메뉴 건너뛰기




Volumn 134, Issue 10 SUPPL., 2004, Pages

Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, explains the "L-arginine paradox" and acts as a novel cardiovascular risk factor

Author keywords

Atherosclerosis; Coronary heart disease; Endothelium; Nitric oxide; Oxidative stress; Prognosis

Indexed keywords

ARGININE; C REACTIVE PROTEIN; CITRULLINE; DIMETHYLARGININASE; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; S ADENOSYLMETHIONINE;

EID: 4744339386     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/134.10.2842s     Document Type: Conference Paper
Times cited : (313)

References (61)
  • 2
    • 0025283892 scopus 로고
    • Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension
    • Panza, J. A., Quyyumi, A. A., Brush, J. E. & Epstein, S. E. (1990) Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N. Engl. J. Med. 323: 22-27.
    • (1990) N. Engl. J. Med. , vol.323 , pp. 22-27
    • Panza, J.A.1    Quyyumi, A.A.2    Brush, J.E.3    Epstein, S.E.4
  • 3
    • 0027367617 scopus 로고
    • Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults
    • Celermajer, D. S., Sorensen, K. E., Georgakopoulos, D., Bull, C., Thomas, O., Robinson, J. & Deanfield, J. E. (1993) Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation 88: 2149-2155.
    • (1993) Circulation , vol.88 , pp. 2149-2155
    • Celermajer, D.S.1    Sorensen, K.E.2    Georgakopoulos, D.3    Bull, C.4    Thomas, O.5    Robinson, J.6    Deanfield, J.E.7
  • 4
    • 0027381832 scopus 로고
    • Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus
    • Johnstone, M. T., Creager, S. J., Scales, K. M., Cusco, J. A., Lee, B. K. & Creager, M. A. (1993) Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. Circulation 88: 2510-2516.
    • (1993) Circulation , vol.88 , pp. 2510-2516
    • Johnstone, M.T.1    Creager, S.J.2    Scales, K.M.3    Cusco, J.A.4    Lee, B.K.5    Creager, M.A.6
  • 5
    • 0031018333 scopus 로고    scopus 로고
    • Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans
    • Tawakol, A., Omland, T., Gerhard, M., Wu, J. T. & Creager, M. A. (1997) Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans. Circulation 95: 1119-1121.
    • (1997) Circulation , vol.95 , pp. 1119-1121
    • Tawakol, A.1    Omland, T.2    Gerhard, M.3    Wu, J.T.4    Creager, M.A.5
  • 7
    • 0026548912 scopus 로고
    • Accumulation of an endogenous inhibitor of NO synthesis in chronic renal failure
    • Vallance, P., Leone, A., Calver, A., Collier, J. & Moncada, S. (1992) Accumulation of an endogenous inhibitor of NO synthesis in chronic renal failure. Lancet 339: 572-575.
    • (1992) Lancet , vol.339 , pp. 572-575
    • Vallance, P.1    Leone, A.2    Calver, A.3    Collier, J.4    Moncada, S.5
  • 8
    • 0026020073 scopus 로고
    • Arginine restores cholinergic relaxation of hypercholesterolemic rabbit thoracic aorta
    • Cooke, J. P., Andon, N. A., Girerd, X. J., Hirsch, A. T. & Creager, M. A. (1991) Arginine restores cholinergic relaxation of hypercholesterolemic rabbit thoracic aorta. Circulation 83: 1057-1062.
    • (1991) Circulation , vol.83 , pp. 1057-1062
    • Cooke, J.P.1    Andon, N.A.2    Girerd, X.J.3    Hirsch, A.T.4    Creager, M.A.5
  • 9
    • 0029124027 scopus 로고
    • Supplementation of hypercholesterolaemic rabbits with L-arginine reduces the vascular release of superoxide anions and restores NO production
    • Böger, R. H., Bode-Böger, S. M., Mügge, A., Kienke, S., Brandes, R., Dwenger, A. & Frölich, J. C. (1995) Supplementation of hypercholesterolaemic rabbits with L-arginine reduces the vascular release of superoxide anions and restores NO production. Atherosclerosis 117: 273-284.
