Uric acid-induced endothelial dysfunction is associated with mitochondrial alterations and decreased intracellular ATP concentrations

Nephron - Experimental Nephrology

Volumn 121, Issue 3-4, 2013, Pages

  Sánchez Lozada, Laura Gabriela ^a,d   Lanaspa, Miguel A ^d   Cristóbal García, Magdalena ^a   García Arroyo, Fernando ^a   Soto, Virgilia ^b   Cruz Robles, David ^c   Nakagawa, Takahiko ^a   Yu, Min A ^e   Kang, Duk Hee ^e   Johnson, Richard J ^d  

^a Laboratory of Renal Physiopathology   (Mexico)

^b Pathology Department   (United States)

^c INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^e Ewha Womans University School of Medicine   (South Korea)

Author keywords

Endothelial dysfunction; Mitochondria; Nitric oxide; Uric acid

Indexed keywords

ACONITASE 2; ADENOSINE TRIPHOSPHATE; ENOYL COENZYME A HYDRATASE 1; ENZYME; MITOCHONDRIAL DNA; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; URATE OXIDASE; URIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; GLOMERULOSCLEROSIS; HYPERURICEMIA; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CORTEX; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; ANIMAL; CELL CULTURE; DRUG EFFECTS; HUMAN; INTRACELLULAR FLUID; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TOXICITY; VASCULAR ENDOTHELIUM;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HUMANS; INTRACELLULAR FLUID; MALE; MITOCHONDRIA; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; URIC ACID;

EID: 84870766457     PISSN: None     EISSN: 16602129     Source Type: Journal    
DOI: 10.1159/000345509     Document Type: Article

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