메뉴 건너뛰기




Volumn 195, Issue 3, 2004, Pages 278-287

Epidermal CYP2 family cytochromes P450

Author keywords

CYP; Cytochromes P450; Epidermis; Keratinocyte; Skin

Indexed keywords

ARACHIDONIC ACID; BETA NAPHTHOFLAVONE; CYTOCHROME P450; CYTOCHROME P450 2; CYTOCHROME P450 2A6; CYTOCHROME P450 2A7; CYTOCHROME P450 2B6; CYTOCHROME P450 2C18; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 2J2; CYTOCHROME P450 2R1; CYTOCHROME P450 2S1; CYTOCHROME P450 2U1; CYTOCHROME P450 2W1; DEXAMETHASONE; ESTRADIOL; ESTRONE; LINOLEIC ACID; MELATONIN; PROGESTERONE; RETINOIC ACID; RETINOL; SALICYLIC ACID; TESTOSTERONE; TRYPTAMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VITAMIN D;

EID: 1542616893     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2003.09.020     Document Type: Review
Times cited : (71)

References (58)
  • 1
    • 0030575329 scopus 로고    scopus 로고
    • Cytochrome P-450-dependent drug metabolism in skin
    • Ahmad N., Agarwal R., Mukhtar H. Cytochrome P-450-dependent drug metabolism in skin. Clin. Dermatol. 14:1996;407-415.
    • (1996) Clin. Dermatol. , vol.14 , pp. 407-415
    • Ahmad, N.1    Agarwal, R.2    Mukhtar, H.3
  • 3
    • 0035052250 scopus 로고    scopus 로고
    • Expression of multiple cytochromes P450 enzymes and multidrug resistance-associated transport proteins in human skin keratinocytes
    • Baron J.M., Höller D., Schiffer R., Frankenberg S., Neis M., Merk H.F., Jugert F.K. Expression of multiple cytochromes P450 enzymes and multidrug resistance-associated transport proteins in human skin keratinocytes. J. Invest. Dermatol. 116:2001;541-548.
    • (2001) J. Invest. Dermatol. , vol.116 , pp. 541-548
    • Baron, J.M.1    Höller, D.2    Schiffer, R.3    Frankenberg, S.4    Neis, M.5    Merk, H.F.6    Jugert, F.K.7
  • 5
    • 0020059595 scopus 로고
    • Epidermis: A site of drug metabolism in neonatal rat skin
    • Bickers D.R., Dutta-Choudhury T., Mukhtar H. Epidermis: a site of drug metabolism in neonatal rat skin. Mol. Pharmacol. 21:1982;239-247.
    • (1982) Mol. Pharmacol. , vol.21 , pp. 239-247
    • Bickers, D.R.1    Dutta-Choudhury, T.2    Mukhtar, H.3
  • 6
    • 0027404624 scopus 로고
    • Vitamin D, calcium, and epidermal differentiation
    • Bikle D.D., Pillai S. Vitamin D, calcium, and epidermal differentiation. Endocr. Rev. 14:1993;3-19.
    • (1993) Endocr. Rev. , vol.14 , pp. 3-19
    • Bikle, D.D.1    Pillai, S.2
  • 9
    • 0141732321 scopus 로고    scopus 로고
    • De-orphanization of cytochrome P450 2R1: A microsomal vitamin D 25-hydroxylase
    • Cheng J.B., Motola D.L., Mangelsdorf D.J., Russell D.W. De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxylase. J. Biol. Chem. 278:2003;38084-38093.
    • (2003) J. Biol. Chem. , vol.278 , pp. 38084-38093
    • Cheng, J.B.1    Motola, D.L.2    Mangelsdorf, D.J.3    Russell, D.W.4
  • 10
    • 0042352219 scopus 로고    scopus 로고
    • Induction of drug-metabolizing enzymes: A path to the discovery of multiple cytochromes P450
    • Conney A.H. Induction of drug-metabolizing enzymes: a path to the discovery of multiple cytochromes P450. Annu. Rev. Pharmacol. Toxicol. 43:2003;1-30.
    • (2003) Annu. Rev. Pharmacol. Toxicol. , vol.43 , pp. 1-30
    • Conney, A.H.1
  • 11
    • 0028315963 scopus 로고
    • Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors
    • Czerwinski M., McLemore T.L., Gelboin H.V., Gonzalez F.J. Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors. Cancer Res. 54:1994;1085-1091.
