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Volumn 170, Issue 18, 2010, Pages 1622-1631

Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; HOMOCYSTEINE; PLACEBO; VITAMIN B GROUP;

EID: 77957949167     PISSN: 00039926     EISSN: 15383679     Source Type: Journal    
DOI: 10.1001/archinternmed.2010.348     Document Type: Review
Times cited : (429)

References (44)
  • 1
    • 0025756673 scopus 로고
    • Hyperhomocysteinemia: An independent risk factor for vascular disease
    • Clarke R, Daly L, Robinson K, et al. Hyperhomocysteinemia: an independent risk factor for vascular disease.NEngl J Med. 1991;324(17):1149-1155.
    • (1991) NEngl J Med , vol.324 , Issue.17 , pp. 1149-1155
    • Clarke, R.1    Daly, L.2    Robinson, K.3
  • 2
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: Probable benefits of increasing folic acid intakes
    • Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA. 1995;274(13):1049- 1057.
    • (1995) JAMA , vol.274 , Issue.13 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.2    Omenn, G.S.3    Motulsky, A.G.4
  • 3
    • 0032417638 scopus 로고    scopus 로고
    • Plasma homocysteine and coronary heart disease: Systematic review of published epidemiological studies
    • DOI 10.1097/00043798-199808000-00004
    • Danesh J, Lewington S. Plasma homocysteine and coronary heart disease: systematic review of published epidemiological studies. J Cardiovasc Risk. 1998;5(4):229-232. (Pubitemid 29030108)
    • (1998) Journal of Cardiovascular Risk , vol.5 , Issue.4 , pp. 229-232
    • Danesh, J.1    Lewington, S.2
  • 5
    • 0014545138 scopus 로고
    • Vascular pathology of homocysteinemia: Implications for the pathogenesis of arteriosclerosis
    • McCully KS. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol. 1969;56(1):111-128.
    • (1969) Am J Pathol , vol.56 , Issue.1 , pp. 111-128
    • McCully, K.S.1
  • 6
    • 0033817657 scopus 로고    scopus 로고
    • Vascular complications of severe hyperhomocysteinemia in patients with homocystinuria due to cystathionine beta-synthase deficiency: Effects of homocysteine-lowering therapy
    • Yap S, Naughten ER, Wilcken B, Wilcken DE, Boers GH. Vascular complications of severe hyperhomocysteinemia in patients with homocystinuria due to cystathionine beta-synthase deficiency: effects of homocysteine-lowering therapy. Semin Thromb Hemost. 2000;26(3):335-340.
    • (2000) Semin Thromb Hemost , vol.26 , Issue.3 , pp. 335-340
    • Yap, S.1    Naughten, E.R.2    Wilcken, B.3    Wilcken, D.E.4    Boers, G.H.5
  • 7
    • 27744603884 scopus 로고    scopus 로고
    • Dose-dependent effects of folic acid on blood concentrations of homocysteine: A meta-analysis of the randomized trials
    • Homocysteine Lowering Trialists' Collaboration
    • Homocysteine Lowering Trialists' Collaboration. Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr. 2005;82(4):806-812.
    • (2005) Am J Clin Nutr , vol.82 , Issue.4 , pp. 806-812
  • 8
    • 1242278327 scopus 로고    scopus 로고
    • Blinded comparison of folic acid and placebo in patients with ischaemic heart disease: An outcome trial
    • abstract
    • Baker F, Picton D, Blackwood S, et al. Blinded comparison of folic acid and placebo in patients with ischaemic heart disease: an outcome trial [abstract]. Circulation. 2002;106(suppl 2):741S.
    • (2002) Circulation , vol.106 , Issue.SUPPL. 2
    • Baker, F.1    Picton, D.2    Blackwood, S.3
  • 9
    • 1342309318 scopus 로고    scopus 로고
    • Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: The Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial
    • Toole JF, Malinow MR, Chambless LE, et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA. 2004;291(5):565-575.