    • (1995) Atherosclerosis , vol.117 , pp. 273-284
    • Böger, R.H.1    Bode-Böger, S.M.2    Mügge, A.3    Kienke, S.4    Brandes, R.5    Dwenger, A.6    Frölich, J.C.7
  • 10
    • 0342378190 scopus 로고    scopus 로고
    • Dietary L-arginine slows the progression of atherosclerosis in cholesterol-fed rabbits-comparison with lovastatin
    • Böger, R. H., Bode-Böger, S. M., Phivthong-ngam, L., Böhme, M., Brandes, R. P., Mügge, A. & Frölich, J. C. (1997) Dietary L-arginine slows the progression of atherosclerosis in cholesterol-fed rabbits-comparison with lovastatin. Circulation 96: 1282-1290.
    • (1997) Circulation , vol.96 , pp. 1282-1290
    • Böger, R.H.1    Bode-Böger, S.M.2    Phivthong-Ngam, L.3    Böhme, M.4    Brandes, R.P.5    Mügge, A.6    Frölich, J.C.7
  • 13
    • 0028293434 scopus 로고
    • Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine
    • Tsao, P. S., McEvoy, L. M., Drexler, H., Butcher, E. C. & Cooke, J. P. (1994) Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine. Circulation 89: 2176-218.
    • (1994) Circulation , vol.89 , pp. 2176-2218
    • Tsao, P.S.1    McEvoy, L.M.2    Drexler, H.3    Butcher, E.C.4    Cooke, J.P.5
  • 14
    • 0031821197 scopus 로고    scopus 로고
    • Dietary L-arginine decreases myointimal cell proliferation and vascular leukocyte accumulation in cholesterol-fed rabbits
    • Böger, R. H., Bode-Böger, S. M., Kienke, S., Nafe, R., Stan, A. C. & Frölich, J. C. (1998) Dietary L-arginine decreases myointimal cell proliferation and vascular leukocyte accumulation in cholesterol-fed rabbits. Atherosclerosis 136: 67-77.
    • (1998) Atherosclerosis , vol.136 , pp. 67-77
    • Böger, R.H.1    Bode-Böger, S.M.2    Kienke, S.3    Nafe, R.4    Stan, A.C.5    Frölich, J.C.6
  • 15
    • 0025772530 scopus 로고
    • L-Arginine does not restore endothelial dysfunction in atherosclerotic rabbit aorta in vitro
    • Mügge, A. & Harrison, D. G. (1991) L-Arginine does not restore endothelial dysfunction in atherosclerotic rabbit aorta in vitro. Blood Vessels 28: 354-357.
    • (1991) Blood Vessels , vol.28 , pp. 354-357
    • Mügge, A.1    Harrison, D.G.2
  • 16
    • 0025750850 scopus 로고
    • Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells
    • Pollock, J. S., Förstermann, U., Mitchell, J. A., Warner, T. D., Schmidt, H. H., Nakane, M. & Murad, F. (1991) Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 88: 10480-10484.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 10480-10484
    • Pollock, J.S.1    Förstermann, U.2    Mitchell, J.A.3    Warner, T.D.4    Schmidt, H.H.5    Nakane, M.6    Murad, F.7
  • 18
    • 0026531080 scopus 로고
    • Reduced plasma L-arginine in hypercholesterolemia
    • Jeserich, M., Münzel, T., Just, H. & Drexler, H. (1992) Reduced plasma L-arginine in hypercholesterolemia. Lancet 339: 561.
    • (1992) Lancet , vol.339 , pp. 561
    • Jeserich, M.1    Münzel, T.2    Just, H.3    Drexler, H.4
  • 19
    • 0342757751 scopus 로고    scopus 로고
    • Hypothesis: Endogenous nitric oxide synthase inhibitors are responsible for the L-arginine paradox
    • 23810
    • Tsikas, D., Böger, R. H., Sandmann, J., Bode-Böger, S. M. & Frölich, J. C. (2000) Hypothesis: endogenous nitric oxide synthase inhibitors are responsible for the L-arginine paradox. FEBS Lett. 23810: 1-3.
    • (2000) FEBS Lett. , pp. 1-3
    • Tsikas, D.1    Böger, R.H.2    Sandmann, J.3    Bode-Böger, S.M.4    Frölich, J.C.5
  • 20
    • 0028796920 scopus 로고
    • Effects of an endogenous inhibitor of nitric oxide synthesis on postcapillary venules
    • Kurose, I., Wolf, R., Grisham, M. B. & Granger, D. N. (1995) Effects of an endogenous inhibitor of nitric oxide synthesis on postcapillary venules. Am. J. Physiol. 268: H2224-H2231.
