Incomplete and transitory decrease of glycolysis: A new paradigm for anti-angiogenic therapy?

Cell Cycle

Volumn 13, Issue 1, 2014, Pages 16-22

  Schoors, Sandra ^a   Cantelmo, Anna Rita ^a   Georgiadou, Maria ^a   Stapor, Peter ^a   Wang, Xingwu ^a   Quaegebeur, Annelies ^a   Cauwenberghs, Sandra ^a   Wong, Brian W ^a   Bifari, Francesco ^a   Decimo, Ilaria ^a   Schoonjans, Luc ^a   De Bock, Katrien ^a   Dewerchin, Mieke ^a   Carmeliet, Peter ^a  

^a Vesalius Research Center   (Belgium)

Author keywords

Angiogenesis; Endothelial cell; Glycolysis; Metabolism; Vessel sprouting

Indexed keywords

3 (3 PYRIDINYL) 1 (4 PYRIDINYL) 2 PROPEN 1 ONE; ADENOSINE TRIPHOSPHATE; ANGIOGENESIS INHIBITOR; CAPECITABINE; CISPLATIN; DOXORUBICIN; GLYCOLYTIC ENZYME; PHOSPHOFRUCTOKINASE FRUCTOSE 2,6 BIPHOSPHATASE 3; SORAFENIB; TRANSCRIPTION FACTOR ERG; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTIANGIOGENIC THERAPY; ARTICLE; BLASTOCYST; BONE MARROW SUPPRESSION; CELL ELONGATION; CELL METABOLISM; CELL MIGRATION; CELL PROLIFERATION; EMBRYONIC STEM CELL; ENDOTHELIUM CELL; GENE OVEREXPRESSION; GLYCOLYSIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PHENOTYPE; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TIME LAPSE IMAGING; TUMOR SPHEROID; WILD TYPE;

ANGIOGENESIS; ENDOTHELIAL CELL; GLYCOLYSIS; METABOLISM; VESSEL SPROUTING;

ANIMALS; BLOOD VESSELS; CELL LINEAGE; CELL PROLIFERATION; ENDOTHELIAL CELLS; GLYCOLYSIS; HUMANS; MICE; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHOFRUCTOKINASE-2; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 84892599925     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.27519     Document Type: Article

References (26)

