Plasma/blood pharmacokinetics and metabolism after dermal exposure to para-aminophenol or para-phenylenediamine

Food and Chemical Toxicology

Volumn 44, Issue 3, 2006, Pages 371-379

  Dressler, William E ^a   Appelqvist, Terence ^b  

^a CIT ^*  (United States)

^b CIT   (France)

Author keywords

Metabolism; N acetyltransferase 1; para Aminophenol, CAS 123 30 8; para Phenylenediamine, CAS 106 50 3; Paracetamol, CAS 103 90 2; Pig; Rat; Skin; Systemic exposure

Indexed keywords

4 AMINOPHENOL; 4 PHENYLENEDIAMINE; ACYLTRANSFERASE; DIAMINE DERIVATIVE; GLUCURONIDE; PARACETAMOL; SULFATE; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; EXPOSURE; FEMALE; HALF LIFE TIME; HUMAN; MALE; METABOLISM; METABOLITE; MINIPIG; NONHUMAN; RADIOACTIVITY; RAT; SAFETY; SKIN; TOXICITY TESTING; TOXICOKINETICS;

ABSORPTION; ADMINISTRATION, ORAL; ADMINISTRATION, TOPICAL; AMINOPHENOLS; ANIMALS; AREA UNDER CURVE; ARYLAMINE N-ACETYLTRANSFERASE; CARBON RADIOISOTOPES; COLORING AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HAIR DYES; HALF-LIFE; ISOENZYMES; MALE; MUTAGENS; PHENYLENEDIAMINES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SWINE; SWINE, MINIATURE;

ANIMALIA; SUS SCROFA;

EID: 28844483830     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2005.08.009     Document Type: Article

References (24)

1. Anon. Compendium of abstracts from long term cancer studies reported by the National Toxicology Program from 1976-1992 Environmental Health Perspectives 101 Suppl. 1 1993
2. K.C. Brown Hair coloring D. Johnson Hair and Hair Care 1997 Marcel Dekker NY 191 215
3. R.A.M. Case, M.E. Hosker, D.B. McDonald, and J.T. Pearson Tumours of the urinary bladder in workmen engaged in the manufacture and use of certain dyestuff intermediates in the British chemical industry. Part 1. The role of aniline, benzidine, alpha-naphthylamine and beta-naphthylamine British Journal of Industrial Medicine 11 1954 75 104
4. G.W. Cleary Transdermal delivery systems: a medical rationale V.P. Shah H.I. Maibach Topical Drug Bioavailability, Bioequivalence and Penetration 1993 Plenum Press New York, USA 17 68
5. ECB, 2003. European Chemicals Bureau, Institute on Health and Consumer Protection. Technical guidance document on risk assessment. Part I, Ispra, Italy, p. 127.
6. K. Golka, V. Prior, M. Blaszkewicz, and H.M. Bolt The enhanced bladder cancer susceptibility of NAT2 slow acetylators towards aromatic amines: a review considering ethnic differences Toxicology Letters 128 2003 229 241
7. D.M. Grant, N.C. Hughes, S.A. Janezic, G.H. Goodfellow, H.J. Chen, A. Gaedigk, V.L. Yu, and R. Grewal Human acetyltransferase polymorphisms Mutation Research 376 1997 61 70
8. J. Green, E. Banks, A. Berrington, S. Darby, H. Deo, and R. Newton N-acetyltransferase 2 and bladder cancer: an overview and consideration of the evidence for gene-environment interaction British Journal of Cancer 83 3 2000 412 417
9. F.P. Guengerich Metabolic activation of carcinogens Pharmacological Therapy 54 1992 17 61
10. D.W. Hein, M.A. Doll, A.J. Fretland, M.A. Leff, S.J. Webb, G.H. Xaio, U.S. Devanaboyina, N.A. Nangju, and Y. Fung Molecular genetics and epidemiology of NAT1 and NAT2 acetylation polymorphisms Cancer Epidemiology, Biomarkers and Prevention 9 2000 29 42
11. 14C]- paraphenylenediamine-containing oxidative hair dye and correlation with in vitro percutaneous absorption in human and pig skin Food Chemical Toxicology 42 2004 1227 1236
12. L.E. Johns, and R.S. Houlston N-acetyltransferase-2 and bladder cancer risk: a meta-analysis Environmental and Molecular Mutagenesis 36 2000 221 227
13. F.F. Kadlubar, M.A. Butler, K.R. Kaderlik, H.-C. Chou, and N. Lang Polymorphisms for aromatic amine metabolism in humans: relevance for human carcinogenesis Environmental Health Perspectives 98 1992 69 74
14. Y. Kawakubo, Y. Yamazoe, R. Kato, and T. Nishikawa High capacity of human skin for N-acetylation of arylamines Skin Pharmacology 3 1990 180 185
15. Y. Kawakubo, H.F. Merck, T. Al Masaoudi, S. Sieben, and B. Bloemeke N-acetylation of paraphenylenediamine in human skin and keratinocytes Journal of Pharmacology and Experimental Therapeutics 292 1 2000 150 155
16. G.J. Nohynek, J.A. Skare, W.J.A. Meuling, D.W. Hein, A.T.H.J. de Bie, and H. Toutain Urinary acetylated metabolites and N-acetyltransferase-2 genotype in human subjects treated with a para-phenylenediamine-containing oxidative hair dye Food and Chemical Toxicology 45 2004 1885 1891
17. G.J. Nohynek, D. Duche, A. Garrigue, P.A. Meunier, H. Toutain, and J. Leclaire Under the skin: biotransformation of para-aminophenol and para-phenylenediamine in reconstructed human epidermis and human hepatocytes Toxicology Letters 158 2005 196 212
18. L. Rehn Blasengeschwülste bei Fuchsinarbeitern Archiv für klinische Chirurgie 50 1895 588 600
19. SCCNFP, 2003. The SCCNFP's Notes of Guidance for Testing of Cosmetic Ingredients and their Safety Evaluation, adopted 20 October 2003. Available from:〈http://europa.eu.int/comm/food/fs/sc/sccp/outcome_en.html〉.
20. H. Schaefer, and T.E. Redelmeier Factors effecting percutaneous penetration H. Schaefer T.E. Redelmeier Skin Barrier 1996 Karger Verlag Basel, Switzerland 153 163
21. L.A. Stanley, J.A. Skare, E. Doyle, R. Powrie, D.D. d'Angelo, and C.R. Elcombe Lack of evidence for metabolism of para-phenylenediamine by human cytochrome P-450 enzymes Toxicology 210 2005 147 157
22. J.J.M. Van de Sandt, A.A.J.J.L. Rutten, and B. Van Ommen Species-specific cutaneous biotransformation of the pesticide propoxur during percutaneous absorption in vitro Toxicology Applied Pharmacology 123 1 1993 144 150
23. I. Walter-Sack, V. Lucknow, R. Guserle, and E. Weber Untersuchungen der relativen Bioverfügbarkeit von Paracetamol nach Gabe von festen und flüssigen oralen Zubereitungen sowie rektalen Applikationsformen Arzneimittelforschung 39 1 1989 719 724
24. J.J. Yourick, and R.L. Bronaugh Percutaneous penetration and metabolism of 2-nitro-p-phenylenediamine in human and fuzzy rat skin Toxicology and Applied Pharmacology 166 1 2000 13 23