    • (1994) Cancer Res. , vol.54 , pp. 1085-1091
    • Czerwinski, M.1    McLemore, T.L.2    Gelboin, H.V.3    Gonzalez, F.J.4
  • 12
    • 0026729695 scopus 로고
    • Multistage carcinogenesis in mouse skin
    • DiGiovanni J. Multistage carcinogenesis in mouse skin. Pharmacol. Ther. 54:1992;63-128.
    • (1992) Pharmacol. Ther. , vol.54 , pp. 63-128
    • Digiovanni, J.1
  • 13
    • 0037478407 scopus 로고    scopus 로고
    • Human hepatic cytochromes P450: Function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts
    • Ding X., Kaminsky L.S. Human hepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annu. Rev. Pharmacol. Toxicol. 43:2003;149-173.
    • (2003) Annu. Rev. Pharmacol. Toxicol. , vol.43 , pp. 149-173
    • Ding, X.1    Kaminsky, L.S.2
  • 14
    • 0028798734 scopus 로고
    • Expression and alternative splicing of the cytochrome P-450 CYP2A7
    • Ding S., Lake B.G., Friedberg T., Wolf C.R. Expression and alternative splicing of the cytochrome P-450 CYP2A7. Biochem. J. 306:1995;161-166.
    • (1995) Biochem. J. , vol.306 , pp. 161-166
    • Ding, S.1    Lake, B.G.2    Friedberg, T.3    Wolf, C.R.4
  • 15
    • 0032811460 scopus 로고    scopus 로고
    • The role of CYP2B6 in human xenobiotic metabolism
    • Ekins S., Wrighton S.A. The role of CYP2B6 in human xenobiotic metabolism. Drug Metab. Rev. 31:1999;719-754.
    • (1999) Drug Metab. Rev. , vol.31 , pp. 719-754
    • Ekins, S.1    Wrighton, S.A.2
  • 16
    • 0034144388 scopus 로고    scopus 로고
    • The human CYP2C locus: A prototype for intergenic and exon repetition splicing events
    • Finta C., Zaphiropoulos P.G. The human CYP2C locus: a prototype for intergenic and exon repetition splicing events. Genomics. 63:2000;433-438.
    • (2000) Genomics , vol.63 , pp. 433-438
    • Finta, C.1    Zaphiropoulos, P.G.2
  • 17
    • 0026440122 scopus 로고
    • Sequence of a novel cytochrome CYP2B cDNA coding for a protein which is expressed in a sebaceous gland, but not in the liver
    • Friedberg T., Grassow M.A., Bartlomowicz-Oesch B., Siegert P., Arand M., Adesnik M., Oesch F. Sequence of a novel cytochrome CYP2B cDNA coding for a protein which is expressed in a sebaceous gland, but not in the liver. Biochem. J. 287:1992;775-783.
    • (1992) Biochem. J. , vol.287 , pp. 775-783
    • Friedberg, T.1    Grassow, M.A.2    Bartlomowicz-Oesch, B.3    Siegert, P.4    Arand, M.5    Adesnik, M.6    Oesch, F.7
  • 18
    • 0035166533 scopus 로고    scopus 로고
    • Cytochrome P450 4A11 in human keratinocytes: Effects of ultraviolet irradiation
    • Gonzalez M.-C., Marteau C., Franchi J., Migliore-Samour D. Cytochrome P450 4A11 in human keratinocytes: effects of ultraviolet irradiation. Br. J. Dermatol. 145:2001;749-757.
    • (2001) Br. J. Dermatol. , vol.145 , pp. 749-757
    • Gonzalez, M.-C.1    Marteau, C.2    Franchi, J.3    Migliore-Samour, D.4
  • 20
    • 0035175053 scopus 로고    scopus 로고
    • Organization, structure, and evolution of the CYP2 gene cluster on human chromosome 19
    • Hoffman S.M.G., Nelson D.R., Keeney D.S. Organization, structure, and evolution of the CYP2 gene cluster on human chromosome 19. Pharmacogenetics. 11:2001;687-698.