    • (1995) Am. J. Physiol. , vol.268
    • Kurose, I.1    Wolf, R.2    Grisham, M.B.3    Granger, D.N.4
  • 21
    • 0028818990 scopus 로고
    • Response of cerebral blood vesels to an endogenous inhibitor of nitric oxide synthase
    • Faraci, F. M., Brian, J. E. & Heistad, D. D. (1995) Response of cerebral blood vesels to an endogenous inhibitor of nitric oxide synthase. Am. J. Physiol. 269: H1522-H1527.
    • (1995) Am. J. Physiol. , vol.269
    • Faraci, F.M.1    Brian, J.E.2    Heistad, D.D.3
  • 23
  • 25
  • 27
    • 4744347132 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine enhances superoxide production in human endothelial cells
    • abs.
    • Lin, P. S., Böger, R. H., Bode-Böger, S. M., Tsao, P. S. & Cooke, J. P. (1997) Asymmetric dimethylarginine enhances superoxide production in human endothelial cells. Circulation 96 (suppl.): I-45 (abs.).
    • (1997) Circulation , vol.96 , Issue.SUPPL.
    • Lin, P.S.1    Böger, R.H.2    Bode-Böger, S.M.3    Tsao, P.S.4    Cooke, J.P.5
  • 29
    • 0027256181 scopus 로고
    • Effect of local intra-arterial asymmetric dimethylarginine (ADMA) on the forearm arteriolar bed of healthy volunteers
    • Calver, A., Collier, J., Leone, A., Moncada, S. & Vallance, P. (1993) 1993. Effect of local intra-arterial asymmetric dimethylarginine (ADMA) on the forearm arteriolar bed of healthy volunteers. J. Hum. Hypertens. 7: 193-194.
    • (1993) J. Hum. Hypertens. , vol.7 , pp. 193-194
    • Calver, A.1    Collier, J.2    Leone, A.3    Moncada, S.4    Vallance, P.5
  • 30
    • 0041733065 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolised by dimethylarginine dimethylaminohydolase
    • Achan, V., Broadhead, M., Malaki, M., Whitley, G., Leiper, J., MacAllister, R. & Vallance, P. (2003) Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolised by dimethylarginine dimethylaminohydolase. Arterioscler. Thromb. Vasc. Biol. 23: 1455-1459.
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 1455-1459
    • Achan, V.1    Broadhead, M.2    Malaki, M.3    Whitley, G.4    Leiper, J.5    MacAllister, R.6    Vallance, P.7
  • 32
    • 0842347848 scopus 로고    scopus 로고
    • The emerging role of ADMA as a novel cardiovascular risk factor
    • Böger, R. H. (2003) The emerging role of ADMA as a novel cardiovascular risk factor. Cardiovasc. Res. 59: 824-833.
    • (2003) Cardiovasc. Res. , vol.59 , pp. 824-833
    • Böger, R.H.1
  • 33
    • 0032032823 scopus 로고    scopus 로고
    • Protein methylation: A signal event in post-translational modification
    • Aletta, J. M., Cimato, T. R. & Ettinger, M. J. (1998) Protein methylation: a signal event in post-translational modification. Trends Biochem. Sci. 23: 89-91.
    • (1998) Trends Biochem. Sci. , vol.23 , pp. 89-91
    • Aletta, J.M.1    Cimato, T.R.2    Ettinger, M.J.3
  • 34
    • 0344791653 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine plasma concentrations differ in patients with end-stage renal disease: Relationship to treatment method and atherosclerotic disease
    • Kielstein, J. T. Böger, R. H., Bode-Böger, S. M., Schäffer, J., Barbey, M., Koch, K. M. & Frölich, J. C. (1999) Asymmetric dimethylarginine plasma concentrations differ in patients with end-stage renal disease: relationship to treatment method and atherosclerotic disease. J. Am. Soc. Nephrol. 10: 594-600.
