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Volumn 12, Issue 10, 2012, Pages 699-709

Controlling escape from angiogenesis inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

AFLIBERCEPT; ANGIOGENESIS INHIBITOR; AXITINIB; BEVACIZUMAB; BIOLOGICAL MARKER; CABOZANTINIB; EVEROLIMUS; FIRTECAN PEGOL; FORETINIB; MITOXANTRONE; ONARTUZUMAB; PAZOPANIB; PF 04217903; PLERIXAFOR; PREDNISONE; R 428; SEMAPHORIN 3A; SOMATOMEDIN B RECEPTOR; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; SORAFENIB; SUNITINIB; TIVANTINIB; UNCLASSIFIED DRUG; VANDETANIB; VASCULOTROPIN;

EID: 84866693927     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3366     Document Type: Review
Times cited : (238)

References (191)
  • 1
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara, N. & Kerbel, R. S. Angiogenesis as a therapeutic target. Nature 438, 967-974 (2005).
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 2
    • 34047175559 scopus 로고    scopus 로고
    • Targeting VEGF-A to treat cancer and age-related macular degeneration
    • Ferrara, N., Mass, R. D., Campa, C. & Kim, R. Targeting VEGF-A to treat cancer and age-related macular degeneration. Annu. Rev. Med. 58, 491-504 (2007).
    • (2007) Annu. Rev. Med. , vol.58 , pp. 491-504
    • Ferrara, N.1    Mass, R.D.2    Campa, C.3    Kim, R.4
  • 3
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: Mechanisms of anti-tumour activity
    • Ellis, L. M. & Hicklin, D. J. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nature Rev. Cancer 8, 579-591 (2008).
    • (2008) Nature Rev. Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 4
    • 3042548695 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts
    • Inai, T. et al. Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am. J. Pathol. 165, 35-52 (2004).
    • (2004) Am. J. Pathol. , vol.165 , pp. 35-52
    • Inai, T.1
  • 5
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain, R. K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307, 58-62 (2005).
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 6
    • 13444278498 scopus 로고    scopus 로고
    • Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies
    • Gerber, H. P. & Ferrara, N. Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies. Cancer Res. 65, 671-680 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 671-680
    • Gerber, H.P.1    Ferrara, N.2
  • 7
    • 77955123285 scopus 로고    scopus 로고
    • Effects of anti-VEGF treatment duration on tumor growth, tumor regrowth, and treatment efficacy
    • Bagri, A. et al. Effects of anti-VEGF treatment duration on tumor growth, tumor regrowth, and treatment efficacy. Clin. Cancer Res. 16, 3887-3900 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 3887-3900
    • Bagri, A.1
  • 8
    • 79952602636 scopus 로고    scopus 로고
    • In the end what matters most? A review of clinical endpoints in advanced breast cancer
    • Verma, S. et al. In the end what matters most? A review of clinical endpoints in advanced breast cancer. Oncologist 16, 25-35 (2011).
    • (2011) Oncologist , vol.16 , pp. 25-35
    • Verma, S.1
  • 9
    • 79953244361 scopus 로고    scopus 로고
    • Antiangiogenic therapy: Impact on invasion, disease progression, and metastasis
    • Ebos, J. M. & Kerbel, R. S. Antiangiogenic therapy: impact on invasion, disease progression, and metastasis. Nature Rev. Clin. Oncol. 8, 210-221 (2011).
    • (2011) Nature Rev. Clin. Oncol. , vol.8 , pp. 210-221
    • Ebos, J.M.1    Kerbel, R.S.2
  • 10
    • 84860169991 scopus 로고    scopus 로고
    • Bevacizumab-based therapies in the first-line treatment of metastatic colorectal cancer
    • Strickler, J. H. & Hurwitz, H. I. Bevacizumab-based therapies in the first-line treatment of metastatic colorectal cancer. Oncologist 17, 513-524 (2012).
    • (2012) Oncologist , vol.17 , pp. 513-524
    • Strickler, J.H.1    Hurwitz, H.I.2
  • 11
    • 79959986387 scopus 로고    scopus 로고
    • Recent advances in small molecule inhibitors of VEGFR and EGFR signaling pathways
    • Zhong, H. & Bowen, J. P. Recent advances in small molecule inhibitors of VEGFR and EGFR signaling pathways. Curr. Top. Med. Chem. 11, 1571-1590 (2011).
    • (2011) Curr. Top. Med. Chem. , vol.11 , pp. 1571-1590
    • Zhong, H.1    Bowen, J.P.2
  • 12
    • 79955829332 scopus 로고    scopus 로고
    • Development of second-generation VEGFR tyrosine kinase inhibitors: Current status
    • Bhargava, P. & Robinson, M. O. Development of second-generation VEGFR tyrosine kinase inhibitors: current status. Curr. Oncol. Rep. 13, 103-111 (2011).
    • (2011) Curr. Oncol. Rep. , vol.13 , pp. 103-111
    • Bhargava, P.1    Robinson, M.O.2
  • 13
    • 80155142474 scopus 로고    scopus 로고
    • Rapamycin passes the torch: A new generation of mTOR inhibitors
    • Benjamin, D., Colombi, M., Moroni, C. & Hall, M. N. Rapamycin passes the torch: a new generation of mTOR inhibitors. Nature Rev. Drug Discov. 10, 868-880 (2012).
    • (2012) Nature Rev. Drug Discov. , vol.10 , pp. 868-880
    • Benjamin, D.1    Colombi, M.2    Moroni, C.3    Hall, M.N.4
  • 15
    • 79952216582 scopus 로고    scopus 로고
    • Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors
    • Falcon, B. L. et al. Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors. Cancer Res. 71, 1573-1583 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 1573-1583
    • Falcon, B.L.1
  • 16
    • 80051590039 scopus 로고    scopus 로고
    • Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: Distinct from rapamycin
    • Bhagwat, S. V. et al. Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin. Mol. Cancer Ther. 10, 1394-1406 (2011).
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 1394-1406
    • Bhagwat, S.V.1
  • 17
    • 79951864002 scopus 로고    scopus 로고
    • Survival benefit with proapoptotic molecular and pathologic responses from dual targeting of mammalian target of rapamycin and epidermal growth factor receptor in a preclinical model of pancreatic neuroendocrine carcinogenesis
    • Chiu, C. W., Nozawa, H. & Hanahan, D. Survival benefit with proapoptotic molecular and pathologic responses from dual targeting of mammalian target of rapamycin and epidermal growth factor receptor in a preclinical model of pancreatic neuroendocrine carcinogenesis. J. Clin. Oncol. 28, 4425-4433 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 4425-4433
    • Chiu, C.W.1    Nozawa, H.2    Hanahan, D.3
  • 18
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller, K. et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N. Engl. J. Med. 357, 2666-2676 (2007).
    • (2007) N. Engl. J. Med. , vol.357 , pp. 2666-2676
    • Miller, K.1
  • 19
    • 73349120007 scopus 로고    scopus 로고
    • Independent review of E2100: A phase III trial of bevacizumab plus paclitaxel versus paclitaxel in women with metastatic breast cancer
    • Gray, R., Bhattacharya, S., Bowden, C., Miller, K. & Comis, R. L. Independent review of E2100: a phase III trial of bevacizumab plus paclitaxel versus paclitaxel in women with metastatic breast cancer. J. Clin. Oncol. 27, 4966-4972 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 4966-4972
    • Gray, R.1    Bhattacharya, S.2    Bowden, C.3    Miller, K.4    Comis, R.L.5
  • 20
    • 79953874259 scopus 로고    scopus 로고
    • RIBBON-1: Randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer
    • Robert, N. J. et al. RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer. J. Clin. Oncol. 29, 1252-1260 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 1252-1260
    • Robert, N.J.1
  • 21
    • 81155123190 scopus 로고    scopus 로고
    • RIBBON-2: A randomized, double-blind, placebo-controlled, phase III trial evaluating the efficacy and safety of bevacizumab in combination with chemotherapy for second-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
    • Brufsky, A. M. et al. RIBBON-2: a randomized, double-blind, placebo-controlled, phase III trial evaluating the efficacy and safety of bevacizumab in combination with chemotherapy for second-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer. J. Clin. Oncol. 29, 4286-4293 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 4286-4293
    • Brufsky, A.M.1
  • 22
    • 84863726318 scopus 로고    scopus 로고
    • Patients with metastatic breast cancer using bevacizumab as a treatment: Is there still a role for it?
    • Lohmann, A. E. & Chia, S. Patients with metastatic breast cancer using bevacizumab as a treatment: is there still a role for it? Curr. Treat. Options Oncol. 13, 249-262 (2012).