    • (2004) JAMA , vol.291 , Issue.5 , pp. 565-575
    • Toole, J.F.1    Malinow, M.R.2    Chambless, L.E.3
  • 10
    • 33645796222 scopus 로고    scopus 로고
    • Homocysteine lowering and cardiovascular events after acute myocardial infarction
    • NORVIT Trial Investigators
    • Bønaa KH, Njølstad I, Ueland PM, et al; NORVIT Trial Investigators. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med. 2006;354(15):1578-1588.
    • (2006) N Engl J Med , vol.354 , Issue.15 , pp. 1578-1588
    • Bønaa, K.H.1    Njølstad, I.2    Ueland, P.M.3
  • 11
    • 33645753544 scopus 로고    scopus 로고
    • Homocysteine lowering with folic acid and B-vitamins in vascular disease
    • Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators published correction appears in N Engl J Med. 2006;355(7):746
    • Lonn E, Yusuf S, Arnold MJ, et al; Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators. Homocysteine lowering with folic acid and B-vitamins in vascular disease [published correction appears in N Engl J Med. 2006;355(7):746]. N Engl J Med. 2006;354(15):1567-1577.
    • (2006) N Engl J Med , vol.354 , Issue.15 , pp. 1567-1577
    • Lonn, E.1    Yusuf, S.2    Arnold, M.J.3
  • 12
    • 34548566329 scopus 로고    scopus 로고
    • Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: A randomized controlled trial
    • Veterans Affairs Site Investigators published correction appears in JAMA. 2008;300(2)170
    • Jamison RL, Hartigan P, Kaufman JS, et al; Veterans Affairs Site Investigators. Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial [published correction appears in JAMA. 2008;300(2)170]. JAMA. 2007;298(10):1163-1170.
    • (2007) JAMA , vol.298 , Issue.10 , pp. 1163-1170
    • Jamison, R.L.1    Hartigan, P.2    Kaufman, J.S.3
  • 13
    • 43049176549 scopus 로고    scopus 로고
    • Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: A randomized trial
    • Albert CM, Cook NR, Gaziano JM, et al. Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial. JAMA. 2008;299(17):2027-2036.
    • (2008) JAMA , vol.299 , Issue.17 , pp. 2027-2036
    • Albert, C.M.1    Cook, N.R.2    Gaziano, J.M.3
  • 14
    • 49949101867 scopus 로고    scopus 로고
    • Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: A randomized controlled trial
    • Ebbing M, Bleie Ø, Ueland PM, et al. Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial. JAMA. 2008;300(7):795-804.
    • (2008) JAMA , vol.300 , Issue.7 , pp. 795-804
    • Ebbing, M.1    Bleie, Ø.2    Ueland, P.M.3
  • 15
    • 77953867844 scopus 로고    scopus 로고
    • 12 vs placebo on mortality and major morbidity in myocardial infarction survivors: A randomized trial
    • Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group
    • 12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial. JAMA. 2010;303(24):2486-2494.
    • (2010) JAMA , vol.303 , Issue.24 , pp. 2486-2494
  • 17
    • 57649219087 scopus 로고    scopus 로고
    • Baseline characteristics of participants in the Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) trial
    • FAVORIT Study Investigators
    • Bostom AG, Carpenter MA, Hunsicker L, et al; FAVORIT Study Investigators. Baseline characteristics of participants in the Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) trial. Am J Kidney Dis. 2009;53(1):121-128.
    • (2009) Am J Kidney Dis , vol.53 , Issue.1 , pp. 121-128
    • Bostom, A.G.1    Carpenter, M.A.2    Hunsicker, L.3
  • 18
    • 47949084265 scopus 로고    scopus 로고
    • The SU.FOL.OM3 Study: A secondary prevention trial testing the impact of supplementation with folate and B-vitamins and/or omega-3 PUFA on fatal and non fatal cardiovascular events, design, methods and participants characteristics
    • doi:10.1186/1745-6215-9-35
    • Galan P, Briancon S, Blacher J, Czernichow S, Hercberg S. The SU.FOL.OM3 Study: a secondary prevention trial testing the impact of supplementation with folate and B-vitamins and/or omega-3 PUFA on fatal and non fatal cardiovascular events, design, methods and participants characteristics. Trials. 2008;9:35. doi:10.1186/1745-6215-9-35.
