Xenobiotic-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models

Archives of Toxicology

Volumn 88, Issue 12, 2014, Pages 2135-2190

  Oesch, F ^a   Fabian, E ^b   Guth, K ^b   Landsiedel, R ^b  

^a Oesch Tox Toxicological Consulting and Expert Opinions GmbH and CoKG   (Germany)

^b BASF SE   (Germany)

Author keywords

Cutaneous xenobiotic metabolism; Guinea pig; Human skin models; Mouse; Pig; Rat; Species differences

Indexed keywords

COSMETIC; ENZYME; ESTERASE; UNCLASSIFIED DRUG; XENOBIOTIC METABOLIZING ENZYME; CYTOCHROME P450; XENOBIOTIC AGENT;

ANIMAL CELL; CONTROLLED STUDY; ENZYME ACTIVITY; GENOTOXICITY; GUINEA PIG; HUMAN; HUMAN CELL; KERATINOCYTE; NONHUMAN; REVIEW; SENSITIZATION; SKIN; SKIN CARE; SKIN CELL; SPECIES DIFFERENCE; XENOBIOTIC METABOLISM; ANIMAL; BIOLOGICAL MODEL; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MOUSE; RAT; SKIN ABSORPTION; TOXICITY TESTING;

CAVIA; RATTUS; SUIDAE;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; GUINEA PIGS; HUMANS; MICE; MODELS, BIOLOGICAL; RATS; SKIN; SKIN ABSORPTION; SPECIES SPECIFICITY; TOXICITY TESTS; XENOBIOTICS;

EID: 84912572371     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1382-8     Document Type: Review

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