    • (2012) Curr. Treat. Options Oncol. , vol.13 , pp. 249-262
    • Lohmann, A.E.1    Chia, S.2
  • 23
    • 40949111793 scopus 로고    scopus 로고
    • Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab-an Eastern Cooperative Oncology Group Study
    • Dowlati, A., Gray, R., Sandler, A. B., Schiller, J. H. & Johnson, D. H. Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab-an Eastern Cooperative Oncology Group Study. Clin. Cancer Res. 14, 1407-1412 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 1407-1412
    • Dowlati, A.1    Gray, R.2    Sandler, A.B.3    Schiller, J.H.4    Johnson, D.H.5
  • 24
    • 67650380136 scopus 로고    scopus 로고
    • Biomarkers of response and resistance to antiangiogenic therapy
    • Jain, R. K. et al. Biomarkers of response and resistance to antiangiogenic therapy. Nature Rev. Clin. Oncol. 6, 327-338 (2009).
    • (2009) Nature Rev. Clin. Oncol. , vol.6 , pp. 327-338
    • Jain, R.K.1
  • 25
    • 77952673621 scopus 로고    scopus 로고
    • Mechanisms of resistance to anti-angiogenic therapy and development of third-generation anti-angiogenic drug candidates
    • Loges, S., Schmidt, T. & Carmeliet, P. Mechanisms of resistance to anti-angiogenic therapy and development of third-generation anti-angiogenic drug candidates. Genes Cancer 1, 12-25 (2010).
    • (2010) Genes Cancer , vol.1 , pp. 12-25
    • Loges, S.1    Schmidt, T.2    Carmeliet, P.3
  • 26
    • 74949105013 scopus 로고    scopus 로고
    • Biomarkers of antiangiogenic therapy: How do we move from candidate biomarkers to valid biomarkers?
    • Duda, D. G., Ancukiewicz, M. & Jain, R. K. Biomarkers of antiangiogenic therapy: how do we move from candidate biomarkers to valid biomarkers? J. Clin. Oncol. 28, 183-185 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 183-185
    • Duda, D.G.1    Ancukiewicz, M.2    Jain, R.K.3
  • 27
    • 78649537524 scopus 로고    scopus 로고
    • Biomarkers to predict the clinical efficacy of bevacizumab in cancer
    • Jubb, A. M. & Harris, A. L. Biomarkers to predict the clinical efficacy of bevacizumab in cancer. Lancet Oncol. 11, 1172-1183 (2010).
    • (2010) Lancet Oncol. , vol.11 , pp. 1172-1183
    • Jubb, A.M.1    Harris, A.L.2
  • 28
    • 84863897798 scopus 로고    scopus 로고
    • Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: A biomarker evaluation from the AVAGAST randomized phase III trial
    • Van Cutsem, E. et al. Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a biomarker evaluation from the AVAGAST randomized phase III trial. J. Clin. Oncol. 30, 2119-2127 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 2119-2127
    • Van Cutsem, E.1
  • 29
    • 84863092492 scopus 로고    scopus 로고
    • VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: An analysis of data from the AViTA and AVOREN randomised trials
    • Lambrechts, D. et al. VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: an analysis of data from the AViTA and AVOREN randomised trials. Lancet Oncol. 13, 724-733 (2012).
    • (2012) Lancet Oncol. , vol.13 , pp. 724-733
    • Lambrechts, D.1
  • 30
    • 79959944026 scopus 로고    scopus 로고
    • Antiangiogenic therapy, hypoxia, and metastasis: Risky liaisons, or not?
    • De Bock, K., Mazzone, M. & Carmeliet, P. Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not? Nature Rev. Clin. Oncol. 8, 393-404 (2011).
    • (2011) Nature Rev. Clin. Oncol. , vol.8 , pp. 393-404
    • De Bock, K.1    Mazzone, M.2    Carmeliet, P.3
  • 31
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers, G. & Hanahan, D. Modes of resistance to anti-angiogenic therapy. Nature Rev. Cancer 8, 592-603 (2008).
    • (2008) Nature Rev. Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 32
    • 80051659097 scopus 로고    scopus 로고
    • Acquired drug resistance to vascular endothelial growth factor receptor 2 tyrosine kinase inhibitor in human vascular endothelial cells
    • Arao, T. et al. Acquired drug resistance to vascular endothelial growth factor receptor 2 tyrosine kinase inhibitor in human vascular endothelial cells. Anticancer Res. 31, 2787-2796 (2011).
    • (2011) Anticancer Res. , vol.31 , pp. 2787-2796
    • Arao, T.1
  • 33
    • 81155132190 scopus 로고    scopus 로고
    • Tumor-surrogate blood vessel subtypes exhibit differential susceptibility to anti-VEGF therapy
    • Sitohy, B., Nagy, J. A., Jaminet, S. C. & Dvorak, H. F. Tumor-surrogate blood vessel subtypes exhibit differential susceptibility to anti-VEGF therapy. Cancer Res. 71, 7021-7028 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 7021-7028
    • Sitohy, B.1    Nagy, J.A.2    Jaminet, S.C.3    Dvorak, H.F.4
  • 34
    • 84866673261 scopus 로고    scopus 로고
    • Sorafenib exposure decreases over time in patients with hepatocellular carcinoma
    • Arrondeau, J. et al. Sorafenib exposure decreases over time in patients with hepatocellular carcinoma. Invest. New Drugs 30, 2046-2049 (2012).
    • (2012) Invest. New Drugs , vol.30 , pp. 2046-2049
    • Arrondeau, J.1
  • 35
    • 82555189379 scopus 로고    scopus 로고
    • Lysosomal sequestration of sunitinib: A novel mechanism of drug resistance
    • Gotink, K. J. et al. Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance. Clin. Cancer Res. 17, 7337-7346 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 7337-7346
    • Gotink, K.J.1
  • 36
    • 84859266060 scopus 로고    scopus 로고
    • The possible role of chemotherapy in antiangiogenic drug resistance
    • Bocci, G. & Loupakis, F. The possible role of chemotherapy in antiangiogenic drug resistance. Med. Hypotheses 78, 646-648 (2012).
    • (2012) Med. Hypotheses , vol.78 , pp. 646-648
    • Bocci, G.1    Loupakis, F.2
  • 37
    • 56749169353 scopus 로고    scopus 로고
    • Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: Results from a large observational cohort study (BRiTE)
    • Grothey, A. et al. Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE). J. Clin. Oncol. 26, 5326-5334 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 5326-5334
    • Grothey, A.1
  • 38
    • 84866726619 scopus 로고    scopus 로고
    • Survival outcomes of bevacizumab beyond progression in metastatic colorectal cancer patients treated in US community oncology
    • 1 Jun 2012 doi:10.1016/j.clcc.2012.05.005
    • Cartwright, T. H. et al. Survival outcomes of bevacizumab beyond progression in metastatic colorectal cancer patients treated in US community oncology. Clin Colorectal Cancer 1 Jun 2012 (doi:10.1016/j.clcc.2012.05.005).
    • Clin Colorectal Cancer
    • Cartwright, T.H.1
  • 39
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • Chaffer, C. L. & Weinberg, R. A. A perspective on cancer cell metastasis. Science 331, 1559-1564 (2011).
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 40
    • 80054864382 scopus 로고    scopus 로고
    • Reappraising antiangiogenic therapy for breast cancer
    • Kerbel, R. S. Reappraising antiangiogenic therapy for breast cancer. Breast 20, S56-S60 (2011).
    • (2011) Breast , vol.20
    • Kerbel, R.S.1
  • 41
    • 84857951632 scopus 로고    scopus 로고
    • Addition of bevacizumab to first-line chemotherapy in advanced colorectal cancer: A systematic review and meta-analysis, with emphasis on chemotherapy subgroups
    • Macedo, L. T., da Costa Lima, A. B. & Sasse, A. D. Addition of bevacizumab to first-line chemotherapy in advanced colorectal cancer: a systematic review and meta-analysis, with emphasis on chemotherapy subgroups. BMC Cancer 12, 89 (2012).
    • (2012) BMC Cancer , vol.12 , pp. 89
    • MacEdo, L.T.1    Da Costa Lima, A.B.2    Sasse, A.D.3
  • 42
    • 84861190138 scopus 로고    scopus 로고
    • A preclinical and clinical review of aflibercept for the management of cancer
    • Gaya, A. & Tse, V. A preclinical and clinical review of aflibercept for the management of cancer. Cancer Treat. Rev. 38, 484-493 (2012).
    • (2012) Cancer Treat. Rev. , vol.38 , pp. 484-493
    • Gaya, A.1    Tse, V.2
  • 43
    • 0034048358 scopus 로고    scopus 로고
    • Less is more, regularly: Metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice
    • Hanahan, D., Bergers, G. & Bergsland, E. Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice. J. Clin. Invest. 10 5, 1045-1047 (2000).
    • (2000) J. Clin. Invest. , vol.105 , pp. 1045-1047
    • Hanahan, D.1    Bergers, G.2    Bergsland, E.3
  • 44
    • 67349094407 scopus 로고    scopus 로고
    • Improving conventional or low dose metronomic chemotherapy with targeted antiangiogenic drugs
    • Kerbel, R. S. Improving conventional or low dose metronomic chemotherapy with targeted antiangiogenic drugs. Cancer Res. Treat. 39, 150-159 (2007).
