human endothelial cells. Proc. Natl. Acad. Sci. USA. 71:1974;1906-1909.
11. Kang E., Yu S.H. Procoagulant effect of Hantaan virus infection in cultured human umbilical vein endothelial cells. Kor. J. Nephrol. 11:1992;315-325.
12. Hogan M., Cerami A., Bucala R. Advanced glycosylation endproducts block the antiproliferative effect of nitric oxide. J. Clin. Invest. 90:1992;1110-1115.
13. Chang J.C.F., Ulrich P.C., Buccala R., Cerami A. Detection of an advanced glycosylation product bound to protein in situ. J. Biol. Chem. 260:1985;7970-7974.
14. Gorczyca W., Tuziak T., Kram A., Melamed M.R., Darzynkiewicz Z. Detection of apoptosis-associated DNA strand breaks in fine-needle aspiration biopsies by in situ end labeling of fragmented DNA. Cytometry. 15:1994;169-175.
15. Brownlee M. Lilly lecture 1993. Glycation and diabetic complications. Diabetes. 43:1994;836-841.
16. McCane D.R., Dyer D.G., Dunn J.A, Bailie K.E. Millard reaction products and their relation to complications in insulin-dependent diabetes mellitus. J. Clin. Invest. 91:1993;2470-2478.
17. Monnier V.M., Kohn R.R., Cerami A. Accelerated age-related browning of human collagen in diabetes mellitus. Proc. Natl. Acad. Sci. USA. 81:1984;583-584.
18. Greeno E.W., Bach R.P., Moldow C.F. Apoptosis is associated with increased cell surface tissue factor procoagulant activity. Lab. Invest. 75:1996;281-290.
19. Berg T.J., Tojesen P.A., Jorgensen K.D., Hanssen K.F. Increased serum levels of advanced glycation end products in children and adolescents with IDDM. Diabetes Care. 20:1997;1006-1008.