Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells

Journal of Biological Chemistry

Volumn 284, Issue 19, 2009, Pages 12691-12700

  Sugiyama, Toru ^a   Levy, Bruce D ^a   Michel, Thomas ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOPTERIN; COFACTOR; CONCENTRATION OF; DEPHOSPHORYLATION; DIHYDROFOLATE REDUCTASE; GTP CYCLOHYDROLASE; INHIBITORY SITES; ISOFORM; KEY DETERMINANTS; NITRIC-OXIDE SYNTHASE; RATE-LIMITING ENZYMES; REACTIVE OXYGEN SPECIES; REDOX REGULATION; REDOX-ACTIVE; RELATIVE CONCENTRATION; SIGNALING PATHWAYS; SMALL INTERFERENCE RNA; SYNTHASE; SYNTHETIC PATHWAYS; TETRAHYDROBIOPTERIN; VASCULAR CELLS; VASCULAR ENDOTHELIAL CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR;

AMINO ACIDS; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; BLOOD VESSEL PROSTHESES; COENZYMES; ENZYME ACTIVITY; ENZYMES; NUCLEIC ACIDS; OXYGEN; RECYCLING; RNA; SELF ASSEMBLY; SIGNALING;

ENDOTHELIAL CELLS;

BIOPTERIN; DIHYDROBIOPTERIN; DIHYDROFOLATE REDUCTASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TETRAHYDROBIOPTERIN; VASCULOTROPIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; BIOSYNTHESIS; CELL LEVEL; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION; PHOSPHORYLATION AND DEPHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; RNA INTERFERENCE; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

ANIMALS; AORTA; BIOPTERIN; CATTLE; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GTP CYCLOHYDROLASE; HUMANS; HYDROGEN PEROXIDE; IMMUNOBLOTTING; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TETRAHYDROFOLATE DEHYDROGENASE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 67649781721     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M809295200     Document Type: Article

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