    • (2001) Pharmacogenetics , vol.11 , pp. 687-698
    • Hoffman, S.M.G.1    Nelson, D.R.2    Keeney, D.S.3
  • 21
    • 0000143938 scopus 로고
    • Skin as a xenobiotic metabolizing organ
    • Hotchkiss S.A.M. Skin as a xenobiotic metabolizing organ. Prog. Drug Metab. 13:1992;217-262.
    • (1992) Prog. Drug Metab. , vol.13 , pp. 217-262
    • Hotchkiss, S.A.M.1
  • 22
    • 0035885281 scopus 로고    scopus 로고
    • Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450
    • Janmohamed A., Dolphin C.T., Phillips I.R., Shephard E.A. Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450. Biochem. Pharmacol. 62:2001;777-786.
    • (2001) Biochem. Pharmacol. , vol.62 , pp. 777-786
    • Janmohamed, A.1    Dolphin, C.T.2    Phillips, I.R.3    Shephard, E.A.4
  • 23
    • 0028366090 scopus 로고
    • Multiple cytochromes P450 isozymes in murine skin: Induction of P450 1A, 2B, 2E, and 3A by dexamethasone
    • Jugert F.K., Agarwal R., Kuhn A., Bickers D.R., Merk H.F., Mukhtar H. Multiple cytochromes P450 isozymes in murine skin: induction of P450 1A, 2B, 2E, and 3A by dexamethasone. J. Invest. Dermatol. 102:1994;970-975.
    • (1994) J. Invest. Dermatol. , vol.102 , pp. 970-975
    • Jugert, F.K.1    Agarwal, R.2    Kuhn, A.3    Bickers, D.R.4    Merk, H.F.5    Mukhtar, H.6
  • 24
    • 23544451588 scopus 로고
    • Skin metabolism
    • F.N. Marzulli, & H.I. Maibach. New York: Hemisphere Publishing Corp.
    • Kao J., Carver M.P. Skin metabolism. Marzulli F.N., Maibach H.I. Dermatotoxicology. 4th ed. 1991;143-200 Hemisphere Publishing Corp. New York.
    • (1991) Dermatotoxicology 4th Ed. , pp. 143-200
    • Kao, J.1    Carver, M.P.2
  • 26
    • 0033610838 scopus 로고    scopus 로고
    • Differentiating keratinocytes express a novel cytochrome P450 enzyme, CYP2B19, having arachidonate oxygenase activity
    • Keeney D.S., Skinner C., Travers J.B., Capdevila J.H., Nanney L.B., King L.E. Jr., Waterman M.R. Differentiating keratinocytes express a novel cytochrome P450 enzyme, CYP2B19, having arachidonate oxygenase activity. J. Biol. Chem. 273:1998;32071-32079.
    • (1998) J. Biol. Chem. , vol.273 , pp. 32071-32079
    • Keeney, D.S.1    Skinner, C.2    Travers, J.B.3    Capdevila, J.H.4    Nanney, L.B.5    King Jr., L.E.6    Waterman, M.R.7
  • 27
    • 0032502795 scopus 로고    scopus 로고
    • A keratinocyte-specific epoxygenase, CYP2B12, metabolizes arachidonic acid with unusual selectivity, producing a single major epoxyeicosatrienoic acid
    • Keeney D.S., Skinner C., Wei S., Friedberg T., Waterman M.R. A keratinocyte-specific epoxygenase, CYP2B12, metabolizes arachidonic acid with unusual selectivity, producing a single major epoxyeicosatrienoic acid. J. Biol. Chem. 273:1998;9279-9284.
    • (1998) J. Biol. Chem. , vol.273 , pp. 9279-9284
    • Keeney, D.S.1    Skinner, C.2    Wei, S.3    Friedberg, T.4    Waterman, M.R.5
  • 28
    • 0032604625 scopus 로고    scopus 로고
    • Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs
    • Klose T.S., Blaisdell J.A., Goldstein J.A. Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs. J. Biochem. Mol. Toxicol. 13:1999;289-295.
    • (1999) J. Biochem. Mol. Toxicol. , vol.13 , pp. 289-295
    • Klose, T.S.1    Blaisdell, J.A.2    Goldstein, J.A.3
  • 29
    • 0042818179 scopus 로고    scopus 로고
    • Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes
    • Ladd P.A., Du L., Capdevila J.H., Mernaugh R., Keeney D.S. Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes. J. Biol. Chem. 278:2003;35184-35192.