    • (2008) Trials , vol.9 , pp. 35
    • Galan, P.1    Briancon, S.2    Blacher, J.3    Czernichow, S.4    Hercberg, S.5
  • 19
    • 77957970619 scopus 로고    scopus 로고
    • Accessed June 1, 2010
    • China Stroke Primary Prevention Trial. http://clinicaltrials.gov/ct2/ results?term=NCT00794885. Accessed June 1, 2010.
    • China Stroke Primary Prevention Trial
  • 20
    • 31344459617 scopus 로고    scopus 로고
    • Homocysteine-lowering trials for prevention of cardiovascular events: A review of the design and power of the large randomized trials
    • B-Vitamin Treatment Trialists' Collaboration
    • B-Vitamin Treatment Trialists' Collaboration. Homocysteine-lowering trials for prevention of cardiovascular events: a review of the design and power of the large randomized trials. Am Heart J. 2006;151(2):282-287.
    • (2006) Am Heart J , vol.151 , Issue.2 , pp. 282-287
  • 21
    • 36849033437 scopus 로고    scopus 로고
    • Homocysteine-lowering trials for prevention of vascular disease: Protocol for a collaborative meta-analysis
    • B-Vitamin Treatment Trialists' Collaboration
    • Clarke R, Armitage J, Lewington S, Collins R; B-Vitamin Treatment Trialists' Collaboration. Homocysteine-lowering trials for prevention of vascular disease: protocol for a collaborative meta-analysis. Clin Chem Lab Med. 2007;45(12):1575-1581.
    • (2007) Clin Chem Lab Med , vol.45 , Issue.12 , pp. 1575-1581
    • Clarke, R.1    Armitage, J.2    Lewington, S.3    Collins, R.4
  • 22
    • 77957937786 scopus 로고
    • Worldwide Evidence 1985-1990
    • Early Breast Cancer Trialists' Collaborative Group Oxford, England: Oxford University Press
    • Early Breast Cancer Trialists' Collaborative Group. Worldwide Evidence 1985-1990. Oxford, England: Oxford University Press; 1990. Treatment of Early Breast Cancer; vol 1.
    • (1990) Treatment of Early Breast Cancer , vol.1
  • 23
    • 0021810226 scopus 로고
    • Intravenous and intracoronary fibrinolytic therapy in acute myocardial infarction: Overview of results on mortality, reinfarction and side-effects from 33 randomized controlled trials
    • Yusuf S, Collins R, Peto R, et al. Intravenous and intracoronary fibrinolytic therapy in acute myocardial infarction: overview of results on mortality, reinfarction and side-effects from 33 randomized controlled trials. Eur Heart J. 1985;6(7):556-585. (Pubitemid 15046383)
    • (1985) European Heart Journal , vol.6 , Issue.7 , pp. 556-585
    • Yusuf, S.1    Collins, R.2    Peto, R.3
  • 24
    • 33645743547 scopus 로고    scopus 로고
    • Improvement in stroke mortality in Canada and the United States, 1990 to 2002
    • Yang Q, Botto LD, Erickson JD, et al. Improvement in stroke mortality in Canada and the United States, 1990 to 2002. Circulation. 2006;113(10):1335-1343.
    • (2006) Circulation , vol.113 , Issue.10 , pp. 1335-1343
    • Yang, Q.1    Botto, L.D.2    Erickson, J.D.3
  • 26
    • 34249730020 scopus 로고    scopus 로고
    • Efficacy of folic acid supplementation in stroke prevention: A meta-analysis
    • DOI 10.1016/S0140-6736(07)60854-X, PII S014067360760854X
    • Wang X, Qin X, Demirtas H, et al. Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. Lancet. 2007;369(9576):1876-1882. (Pubitemid 46829358)
    • (2007) Lancet , vol.369 , Issue.9576 , pp. 1876-1882
    • Wang, X.1    Qin, X.2    Demirtas, H.3    Li, J.4    Mao, G.5    Huo, Y.6    Sun, N.7    Liu, L.8    Xu, X.9
  • 27
    • 34547743420 scopus 로고    scopus 로고
    • Homocysteine-lowering therapy: A role in stroke prevention?