1. Potente M, Gerhardt H, Carmeliet P. Basic and therapeutic aspects of angiogenesis. Cell 2011; 146:873-87; PMID:21925313; http://dx.doi.org/10.1016/j. cell.2011.08.039
2. Ebos JM, Kerbel RS. Antiangiogenic therapy: impact on invasion, disease progression, and metastasis. Nat Rev Clin Oncol 2011; 8: 210-21; PMID:21364524; http://dx.doi.org/10.1038/nrclinonc.2011.21
3. Singh M, Ferrara N. Modeling and predicting clinical efficacy for drugs targeting the tumor milieu. Nat Biotechnol 2012; 30: 648-57; PMID:22781694; http://dx.doi.org/10.1038/nbt.2286
4. De Bock K, Georgiadou M, Schoors S, Kuchnio A, Wong BW, Cantelmo AR, Quaegebeur A, Ghesquière B, Cauwenberghs S, Eelen G, et al. Role of PFKFB3-driven glycolysis in vessel sprouting. Cell 2013; 154: 651-63; PMID:23911327; http://dx.doi.org/10.1016/j.cell.2013.06.037
5. Schoors S, De Bock K, Cantelmo AR, Georgiadou M, Ghesquière B, Cauwenberghs S, Kuchnio A, Wong BW, Quaegebeur A, Goveia J, et al. Partial and transient reduction of glycolysis by PFKFB3-blockade reduces pathological angiogenesis. Cell Metab 2013; (accepted); http://dx.doi.org/10.1016/j.cmet. 2013.11.008
6. De Bock K, Georgiadou M, Carmeliet P. Role of endothelial cell metabolism in vessel sprouting. Cell Metab 2013; 18: 634-47; PMID:23973331; http://dx.doi.org/10.1016/j.cmet.2013.08.001
7. Lunt SY, Vander Heiden MG. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol 2011; 27:441-64; PMID:21985671; http://dx.doi.org/10.1146/annurev-cellbio-092910-154237
8. Almeida A, Bolaños JP, Moncada S. E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation. Proc Natl Acad Sci U S A 2010; 107: 738-41; PMID:20080744; http://dx.doi.org/10. 1073/pnas.0913668107
9. Maître JL, Heisenberg CP. The role of adhesion energy in controlling cell-cell contacts. Curr Opin Cell Biol 2011; 23: 508-14; PMID:21807491; http://dx.doi.org/10.1016/j.ceb.2011.07.004
10. Jakobsson L, Franco CA, Bentley K, Collins RT, Ponsioen B, Aspalter IM, Rosewell I, Busse M, Thurston G, Medvinsky A, et al. Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting. Nat Cell Biol 2010; 12:943-53; PMID:20871601; http://dx.doi.org/10.1038/ncb2103
11. Sola-Penna M, Da Silva D, Coelho WS, Marinho-Carvalho MM, Zancan P. Regulation of mammalian muscle type 6-phosphofructo-1-kinase and its implication for the control of the metabolism. IUBMB Life 2010; 62: 791-6; PMID:21117169; http://dx.doi.org/10.1002/iub.393
12. Clem BF, O'Neal J, Tapolsky G, Clem AL, Imbert-Fernandez Y, Kerr DA 2nd, Klarer AC, Redman R, Miller DM, Trent JO, et al. Targeting 6-phosphofructo-2- kinase (PFKFB3) as a therapeutic strategy against cancer. Mol Cancer Ther 2013; 12: 1461-70; PMID:23674815; http://dx.doi.org/10.1158/1535-7163.MCT-13-0097
13. Rodríguez-Prados JC, Través PG, Cuenca J, Rico D, Aragonés J, Martín-Sanz P, Cascante M, Boscá L. Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation. J Immunol 2010; 185: 605-14; PMID:20498354; http://dx.doi.org/10.4049/jimmunol.0901698
14. Herrero-Mendez A, Almeida A, Fernández E, Maestre C, Moncada S, Bolaños JP. The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1. Nat Cell Biol 2009; 11:747-52; PMID:19448625; http://dx.doi.org/10.1038/ncb1881
15. Rolfe DF, Brown GC. Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiol Rev 1997; 77: 731-58; PMID:9234964 (Pubitemid 27328739)
16. Kilburn DG, Lilly MD, Webb FC. The energetics of mammalian cell growth. J Cell Sci 1969; 4: 645-54; PMID:5817088
17. Locasale JW, Cantley LC. Altered metabolism in cancer. BMC Biol 2010; 8:88; PMID:20598111; http://dx.doi.org/10.1186/1741-7007-8-88
18. Telang S, Clem BF, Klarer AC, Clem AL, Trent JO, Bucala R, Chesney J. Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation. J Transl Med 2012; 10:95; PMID:22591674; http://dx.doi.org/10.1186/ 1479-5876-10-95
19. Clem B, Telang S, Clem A, Yalcin A, Meier J, Simmons A, Rasku MA, Arumugam S, Dean WL, Eaton J, et al. Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol Cancer Ther 2008; 7: 110-20; PMID:18202014; http://dx.doi.org/10.1158/1535- 7163.MCT-07-0482
20. Climent F, Roset F, Repiso A, Pérez de la Ossa P. Red cell glycolytic enzyme disorders caused by mutations: an update. Cardiovasc Hematol Disord Drug Targets 2009; 9: 95-106; PMID:19519368; http://dx.doi.org/10.2174/ 187152909788488636
21. Dirkx R, Meyhi E, Asselberghs S, Reddy J, Baes M, Van Veldhoven PP. oxidation in hepatocyte cultures from mice with peroxisomal gene knockouts. Biochem Biophys Res Commun 2007; 357:718-23; PMID:17442273; http://dx.doi.org/ 10.1016/j.bbrc.2007.03.198 (Pubitemid 46653839)
22. Pospisilik JA, Schramek D, Schnidar H, Cronin SJ, Nehme NT, Zhang X, Knauf C, Cani PD, Aumayr K, Todoric J, et al. Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell 2010; 140:148-60; PMID:20074523; http://dx.doi.org/10.1016/j.cell. 2009.12.027
23. Thathiah A, Spittaels K, Hoffmann M, Staes M, Cohen A, Horré K, Vanbrabant M, Coun F, Baekelandt V, Delacourte A, et al. The orphan G protein-coupled receptor 3 modulates amyloidbeta peptide generation in neurons. Science 2009; 323: 946-51; PMID:19213921; http://dx.doi.org/10.1126/science. 1160649
24. Arbiser JL, Moses MA, Fernandez CA, Ghiso N, Cao Y, Klauber N, Frank D, Brownlee M, Flynn E, Parangi S, et al. Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways. Proc Natl Acad Sci U S A 1997; 94: 861-6; PMID:9023347; http://dx.doi.org/10.1073/pnas.94.3.861 (Pubitemid 27074412)
25. Mazzone M, Dettori D, Leite de Oliveira R, Loges S, Schmidt T, Jonckx B, Tian YM, Lanahan AA, Pollard P, Ruiz de Almodovar C, et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 2009; 136: 839-51; PMID:19217150; http://dx.doi.org/10.1016/j.cell.2009.01.020
26. Zacchigna S, Oh H, Wilsch-Bräuninger M, Missol-Kolka E, Jászai J, Jansen S, Tanimoto N, Tonagel F, Seeliger M, Huttner WB, et al. Loss of the cholesterol-binding protein prominin-1/CD133 causes disk dysmorphogenesis and photoreceptor degeneration. J Neurosci 2009; 29: 2297-308; PMID:19228982; http://dx.doi.org/10.1523/JNEUROSCI.2034-08.2009