    • (2003) J. Biol. Chem. , vol.278 , pp. 35184-35192
    • Ladd, P.A.1    Du, L.2    Capdevila, J.H.3    Mernaugh, R.4    Keeney, D.S.5
  • 30
    • 0003032331 scopus 로고    scopus 로고
    • Biotransformations in the skin
    • F.N. Marzulli, & H.I. Maibach. New York: Hemisphere Publishing Corp.
    • Merk H.F., Jugert F.K., Frankenberg S. Biotransformations in the skin. Marzulli F.N., Maibach H.I. Dermatotoxicology. 5th ed. 1996;61-73 Hemisphere Publishing Corp. New York.
    • (1996) Dermatotoxicology 5th Ed. , pp. 61-73
    • Merk, H.F.1    Jugert, F.K.2    Frankenberg, S.3
  • 31
    • 0023901028 scopus 로고
    • A novel human cytochrome P450 gene (P450IIB): Chromosomal localization and evidence for alternative splicing
    • Miles J.S., Spurr N.K., Gough A.C., Jowett T., McLaren A.W., Brook J.D., Wolf C.R. A novel human cytochrome P450 gene (P450IIB): chromosomal localization and evidence for alternative splicing. Nucleic Acids Res. 16:1988;5783-5795.
    • (1988) Nucleic Acids Res. , vol.16 , pp. 5783-5795
    • Miles, J.S.1    Spurr, N.K.2    Gough, A.C.3    Jowett, T.4    McLaren, A.W.5    Brook, J.D.6    Wolf, C.R.7
  • 32
    • 0342969963 scopus 로고
    • Cutaneous cytochrome P-450
    • H. Mukhtar. Boca Raton: CRC Press
    • Mukhtar H. Cutaneous cytochrome P-450. Mukhtar H. Pharmacology of the Skin. 1992;139-147 CRC Press, Boca Raton.
    • (1992) Pharmacology of the Skin , pp. 139-147
    • Mukhtar, H.1
  • 33
    • 0037068964 scopus 로고    scopus 로고
    • Clinical importance of the cytochromes P450
    • Nebert D.W., Russell D.W. Clinical importance of the cytochromes P450. Lancet. 360:2002;1155-1162.
    • (2002) Lancet , vol.360 , pp. 1155-1162
    • Nebert, D.W.1    Russell, D.W.2
  • 36
    • 0842312531 scopus 로고    scopus 로고
    • Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, and nomenclature recommendations for genes, pseudogenes, and alternative splice variants
    • (in press)
    • Nelson D.R., Zeldin D., Hoffman S.M.G., Maltais L., Wain H., Nebert D.W. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, and nomenclature recommendations for genes, pseudogenes, and alternative splice variants. Pharmacogenetics. 2004;. (in press).
    • (2004) Pharmacogenetics
    • Nelson, D.R.1    Zeldin, D.2    Hoffman, S.M.G.3    Maltais, L.4    Wain, H.5    Nebert, D.W.6
  • 37
    • 0024349122 scopus 로고
    • Characterization of distinct forms of cytochromes P-450, epoxide metabolizing enzymes and UDP-glucuronosyl transferases in rat skin
    • Pham M.-A., Magdalou J., Totis M., Fournel-Gigleux S., Siest G., Hammock B.D. Characterization of distinct forms of cytochromes P-450, epoxide metabolizing enzymes and UDP-glucuronosyl transferases in rat skin. Biochem. Pharmacol. 38:1989;2187-2194.
    • (1989) Biochem. Pharmacol. , vol.38 , pp. 2187-2194
    • Pham, M.-A.1    Magdalou, J.2    Totis, M.3    Fournel-Gigleux, S.4    Siest, G.5    Hammock, B.D.6
  • 39
    • 0025982954 scopus 로고
    • Distribution of constitutive and polycyclic aromatic hydrocarbon-induced cytochrome P-450 activities in murine epidermal cells that differ in their stages of differentiation
    • B.E. Butterworth, T.J. Slaga, W. Farland, & M. McClain. New York: Wiley
    • Reiners J.J. Jr., Cantu A.R., Pavone A. Distribution of constitutive and polycyclic aromatic hydrocarbon-induced cytochrome P-450 activities in murine epidermal cells that differ in their stages of differentiation. Butterworth B.E., Slaga T.J., Farland W., McClain M. Chemically Induced Cell Proliferation Implications for Risk Assessment. 1991;123-135 Wiley, New York.