    • DOI 10.1016/S1474-4422(07)70219-3, PII S1474442207702193
    • Spence JD. Homocysteine-lowering therapy: a role in stroke prevention? Lancet Neurol. 2007;6(9):830-838. (Pubitemid 47241275)
    • (2007) Lancet Neurology , vol.6 , Issue.9 , pp. 830-838
    • Spence, J.D.1
  • 28
    • 0242654867 scopus 로고    scopus 로고
    • Effects of different blood-pressure-lowering regimens on major cardiovascular events: Results of prospectively-designed overviews of randomised trials
    • Blood Pressure Lowering Treatment Trialists' Collaboration
    • Turnbull F; Blood Pressure Lowering Treatment Trialists' Collaboration. Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Lancet. 2003;362(9395):1527-1535.
    • (2003) Lancet , vol.362 , Issue.9395 , pp. 1527-1535
    • Turnbull, F.1
  • 29
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    • Cholesterol Treatment Trialists' Collaboration published corrections appear in Lancet. 2005;366(9494):1358 and 2008;371(9630)2084
    • Baigent C, Keech A, Kearney PM, et al; Cholesterol Treatment Trialists' Collaboration. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins [published corrections appear in Lancet. 2005;366(9494):1358 and 2008;371(9630)2084]. Lancet. 2006;366(9493):1267-1278.
    • (2006) Lancet , vol.366 , Issue.9493 , pp. 1267-1278
    • Baigent, C.1    Keech, A.2    Kearney, P.M.3
  • 30
    • 33845503323 scopus 로고    scopus 로고
    • Effect of folic acid supplementation on risk of cardiovascular diseases: A meta-analysis of randomized controlled trials
    • DOI 10.1001/jama.296.22.2720
    • Bazzano LA, Reynolds K, Holder KN, He J. Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials. JAMA. 2006;296(22):2720-2726. (Pubitemid 44917549)
    • (2006) Journal of the American Medical Association , vol.296 , Issue.22 , pp. 2720-2726
    • Bazzano, L.A.1    Reynolds, K.2    Holder, K.N.3    He, J.4
  • 31
    • 68849095595 scopus 로고    scopus 로고
    • Folic acid supplementation and cardiovascular disease: The state of the art
    • Bazzano LA. Folic acid supplementation and cardiovascular disease: the state of the art. Am J Med Sci. 2009;338(1):48-49.
    • (2009) Am J Med Sci , vol.338 , Issue.1 , pp. 48-49
    • Bazzano, L.A.1
  • 32
    • 0036324027 scopus 로고    scopus 로고
    • Epidemiologic studies of folate and colorectal neoplasia: A review
    • Giovannucci E. Epidemiologic studies of folate and colorectal neoplasia: a review. J Nutr. 2002;132(8)(suppl):2350S-2355S.
    • (2002) J Nutr , vol.132 , Issue.8 SUPPL.
    • Giovannucci, E.1
  • 33
    • 33846998339 scopus 로고    scopus 로고
    • Folate and risk of breast cancer: Ameta-analysis
    • Larsson SC, Giovannucci E, Wolk A. Folate and risk of breast cancer: ameta-analysis. J Natl Cancer Inst. 2007;99(1):64-76.
    • (2007) J Natl Cancer Inst , vol.99 , Issue.1 , pp. 64-76
    • Larsson, S.C.1    Giovannucci, E.2    Wolk, A.3
  • 34
    • 16544370325 scopus 로고    scopus 로고
    • Will mandatory folic acid fortification prevent or promote cancer?
    • Kim YI. Will mandatory folic acid fortification prevent or promote cancer? Am J Clin Nutr. 2004;80(5):1123-1128.