    • (2007) Cancer Res. Treat. , vol.39 , pp. 150-159
    • Kerbel, R.S.1
  • 45
    • 84861111904 scopus 로고    scopus 로고
    • Metronomic chemotherapy combined with bevacizumab and erlotinib in patients with metastatic HER2-negative breast cancer: Clinical and biological activity
    • Montagna, E. et al. Metronomic chemotherapy combined with bevacizumab and erlotinib in patients with metastatic HER2-negative breast cancer: clinical and biological activity. Clin. Breast Cancer 12, 207-214 (2012).
    • (2012) Clin. Breast Cancer , vol.12 , pp. 207-214
    • Montagna, E.1
  • 46
    • 60549092506 scopus 로고    scopus 로고
    • Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells
    • Lee, K. et al. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc. Natl Acad. Sci. USA 106, 2353-2358 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 2353-2358
    • Lee, K.1
  • 47
    • 67651166780 scopus 로고    scopus 로고
    • Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition
    • Rapisarda, A. et al. Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition. Mol. Cancer Ther. 8, 1867-1877 (2009).
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 1867-1877
    • Rapisarda, A.1
  • 48
    • 77950815444 scopus 로고    scopus 로고
    • Potent preclinical impact of metronomic low-dose oral topotecan combined with the antiangiogenic drug pazopanib for the treatment of ovarian cancer
    • Hashimoto, K. et al. Potent preclinical impact of metronomic low-dose oral topotecan combined with the antiangiogenic drug pazopanib for the treatment of ovarian cancer. Mol. Cancer Ther. 9, 996-1006 (2010).
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 996-1006
    • Hashimoto, K.1
  • 49
    • 84863364424 scopus 로고    scopus 로고
    • Sunitinib plus paclitaxel in patients with advanced esophageal cancer: A phase II study from the Hoosier Oncology Group
    • Schmitt, J. M. et al. Sunitinib plus paclitaxel in patients with advanced esophageal cancer: a phase II study from the Hoosier Oncology Group. J. Thorac Oncol. 7, 760-763 (2012).
    • (2012) J. Thorac Oncol. , vol.7 , pp. 760-763
    • Schmitt, J.M.1
  • 50
    • 80054683755 scopus 로고    scopus 로고
    • Sunitinib in combination with paclitaxel plus carboplatin in patients with advanced solid tumors: Phase i study results
    • Heath, E. I. et al. Sunitinib in combination with paclitaxel plus carboplatin in patients with advanced solid tumors: phase I study results. Cancer Chemother. Pharmacol. 68, 703-712 (2011).
    • (2011) Cancer Chemother. Pharmacol. , vol.68 , pp. 703-712
    • Heath, E.I.1
  • 51
    • 84856547073 scopus 로고    scopus 로고
    • Gemcitabine plus sorafenib in patients with advanced pancreatic cancer: A phase ii trial of the university of chicago phase II consortium
    • Kindler, H. L. et al. Gemcitabine plus sorafenib in patients with advanced pancreatic cancer: a phase II trial of the University of Chicago Phase II Consortium. Invest. New Drugs 30, 382-386 (2012).
    • (2012) Invest. New Drugs , vol.30 , pp. 382-386
    • Kindler, H.L.1
  • 52
    • 84868107516 scopus 로고    scopus 로고
    • BAYPAN study: A double-blind phase III randomized trial comparing gemcitabine plus sorafenib and gemcitabine plus placebo in patients with advanced pancreatic cancer
    • 5 Jul 2012 doi:10.1093/annonc/mds135
    • Goncalves, A. et al. BAYPAN study: a double-blind phase III randomized trial comparing gemcitabine plus sorafenib and gemcitabine plus placebo in patients with advanced pancreatic cancer. Ann. Oncol. 5 Jul 2012 (doi:10.1093/annonc/mds135).
    • Ann. Oncol.
    • Goncalves, A.1
  • 53
    • 84860625265 scopus 로고    scopus 로고
    • First-line treatment of advanced breast cancer with sunitinib in combination with docetaxel versus docetaxel alone: Results of a prospective, randomized phase III study
    • Bergh, J. et al. First-line treatment of advanced breast cancer with sunitinib in combination with docetaxel versus docetaxel alone: results of a prospective, randomized phase III study. J. Clin. Oncol. 30, 921-929 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 921-929
    • Bergh, J.1
  • 54
    • 79959286206 scopus 로고    scopus 로고
    • Randomized, placebo-controlled, double-blind, phase II study of axitinib plus docetaxel versus docetaxel plus placebo in patients with metastatic breast cancer
    • Rugo, H. S. et al. Randomized, placebo-controlled, double-blind, phase II study of axitinib plus docetaxel versus docetaxel plus placebo in patients with metastatic breast cancer. J. Clin. Oncol. 29, 2459-2465 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 2459-2465
    • Rugo, H.S.1
  • 55
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • Casanovas, O., Hicklin, D. J., Bergers, G. & Hanahan, D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 8, 299-309 (2005).
    • (2005) Cancer Cell , vol.8 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 56
    • 60749124285 scopus 로고    scopus 로고
    • Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade
    • Huang, J. et al. Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade. Int. J. Oncol. 34, 79-87 (2009).
    • (2009) Int. J. Oncol. , vol.34 , pp. 79-87
    • Huang, J.1
  • 57
    • 72249111162 scopus 로고    scopus 로고
    • Anti-FGF2 approaches as a strategy to compensate resistance to anti-VEGF therapy: Long-pentraxin 3 as a novel antiangiogenic FGF2-antagonist
    • Alessi, P. et al. Anti-FGF2 approaches as a strategy to compensate resistance to anti-VEGF therapy: long-pentraxin 3 as a novel antiangiogenic FGF2-antagonist. Eur. Cytokine Netw. 20, 225-234 (2009).
    • (2009) Eur. Cytokine Netw. , vol.20 , pp. 225-234
    • Alessi, P.1
  • 58
    • 79960227968 scopus 로고    scopus 로고
    • VEGF and angiopoietin signaling in tumor angiogenesis and metastasis
    • Saharinen, P., Eklund, L., Pulkki, K., Bono, P. & Alitalo, K. VEGF and angiopoietin signaling in tumor angiogenesis and metastasis. Trends Mol. Med. 17, 347-362 (2011).
    • (2011) Trends Mol. Med. , vol.17 , pp. 347-362
    • Saharinen, P.1    Eklund, L.2    Pulkki, K.3    Bono, P.4    Alitalo, K.5
  • 59
    • 78651461701 scopus 로고    scopus 로고
    • HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF
    • Rolny, C. et al. HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. Cancer Cell 19, 31-44 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 31-44
    • Rolny, C.1
  • 60
    • 84862088276 scopus 로고    scopus 로고
    • Importance of fibroblast growth factor receptor in neovascularization and tumor escape from antiangiogenic therapy
    • Saylor, P. J., Escudier, B. & Michaelson, M. D. Importance of fibroblast growth factor receptor in neovascularization and tumor escape from antiangiogenic therapy. Clin. Genitourin. Cancer 10, 77-83 (2012).
    • (2012) Clin. Genitourin. Cancer , vol.10 , pp. 77-83
    • Saylor, P.J.1    Escudier, B.2    Michaelson, M.D.3
  • 61
    • 48349129069 scopus 로고    scopus 로고
    • Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
    • Tammela, T. et al. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 454, 656-660 (2008).
    • (2008) Nature , vol.454 , pp. 656-660
    • Tammela, T.1
  • 62
    • 63649107910 scopus 로고    scopus 로고
    • Antiangiogenic gene therapy with soluble VEGFR-1,-2, and-3 reduces the growth of solid human ovarian carcinoma in mice
    • Sallinen, H. et al. Antiangiogenic gene therapy with soluble VEGFR-1,-2, and-3 reduces the growth of solid human ovarian carcinoma in mice. Mol. Ther. 17, 278-284 (2009).
    • (2009) Mol. Ther. , vol.17 , pp. 278-284
    • Sallinen, H.1
  • 63
    • 79952960682 scopus 로고    scopus 로고
    • Antiangiogenic therapies: Is VEGF-A inhibition alone enough? Expert Rev
    • Gordon, M. S. Antiangiogenic therapies: is VEGF-A inhibition alone enough? Expert Rev. Anticancer Ther. 11, 485-496 (2011).
    • (2011) Anticancer Ther. , vol.11 , pp. 485-496
    • Gordon, M.S.1
  • 64
    • 61649113720 scopus 로고    scopus 로고
    • Endogenous inhibitors of angiogenesis: A historical review
    • Ribatti, D. Endogenous inhibitors of angiogenesis: a historical review. Leuk. Res. 33, 638-644 (2009).
