Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency

Free Radical Biology and Medicine

Volumn 50, Issue 11, 2011, Pages 1639-1646

  Crabtree, Mark J ^a   Hale, Ashley B ^a   Channon, Keith M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Dihydrofolate reductase; eNOS uncoupling; Free radicals; hph 1; Methotrexate; Superoxide; Tetrahydrobiopterin

Indexed keywords

BIOPTERIN; DIHYDROBIOPTERIN; DIHYDROFOLATE REDUCTASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; MESSENGER RNA; METHOTREXATE; NITRIC OXIDE; SMALL INTERFERING RNA; SUPEROXIDE; TETRAHYDROBIOPTERIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; ELECTROCHEMICAL DETECTION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENE OVEREXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KNOCKOUT MOUSE; LOW DRUG DOSE; LUNG HOMOGENATE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; BIOPTERIN; ENDOTHELIUM; METHOTREXATE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NITRIC OXIDE SYNTHASE; OXIDATION-REDUCTION; OXIDATIVE COUPLING; RNA, SMALL INTERFERING; TETRAHYDROFOLATE DEHYDROGENASE; TRANSGENES;

MUS;

EID: 79955613244     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.03.010     Document Type: Article

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