    • (1999) J. Am. Soc. Nephrol. , vol.10 , pp. 594-600
    • Kielstein, J.T.1    Böger, R.H.2    Bode-Böger, S.M.3    Schäffer, J.4    Barbey, M.5    Koch, K.M.6    Frölich, J.C.7
  • 36
    • 0028987629 scopus 로고
    • G-dimethylarginine dimethylaminohydrolase in human tissues using a monoclonal antibody
    • G-dimethylarginine dimethylaminohydrolase in human tissues using a monoclonal antibody. J. Biochem. 117: 237-238.
    • (1995) J. Biochem. , vol.117 , pp. 237-238
    • Kimoto, M.1    Whitley, G.S.2    Tsuji, H.3    Ogawa, T.4
  • 37
    • 0033214074 scopus 로고    scopus 로고
    • Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases
    • Leiper, J. M., Santa Maria, J., Chubb, A., MacAllister, R. J., Charles, I. G., Whitley, G. S. & Vallance, P. (1999) Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases. Biochem. J. 343: 209-214.
    • (1999) Biochem. J. , vol.343 , pp. 209-214
    • Leiper, J.M.1    Santa Maria, J.2    Chubb, A.3    MacAllister, R.J.4    Charles, I.G.5    Whitley, G.S.6    Vallance, P.7
  • 38
    • 0033594888 scopus 로고    scopus 로고
    • Novel mechanism for endothelial dysfunction: Dysregulation of dimethylarginine dimethylaminohydrolase
    • Ito, A., Tsao, P. S., Adimoolam, S., Kimoto, M., Ogawa, T. & Cooke, J. P. (1999) Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 99: 3092-3095.
    • (1999) Circulation , vol.99 , pp. 3092-3095
    • Ito, A.1    Tsao, P.S.2    Adimoolam, S.3    Kimoto, M.4    Ogawa, T.5    Cooke, J.P.6
  • 39
    • 0037108966 scopus 로고    scopus 로고
    • S-Nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: Further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase
    • Leiper, J., Murray-Rust, J., McDonald, N. & Vallance, P. (2002) S-Nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase. Proc. Natl. Acad. Sci. U.S.A. 99: 13527-13532.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 13527-13532
    • Leiper, J.1    Murray-Rust, J.2    McDonald, N.3    Vallance, P.4
  • 40
    • 0037216677 scopus 로고    scopus 로고
    • ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia. Effects of L-arginine and B vitamins
    • Sydow, K., Schwedhelm, E., Arakawa, N., Bode-Böger, S. M., Tsikas, D., Hornig, B., Frölich, J. C. & Böger, R. H. (2003) ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia. Effects of L-arginine and B vitamins. Cardiovasc. Res. 57: 244-252.
    • (2003) Cardiovasc. Res. , vol.57 , pp. 244-252
    • Sydow, K.1    Schwedhelm, E.2    Arakawa, N.3    Bode-Böger, S.M.4    Tsikas, D.5    Hornig, B.6    Frölich, J.C.7    Böger, R.H.8
  • 42
    • 0242640310 scopus 로고    scopus 로고
    • Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease
    • Böger, R. H., Bode-Böger, S. M., Thiele, W., Junker, W., Alexander, K. & Frölich, J. C. (1997) Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease. Circulation 95: 2068-2074.
    • (1997) Circulation , vol.95 , pp. 2068-2074
    • Böger, R.H.1    Bode-Böger, S.M.2    Thiele, W.3    Junker, W.4    Alexander, K.5    Frölich, J.C.6
  • 43
  • 45
    • 0032557388 scopus 로고    scopus 로고
    • Increased endogenous nitric oxide synthase inhibitor in patients with congestive heart failure
    • Usui, M., Matsuoka, H., Miyazaki, H., Ueda, S., Okuda, S. & Imaizumi, T. (1998) Increased endogenous nitric oxide synthase inhibitor in patients with congestive heart failure. Life Sci. 62: 2425-2430.
    • (1998) Life Sci. , vol.62 , pp. 2425-2430
    • Usui, M.1    Matsuoka, H.2    Miyazaki, H.3    Ueda, S.4    Okuda, S.5    Imaizumi, T.6
  • 47
    • 0033537633 scopus 로고    scopus 로고
    • Endogenous nitric oxide synthase inhibitor. A novel marker of atherosclerosis
    • Miyazaki, H., Matsuoka, H. & Cooke, J. P. (1999) Endogenous nitric oxide synthase inhibitor. A novel marker of atherosclerosis. Circulation 99: 1141-1146.