    • (2009) Leuk. Res. , vol.33 , pp. 638-644
    • Ribatti, D.1
  • 65
    • 77950948813 scopus 로고    scopus 로고
    • Evading tumor evasion: Current concepts and perspectives of anti-angiogenic cancer therapy
    • Abdollahi, A. & Folkman, J. Evading tumor evasion: current concepts and perspectives of anti-angiogenic cancer therapy. Drug Resist. Updat. 13, 16-28 (2010).
    • (2010) Drug Resist. Updat. , vol.13 , pp. 16-28
    • Abdollahi, A.1    Folkman, J.2
  • 66
    • 79956328903 scopus 로고    scopus 로고
    • Molecular mechanisms and clinical applications of angiogenesis
    • Carmeliet, P. & Jain, R. K. Molecular mechanisms and clinical applications of angiogenesis. Nature 473, 298-307 (2011).
    • (2011) Nature , vol.473 , pp. 298-307
    • Carmeliet, P.1    Jain, R.K.2
  • 67
    • 56749174211 scopus 로고    scopus 로고
    • FLT1 and its ligands VEGFB and PlGF: Drug targets for anti-angiogenic therapy?
    • Fischer, C., Mazzone, M., Jonckx, B. & Carmeliet, P. FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy? Nature Rev. Cancer 8, 942-956 (2008).
    • (2008) Nature Rev. Cancer , vol.8 , pp. 942-956
    • Fischer, C.1    Mazzone, M.2    Jonckx, B.3    Carmeliet, P.4
  • 68
    • 77950254591 scopus 로고    scopus 로고
    • Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth
    • Hashizume, H. et al. Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth. Cancer Res. 70, 2213-2223 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 2213-2223
    • Hashizume, H.1
  • 69
    • 35548982639 scopus 로고    scopus 로고
    • Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
    • Fischer, C. et al. Anti-PlGF inhibits growth of VEGF(R)-inhibitor- resistant tumors without affecting healthy vessels. Cell 131, 463-475 (2007).
    • (2007) Cell , vol.131 , pp. 463-475
    • Fischer, C.1
  • 70
    • 77950960449 scopus 로고    scopus 로고
    • Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease
    • Van de Veire, S. et al. Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease. Cell 141, 178-190 (2010).
    • (2010) Cell , vol.141 , pp. 178-190
    • Van De Veire, S.1
  • 71
    • 77950953984 scopus 로고    scopus 로고
    • PlGF blockade does not inhibit angiogenesis during primary tumor growth
    • Bais, C. et al. PlGF blockade does not inhibit angiogenesis during primary tumor growth. Cell 141, 166-177 (2010).
    • (2010) Cell , vol.141 , pp. 166-177
    • Bais, C.1
  • 72
    • 30944452436 scopus 로고    scopus 로고
    • Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: Continued experience of a phase i trial in rectal cancer patients
    • Willett, C. G. et al. Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients. J. Clin. Oncol. 23, 8136-8139 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 8136-8139
    • Willett, C.G.1
  • 73
    • 49249087039 scopus 로고    scopus 로고
    • Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma
    • Rini, B. I. et al. Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma. J. Clin. Oncol. 26, 3743-3748 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 3743-3748
    • Rini, B.I.1
  • 74
    • 33846149645 scopus 로고    scopus 로고
    • AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    • Batchelor, T. T. et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 11, 83-95 (2007).
    • (2007) Cancer Cell , vol.11 , pp. 83-95
    • Batchelor, T.T.1
  • 75
    • 79952271819 scopus 로고    scopus 로고
    • Placental growth factor upregulation is a host response to antiangiogenic therapy
    • Bagley, R. G. et al. Placental growth factor upregulation is a host response to antiangiogenic therapy. Clin. Cancer Res. 17, 976-988 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 976-988
    • Bagley, R.G.1
  • 76
    • 2542628099 scopus 로고    scopus 로고
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
    • Tong, R. T. et al. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res. 64, 3731-3736 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 3731-3736
    • Tong, R.T.1
  • 77
    • 34447121919 scopus 로고    scopus 로고
    • Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy
    • Dickson, P. V. et al. Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy. Clin. Cancer Res. 13, 3942-3950 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , pp. 3942-3950
    • Dickson, P.V.1
  • 78
    • 67649583236 scopus 로고    scopus 로고
    • Differential effect of sunitinib on the distribution of temozolomide in an orthotopic glioma model
    • Zhou, Q. & Gallo, J. M. Differential effect of sunitinib on the distribution of temozolomide in an orthotopic glioma model. Neuro Oncol. 11, 301-310 (2009).
    • (2009) Neuro Oncol. , vol.11 , pp. 301-310
    • Zhou, Q.1    Gallo, J.M.2
  • 79
    • 80455129817 scopus 로고    scopus 로고
    • 3 his-annexin A5 micro-SPECT demonstrates increased cell death by irinotecan during the vascular normalization window caused by bevacizumab
    • 3 His-annexin A5 micro-SPECT demonstrates increased cell death by irinotecan during the vascular normalization window caused by bevacizumab. J. Nucl. Med. 52, 1786-1794 (2011).
    • (2011) J. Nucl. Med. , vol.52 , pp. 1786-1794
    • Vangestel, C.1
  • 80
    • 79960134214 scopus 로고    scopus 로고
    • Time-course imaging of therapeutic functional tumor vascular normalization by antiangiogenic agents
    • Zhang, Q. et al. Time-course imaging of therapeutic functional tumor vascular normalization by antiangiogenic agents. Mol. Cancer Ther. 10, 1173-1184 (2011).
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 1173-1184
    • Zhang, Q.1
  • 81
    • 84862561507 scopus 로고    scopus 로고
    • Bevacizumab-induced alterations in vascular permeability and drug delivery: A novel approach to augment regional chemotherapy for in-transit melanoma
    • Turley, R. S. et al. Bevacizumab-induced alterations in vascular permeability and drug delivery: a novel approach to augment regional chemotherapy for in-transit melanoma. Clin. Cancer Res. 18, 3328-3339 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 3328-3339
    • Turley, R.S.1
  • 82
    • 84863655863 scopus 로고    scopus 로고
    • Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner
    • Chauhan, V. P. et al. Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner. Nature Nanotechnol. 7, 383-388 (2012).
    • (2012) Nature Nanotechnol. , vol.7 , pp. 383-388
    • Chauhan, V.P.1
  • 83
    • 33750360895 scopus 로고    scopus 로고
    • Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: Theory and clinical practice
    • Willett, C. G. et al. Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice. Semin. Oncol. 33, S35-S40 (2006).
    • (2006) Semin. Oncol. , vol.33
    • Willett, C.G.1
  • 85
    • 67649921334 scopus 로고    scopus 로고
    • Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: A multidisciplinary phase II study
    • Willett, C. G. et al. Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study. J. Clin. Oncol. 27, 3020-3026 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 3020-3026
    • Willett, C.G.1
  • 86
    • 34547637867 scopus 로고    scopus 로고
    • Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102
    • Sennino, B. et al. Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102. Cancer Res. 67, 7358-7367 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 7358-7367
    • Sennino, B.1
  • 87
    • 77949494504 scopus 로고    scopus 로고
    • Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma
    • Helfrich, I. et al. Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma. J. Exp. Med. 207, 491-503 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 491-503
    • Helfrich, I.1
  • 88
    • 32944478893 scopus 로고    scopus 로고
    • Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumors
    • Nakahara, T., Norberg, S. M., Shalinsky, D. R., Hu-Lowe, D. D. & McDonald, D. M. Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumors. Cancer Res. 66, 1434-1445 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 1434-1445
    • Nakahara, T.1    Norberg, S.M.2    Shalinsky, D.R.3    Hu-Lowe, D.D.4    McDonald, D.M.5
  • 89
    • 79960924361 scopus 로고    scopus 로고
    • Vascular normalization: A real benefit?
    • Ribatti, D. Vascular normalization: a real benefit? Cancer Chemother. Pharmacol. 68, 275-278 (2011).
    • (2011) Cancer Chemother. Pharmacol. , vol.68 , pp. 275-278
    • Ribatti, D.1
  • 90
    • 84855931910 scopus 로고    scopus 로고
    • Rapid decrease in delivery of chemotherapy to tumors after anti-VEGF therapy: Implications for scheduling of anti-angiogenic drugs
    • Van der Veldt, A. A. et al. Rapid decrease in delivery of chemotherapy to tumors after anti-VEGF therapy: implications for scheduling of anti-angiogenic drugs. Cancer Cell 21, 82-91 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 82-91
    • Van Der Veldt, A.A.1
  • 91
    • 84859156795 scopus 로고    scopus 로고
    • Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model
    • Pastuskovas, C. V. et al. Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model. Mol. Cancer Ther. 11, 752-762 (2012).
    • (2012) Mol. Cancer Ther. , vol.11 , pp. 752-762
    • Pastuskovas, C.V.1
  • 92
    • 0033580889 scopus 로고    scopus 로고
    • Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
    • Holash, J. et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 284, 1994-1998 (1999).
