Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

Nature

Volumn 404, Issue 6779, 2000, Pages 787-790

  Nishikawa, Takeshi ^a,b   Edelstein, Diane ^a   Du, Xue Liang ^a   Yamagishi, Sho Ichi ^a   Matsumura, Takeshi ^a   Kaneda, Yasufumi ^c   Yorek, Mark A ^d   Beebe, David ^e   Oates, Peter J ^e   Hammes, Hans Peter ^f   Glardino, Ida ^a   Brownlee, Michael ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^c OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^d UNIVERSITY OF IOWA   (United States)

^e PFIZER INC   (United States)

^f JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE REDUCTASE; CYTOCHROME C OXIDASE; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; SORBITOL; SUPEROXIDE; UNCOUPLING PROTEIN 1;

ANIMAL CELL; ARTICLE; ENZYME ACTIVATION; GLUCOSE TRANSPORT SYSTEM; HYPERGLYCEMIA; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PATHOGENESIS; PRIORITY JOURNAL; RESPIRATORY CHAIN;

ANIMALS; ASPARTIC ACID; BLOOD GLUCOSE; CARBONYL CYANIDE M-CHLOROPHENYL HYDRAZONE; CARRIER PROTEINS; CATTLE; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX II; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; GLYCOSYLATION END PRODUCTS, ADVANCED; HYPERGLYCEMIA; ION CHANNELS; MALATES; MEMBRANE PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MULTIENZYME COMPLEXES; NF-KAPPA B; OXIDOREDUCTASES; PROTEIN KINASE C; REACTIVE OXYGEN SPECIES; ROTENONE; SORBITOL; SUCCINATE DEHYDROGENASE; SUPEROXIDE DISMUTASE; THENOYLTRIFLUOROACETONE; UNCOUPLING AGENTS;

ANIMALIA; BOVINAE;

EID: 0034643340     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35008121     Document Type: Article

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