    • (1999) Circulation , vol.99 , pp. 1141-1146
    • Miyazaki, H.1    Matsuoka, H.2    Cooke, J.P.3
  • 49
    • 3142552157 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine and the risk of coronary heart disease: Relationship with traditional risk factors as assessed in the multicenter CARDIAC study
    • abs.
    • Böger, R. H., Lenzen, H., Hanefeld, C., Bartling, A., Osterziel, K. J., Kusus, M., Schmidt-Lucke, C., Strödter, D., Berger, J. et al. (2004) Asymmetric dimethylarginine and the risk of coronary heart disease: relationship with traditional risk factors as assessed in the multicenter CARDIAC study. J. Am. Coll. Cardiol. 43 (suppl.): 515A (abs.).
    • (2004) J. Am. Coll. Cardiol. , vol.43 , Issue.SUPPL.
    • Böger, R.H.1    Lenzen, H.2    Hanefeld, C.3    Bartling, A.4    Osterziel, K.J.5    Kusus, M.6    Schmidt-Lucke, C.7    Strödter, D.8    Berger, J.9
  • 50
    • 12244262222 scopus 로고    scopus 로고
    • Asymmetrical dimethylarginine (ADMA) in critically ill patients: High plasma ADMA concentration is an independent risk factor of ICU mortality
    • Nijveldt, R. J., Teerlink, T., van der Hoven, B., Siroen, M. P., Kuik, D. J., Rauwerda, J. A. & van Leeuwen, P. A. (2003) Asymmetrical dimethylarginine (ADMA) in critically ill patients: high plasma ADMA concentration is an independent risk factor of ICU mortality. Clin. Nutr. 22: 23-30.
    • (2003) Clin. Nutr. , vol.22 , pp. 23-30
    • Nijveldt, R.J.1    Teerlink, T.2    Van Der Hoven, B.3    Siroen, M.P.4    Kuik, D.J.5    Rauwerda, J.A.6    Van Leeuwen, P.A.7
  • 51
    • 0142209281 scopus 로고    scopus 로고
    • Plasma levels of asymmetrical dimethylarginine and adverse cardiovascular events after percutaneous coronary intervention
    • Lu, T. M., Ding, Y. A., Lin, S. J., Lee, W. S. & Tai, H. C. (2003) Plasma levels of asymmetrical dimethylarginine and adverse cardiovascular events after percutaneous coronary intervention. Eur. Heart J. 24: 1912-1919.
    • (2003) Eur. Heart J. , vol.24 , pp. 1912-1919
    • Lu, T.M.1    Ding, Y.A.2    Lin, S.J.3    Lee, W.S.4    Tai, H.C.5
  • 52
    • 4243352021 scopus 로고    scopus 로고
    • Plasma levels of ADMA are increased and inversely related to endothelium-mediated vasodilation in patients with chronic heart failure: A new predictor of endothelial dysfunction?
    • abs.
    • Hornig, B., Arakawa, N., Böger, R. H., Bode-Böger, S. M., Frölich, J. C. & Drexler, H. (1998) Plasma levels of ADMA are increased and inversely related to endothelium-mediated vasodilation in patients with chronic heart failure: a new predictor of endothelial dysfunction? Circulation 98 (suppl.): I-318 (abs.).
    • (1998) Circulation , vol.98 , Issue.SUPPL.
    • Hornig, B.1    Arakawa, N.2    Böger, R.H.3    Bode-Böger, S.M.4    Frölich, J.C.5    Drexler, H.6
  • 53
    • 0029093320 scopus 로고
    • Accumulation of endogenous inhibitors for nitric oxide synthesis and decreased content of L-arginine in regenerated endothelial cells
    • Azuma, H., Sato, J., Hamasaki, H., Sugimoto, A., Isotani, E. & Obayashi, S. (1995) Accumulation of endogenous inhibitors for nitric oxide synthesis and decreased content of L-arginine in regenerated endothelial cells. Br. J. Pharmacol. 115: 1001-1004.