    • (1999) Science , vol.284 , pp. 1994-1998
    • Holash, J.1
  • 93
    • 0033822622 scopus 로고    scopus 로고
    • Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption
    • Rubenstein, J. L. et al. Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. Neoplasia 2, 306-314 (2000).
    • (2000) Neoplasia , vol.2 , pp. 306-314
    • Rubenstein, J.L.1
  • 94
    • 0030722076 scopus 로고    scopus 로고
    • Non-small-cell lung carcinoma tumor growth without morphological evidence of neo-angiogenesis
    • Pezzella, F. et al. Non-small-cell lung carcinoma tumor growth without morphological evidence of neo-angiogenesis. Am. J. Pathol. 151, 1417-1423 (1997).
    • (1997) Am. J. Pathol. , vol.151 , pp. 1417-1423
    • Pezzella, F.1
  • 95
  • 96
    • 0037143739 scopus 로고    scopus 로고
    • Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma
    • Kim, E. S. et al. Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma. Proc. Natl Acad. Sci. USA 99, 11399-11404 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 11399-11404
    • Kim, E.S.1
  • 97
    • 33845877157 scopus 로고    scopus 로고
    • Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
    • Noguera-Troise, I. et al. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 444, 1032-1037 (2006).
    • (2006) Nature , vol.444 , pp. 1032-1037
    • Noguera-Troise, I.1
  • 98
    • 33845907380 scopus 로고    scopus 로고
    • Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
    • Ridgway, J. et al. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 444, 1083-1087 (2006).
    • (2006) Nature , vol.444 , pp. 1083-1087
    • Ridgway, J.1
  • 99
    • 82655164839 scopus 로고    scopus 로고
    • Dll4-Notch signaling as a therapeutic target in tumor angiogenesis
    • Kuhnert, F., Kirshner, J. R. & Thurston, G. Dll4-Notch signaling as a therapeutic target in tumor angiogenesis. Vasc. Cell 3, 20 (2011).
    • (2011) Vasc. Cell , vol.3 , Issue.20
    • Kuhnert, F.1    Kirshner, J.R.2    Thurston, G.3
  • 100
    • 80052803473 scopus 로고    scopus 로고
    • DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo
    • Li, J. L. et al. DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo. Cancer Res. 71, 6073-6083 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 6073-6083
    • Li, J.L.1
  • 101
    • 76749157186 scopus 로고    scopus 로고
    • Chronic DLL4 blockade induces vascular neoplasms
    • Yan, M. et al. Chronic DLL4 blockade induces vascular neoplasms. Nature 463, e6-e7 (2010).
    • (2010) Nature , vol.463
    • Yan, M.1
  • 102
    • 79251473728 scopus 로고    scopus 로고
    • Impact of exploratory biomarkers on the treatment effect of bevacizumab in metastatic breast cancer
    • Jubb, A. M. et al. Impact of exploratory biomarkers on the treatment effect of bevacizumab in metastatic breast cancer. Clin. Cancer Res. 17, 372-381 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 372-381
    • Jubb, A.M.1
  • 103
    • 55949096784 scopus 로고    scopus 로고
    • Role of the microenvironment in tumor growth and in refractoriness/ resistance to anti-angiogenic therapies
    • Shojaei, F. & Ferrara, N. Role of the microenvironment in tumor growth and in refractoriness/resistance to anti-angiogenic therapies. Drug Resist. Updat. 11, 219-230 (2008).
    • (2008) Drug Resist. Updat. , vol.11 , pp. 219-230
    • Shojaei, F.1    Ferrara, N.2
  • 104
    • 77951754469 scopus 로고    scopus 로고
    • Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained
    • Ko, J. S. et al. Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained. Cancer Res. 70, 3526-3536 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 3526-3536
    • Ko, J.S.1
  • 105
    • 79957923609 scopus 로고    scopus 로고
    • Macrophage regulation of tumor angiogenesis: Implications for cancer therapy
    • Squadrito, M. L. & De Palma, M. Macrophage regulation of tumor angiogenesis: implications for cancer therapy. Mol. Aspects Med. 32, 123-145 (2011).
    • (2011) Mol. Aspects Med. , vol.32 , pp. 123-145
    • Squadrito, M.L.1    De Palma, M.2
  • 106
    • 79958052123 scopus 로고    scopus 로고
    • MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy
    • Finke, J. et al. MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy. Int. Immunopharmacol. 11, 856-861 (2011).
    • (2011) Int. Immunopharmacol. , vol.11 , pp. 856-861
    • Finke, J.1
  • 107
    • 84855817522 scopus 로고    scopus 로고
    • Immunology in the clinic review series; Focus on cancer: Tumour-associated macrophages: Undisputed stars of the inflammatory tumour microenvironment
    • Allavena, P. & Mantovani, A. Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment. Clin. Exp. Immunol. 167, 195-205 (2012).
    • (2012) Clin. Exp. Immunol. , vol.167 , pp. 195-205
    • Allavena, P.1    Mantovani, A.2
  • 108
    • 77950931419 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Regulators of the tumor microenvironment
    • Kessenbrock, K., Plaks, V. & Werb, Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141, 52-67 (2010).
    • (2010) Cell , vol.141 , pp. 52-67
    • Kessenbrock, K.1    Plaks, V.2    Werb, Z.3
  • 109
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: Functions of cells recruited to the tumor microenvironment
    • Hanahan, D. & Coussens, L. M. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 21, 309-322 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 110
    • 34547820876 scopus 로고    scopus 로고
    • + myeloid cells
    • + myeloid cells. Nature Biotech. 25, 911-920 (2007).
    • (2007) Nature Biotech. , vol.25 , pp. 911-920
    • Shojaei, F.1
  • 111
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo, A. et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121, 335-348 (2005).
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1
  • 112
    • 76249133170 scopus 로고    scopus 로고
    • Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma
    • Huang, D. et al. Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma. Cancer Res. 70, 1063-1071 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 1063-1071
    • Huang, D.1
  • 113
    • 80052453669 scopus 로고    scopus 로고
    • Anti-VEGF treatment-resistant pancreatic cancers secrete proinflammatory factors that contribute to malignant progression by inducing an EMT cell phenotype
    • Carbone, C. et al. Anti-VEGF treatment-resistant pancreatic cancers secrete proinflammatory factors that contribute to malignant progression by inducing an EMT cell phenotype. Clin. Cancer Res. 17, 5822-5832 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 5822-5832
    • Carbone, C.1
  • 114
    • 79960393113 scopus 로고    scopus 로고
    • reg cells
    • reg cells. Nature 475, 226-230 (2011).
    • (2011) Nature , vol.475 , pp. 226-230
    • Facciabene, A.1
  • 115
    • 70449635893 scopus 로고    scopus 로고
    • Tumor and stromal pathways mediating refractoriness/resistance to anti-angiogenic therapies
    • Crawford, Y. & Ferrara, N. Tumor and stromal pathways mediating refractoriness/resistance to anti-angiogenic therapies. Trends Pharmacol. Sci. 30, 624-630 (2009).
    • (2009) Trends Pharmacol. Sci. , vol.30 , pp. 624-630
    • Crawford, Y.1    Ferrara, N.2
  • 116
    • 80055002232 scopus 로고    scopus 로고
    • Periostin: A putative mediator involved in tumour resistance to anti-angiogenic therapy?
    • Wang, W., Ma, J. L., Jia, W. D. & Xu, G. L. Periostin: a putative mediator involved in tumour resistance to anti-angiogenic therapy? Cell Biol. Int. 35, 1085-1088 (2011).
    • (2011) Cell Biol. Int. , vol.35 , pp. 1085-1088
    • Wang, W.1    Ma, J.L.2    Jia, W.D.3    Xu, G.L.4
  • 117
    • 84862313154 scopus 로고    scopus 로고
    • Cancer-associated-fibroblasts and tumour cells: A diabolic liaison driving cancer progression
    • Cirri, P. & Chiarugi, P. Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression. Cancer Metastasis Rev. 31, 195-208 (2012).
    • (2012) Cancer Metastasis Rev. , vol.31 , pp. 195-208
    • Cirri, P.1    Chiarugi, P.2
  • 118
    • 70350225520 scopus 로고    scopus 로고
    • Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1α, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer
    • Xu, L. et al. Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1α, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer. Cancer Res. 69, 7905-7910 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 7905-7910
    • Xu, L.1
  • 119
    • 77949697909 scopus 로고    scopus 로고
    • Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice
    • Kioi, M. et al. Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J. Clin. Invest. 120, 694-705 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 694-705
    • Kioi, M.1
  • 120
    • 79958107497 scopus 로고    scopus 로고
    • Targeting SDF-1/CXCR4 to inhibit tumour vasculature for treatment of glioblastomas
    • Tseng, D., Vasquez-Medrano, D. A. & Brown, J. M. Targeting SDF-1/CXCR4 to inhibit tumour vasculature for treatment of glioblastomas. Br. J. Cancer 104, 1805-1809 (2011).