    • (1991) Chemically Induced Cell Proliferation Implications for Risk Assessment , pp. 123-135
    • Reiners Jr., J.J.1    Cantu, A.R.2    Pavone, A.3
  • 40
    • 0036223831 scopus 로고    scopus 로고
    • Summary of information on human CYP enzymes: Human P450 metabolism data
    • Rendic S. Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab. Rev. 34(1 and 2):2002;83-448.
    • (2002) Drug Metab. Rev. , vol.34 , Issue.1-2 , pp. 83-448
    • Rendic, S.1
  • 42
    • 0036156514 scopus 로고    scopus 로고
    • Identification of a novel dioxin-inducible cytochrome P450
    • Rivera S.P., Saarikoski S.T., Hankinson O. Identification of a novel dioxin-inducible cytochrome P450. Mol. Pharmacol. 61:2002;255-259.
    • (2002) Mol. Pharmacol. , vol.61 , pp. 255-259
    • Rivera, S.P.1    Saarikoski, S.T.2    Hankinson, O.3
  • 46
    • 0029811581 scopus 로고    scopus 로고
    • Induction of ceramide glucosyltransferase activity in cultured human keratinocytes
    • Sando G.N., Howard E.J., Madison K.C. Induction of ceramide glucosyltransferase activity in cultured human keratinocytes. J. Biol. Chem. 271:1996;22044-22051.
    • (1996) J. Biol. Chem. , vol.271 , pp. 22044-22051
    • Sando, G.N.1    Howard, E.J.2    Madison, K.C.3
  • 47
    • 0033009103 scopus 로고    scopus 로고
    • P450 subfamily CYP2J and their role in bioactivation of arachidonic acid in extrahepatic tissues
    • Scarborough P.E., Ma J., Qu W., Zeldin D.C. P450 subfamily CYP2J and their role in bioactivation of arachidonic acid in extrahepatic tissues. Drug Metab. Rev. 31:1999;205-234.
    • (1999) Drug Metab. Rev. , vol.31 , pp. 205-234
    • Scarborough, P.E.1    Ma, J.2    Qu, W.3    Zeldin, D.C.4
  • 48
    • 0033651177 scopus 로고    scopus 로고
    • Characterization of human CYP2G genes: Widespread loss-of-function mutations and genetic polymorphism
    • Sheng J., Guo J., Hua Z., Caggana M., Ding X. Characterization of human CYP2G genes: widespread loss-of-function mutations and genetic polymorphism. Pharmacogenetics. 10:2000;667-678.
    • (2000) Pharmacogenetics , vol.10 , pp. 667-678
    • Sheng, J.1    Guo, J.2    Hua, Z.3    Caggana, M.4    Ding, X.5
  • 49
    • 0037454384 scopus 로고    scopus 로고
    • Cutaneous expression of cytochrome P450 CYP2S1: Individuality in regulation by therapeutic agents for psoriasis and other skin diseases
    • Smith G., Wolf C.R., Deeni Y.Y., Dawe R.S., Evans A.T., Comrie M.M., Ferguson J., Ibbotson S.H. Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases. Lancet. 361:2003;1336-1343.
    • (2003) Lancet , vol.361 , pp. 1336-1343
    • Smith, G.1    Wolf, C.R.2    Deeni, Y.Y.3    Dawe, R.S.4    Evans, A.T.5    Comrie, M.M.6    Ferguson, J.7    Ibbotson, S.H.8
  • 50
    • 0034802185 scopus 로고    scopus 로고
    • Identification and localization of five CYP2Cs in murine extrahepatic tissues and their metabolism of arachidonic acid to regio- and stereoselective products
    • Tsao C.-C., Coulter S.J., Chen A., Luo G., Clayton N.P., Maronpot R., Goldstein J.A., Zeldin D.C. Identification and localization of five CYP2Cs in murine extrahepatic tissues and their metabolism of arachidonic acid to regio- and stereoselective products. J. Pharmacol. Exp. Ther. 299:2001;39-47.