    • (2004) Am J Clin Nutr , vol.80 , Issue.5 , pp. 1123-1128
    • Kim, Y.I.1
  • 35
    • 34447550432 scopus 로고    scopus 로고
    • A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: A hypothesis
    • DOI 10.1158/1055-9965.EPI-07-0329
    • Mason JB, Dickstein A, Jacques PF, et al. A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomarkers Prev. 2007;16(7):1325-1329. (Pubitemid 47076861)
    • (2007) Cancer Epidemiology Biomarkers and Prevention , vol.16 , Issue.7 , pp. 1325-1329
    • Mason, J.B.1    Dickstein, A.2    Jacques, P.F.3    Haggarty, P.4    Selhub, J.5    Dallal, G.6    Rosenberg, I.H.7
  • 36
    • 34249979299 scopus 로고    scopus 로고
    • Folic acid for the prevention of colorectal adenomas: A randomized clinical trial
    • Polyp Prevention Study Group
    • Cole BF, Baron JA, Sandler RS, et al; Polyp Prevention Study Group. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA. 2007;297(21):2351-2359.
    • (2007) JAMA , vol.297 , Issue.21 , pp. 2351-2359
    • Cole, B.F.1    Baron, J.A.2    Sandler, R.S.3
  • 37
    • 64949110935 scopus 로고    scopus 로고
    • Folic acid and risk of prostate cancer: Results from a randomized clinical trial
    • Figueiredo JC, Grau MV, Haile RW, et al. Folic acid and risk of prostate cancer: results from a randomized clinical trial. J Natl Cancer Inst. 2009;101(6):432-435.
    • (2009) J Natl Cancer Inst , vol.101 , Issue.6 , pp. 432-435
    • Figueiredo, J.C.1    Grau, M.V.2    Haile, R.W.3
  • 38
    • 37349129228 scopus 로고    scopus 로고
    • Aspirin and Folic Acid for the Prevention of Recurrent Colorectal Adenomas
    • DOI 10.1053/j.gastro.2007.10.014, PII S0016508507018136
    • Logan RFA, Grainge MJ, Shepherd VC, Armitage NC, Muir KR; ukCAP Trial Group. Aspirin and folic acid for the prevention of recurrent colorectal adenomas. Gastroenterology. 2008;134(1):29-38. (Pubitemid 350309319)
    • (2008) Gastroenterology , vol.134 , Issue.1 , pp. 29-38
    • Logan, R.F.A.1    Grainge, M.J.2    Shepherd, V.C.3    Armitage, N.C.4    Muir, K.R.5
  • 39
    • 72749116444 scopus 로고    scopus 로고
    • A randomized trial of folic acid supplementation and risk of recurrent colorectal adenoma
    • Wu K, Plarz EA, Willett WC, et al. A randomized trial of folic acid supplementation and risk of recurrent colorectal adenoma. Am J Clin Nutr. 2009;90(6):1623-1631.
    • (2009) Am J Clin Nutr , vol.90 , Issue.6 , pp. 1623-1631
    • Wu, K.1    Plarz, E.A.2    Willett, W.C.3
  • 41
    • 74049120835 scopus 로고    scopus 로고
    • Total folate and folic acid intake from foods and dietary supplements in the United States: 2003-2006
    • Bailey RL, Dodd KW, Gahche JJ, et al. Total folate and folic acid intake from foods and dietary supplements in the United States: 2003-2006. Am J Clin Nutr. 2010;91(1):231-237.
    • (2010) Am J Clin Nutr , vol.91 , Issue.1 , pp. 231-237
    • Bailey, R.L.1    Dodd, K.W.2    Gahche, J.J.3
  • 43
    • 0035919139 scopus 로고    scopus 로고
    • Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects
    • Honein MA, Paulozzi LJ, Mathews TJ, Erickson JD, Wong LY. Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. JAMA. 2001;285(23):2981-2986.
    • (2001) JAMA , vol.285 , Issue.23 , pp. 2981-2986
    • Honein, M.A.1    Paulozzi, L.J.2    Mathews, T.J.3    Erickson, J.D.4    Wong, L.Y.5
  • 44
    • 3142770577 scopus 로고    scopus 로고
    • Folic acid food fortification in Canada
    • Ray JG. Folic acid food fortification in Canada. Nutr Rev. 2004;62(6, pt 2):S35-S39. (Pubitemid 38916078)
    • (2004) Nutrition Reviews , vol.62 , Issue.6 I
    • Ray, J.G.1


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