    • (2011) Br. J. Cancer , vol.104 , pp. 1805-1809
    • Tseng, D.1    Vasquez-Medrano, D.A.2    Brown, J.M.3
  • 121
    • 77949900433 scopus 로고    scopus 로고
    • Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: Combating tumor evasion of antiangiogenic therapy
    • Priceman, S. J. et al. Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Blood 11 5, 1461-1471 (2010).
    • (2010) Blood , vol.115 , pp. 1461-1471
    • Priceman, S.J.1
  • 122
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
    • Ebos, J. M. et al. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 15, 232-239 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 232-239
    • Ebos, J.M.1
  • 123
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Paez-Ribes, M. et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 15, 220-231 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 220-231
    • Paez-Ribes, M.1
  • 124
    • 84860591982 scopus 로고    scopus 로고
    • Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice
    • Maione, F. et al. Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice. J. Clin. Invest. 122, 1832-1848 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 1832-1848
    • Maione, F.1
  • 125
    • 84863704553 scopus 로고    scopus 로고
    • Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors
    • Sennino, B. et al. Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors. Cancer Discov. 2, 270-287 (2012).
    • (2012) Cancer Discov. , vol.2 , pp. 270-287
    • Sennino, B.1
  • 126
    • 84863754907 scopus 로고    scopus 로고
    • VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex
    • Lu, K. V. et al. VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex. Cancer Cell 22, 21-35 (2012).
    • (2012) Cancer Cell , vol.22 , pp. 21-35
    • Lu, K.V.1
  • 127
    • 84858114637 scopus 로고    scopus 로고
    • Tumour growth inhibition and anti-metastatic activity of a mutated furin-resistant Semaphorin 3E isoform
    • Casazza, A. et al. Tumour growth inhibition and anti-metastatic activity of a mutated furin-resistant Semaphorin 3E isoform. EMBO Mol. Med. 4, 234-250 (2012).
    • (2012) EMBO Mol. Med. , vol.4 , pp. 234-250
    • Casazza, A.1
  • 128
    • 84857407549 scopus 로고    scopus 로고
    • Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia
    • Conley, S. J. et al. Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proc. Natl Acad. Sci. USA 109, 2784-2789 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 2784-2789
    • Conley, S.J.1
  • 129
    • 84855912001 scopus 로고    scopus 로고
    • Pericyte depletion results in hypoxia-associated epithelial-to- mesenchymal transition and metastasis mediated by Met signaling pathway
    • Cooke, V. G. et al. Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by Met signaling pathway. Cancer Cell 21, 66-81 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 66-81
    • Cooke, V.G.1
  • 130
    • 84859423059 scopus 로고    scopus 로고
    • Acceleration of clear cell renal cell carcinoma growth in mice following bevacizumab/Avastin treatment: The role of CXCL cytokines
    • Grepin, R. et al. Acceleration of clear cell renal cell carcinoma growth in mice following bevacizumab/Avastin treatment: the role of CXCL cytokines. Oncogene 31, 1683-1694 (2012).
    • (2012) Oncogene , vol.31 , pp. 1683-1694
    • Grepin, R.1
  • 131
    • 84863725047 scopus 로고    scopus 로고
    • Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model
    • He, S. et al. Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model. J. Pathol. 227, 431-445 (2012).
    • (2012) J. Pathol. , vol.227 , pp. 431-445
    • He, S.1
  • 132
    • 84862776792 scopus 로고    scopus 로고
    • HGF/c-Met pathway is one of the mediators of sunitinib-induced tumor cell type-dependent metastasis
    • Shojaei, F., Simmons, B. H., Lee, J. H., Lappin, P. B. & Christensen, J. G. HGF/c-Met pathway is one of the mediators of sunitinib-induced tumor cell type-dependent metastasis. Cancer Lett. 320, 48-55 (2012).
    • (2012) Cancer Lett. , vol.320 , pp. 48-55
    • Shojaei, F.1    Simmons, B.H.2    Lee, J.H.3    Lappin, P.B.4    Christensen, J.G.5
  • 133
    • 84863715967 scopus 로고    scopus 로고
    • Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumor models
    • Singh, M. et al. Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumor models. J. Pathol. 227, 417-430 (2012).
    • (2012) J. Pathol. , vol.227 , pp. 417-430
    • Singh, M.1
  • 134
    • 84863718886 scopus 로고    scopus 로고
    • Differential drug-class specific metastatic effects following treatment with a panel of angiogenesis inhibitors
    • Chung, A. S. et al. Differential drug-class specific metastatic effects following treatment with a panel of angiogenesis inhibitors. J. Pathol. 227, 404-416 (2012).
    • (2012) J. Pathol. , vol.227 , pp. 404-416
    • Chung, A.S.1
  • 135
    • 70349329537 scopus 로고    scopus 로고
    • Crosstalk in Met receptor oncogenesis
    • Lai, A. Z., Abella, J. V. & Park, M. Crosstalk in Met receptor oncogenesis. Trends Cell Biol. 19, 542-551 (2009).
    • (2009) Trends Cell Biol. , vol.19 , pp. 542-551
    • Lai, A.Z.1    Abella, J.V.2    Park, M.3
  • 136
    • 65749084249 scopus 로고    scopus 로고
    • VEGFR1 (Flt1) regulates Rab4 recycling to control fibronectin polymerization and endothelial vessel branching
    • Jones, M. C. et al. VEGFR1 (Flt1) regulates Rab4 recycling to control fibronectin polymerization and endothelial vessel branching. Traffic 10, 754-766 (2009).
    • (2009) Traffic , vol.10 , pp. 754-766
    • Jones, M.C.1
  • 138
    • 84874786083 scopus 로고    scopus 로고
    • Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion
    • 14 May 2012 doi:10.1038/onc.2012.148
    • Muller, P. A. et al. Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion. Oncogene 14 May 2012 (doi:10.1038/onc. 2012.148).
    • Oncogene
    • Muller, P.A.1
  • 139
    • 69549122382 scopus 로고    scopus 로고
    • Usefulness of HIF-1 imaging for determining optimal timing of combining bevacizumab and radiotherapy
    • Ou, G. et al. Usefulness of HIF-1 imaging for determining optimal timing of combining bevacizumab and radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 75, 463-467 (2009).
    • (2009) Int. J. Radiat. Oncol. Biol. Phys. , vol.75 , pp. 463-467
    • Ou, G.1
  • 140
    • 76349095132 scopus 로고    scopus 로고
    • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    • Semenza, G. L. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29, 625-634 (2010).
    • (2010) Oncogene , vol.29 , pp. 625-634
    • Semenza, G.L.1
  • 141
    • 0041382820 scopus 로고    scopus 로고
    • The hypoxic response of tumors is dependent on their microenvironment
    • Blouw, B. et al. The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell 4, 133-146 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 133-146
    • Blouw, B.1
  • 142
    • 67349129399 scopus 로고    scopus 로고
    • Role of the hypoxic tumor microenvironment in the resistance to anti-angiogenic therapies
    • Rapisarda, A. & Melillo, G. Role of the hypoxic tumor microenvironment in the resistance to anti-angiogenic therapies. Drug Resist. Updat. 12, 74-80 (2009).
    • (2009) Drug Resist. Updat. , vol.12 , pp. 74-80
    • Rapisarda, A.1    Melillo, G.2
  • 143
    • 79957534572 scopus 로고    scopus 로고
    • Targeting hypoxia in cancer therapy
    • Wilson, W. R. & Hay, M. P. Targeting hypoxia in cancer therapy. Nature Rev. Cancer 11, 393-410 (2011).
    • (2011) Nature Rev. Cancer , vol.11 , pp. 393-410
    • Wilson, W.R.1    Hay, M.P.2
  • 144
    • 1242271198 scopus 로고    scopus 로고
    • Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: Mechanism and therapeutic implications
    • Rapisarda, A. et al. Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications. Cancer Res. 64, 1475-1482 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 1475-1482
    • Rapisarda, A.1
  • 145
    • 80052691602 scopus 로고    scopus 로고
    • Potent and sustained inhibition of HIF-1α and downstream genes by a polyethyleneglycol-SN38 conjugate, EZN-2208, results in anti-angiogenic effects
    • Sapra, P. et al. Potent and sustained inhibition of HIF-1α and downstream genes by a polyethyleneglycol-SN38 conjugate, EZN-2208, results in anti-angiogenic effects. Angiogenesis 14, 245-253 (2011).
    • (2011) Angiogenesis , vol.14 , pp. 245-253
    • Sapra, P.1
  • 146
    • 0032169214 scopus 로고    scopus 로고
    • Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1α/ARNT
    • Zelzer, E. et al. Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1α/ARNT. EMBO J. 17, 5085-5094 (1998).
    • (1998) EMBO J. , vol.17 , pp. 5085-5094
    • Zelzer, E.1
  • 147
    • 79959990517 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor blockade reduces tumor angiogenesis and enhances the effects of bevacizumab for a human gastric cancer cell line, MKN45
    • Li, H. et al. Insulin-like growth factor-I receptor blockade reduces tumor angiogenesis and enhances the effects of bevacizumab for a human gastric cancer cell line, MKN45. Cancer 11 7, 3135-3147 (2011).
