Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus

Diabetologia

Volumn 43, Issue 11, 2000, Pages 1435-1438

  Heitzer, T ^a   Krohn, K ^a   Albers, S ^a   Meinertz, T ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Acetylcholine; Diabetes mellitus; Endothelium; Endothelium dependent vasodilation; N(G) monomethyl L arginine; Nitric oxide; Tetrahydrobiopterin

Indexed keywords

ACETYLCHOLINE; ENDOTHELIUM DERIVED RELAXING FACTOR; NITRIC OXIDE; NITROPRUSSIDE SODIUM; TETRAHYDROBIOPTERIN;

ADULT; ARTICLE; BLOOD VESSEL TONE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FOREARM BLOOD FLOW; HUMAN; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM; VEIN OCCLUSION PLETHYSMOGRAPHY;

ACETYLCHOLINE; BIOPTERIN; BLOOD FLOW VELOCITY; DIABETES MELLITUS, TYPE 2; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; FEMALE; FOREARM; HUMANS; INFUSIONS, INTRA-ARTERIAL; MALE; MIDDLE AGED; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE; OMEGA-N-METHYLARGININE; PLETHYSMOGRAPHY; VASODILATION; VASODILATOR AGENTS;

EID: 0033752910     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051551     Document Type: Article

References (10)

1. Tetrahydrobiopterin restores endothelial function in hypercholesterolemia
2. Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers: Evidence for a dysfunctiohal nitric oxide synthase
3. Acute amelioration of diabetic endothelial dysfunction with a derivative of the nitric oxide synthase cofactor, tetrahydrobiopterin
4. Atherosclerosis and the two faces of endothelial nitric oxide synthase
5. Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta
6. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus
7. Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity
8. 2α and platelet activation in diabetes mellitus: Effects of improved metabolic control and vitamin E supplementation
9. Oxidation of tetrahydrobiopterin by peroxynitrite: Implications for vascular endothelial function
10. Increased nitrotyrosine in the diabetic placenta: Evidence for oxidative stress