    • (1995) Br. J. Pharmacol. , vol.115 , pp. 1001-1004
    • Azuma, H.1    Sato, J.2    Hamasaki, H.3    Sugimoto, A.4    Isotani, E.5    Obayashi, S.6
  • 54
    • 0027477076 scopus 로고
    • Response of human coronary arteries after injury by coronary angioplasty
    • el-Tamimi, H., Davies, G. J., Crea, F. & Maseri, A. (1993) Response of human coronary arteries after injury by coronary angioplasty. J. Am. Coll. Cardiol. 21: 1152-1157.
    • (1993) J. Am. Coll. Cardiol. , vol.21 , pp. 1152-1157
    • El-Tamimi, H.1    Davies, G.J.2    Crea, F.3    Maseri, A.4
  • 55
    • 0030999244 scopus 로고    scopus 로고
    • Local intramural delivery of L-arginine enhances nitric oxide generation and inhibits lesion formation after balloon angioplasty
    • Schwarzacher, S. P., Lim, T. T., Wang, B., Kernoff, R. S., Niebauer, J., Cooke, J. P. & Yeung, A. C. (1997) Local intramural delivery of L-arginine enhances nitric oxide generation and inhibits lesion formation after balloon angioplasty. Circulation 95: 1863-1969.
    • (1997) Circulation , vol.95 , pp. 1863-1969
    • Schwarzacher, S.P.1    Lim, T.T.2    Wang, B.3    Kernoff, R.S.4    Niebauer, J.5    Cooke, J.P.6    Yeung, A.C.7
  • 56
    • 0032584177 scopus 로고    scopus 로고
    • Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
    • Laufs, U., La, F., Plutzky, J. & Liao, J. K. (1998) Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation 97: 1129-1135.
    • (1998) Circulation , vol.97 , pp. 1129-1135
    • Laufs, U.1    La, F.2    Plutzky, J.3    Liao, J.K.4
  • 57
    • 1242295337 scopus 로고    scopus 로고
    • Plasma asymmetric dimethylarginine modifies the effect of pravastatin on myocardial blood flow in young adults
    • Janatuinen, T., Laakso, J., Laaksonen, R., Nuutila, P., Lehtimaki, T., Raitakari, O. T. & Knuuti, J. (2003) 2003. Plasma asymmetric dimethylarginine modifies the effect of pravastatin on myocardial blood flow in young adults. Vasc. Med. 2003; 8: 185-189.
    • (2003) Vasc. Med. , vol.8 , pp. 185-189
    • Janatuinen, T.1    Laakso, J.2    Laaksonen, R.3    Nuutila, P.4    Lehtimaki, T.5    Raitakari, O.T.6    Knuuti, J.7
  • 58
    • 10744232622 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA) modulates endothelial function-therapeutic implications
    • Böger, R. H. (2003) Asymmetric dimethylarginine (ADMA) modulates endothelial function-therapeutic implications [Editorial]. Vasc. Med. 8: 149-151.
    • (2003) Vasc. Med. , vol.8 , pp. 149-151
    • Böger, R.H.1
  • 59
    • 3142590235 scopus 로고    scopus 로고
    • Improvement of endothelium-dependent vasodilation by simvastatin is potentiated by combination with L-arginine in patients with elevated asymmetric dimethylarginine levels
    • abs.
    • Böger, G. I., Maas, R., Schwedhelm, E., Bierend, A., Benndorf, R., Kastner, M., Steenpaß, A., & Böger, R. H. (2004) Improvement of endothelium-dependent vasodilation by simvastatin is potentiated by combination with L-arginine in patients with elevated asymmetric dimethylarginine levels. J. Am. Coll. Cardiol. 43 (suppl.): 525A (abs.).
    • (2004) J. Am. Coll. Cardiol. , vol.43 , Issue.SUPPL.
    • Böger, G.I.1    Maas, R.2    Schwedhelm, E.3    Bierend, A.4    Benndorf, R.5    Kastner, M.6    Steenpaß, A.7    Böger, R.H.8
  • 60
    • 4744364072 scopus 로고    scopus 로고
    • Online
    • ADMA Spiegel [Online]. www.adma-spiegel.de [accessed April 28, 2004].
  • 61
    • 4744352653 scopus 로고    scopus 로고
    • Online
    • DLD Diagnostika [Online]. www.dld-diagnostika.de [accessed April 28, 2004].


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.