    • (2011) Cancer , vol.117 , pp. 3135-3147
    • Li, H.1
  • 148
    • 0036559535 scopus 로고    scopus 로고
    • Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis
    • Lopez, T. & Hanahan, D. Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 1, 339-353 (2002).
    • (2002) Cancer Cell , vol.1 , pp. 339-353
    • Lopez, T.1    Hanahan, D.2
  • 149
    • 77953973648 scopus 로고    scopus 로고
    • Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy
    • Ulanet, D. B., Ludwig, D. L., Kahn, C. R. & Hanahan, D. Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy. Proc. Natl Acad. Sci. USA 107, 10791-10798 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 10791-10798
    • Ulanet, D.B.1    Ludwig, D.L.2    Kahn, C.R.3    Hanahan, D.4
  • 150
    • 10744219598 scopus 로고    scopus 로고
    • Regulation of the chemokine receptor CXCR4 by hypoxia
    • Schioppa, T. et al. Regulation of the chemokine receptor CXCR4 by hypoxia. J. Exp. Med. 198, 1391-1402 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 1391-1402
    • Schioppa, T.1
  • 151
    • 0037478437 scopus 로고    scopus 로고
    • Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
    • Pennacchietti, S. et al. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 3, 347-361 (2003).
    • (2003) Cancer Cell , vol.3 , pp. 347-361
    • Pennacchietti, S.1
  • 152
    • 33646365644 scopus 로고    scopus 로고
    • Lysyl oxidase is essential for hypoxia-induced metastasis
    • Erler, J. T. et al. Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 440, 1222-1226 (2006).
    • (2006) Nature , vol.440 , pp. 1222-1226
    • Erler, J.T.1
  • 154
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery, J. P., Acloque, H., Huang, R. Y. & Nieto, M. A. Epithelial-mesenchymal transitions in development and disease. Cell 139, 871-890 (2009).
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 155
    • 77952902430 scopus 로고    scopus 로고
    • Mechanisms of motility in metastasizing cells
    • Yilmaz, M. & Christofori, G. Mechanisms of motility in metastasizing cells. Mol. Cancer Res. 8, 629-642 (2010).
    • (2010) Mol. Cancer Res. , vol.8 , pp. 629-642
    • Yilmaz, M.1    Christofori, G.2
  • 156
    • 60649116273 scopus 로고    scopus 로고
    • Antiangiogenic therapy using bevacizumab in recurrent high-grade glioma: Impact on local control and patient survival
    • Narayana, A. et al. Antiangiogenic therapy using bevacizumab in recurrent high-grade glioma: impact on local control and patient survival. J. Neurosurg. 1 1 0, 173-180 (2009).
    • (2009) J. Neurosurg. , vol.110 , pp. 173-180
    • Narayana, A.1
  • 157
    • 77957109253 scopus 로고    scopus 로고
    • An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies
    • Ye, X. et al. An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies. Oncogene 29, 5254-5264 (2010).
    • (2010) Oncogene , vol.29 , pp. 5254-5264
    • Ye, X.1
  • 158
    • 79960408937 scopus 로고    scopus 로고
    • VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer
    • You, W. K. et al. VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res. 71, 4758-4768 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 4758-4768
    • You, W.K.1
  • 159
    • 83355166909 scopus 로고    scopus 로고
    • Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth
    • Yakes, F. M. et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol. Cancer Ther. 10, 2298-2308 (2011).
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 2298-2308
    • Yakes, F.M.1
  • 160
    • 75749115996 scopus 로고    scopus 로고
    • Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival
    • Gjerdrum, C. et al. Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival. Proc. Natl Acad. Sci. USA 107, 1124-1129 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 1124-1129
    • Gjerdrum, C.1
  • 161
    • 46449103344 scopus 로고    scopus 로고
    • TAM receptor tyrosine kinases: Biologic functions, signaling, and potential therapeutic targeting in human cancer
    • Linger, R. M., Keating, A. K., Earp, H. S. & Graham, D. K. TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer. Adv. Cancer Res. 100, 35-83 (2008).
    • (2008) Adv. Cancer Res. , vol.100 , pp. 35-83
    • Linger, R.M.1    Keating, A.K.2    Earp, H.S.3    Graham, D.K.4
  • 162
    • 76749123429 scopus 로고    scopus 로고
    • R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer
    • Holland, S. J. et al. R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res. 70, 1544-1554 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 1544-1554
    • Holland, S.J.1
  • 163
    • 80053571555 scopus 로고    scopus 로고
    • Cabozantinib (XL184) in metastatic castration-resistant prostate cancer (mCRPC): Results from a phase II randomized discontinuation trial
    • Hussain, M. et al. Cabozantinib (XL184) in metastatic castration-resistant prostate cancer (mCRPC): results from a phase II randomized discontinuation trial. J. Clin. Oncol. Abstr. 29, 4516 (2011).
    • (2011) J. Clin. Oncol. Abstr. , vol.29 , pp. 4516
    • Hussain, M.1
  • 164
    • 79959936054 scopus 로고    scopus 로고
    • Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer
    • Kurzrock, R. et al. Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. J. Clin. Oncol. 29, 2660-2666 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 2660-2666
    • Kurzrock, R.1
  • 165
    • 81255195494 scopus 로고    scopus 로고
    • MET and VEGF: Synergistic targets in castration-resistant prostate cancer
    • Aftab, D. T. & McDonald, D. M. MET and VEGF: synergistic targets in castration-resistant prostate cancer. Clin. Transl. Oncol. 13, 703-709 (2011).
    • (2011) Clin. Transl. Oncol. , vol.13 , pp. 703-709
    • Aftab, D.T.1    McDonald, D.M.2
  • 166
    • 84863230043 scopus 로고    scopus 로고
    • Computer-aided quantitative bone scan assessment of prostate cancer treatment response
    • Brown, M. S. et al. Computer-aided quantitative bone scan assessment of prostate cancer treatment response. Nucl. Med. Commun. 33, 384-394 (2012).
    • (2012) Nucl. Med. Commun. , vol.33 , pp. 384-394
    • Brown, M.S.1
  • 167
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak, K. & Weinberg, R. A. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nature Rev. Cancer 9, 265-273 (2009).
    • (2009) Nature Rev. Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 168
    • 74949090309 scopus 로고    scopus 로고
    • The therapeutic promise of the cancer stem cell concept
    • Frank, N. Y., Schatton, T. & Frank, M. H. The therapeutic promise of the cancer stem cell concept. J. Clin. Invest. 120, 41-50 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 41-50
    • Frank, N.Y.1    Schatton, T.2    Frank, M.H.3
  • 169
    • 33745684527 scopus 로고    scopus 로고
    • Metastasis: A question of life or death
    • Mehlen, P. & Puisieux, A. Metastasis: a question of life or death. Nature Rev. Cancer 6, 449-458 (2006).
    • (2006) Nature Rev. Cancer , vol.6 , pp. 449-458
    • Mehlen, P.1    Puisieux, A.2
  • 170
    • 79551521053 scopus 로고    scopus 로고
    • Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: Results of NSABP protocol C-08
    • Allegra, C. J. et al. Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: results of NSABP protocol C-08. J. Clin. Oncol. 29, 11-16 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 11-16
    • Allegra, C.J.1
  • 171
    • 84856088337 scopus 로고    scopus 로고
    • EMT and dissemination precede pancreatic tumor formation
    • Rhim, A. D. et al. EMT and dissemination precede pancreatic tumor formation. Cell 148, 349-361 (2012).
    • (2012) Cell , vol.148 , pp. 349-361
    • Rhim, A.D.1
  • 172
    • 33749441325 scopus 로고    scopus 로고
    • Rapid vascular regrowth in tumors after reversal of VEGF inhibition
    • Mancuso, M. R. et al. Rapid vascular regrowth in tumors after reversal of VEGF inhibition. J. Clin. Invest. 11 6, 2610-2621 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 2610-2621
    • Mancuso, M.R.1
  • 173
    • 50849089255 scopus 로고    scopus 로고
    • Reversible tumor growth acceleration following bevacizumab interruption in metastatic colorectal cancer patients scheduled for surgery
    • Cacheux, W. et al. Reversible tumor growth acceleration following bevacizumab interruption in metastatic colorectal cancer patients scheduled for surgery. Ann. Oncol. 19, 1659-1661 (2008).
    • (2008) Ann. Oncol. , vol.19 , pp. 1659-1661
    • Cacheux, W.1
  • 174
    • 79959765946 scopus 로고    scopus 로고
    • DCE-MRI biomarkers of tumour heterogeneity predict CRC liver metastasis shrinkage following bevacizumab and FOLFOX-6
    • O'Connor, J. P. et al. DCE-MRI biomarkers of tumour heterogeneity predict CRC liver metastasis shrinkage following bevacizumab and FOLFOX-6. Br. J. Cancer 105, 139-145 (2011).