    • (2001) J. Pharmacol. Exp. Ther. , vol.299 , pp. 39-47
    • Tsao, C.-C.1    Coulter, S.J.2    Chen, A.3    Luo, G.4    Clayton, N.P.5    Maronpot, R.6    Goldstein, J.A.7    Zeldin, D.C.8
  • 51
    • 0032518169 scopus 로고    scopus 로고
    • Cloning and expression of CYP2F3, a cytochrome P450 that bioactivates the selective pneumotoxins 3-methylindole and naphthalene
    • Wang H., Lanza D.L., Yost G.S. Cloning and expression of CYP2F3, a cytochrome P450 that bioactivates the selective pneumotoxins 3-methylindole and naphthalene. Arch. Biochem. Biophys. 349:1998;329-340.
    • (1998) Arch. Biochem. Biophys. , vol.349 , pp. 329-340
    • Wang, H.1    Lanza, D.L.2    Yost, G.S.3
  • 52
    • 0346243562 scopus 로고    scopus 로고
    • Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and a comparison to the syntenic human cluster
    • Wang H., Donley K.M., Keeney D.S., Hoffman S.M.G. Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and a comparison to the syntenic human cluster. Environ. Health Perspect. Toxicogenomics. 111:2003;1835-1842.
    • (2003) Environ. Health Perspect. Toxicogenomics , vol.111 , pp. 1835-1842
    • Wang, H.1    Donley, K.M.2    Keeney, D.S.3    Hoffman, S.M.G.4
  • 53
    • 0034808614 scopus 로고    scopus 로고
    • Intergenic transcripts containing a novel human cytochrome P450 2C exon 1 spliced to sequences from the CYP2C9 gene
    • Warner S.C., Finta C., Zaphiropoulos P.G. Intergenic transcripts containing a novel human cytochrome P450 2C exon 1 spliced to sequences from the CYP2C9 gene. Mol. Biol. Evol. 18:2001;1841-1848.
    • (2001) Mol. Biol. Evol. , vol.18 , pp. 1841-1848
    • Warner, S.C.1    Finta, C.2    Zaphiropoulos, P.G.3
  • 54
    • 0033786280 scopus 로고    scopus 로고
    • Induction of mouse CYP2J by pyrazole in the eye, kidney, liver, lung, olfactory mucosa, and small intestine, but not in the heart
    • Xie Q., Zhang Q.-Y., Zhang Y., Su T., Gu J., Kaminsky L.S., Ding X. Induction of mouse CYP2J by pyrazole in the eye, kidney, liver, lung, olfactory mucosa, and small intestine, but not in the heart. Drug Metab. Dispos. 28:2000;1311-1316.
    • (2000) Drug Metab. Dispos. , vol.28 , pp. 1311-1316
    • Xie, Q.1    Zhang, Q.-Y.2    Zhang, Y.3    Su, T.4    Gu, J.5    Kaminsky, L.S.6    Ding, X.7
  • 55
    • 0024464027 scopus 로고
    • CDNA cloning and sequence and cDNA-directed expression of human P450 IIBI: Identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver
    • Yamano S., Nhamburo P.T., Aoyama T., Meyer U.A., Inaba T., Kalow W., Gelboin H.V., McBride O.W., Gonzalez F.J. cDNA cloning and sequence and cDNA-directed expression of human P450 IIBI: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver. Biochemistry. 28:1989;7340-7348.
    • (1989) Biochemistry , vol.28 , pp. 7340-7348
    • Yamano, S.1    Nhamburo, P.T.2    Aoyama, T.3    Meyer, U.A.4    Inaba, T.5    Kalow, W.6    Gelboin, H.V.7    McBride, O.W.8    Gonzalez, F.J.9
  • 57
    • 0033168090 scopus 로고    scopus 로고
    • RNA molecules containing exons originating from different members of the cytochrome P450 2C gene subfamily (CYP2C) in human epidermis and liver
    • Zaphiropoulos P.G. RNA molecules containing exons originating from different members of the cytochrome P450 2C gene subfamily (CYP2C) in human epidermis and liver. Nucleic Acids Res. 27:1999;2585-2590.
    • (1999) Nucleic Acids Res. , vol.27 , pp. 2585-2590
    • Zaphiropoulos, P.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.