Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis

Circulation Research

Volumn 95, Issue 8, 2004, Pages 830-840

  McMurtry, M Sean ^a   Bonnet, Sebastien ^a   Wu, Xichen ^a   Dyck, Jason R B ^a   Haromy, Alois ^a   Hashimoto, Kyoko ^a   Michelakis, Evangelos D ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF ALBERTA HOSPITAL   (Canada)

Author keywords

Apoptosis; Proliferation; Smooth muscle; Vascular remodeling

Indexed keywords

BROXURIDINE; CASPASE 3; CELL NUCLEUS ANTIGEN; CYTOCHROME C; DICHLOROACETIC ACID; DRINKING WATER; HYDROGEN PEROXIDE; MONOCROTALINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTERY MEDIA; ARTICLE; CELL ASSAY; CELL MEMBRANE DEPOLARIZATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENE TARGETING; GENE THERAPY; HEART RIGHT VENTRICLE HYPERTROPHY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LASER; LUNG VASCULAR RESISTANCE; MICRODISSECTION; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MODULATION; NICK END LABELING; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN SECRETION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; SYSTEMIC VASCULAR RESISTANCE; THICKNESS; UPREGULATION;

ANIMALS; APOPTOSIS; CELL DIVISION; CELLS, CULTURED; DICHLOROACETATE; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION; HEART FAILURE, CONGESTIVE; HEMODYNAMIC PROCESSES; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; KV1.5 POTASSIUM CHANNEL; MITOCHONDRIA; MONOCROTALINE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; ORGAN SPECIFICITY; OXIDATIVE PHOSPHORYLATION; POTASSIUM CHANNELS, VOLTAGE-GATED; PULMONARY ARTERY; RATS; SHAB POTASSIUM CHANNELS; VASCULAR RESISTANCE;

EID: 6344257102     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000145360.16770.9f     Document Type: Article

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