    • (2011) Br. J. Cancer , vol.105 , pp. 139-145
    • O'Connor, J.P.1
  • 175
    • 79952031192 scopus 로고    scopus 로고
    • First-line erlotinib and bevacizumab in patients with locally advanced and/or metastatic non-small-cell lung cancer: A phase II study including molecular imaging
    • Dingemans, A. M. et al. First-line erlotinib and bevacizumab in patients with locally advanced and/or metastatic non-small-cell lung cancer: a phase II study including molecular imaging. Ann. Oncol. 22, 559-566 (2011).
    • (2011) Ann. Oncol. , vol.22 , pp. 559-566
    • Dingemans, A.M.1
  • 176
    • 79953734435 scopus 로고    scopus 로고
    • Correlation of biological aggressiveness assessed by 11C-methionine PET and hypoxic burden assessed by 18F-fluoromisonidazole PET in newly diagnosed glioblastoma
    • Kawai, N. et al. Correlation of biological aggressiveness assessed by 11C-methionine PET and hypoxic burden assessed by 18F-fluoromisonidazole PET in newly diagnosed glioblastoma. Eur. J. Nucl. Med. Mol. Imaging 38, 441-450 (2011).
    • (2011) Eur. J. Nucl. Med. Mol. Imaging , vol.38 , pp. 441-450
    • Kawai, N.1
  • 177
    • 84864683637 scopus 로고    scopus 로고
    • 18F-FDOPA and 18F-FLT positron emission tomography parametric response maps predict response in recurrent malignant gliomas treated with bevacizumab
    • Harris, R. J. et al. 18F-FDOPA and 18F-FLT positron emission tomography parametric response maps predict response in recurrent malignant gliomas treated with bevacizumab. Neuro Oncol. 14, 1079-1089 (2012).
    • (2012) Neuro Oncol. , vol.14 , pp. 1079-1089
    • Harris, R.J.1
  • 178
    • 84861460201 scopus 로고    scopus 로고
    • Correlation of Bevacizumab-induced Hypertension and Outcome in the BOXER Study A Phase II Study of Capecitabine Oxaliplatin (CAPOX) Plus Bevacizumab As Peri-operative Treatment in 45 Patients with Poor-risk Colorectal Liver-only Metastases Unsuitable for Upfront Resection
    • Dewdney, A., Cunningham, D., Barbachano, Y. & Chau, I. Correlation of bevacizumab-induced hypertension and outcome in the BOXER study, a phase II study of capecitabine, oxaliplatin (CAPOX) plus bevacizumab as peri-operative treatment in 45 patients with poor-risk colorectal liver-only metastases unsuitable for upfront resection. Br. J. Cancer 106, 1718-1721 (2011).
    • (2011) Br. J. Cancer , vol.106 , pp. 1718-1721
    • Dewdney, A.1    Cunningham, D.2    Barbachano, Y.3    Chau, I.4
  • 179
    • 80053200932 scopus 로고    scopus 로고
    • An observational study of bevacizumab-induced hypertension as a clinical biomarker of antitumor activity
    • Mir, O. et al. An observational study of bevacizumab-induced hypertension as a clinical biomarker of antitumor activity. Oncologist 16, 1325-1332 (2011).
    • (2011) Oncologist , vol.16 , pp. 1325-1332
    • Mir, O.1
  • 180
    • 79951673901 scopus 로고    scopus 로고
    • Hypertension and overall survival in metastatic colorectal cancer patients treated with bevacizumab-containing chemotherapy
    • Osterlund, P. et al. Hypertension and overall survival in metastatic colorectal cancer patients treated with bevacizumab-containing chemotherapy. Br. J. Cancer 104, 599-604 (2011).
    • (2011) Br. J. Cancer , vol.104 , pp. 599-604
    • Osterlund, P.1
  • 181
    • 34547779489 scopus 로고    scopus 로고
    • Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: Modulation of VEGF and VEGF-related proteins
    • DePrimo, S. E. et al. Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins. J. Transl. Med. 5, 32 (2007).
    • (2007) J. Transl. Med. , vol.5 , pp. 32
    • Deprimo, S.E.1
  • 182
    • 59449108734 scopus 로고    scopus 로고
    • VEGF as a marker for outcome among advanced breast cancer patients receiving anti-VEGF therapy with bevacizumab and vinorelbine chemotherapy
    • Burstein, H. J. et al. VEGF as a marker for outcome among advanced breast cancer patients receiving anti-VEGF therapy with bevacizumab and vinorelbine chemotherapy. Clin. Cancer Res. 14, 7871-7877 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 7871-7877
    • Burstein, H.J.1
  • 183
    • 77957570088 scopus 로고    scopus 로고
    • Biomarkers predicting outcome in patients with advanced renal cell carcinoma: Results from sorafenib phase III treatment approaches in renal cancer global evaluation trial
    • Pena, C., Lathia, C., Shan, M., Escudier, B. & Bukowski, R. M. Biomarkers predicting outcome in patients with advanced renal cell carcinoma: results from sorafenib phase III treatment approaches in renal cancer global evaluation trial. Clin. Cancer Res. 16, 4853-4863 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 4853-4863
    • Pena, C.1    Lathia, C.2    Shan, M.3    Escudier, B.4    Bukowski, R.M.5
  • 184
    • 77950243445 scopus 로고    scopus 로고
    • Plasma cytokine and angiogenic factor profiling identifies markers associated with tumor shrinkage in early-stage non-small cell lung cancer patients treated with pazopanib
    • Nikolinakos, P. G. et al. Plasma cytokine and angiogenic factor profiling identifies markers associated with tumor shrinkage in early-stage non-small cell lung cancer patients treated with pazopanib. Cancer Res. 70, 2171-2179 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 2171-2179
    • Nikolinakos, P.G.1
  • 185
    • 75749096309 scopus 로고    scopus 로고
    • Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: Efficacy and circulating angiogenic biomarkers associated with therapeutic resistance
    • Kopetz, S. et al. Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: efficacy and circulating angiogenic biomarkers associated with therapeutic resistance. J. Clin. Oncol. 28, 453-459 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 453-459
    • Kopetz, S.1
  • 186
    • 54449099774 scopus 로고    scopus 로고
    • Metronomic cyclophosphamide and capecitabine combined with bevacizumab in advanced breast cancer
    • Dellapasqua, S. et al. Metronomic cyclophosphamide and capecitabine combined with bevacizumab in advanced breast cancer. J. Clin. Oncol. 26, 4899-4905 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 4899-4905
    • Dellapasqua, S.1
  • 187
    • 78649484648 scopus 로고    scopus 로고
    • Circulating endothelial cells and endothelial progenitors as predictive markers of clinical response to bevacizumab-based first-line treatment in advanced colorectal cancer patients
    • Ronzoni, M. et al. Circulating endothelial cells and endothelial progenitors as predictive markers of clinical response to bevacizumab-based first-line treatment in advanced colorectal cancer patients. Ann. Oncol. 21, 2382-2389 (2010).
    • (2010) Ann. Oncol. , vol.21 , pp. 2382-2389
    • Ronzoni, M.1
  • 188
    • 84863985437 scopus 로고    scopus 로고
    • A phase II study of lapatinib and bevacizumab as treatment for
    • Rugo, H. S. et al. A phase II study of lapatinib and bevacizumab as treatment for HER2-overexpressing metastatic breast cancer. Breast Cancer Res. Treat. 134, 13-20 (2012).
    • (2012) Breast Cancer Res. Treat. , vol.134 , pp. 13-20
    • Rugo, H.S.1
  • 189
    • 33644863001 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer
    • Wedam, S. B. et al. Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer. J. Clin. Oncol. 24, 769-777 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , pp. 769-777
    • Wedam, S.B.1
  • 190
    • 42549167589 scopus 로고    scopus 로고
    • Circulating biomarkers of bevacizumab activity in patients with breast cancer
    • Denduluri, N. et al. Circulating biomarkers of bevacizumab activity in patients with breast cancer. Cancer Biol. Ther. 7, 15-20 (2008).
    • (2008) Cancer Biol. Ther. , vol.7 , pp. 15-20
    • Denduluri, N.1
  • 191
    • 79955047003 scopus 로고    scopus 로고
    • P53, HER2 and tumor cell apoptosis correlate with clinical outcome after neoadjuvant bevacizumab plus chemotherapy in breast cancer
    • Yang, S. X., Steinberg, S.M., Nguyen, D. & Swain, S.M. p53, HER2 and tumor cell apoptosis correlate with clinical outcome after neoadjuvant bevacizumab plus chemotherapy in breast cancer. Int. J. Oncol. 38, 1445-1452 (2011).
    • (2011) Int. J. Oncol. , vol.38 , pp. 1445-1452
    • Yang, S.X.1    Steinberg, S.M.2    Nguyen, D.3    Swain, S.M.4


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